Abstract: The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.

Abstract: A pin arrangement control apparatus, as well as a system therefor, capable of pin arrangement in any arbitrary pin arrangement patterns are implemented only by slightly modifying a pin setter machine equipped with only basic functions for performing the so-called tenpin bowling. A common pin setter machine equipped with means for setting the first-bowl ten pins, and means for gripping and elevating the set pins, sweeping with the rake and then rearranging the pins is additionally equipped with a selective pin gripping mechanism for gripping only pins corresponding to a pin arrangement pattern given from external. Thus, the pin setter machine is capable of pin arrangement in a specified pin arrangement pattern for rearrangement of the second-bowl pins.

Abstract: A bowling center system includes a plurality of lane pair control systems each including a pinsetting device for each lane, a pinsetter control unit, a game control unit, a bowler input station and a pair of overhead display monitors. The game control unit is operable under the control of a game control program stored in a memory for automatically operating the pinsetter control units during game play to selectively set a sequence of pin patterns on the lane, which patterns may comprise any array of pins. The game control unit responsive to pin fall data received from the gamesetter generates scoring information which is displayed using video graphic displays on the overhead monitors. The game control program can be any one of a plurality of different game programs which may be downloaded to the memory from a memory associated with the manager's control terminal.

Abstract: This invention relates to a modification of existing bowling alley pin setting equipment to facilitate bowling practice. The fixed pivot point of the scissor arms, supported by the scissors deck, is movable from a first position, in which the original pivot point of the scissors arms is maintained, to a second position, in which the pivot point is movable to prevent adequate closing of the scissor arms whereby an undesired pin(s) is not clamped by the scissor arms and remains on the bowling surface where it may be swept away by the sweeper during its sweeping motion. All of the necessary pin(s), required for a desired bowling practice pin combination, a clamped and raised by the scissor arms during the resetting cycle. The invention also relates to a control mechanism for controlling movement of the slidable pivot point.