In Response To Location Of Inner Boundary Of Heavy Component Patents (Class 494/3)
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Patent number: 10272448Abstract: A centrifuge for separating food and beverage products can include a base and an outer housing connected to the top end of the base. The outer housing can include an outlet through which liquid may be dispensed. A rotor may be positioned within the outer housing and can include an annular rotor wall an opened top end, and a closed bottom end defining a lower end of the annular rotor wall. A motor can be operably connected to the rotor and configured to rotate the rotor about an axis of rotation at oscillating rotational speeds. The annular rotor wall can extend upward and radially outward with respect to the axis of rotation from the lower end of the annular rotor wall. The annular rotor wall can extend downward and radially outward with respect to the axis of rotation from the upper end of the annular rotor wall.Type: GrantFiled: January 6, 2017Date of Patent: April 30, 2019Assignee: BOOKER & DAX, LLCInventor: David E. Arnold, III
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Patent number: 10086384Abstract: The invention relates to a centrifugal separator having a separation space with a set of separation plates, an inlet configured to feed a fluid product to be separated into the separation space, the inlet and the separation space being connected in a pressure mediating manner, a first and a second outlet extending from the separation space for discharge of a two phases of the product. A discharge control system is configured to trigger the opening of the second outlet upon a trigger condition, wherein the discharge control system comprises a sensor arranged to determine the inlet pressure and/or the inlet flow of fluid product, and the trigger condtion is associated with a decrease in inlet flow in relation to inlet pressure, indicating an increasing flow resistance downstream of the inlet. The invention further relates to a discharge control system and a method of controlling the intermittent discharge of a centrifugal separator.Type: GrantFiled: March 22, 2013Date of Patent: October 2, 2018Assignee: ALFA LAVAL CORPORATE ABInventors: Peter Thorwid, Roland Isaksson, Hans Moberg, Carl Häggmark, Göran Krook
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Patent number: 9155994Abstract: The invention relates to a system and a method for purifying ship diesel exhaust gases of fine dust particles, and of certain burnt gases, having a spray tower, a venturi washer, a cyclone and a disc centerifuge.Type: GrantFiled: December 17, 2010Date of Patent: October 13, 2015Assignee: Bayer Intellectual Property GMBHInventors: Mischa Theis, Karl Reither
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Patent number: 8974362Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: June 3, 2014Date of Patent: March 10, 2015Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8870733Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: February 13, 2013Date of Patent: October 28, 2014Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher, Douglas G. Evans
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Publication number: 20140315705Abstract: A system operating as a centrifugal, liquid-liquid separator may be controlled, and even optimized, by automatic control of back pressure to establish an optimum position of the dispersion band therein. Optimizing to minimize impurities (from each other) in each of two separated phases is possible, even simultaneously, by reliance on a processor setting the settling lengths of both heavy and light phases at the same value. Settling length, defined in accordance with the invention, reflects a settling velocity multiplied by a residence time. Equating these lengths, for droplets of each in the other liquid, provides superior results over conventional settling theory maximizing settling area. Equalization of residence times did not provide an improvement over conventional settling theory.Type: ApplicationFiled: December 12, 2013Publication date: October 23, 2014Inventors: C. Michael Miller, D. Andrew Bell, Ngai Keung Tam
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Publication number: 20140315704Abstract: A system operating as a centrifugal, liquid-liquid separator may be controlled, and even optimized, by automatic control of back pressure to establish an optimum position of the dispersion band therein. Optimizing to minimize impurities (from each other) in each of two separated phases is possible, even simultaneously, by reliance on a processor setting the settling lengths of both heavy and light phases at the same value. Settling length, defined in accordance with the invention, reflects a settling velocity multiplied by a residence time. Equating these lengths, for droplets of each in the other liquid, provides superior results over conventional settling theory maximizing settling area. Equalization of residence times did not provide an improvement over conventional settling theory.Type: ApplicationFiled: December 12, 2013Publication date: October 23, 2014Inventors: C. Michael Miller, D. Andrew Bell, Ngai Keung Tam
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Patent number: 8747291Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other facts. Highs speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: October 18, 2013Date of Patent: June 10, 2014Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8747289Abstract: An apparatus and method for purifying and harvesting certain cell populations in blood or bone marrow by depleting at least one of red blood cells, granulocytes, or platelets from a sample comprising blood, bone marrow, or stromal vascular fraction cells separated from adipose tissue is disclosed. The apparatus comprises a sterile, single use rigid, self-supporting cartridge within which the automated depletion, purification and harvesting of target cell populations occurs and all components may be distributed.Type: GrantFiled: March 17, 2011Date of Patent: June 10, 2014Assignee: SynGen Inc.Inventor: Philip H. Coelho
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Patent number: 8617042Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: March 18, 2013Date of Patent: December 31, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8562501Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: February 18, 2013Date of Patent: October 22, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8556794Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: February 15, 2012Date of Patent: October 15, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Publication number: 20130260979Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: ApplicationFiled: March 18, 2013Publication date: October 3, 2013Inventors: John E. Nash, William T. Fisher
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Patent number: 8485958Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: August 7, 2012Date of Patent: July 16, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8469871Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: August 12, 2011Date of Patent: June 25, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Patent number: 8394006Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: GrantFiled: April 13, 2012Date of Patent: March 12, 2013Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Publication number: 20130029829Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma while retaining the platelets and other factors. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.Type: ApplicationFiled: August 7, 2012Publication date: January 31, 2013Applicant: KENSEY NASH CORPORATIONInventors: John E. Nash, William T. Fisher
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Patent number: 8317672Abstract: A single use, sterile, self-contained, compact, easy to use centrifugal separation unit provides for quick, reliable platelet concentration from whole blood. Anti-coagulated blood is injected through an elastomeric seal into a separation chamber featuring a tapered barrel and an end cap. At least one port is located in the end cap, at a desired radius from the longitudinal axis. The centrifugal field created by rotation of the chamber stratifies the blood radially, with red blood cells adjacent the wall of the barrel, and plasma found closest to the longitudinal axis. Opening the port causes the pressure of the centrifugal field to eject red blood cells or plasma, thereby increasing the concentration of platelets remaining in the chamber. After ceasing chamber rotation, the concentrated platelets are recovered.Type: GrantFiled: November 19, 2010Date of Patent: November 27, 2012Assignee: Kensey Nash CorporationInventors: John E. Nash, William T. Fisher
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Publication number: 20120129674Abstract: A single use, sterile, self-contained, compact, easy to use centrifugal separation unit provides for quick, reliable platelet concentration from whole blood. Anti-coagulated blood is injected through an elastomeric seal into a separation chamber featuring a tapered barrel and an end cap. At least one port is located in the end cap, at a desired radius from the longitudinal axis. The centrifugal field created by rotation of the chamber stratifies the blood radially, with red blood cells adjacent the wall of the barrel, and plasma found closest to the longitudinal axis. Opening the port causes the pressure of the centrifugal field to eject red blood cells or plasma, thereby increasing the concentration of platelets remaining in the chamber. After ceasing chamber rotation, the concentrated platelets are recovered.Type: ApplicationFiled: November 19, 2010Publication date: May 24, 2012Inventors: John E. Nash, William T. Fisher
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Patent number: 8012077Abstract: A device for separating components of a composition according to density. The device includes a rotatable chamber and a plurality of buoys. The rotatable chamber has an axis of rotation. The plurality of buoys are positioned within the rotatable chamber and about the axis of rotation. The buoys are radially movable between an expanded position in which the buoys are at a first location relative to the axis of rotation and a contracted position in which the buoys are at a second location relative to the axis of rotation. The first location is further from the axis of rotation than the second location is. The buoys are movable in response to force generated during rotation of the rotatable chamber.Type: GrantFiled: May 23, 2008Date of Patent: September 6, 2011Assignee: Biomet Biologics, LLCInventor: Jacy C. Hoeppner
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Patent number: 7695423Abstract: A system for automatically collecting and separating whole blood into its components is described. The system includes a console, which contains all motors, pumps, sensors, valves and control circuitry, and a unique disposable set that includes a cassette supporting a centrifuge with an improved design, pump interfaces with an improved design, component and solution bags, and tubing. Various processes are implemented using a specific disposable set for each process which allows automatic identification of the process to be performed the console.Type: GrantFiled: August 16, 2006Date of Patent: April 13, 2010Assignee: Terumo Medical CorporationInventors: Thomas C. Robinson, Thomas P. Robinson, Richard D'Elia, Thomas Sahines, Paul Eibe
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Publication number: 20100081552Abstract: A continuous self-cleaning centrifuge assembly has a feed inlet (23) to the centrifuge (10) for unclarified liquid, an outlet (29) for clarified liquid, and means (42,39,38) to discharge solids out of a solids holding space (26) in the centrifuge in response to a monitored turbidity parameter of liquid in a detection line (35) in communication with the centrifuge separately from said outlet (29) so that said turbidity is affected by the degree of build up of solids in the centrifuge. In another aspect, a continuous self-cleaning centrifuge assembly has a feed inlet (123) to the centrifuge (110) for unclarified liquid, an outlet (129) for clarified liquid, and means (143,139,138) to discharge solids out of a solids holding space (126) in the centrifuge in response to a monitored turbidity parameter of liquid in an outflow line (128) connected to said outlet (129), wherein said turbidity parameter is the rate of rate of turbidity increase, or second derivative, of the monitored turbidity.Type: ApplicationFiled: November 15, 2007Publication date: April 1, 2010Applicant: WESTFALIA SEPARATOR AUSTRALIA PTY LTDInventor: Chris Kwok On Chan
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Publication number: 20090005230Abstract: A centrifuge with an electric motor (46), composed of a centrifuge outer frame (47), a heavy liquid collecting tank (18), a lower hollow shaft (22), centrifugal units, an upper hollow shaft (38), and a light liquid collecting tank (41). The heavy liquid collecting tank, the lower hollow shaft, the upper hollow shaft, and the light liquid collecting tank are all fixed to the centrifuge outer frame, the centrifugal units are fixed between the upper hollow shaft and the lower hollow shaft, the motor is connected to the upper hollow shaft and drives the upper hollow shaft to rotate, the upper hollow shaft is fixed to two or more centrifugal units connected in series and drives the centrifugal units to rotate, a hollow portion of the upper hollow shaft communicates with the light liquid collecting tank, centrifugal units are fixed to the lower hollow shaft and drive the lower hollow shaft to rotate, the heavy liquid collecting tank is a casing formed between the centrifuge outer frame and the centrifugal units.Type: ApplicationFiled: October 20, 2006Publication date: January 1, 2009Inventor: Shujiang Song
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Patent number: 7396452Abstract: An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.Type: GrantFiled: June 29, 2006Date of Patent: July 8, 2008Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Richard I. Brown
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Patent number: 7314441Abstract: A method for separating particulate matter from a fluid includes feeding a fluid containing a particulate matter into a chamber of a vessel through an inlet, the chamber being at least partially bounded by a peripheral wall and the chamber also communicating with a first outlet and a second outlet. The vessel is rotated such that at least a portion of the particulate matter settles out of the fluid against at least a portion of the peripheral wall. At least a portion of the particulate matter settled against the peripheral is subsequently disturbed so that at least a portion of the particulate matter is resuspend within the fluid. The method further includes removing at least a portion of the fluid having the resuspended particulate matter therein through the first outlet and removing through the second outlet the fluid from which the particulate material has settled out.Type: GrantFiled: May 30, 2006Date of Patent: January 1, 2008Assignee: Econova, Inc.Inventor: Kevin E. Collier
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Patent number: 7241281Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: GrantFiled: April 8, 2002Date of Patent: July 10, 2007Assignee: ThermoGenesis CorporationInventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
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Patent number: 7060017Abstract: A separator includes a vessel having a peripheral wall bounding a chamber. The vessel is rotatable about a rotational axis extending through the vessel. The chamber communicates with an inlet and a first outlet. A tubular member is disposed within the chamber and communicates external thereof. A plurality of fins are disposed within the chamber. Each of the fins extends from toward the tubular member to toward the peripheral wall. A first tube projects from the tubular member to toward the peripheral wall. The first tube has a second outlet in communication with the chamber. The first outlet is disposed closer to the rotational axis than the second outlet such that during use a fluid boundary line first outlet and the second outlet.Type: GrantFiled: April 9, 2004Date of Patent: June 13, 2006Assignee: Econova, Inc.Inventor: Kevin E. Collier
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Patent number: 6910998Abstract: The invention relates to a centrifuge provided with a blood bag system having an upper and lower outlet for separation of blood constituents, containing a rotor which can be driven in a rotative manner about a hub, wherein at least one conventional whole blood bag equipped with an upper outlet and with a lower outlet can be positioned vertically in this blood bag, while the whole blood bag can be arranged on the rotor in such a way that one outlet of the whole blood bag is bent in a radial direction, and the opposite outlet of the whole blood bag is bent in the other radial direction, so that the entire whole blood bag and the outlets thereof adopt an approximately Z- or S-shaped form in its functional position. In this case it is preferred that the upper outlet of the whole blood bag lie radially toward the interior and the lower outlet of the whole blood bag lie radially toward the exterior of the whole blood bag.Type: GrantFiled: December 8, 2001Date of Patent: June 28, 2005Assignee: Andreas Hettich GmbH & Co. KGInventor: Günter Eberle
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Patent number: 6719681Abstract: A multiple-component fluid mixture is separated by feeding the fluid mixture into a chamber of a vessel through an inlet, the chamber being at least partially bounded by a peripheral wall and the chamber also communicating with an outlet. The fluid mixture includes a heavy component and a light component. The vessel is rotated about a rotational axis extending through the vessel such that the heavy component collects toward at least a portion of the peripheral wall of the vessel and the light component collects toward the rotational axis. The light component is removed through the outlet channel. The heavy component is removed through a conduit disposed within the chamber, the conduit extending from the heavy component toward the rotational axis and out of the vessel.Type: GrantFiled: January 25, 2002Date of Patent: April 13, 2004Assignee: Econova, Inc.Inventor: Kevin E. Collier
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Publication number: 20030211927Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.Type: ApplicationFiled: June 16, 2003Publication date: November 13, 2003Applicant: Baxter International Inc.Inventors: Robert J. Cantu, Kyungyoon Min, Douglas W. Reitz, Richard I. Brown
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Publication number: 20030191005Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into container adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the container to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.Type: ApplicationFiled: April 8, 2002Publication date: October 9, 2003Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Pablo Rubinstein
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Patent number: 6582349Abstract: Blood processing systems and methods rotate a processing chamber on a rotating element. The processing chamber includes a first compartment and a second compartment. Blood is conveyed into the first compartment for centrifugal separation into components. A liquid free of blood occupies the second compartment to counter-balance the first compartment during rotation on the rotating element. In one embodiment, the second compartment is served by a single fluid flow access. Prior to use, the single access is coupled to tubing, through which a vacuum is drawn to remove air from the second compartment. While the vacuum exists, communication is opened between the tubing and a source of liquid. The vacuum draws the liquid into the second compartment through the single access, thereby priming the second compartment for use.Type: GrantFiled: September 26, 2000Date of Patent: June 24, 2003Assignee: Baxter International Inc.Inventors: Robert J Cantu, Kyungyoon Min, Douglas W Reitz, Robert I Brown
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Publication number: 20020058575Abstract: An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further separate these intermediate density components by forming an elutriative field or saturated fluidized particle bed. The separation vessel includes a shield for limiting flow into the fluid chamber of relatively high density substances, such as red blood cells. The separation vessel also includes a trap dam with a smooth, gradually sloped downstream section for reducing mixing of substances. Structure is also provided for adding additional plasma to platelets and plasma flowing from the fluid chamber. The system reduces clumping of platelets by limiting contact between the platelets and walls of the separation vessel.Type: ApplicationFiled: November 1, 2001Publication date: May 16, 2002Applicant: Gambro, Inc.Inventors: Dennis Hlavinka, Thomas J. Felt
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Publication number: 20020020680Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.Type: ApplicationFiled: June 20, 2001Publication date: February 21, 2002Inventor: Glen Jorgensen
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Patent number: 6346069Abstract: A solid-liquid/liquid-liquid separator includes a vessel having a peripheral wall bounding a chamber. The chamber communicates with an inlet port and an outlet port. The vessel is rotatable about a rotational axis extending through the vessel. Disposed within the chamber are a plurality of fins. Each of the fins radially outwardly projecting from the rotational axis in substantially parallel alignment with the rotational axis. The fins interact with the peripheral wall to form a plurality of discrete flow channels that longitudinally extend through the vessel. An exit tube is disposed along a portion of the rotational axis of the vessel. The exit tube has a first end disposed within the chamber and an opposing second end in fluid communication with the exterior of vessel. A plurality of extraction tubes radially outwardly projecting from the rotational axis within the chamber.Type: GrantFiled: November 17, 1999Date of Patent: February 12, 2002Assignee: Separation Process Technology, Inc.Inventor: Kevin E. Collier
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Patent number: 6071421Abstract: Systems and methods obtain a platelet suspension with reduced number of leukocytes by centrifugally separating whole blood into red blood cells, a suspension of platelets, and an intermediate layer comprising leukocytes. The systems and methods convey the suspension of platelets from the centrifugal separation chamber to a filter, while maintaining the intermediate layer containing leukocytes inside the centrifugal separation chamber. The systems and methods filter remaining leukocytes from the platelet suspension in the filter.Type: GrantFiled: November 25, 1997Date of Patent: June 6, 2000Assignee: Baxter International Inc.Inventor: Richard I. Brown
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Patent number: 5961842Abstract: Blood separation systems and methods employ a rotating chamber. The chamber includes an inlet region where whole blood enters for centrifugal separation into packed red blood cells, a plasma constituent, and an interface carrying mononuclear cells between the packed red blood cells and the plasma constituent. The packed red blood cells in the chamber have a hematocrit value H.sub.PRBC. A controller operates in a first mode to convey whole blood into the inlet region while removing packed red blood cells and the plasma constituent from the chamber and while maintaining the interface within the chamber. The controller also operates in the first mode to maintain a set H.sub.PRBC by conveying packed red blood cells into the inlet region.Type: GrantFiled: July 1, 1997Date of Patent: October 5, 1999Assignee: Baxter International Inc.Inventors: Kyungyoon Min, Richard I Brown, Robert J Cantu, Daniel F Bischof, William H Cork
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Patent number: 5849178Abstract: An apparatus is provided for centrifuging and further automatically handling a container (110) for separating a component, such as fibrin monomer, from blood. The container (110) comprises a cylindrical member (27) and a piston displaceable in said cylindrical member, said piston comprising a tubular piston rod (8) extending through a top wall (73). The piston divides the cylindrical member (27) into a first chamber (70) positioned above said piston between said piston and the top wall (73), and a second chamber positioned below said piston. The top wall (73) of the container comprises an extension (90) defining a circumferential slit surrounding the outer side of the piston rod (8), whereby one end of said slit communicates in the axial direction with the first chamber. In addition, the first chamber communicates through a plurality of channels with the second chamber.Type: GrantFiled: January 8, 1998Date of Patent: December 15, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Niels Erik Holm, Glenn A. Jorgensen
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Patent number: 5807492Abstract: Blood separation systems and methods separate mono nuclear cells from whole blood. The systems and methods introduce whole blood into a rotating chamber for separation into red blood cells, a plasma constituent, and an interface carrying mono nuclear cells between the red blood cells and the plasma constituent. The systems and methods convey whole blood into the chamber while removing red blood cells and the plasma constituent and while maintaining the interface at a set location within the chamber. At an appropriate processing time, the systems and methods move the interface from the set location for removal from the chamber through an outlet path. The outlet path includes a sensing element to locate mono nuclear cells in the outlet path outside the chamber.Type: GrantFiled: November 26, 1997Date of Patent: September 15, 1998Assignee: Baxter International Inc.Inventors: Richard I. Brown, Kyungyoon Min
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Patent number: 5750039Abstract: Systems and methods centrifugally separate mono nuclear cells from whole blood in a separation chamber. The systems and methods control the exit hematocrit value of red blood cells separated in the chamber by recirculating a portion of the red blood cells removed from the chamber for mixing whole blood entering the separation chamber. The systems and methods also control the entry hematocrit value of whole blood entering the separation chamber by recirculating a portion of the plasma constituent removed from the separation chamber for mixing whole blood entering the separation chamber.Type: GrantFiled: November 8, 1996Date of Patent: May 12, 1998Assignee: Baxter International Inc.Inventors: Richard I. Brown, Kyungyoon Min
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Patent number: 5607579Abstract: An apheresis apparatus for increasing the purity and yield of platelets separated from donated whole blood by centrifugation incorporates a centrifuge for separating whole blood into lower, intermediate, and higher density components. The centrifuge has inlet and outlet ports in selective fluid communication with a container for receiving lower density blood component from the outlet port. A pump is coupled to the container and the inlet port for recirculating lower density blood component from the first container through the inlet port into the centrifuge at a first, substantially constant, rate so as to widen the region of the centrifuge occupied by the intermediate density component without causing the intermediate density component to exit the centrifuge, and subsequently at a second rate, so as to displace intermediate density component from the centrifuge.Type: GrantFiled: September 28, 1995Date of Patent: March 4, 1997Assignee: Haemonetics CorporationInventors: Allen Latham, Jr., Glen E. Jorgensen, Theodoor H. S. Sibinga, Joseph R. Plante, Tracey E. Knapp
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Patent number: 5573678Abstract: Systems and methods for separating mono nuclear cells from whole blood rotate a separation chamber about a rotational axis. The systems and methods introduce whole blood into a first region of the chamber during its rotation to separate the whole blood into a plasma constituent, red blood cells, and an interface between the red blood cells and the plasma constituent. The interface carries mono nuclear cells. While conveying whole blood into the first region, the systems and methods collect the plasma constituent in the first region, while also collecting the red blood cells in a second region of the chamber spaced from the inlet region. The systems and methods create, while conveying whole blood into the inlet region, a back flow of plasma constituent along the interface from the second region toward the inlet region. This back flow of plasma maintains a high-relative hematocrit in the second region and a low-relative hematocrit in the inlet region.Type: GrantFiled: June 7, 1995Date of Patent: November 12, 1996Assignee: Baxter International Inc.Inventors: Richard I. Brown, Kyungyoon Min
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Patent number: 5484521Abstract: A rotating drum divided in axial spaced compartments with one of the compartments includes paddles and coalescing material to separate the fluid from the liquid and the other compartment includes stationary oil pumping and water pumping means and an energy recovery means for effectively separating fluid such as oil from liquid such a water. Another embodiment includes a simplified version of the fluid/liquid separator adapted for zero gravity environment and includes means for purging the lines from air prior to pumping the liquid. An electrical sensing circuit including conductivity sensors or an electronic controller including pressure sensors serve to control the rate of removal of the separated component or controlling said purging means.Type: GrantFiled: March 29, 1994Date of Patent: January 16, 1996Assignee: United Technologies CorporationInventor: Robert W. Kramer
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Patent number: 5104526Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.Type: GrantFiled: May 26, 1989Date of Patent: April 14, 1992Assignee: Baxter International Inc.Inventors: Richard I. Brown, Sidney Smith, David E. Cerny, John T. Foley
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Patent number: 5093010Abstract: A method of operating a drum centrifuge having a foraminous drum rotatable about an axis it is centered on comprises first filling a charge of a suspension into the drum while rotating it about its axis so that the charge forms an annular stratified body having an inner surface and the liquid phase of the body passes radially outward and leaves behind the solid phase as a filter cake and then refilling at least one additional charge of a suspension into the drum onto the filter cake while rotating the drum as in the preceding filling step to add the solid phase of the additional charge to the cake already in the drum. Then at least periodically the radial position of the inner surface of the body in the drum is detected and the dry point when the liquid phase has substantially passed radially out of the drum is ascertained to generate outputs corresponding to the detected radial positions and the times same are detected.Type: GrantFiled: December 3, 1990Date of Patent: March 3, 1992Assignee: Krauss-Maffei AktiengesellschaftInventor: Reinhold Schilp
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Patent number: 5076911Abstract: A system and method of separation of therapeutic components from blood. The system includes a dual member centrifuge and a disposable single use fluid transfer set. The set includes an elongated flexible separation chamber having an input port, a separated component output port and a residual fluid output port. The input port and the separated component output ports are located at opposite ends of the elongated separation chamber. The centrifuge includes a receiving chamber with a selectively formed annular slot therein. The separation chamber is positioned in the annularly shaped slot and rotated at a predetermined rotational velocity. Fluids such as whole blood flows through the separation chamber and are separated into various therapeutic components such as platelet rich plasma and residual concentrated red blood cells. Platelet rich plasma can be drawn off as the separated therapeutic component. An alternate two part transfer set provides for highly efficient platelet pheresis.Type: GrantFiled: March 27, 1991Date of Patent: December 31, 1991Assignee: Baxter International Inc.Inventors: Richard J. Brown, Sidney Smith, David E. Cerny, John T. Foley
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Patent number: 5045046Abstract: Apparatus for cleaning dirt/oil/water mixtures that utilizes a rotating drum wherein the inner cylindrical wall of the drum includes a plurality of V-shaped troughs secured in continuous circumferential array with each vee or apex directed radially outward and secured to the inner drum wall. Canted baffle plates of triangular shape are then secured within each trough with triangle base secured at the vee open top and the triangle apex secured at the vee apex. Input dirty oil having water and dirt suspended is input at one end of the drum proximate the base ends of the baffle plates while lighter weight oil products are separated inward along the axis of the drum and heavy dirt and water materials are driven to the baffle apex points from which they may be extracted.Type: GrantFiled: November 13, 1990Date of Patent: September 3, 1991Inventor: Lesley O. Bond
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Patent number: 4846780Abstract: A centrifugal method and apparatus capable of separating a fluid stream composed of a plurality of components with differing specific gravities. The stream contemplated for separation is that of a producing oil well with components of oil, water, natural gas, and particulates. The method and apparatus use centrifugal forces to separate the gaseous, solid, and liquid components from each other. After separation is completed, detector and sensor arrangements are used to maintain liquid levels in the separator and to control the removal of the individual separated fluids from the apparatus.Type: GrantFiled: August 10, 1988Date of Patent: July 11, 1989Assignee: Exxon Production Research CompanyInventors: Jimmie G. Galloway, Lonny R. Kelley, Mark E. Ehrhardt, Tracy A. Fowler
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Patent number: 4820256Abstract: In a previously known centrifugal separator the separation chamber (4) of the centrifuge rotor has an inlet (9) for a mixture of two liquids and relatively heavy solids, a central outlet (23a) for separated light liquid and a periphery outlet (12) for separated solids. A third outlet (35) from the separation chamber (4), situated radially between the first said two outlets (23a, 12), communicates with a recirculation channel, which extends partly through a stationary structure and through which liquid may be conducted from the separation chamber (4) through a sensing device (38) and back to said inlet (9) for mixture. The sensing device (38) is arranged to initiate opening of the periphery outlet (12), when a certain amount of heavy liquid has been separated in the separation chamber (4). A throttle is arranged for limiting of the flow through the recirculation channel.Type: GrantFiled: May 30, 1986Date of Patent: April 11, 1989Assignee: Alfa-Laval Separation ABInventor: Torbjorn Nordstrom
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Patent number: 4679980Abstract: An inventory control device for a pitot pump used in a two-phase flow system, such as a closed-cycle Rankine system or a two-phase cooling loop for space vehicles. In these systems, there is a change of phase between liquid and vapor, dependent upon a change of power level or thermal transport rate. With these systems being used in devices that are subject to significant attitude change or acceleration forces or zero gravity conditions, the inventory control device is gravity insensitive and utilizes a second tube mounted in the pitot pump which is connected to an external accumulator. A pressure relation is established whereby the second tube will maintain a constant level of liquid within the rotating drum of the pitot pump.Type: GrantFiled: December 27, 1984Date of Patent: July 14, 1987Assignee: Sundstrand CorporationInventor: Timothy J. Bland