Abstract: An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.

Abstract: An apparatus for separating at least two discrete volumes of a composite liquid into at least a first component and a second component, comprising a well provided on a rotor near the axis of rotation for receiving a relatively rare blood component, such as mesenchymal stem cells (MSC), or for receiving a fluid that can be used multiple times, such as a washing solution. The well is placed radially outwardly from the axis of rotation and radially inwardly from cavity, which receives bags containing blood or another biologic fluid. The well is placed in a low centrifugal force region relative to the position of the cavity.

Abstract: A centrifugal pellet dryer screen (540) especially adapted for drying polymer pellets and micropellets includes an exterior or outer support screen (542), an inner screen (546) of an irregular or rough surface, and an optional middle screen(s) (544) sandwiched between the outer support screen and the inner screen. The screen layers are in intimate contact and the multi-layer screen assembly produces drier pellets and micropellets exiting the dryer. Plugging of the dryer screens and banding of the pellets or micropellets are significantly reduced.

Abstract: A two-tube centrifuge separates light material and heavy material from an input mixture. A hollow drive shaft rotates a central body member about an axis of rotation. Two hollow arm assemblies, each having circular cross-section, are mounted on diametrically opposite sides of the central body. Each arm assembly includes an outer housing tube, an intermediate tube, and an inner tube that is longer than the intermediate tube. An end cap having a removable plug is mounted on the outer end of the housing-tube of each arm assembly. The inner ends of all three tubes are mechanically interlocked in a manner to cantilever mount the inner and intermediate tubes to the central-body with their outer ends spaced from the internal surface of the end cap. An input-mixture path extends through the hollow drive shaft, through the central-body, and into a cylindrical space between the inner and intermediate tubes of each arm assembly.

Abstract: The present invention provides an apparatus for separating components of a fluid having an outer housing containing a core wherein three separate fluid pathways are provided to allow continuous separation of biological fluids.

Abstract: A centrifuge is provided for the separation and/or treatment of cells in a substantially annular or partially annular separation bag connected by at least one tube to at least one secondary bag. The centrifuge comprises a rotor bowl connected at the upper end of a rotor shaft. The rotor shaft includes a hollow upper portion defining a central compartment for receiving the at least one secondary bag. The rotor bowl includes a separation compartment for receiving the separation bag and an expandable hydraulic chamber located within the separation compartment for selectively squeezing the separation bag within the separation compartment so as to transfer a separated component from the separation bag into a secondary bag in the central compartment. A hydraulic system is connected to the hydraulic chamber by a duct extending through the rotor shaft for pumping a hydraulic liquid to and from the hydraulic chamber.

Abstract: The invention relates to a device and process for centrifugal separation of solid particles from a liquid. The device comprises a vessel rotatable around a vertical axis. The vessel has a separation zone with separation surface elements. The separation surface elements are formed by a plurality of adjacent, axially oriented tubular elements or channels open at both ends. The process is characterized in that the liquid is caused to flow with essentially laminar flow through a plurality of axially oriented, parallel channels and is subjected to a g-number, preferably less than 100, in order to centrifugally deposit the particles on the channel walls.

Abstract: A device and a process for centrifugal separation of solid particles from a liquid is disclosed. The device comprises a vessel rotatable around a vertical axis. The vessel has a separation zone with separation surface elements. The separation surface elements are formed by a plurality of adjacent, axially oriented tubular elements or channels open at both ends. The process is characterized in that the liquid is caused to flow with essentially laminar flow through a plurality of axially oriented, parallel channels and is subjected to a g-number, preferably less than 100, in order to centrifugally deposit the particles on the channel walls.

Abstract: The invention relates to a separating body which can be set into rotation to separate solid or liquid particles of micron or submicron size from a fluid, wherein the body has a large number of separating ducts with singly connected walls over a substantial part of the axial length, where the walls of at least one of the separating ducts are not parallel to the axis of rotation. The tangent of the angle between the tangent planes of the walls of the separating duct and the axis of rotation is designated with tan .alpha., the radial width of the separating duct is designated with d, the length of the separating duct is designated with L and the rotation speed of the separating body is designated with .OMEGA. where these variables are chosen in mutual dependence in a manner such that the dimensionless number (.OMEGA.Ld tan .alpha.)/.nu. is located over a substantial part of the separating duct in the range up to 192, wherein .nu. is the kinematic viscosity of the fluid.

Abstract: A rotational separator for separating particulate material from gas includes a housing having a gas inlet and a gas outlet. A centrifuge is rotatably mounted in the housing along a rotation axis extending through the housing. The centrifuge includes a plurality a radially-spaced individual separation channels which extend parallel to each other and parallel to the rotaton axis. The separation channels extend azimuthally about the rotation axis by less than 360.degree. to prevent azimuthal flows greater than 360.degree. about the rotation axis in any of the individual separation channels.

Abstract: The invention relates to a centrifugal separator with a rotor having a separation chamber, a stack of frusto-conical separation discs arranged spaced from each other in the separation chamber coaxially with the rotor, and means defining centrally in the stack of separation discs radially inside thereof an inlet chamber. Inlet chamber is closed from connection with the separation chamber along the axial extension of the stack but communicates with the separation chamber at least at one end of the stack. The inlet means for introducing a liquid mixture into the inlet chamber and annular acceleration discs are placed coaxially with the rotor in the inlet chamber and arranged for gradual entrainment of incoming mixture in the rotation of the rotor.

Abstract: A rotational separator for separating particulate material from gas includes a housing having a gas inlet, a gas outlet, and an outlet for separated particulate material; a centrifuge mounted for rotation in the housing and including separation channels which extend parallel to a common rotation axis; and a driver for rotating the centrifuge; wherein the particulate material separated has a cross-sectional dimension from about 0.1 to about 5 um, that the separation channels are provided with singly-connected cross-sections over a substantial part of the axial separation channel length, and that the hydraulic diameter of the separation channels and the average axial gas velocity are selected in mutual dependence such that the Reynolds number is less than 2400 and the gas passes through the separation channels in a laminar flow.

Abstract: A centrifugal separator which enables extraction of particles as concentrated liquid of a uniform concentration under a low pressure without damaging to the particles and is particularly suitable for extraction of weak cells such as animal cells. The centrifugal separator includes a plurality of particle collecting chambers (104: 104a) partially defined by an inner wall face (121) of a rotor (103) the diameter of which increases substantially continuously and suddenly comparing with the diameter of another adjacent portion for the inner wall face of the rotor. Particles centrifugally separated from liquid in a separating chamber (109) in the rotor are introduced into the particle collecting chambers in which they are accelerated suddenly to form soil suspension having an increased fluidity. The soil suspension is then introduced into horizontally extending deriving pipes (105: 105a: 105b: 105c: 105d: 105e) of a small sectional area and then extracted to the outside by way of an extracting pipe (118).

Abstract: A throughput centrifuge for the industrial production of proteins from human blood plasma, with a cylindrical centrifuge drum provided with several concentric chambers that communicate at the bottom and with the blood plasma or similar material being supplied to the central zone and a liquid phase continuously extracted from the outer zone. The drum accordingly accommodates plastic containers constituting concentric annular or annular-segmental chambers that communicate through at least one channel at the bottom, wherein the container or containers toward the axis that the drum rotates around have an inlet connection and the container or containers in the outer zone of the drum have an outlet channel at the top, and wherein the outer surfaces of the containers, of the communicating channel or channels, of the outlet channel or channels, and of the inlet connection or connections rest against the inner surfaces of the drum and against structures that can be inserted into and removed from the drum.

Abstract: In a centrifuge rotor for separation of two liquids having different densities from a mixture thereof a stack of conical separation discs (21) is arranged in the separation chamber (13) with the base portions of the separation discs turned towards one end and with the apex portions of the separation discs turned towards the other end of the separation chamber. According to the invention the separation chamber (13) has an inlet for mixture situated at the end, towards which the separation discs turn their apex portions, and an outlet for separated relatively heavy liquid situated at the opposite end. The inlet for liquid mixture as well as both outlets for the separated liquids are situated at the same axial end wall of the centrifuge rotor.

Abstract: A liquid separator has a centrifuge rotor (1) with a set of conical separation discs (21) arranged coaxially in the separation chamber (13). The inlet of the separation chamber is formed as inlet passages (20) which extend radially outwards from a central inlet chamber (16) in the rotor, along that end wall of the separation chamber, towards which the apex ends of the separation discs face. The inlet passages (20) are formed between that end wall and a partition member (18, 19) situated between the rotor end wall and the separation discs (21). The outlet of the separation chamber (13) for separated liquid is formed by a number of channels (22) through the partition member (18, 19) and aligned channels through tubular members (23) bridging said inlet passages (20).

Abstract: A blood centrifugation cell has an outer container, a volume displacement inner body having a central passage, and an inlet conduit extending through the central passage to the bottom of the container. A seal is provided at the lower end of the body sealing the space between the inner conduit and the central passage. The seal permits red blood cells to be sucked from the container at any time during centrifugation without waiting for the cell to become completely filled.

Abstract: A continuous blood centrifugation cell includes a bell shaped outer container rotatable about a central axis, a coaxial inner volume displacement body which has a central longitudinal passage, and a circularly shaped partition which has a central aperture and which is coaxially enclosed between the body and the bottom of the container. A stationary housing is connected to and encloses the upper end of the container and has a coaxial inner conduit, a coaxial intermediate conduit, and a coaxial outer conduit. The housing has a stationary passage near the upper end of the container and is in communication with the lower end of the outer conduit for the removal of the lighter fraction blood components from the container. The intermediate conduit extends downwardly into the central passage of the body and has the lower end thereof closely spaced from the partition for the inlet of blood into the container.

Abstract: A centrifugal bowl separator contains a packet of conical discs having a series of feed discs with an intermediate disc of larger diameter disposed between each adjacent pair of feed discs. The substance to be treated enters a channel at the bottom of the disc packet and the channel discharges only above each feed disc. The material to be treated, namely both the heavy and the lighter components, flows in the spaces above the feed discs, and the heavier component is thrown against the underside of the intermediate disc and is flung from its larger periphery, while the lighter component flows along the upper surface of the feed disc and flows around its edge and out through the space below the feed disc. The spaces between the discs have conductive connection only at the radially outer area.