1,2-oxazoles (including Hydrogenated) Patents (Class 504/271)
  • Patent number: 6831039
    Abstract: The invention relates to 3-(heterocyclyl)-substituted benzoylpyrazois of formula (I), wherein the variables have the following meanings: X is O, NH or N-alkyl; R1 is alkyl; R2, R3, R4, R5 are hydrogen, alkyl or alkyl halide; R6 is halogen, nitro, alkyl halide, alkoxy, halogenalkoxy, alkylthio, halogenalkylthio, alkylsulfonyl or halogenalkylsulfonyl; R7 is hydroxy, alkoxy, alkenyloxy, alkylsulfonyloxy, alkylcarboyloxy, alkylthiocarbonyloxy, phenylsulfonyloxy or phenylcarbonyloxy, and the phenyl radical can be substituted; R8, R9 are alkyl; R10 is hydrogen or alkyl; and R11 is hydrogen or alkyl; and to their agriculturally useable salts. The invention also relates to intermediate products and methods for producing the inventive compounds and to the use of these compounds or products containing them for combating undesirable plants.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: December 14, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulf Neidlein, Norbert Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Ulf Misslitz, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6828276
    Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), C1, C2, C3 are cyclic radicals, X1 is a hetero atom, X2 is a chain of carbon atoms, L is a chain-like element, R1, R2, R3, R4, R5 are various radicals, and Y and Z are monoatomic bridge elements.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: December 7, 2004
    Assignee: Aventis CropScience GmbH
    Inventors: Thomas Seitz, Andreas van Almsick, Lothar Willms, Hermann Bieringer, Thomas Auler, Hubert Menne
  • Publication number: 20040242421
    Abstract: A herbicidal composition which, in addition to comprising customary inert formulation adjuvants, comprises
    Type: Application
    Filed: March 18, 2004
    Publication date: December 2, 2004
    Inventor: Derek Cornes
  • Publication number: 20040236052
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Application
    Filed: March 5, 2004
    Publication date: November 25, 2004
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Publication number: 20040230020
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Application
    Filed: March 19, 2004
    Publication date: November 18, 2004
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Publication number: 20040224849
    Abstract: Herbicidal compositions are described that comprise active substances from the group of the benzoylcyclohexanediones and also safeners. These herbicidal compositions are especially suitable for use against weed plants in crop plant cultures.
    Type: Application
    Filed: June 17, 2004
    Publication date: November 11, 2004
    Inventors: Frank Ziemer, Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Erwin Hacker, Christopher Rosinger
  • Publication number: 20040224848
    Abstract: Herbicidal compositions are described that comprise active substances from the group of the benzoylcyclohexanediones and also safeners. These herbicidal composition are especially suitable for use against weed plants in crop plant cultures.
    Type: Application
    Filed: June 17, 2004
    Publication date: November 11, 2004
    Inventors: Frank Ziemer, Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Erwin Hacker, Christopher Rosinger
  • Patent number: 6809064
    Abstract: Described are herbicidal compositions comprising A) at least one compound from the benzoylcyclohexanedione group and B) at least one compound from the group of the herbicides which act selectively against monocotyledonous and/or dicotyledonous harmful plants in rice. These compositions have a superior action compared with the herbicides employed individually.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: October 26, 2004
    Assignee: Aventis CropScience GmbH
    Inventors: Thomas Auler, Andreas van Almsick, Erwin Hacker, Jean-Claude Millet, Keiji Endo
  • Patent number: 6797277
    Abstract: Water-dispersible, extruded granules for delivering agricultural chemicals, such as pesticides or non-pesticidal materials, to a crop. The granules are extrusion-formed from a blended composition including at least one active chemical ingredient, a solid carrier, and a binder. The active chemical ingredient may or may not be micro-encapsulated. The binder may be added directly to the composition or applied as a coating to the granules after the extrusion process. The binder reduces attrition, chemical volatility, and phytotoxicity. The granules are applied to a crop field by aerial means. The dense granules display good vertical drop characteristics, with little drift. If the crop field has standing water, the water-dispersible granules sink and break up, effecting dispersion of the chemical ingredient. When applied to a dry field, the subsequent exposure to water to the granules effects the same dispersal of chemical ingredient.
    Type: Grant
    Filed: May 29, 2002
    Date of Patent: September 28, 2004
    Assignee: Wilbur-Ellis Company
    Inventors: John L. Heier, David T. Schulteis
  • Publication number: 20040132619
    Abstract: The invention relates to novel selectively herbicidal active compound combinations comprising substituted aryl ketones of the formula (I) 1
    Type: Application
    Filed: February 12, 2004
    Publication date: July 8, 2004
    Inventors: Dieter Feucht, Peter Dahmen, Mark Wilhelm Drewes, Rolf Pontzen, Klaus-Helmut Muller, Stefan Lehr, Hans-Georg Schwarz, Toshio Goto, Shinichi Shirakura
  • Patent number: 6756461
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: June 29, 2004
    Assignee: Specialty Fertilizer Products, LLC
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Patent number: 6753395
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: June 22, 2004
    Assignee: Specialty Fertilizer Products, LLC
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Patent number: 6746989
    Abstract: The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which n represents the numbers 0, 1, 2 or 3, A represents a single bond or represents alkanediyl(alkylene), R1 represents in each case optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl, R2 represents hydrogen, cyano, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkoxycarbonyl or cycloalkyl, R3 represents hydrogen, nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, R4 represents nitro, cyano, carboxyl, carbamoyl, thiocarbamoyl, halogen, or represents in each case optionally substituted alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkylamino, dialkylamino or dialkylaminosulfonyl, Y represents hydrogen or represents in each case optionally substituted
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: June 8, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus-Helmut Müller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Heinz-Jürgen Wroblowsky, Mark Wilhelm Drewes, Dieter Feucht, Rolf Pontzen, Ingo Wetcholowsky
  • Publication number: 20040106521
    Abstract: Novel pyrrole derivatives of formula I 1
    Type: Application
    Filed: October 7, 2003
    Publication date: June 3, 2004
    Applicant: Syngenta Crop Protection, Inc.
    Inventors: Harald Walter, Hermann Schneider
  • Patent number: 6713436
    Abstract: The present invention relates to 1-cycloalkylpyrazolylbenzoyl derivatives of the formula I wherein all variables are as defined in the specification, their agriculturally useful salts, processes for their preparation, and for the use of these compounds or compositions comprising them, for controlling undesirable plants.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: March 30, 2004
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulf Neidlein, Norbert Götz, Ulf Misslitz, Roland Götz, Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Matthias Witschel, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6706837
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Grant
    Filed: June 4, 2003
    Date of Patent: March 16, 2004
    Assignee: Specialty Fertilizer Products, LLC
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Patent number: 6703348
    Abstract: There are described benzoylcyclohexanediones of the formula I, their preparation, and their use as herbicides and plant growth regulators. In this formula (I), R1, R2, R3, R4, R5, R6, R7, Ra, Rb and Rc are various radicals, and Y and Z are a monoatomic bridge element.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: March 9, 2004
    Assignee: Aventis CropScience GmbH
    Inventors: Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Felix Thürwächter
  • Patent number: 6703469
    Abstract: Biodegradable anionic polymers are disclosed which include recurring polymeric subunits preferably made up of dicarboxylic monomers such as maleic anhydride, itaconic anhydride or citraconic anhydride. Free radical polymerization is used in the synthesis of the polymers. The polymers may be complexed with ions and/or mixed with fertilizers or seeds to yield agriculturally useful compositions. The preferred products of the invention may be applied foliarly or to the earth adjacent growing plants in order to enhance nutrient uptake by the plants.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: March 9, 2004
    Assignee: Specialty Fertilizer Products, LLC
    Inventors: John Larry Sanders, Grigory Mazo, Jacob Mazo
  • Publication number: 20040023808
    Abstract: The present invention provided with novel 5-benzyloxymethyl-1,2-isoxazoline derivatives of the formula (1), their preparation method and their use as herbicides. The 5-benzyloxymethyl-1,2-isoxazoline derivatives according to the present invention have sufficiently high herbicidal activity against the weeds in the paddy field rice even at low dose rates and excellent selectivity to transferred rice in particular. As thus, the compounds of the present invention are typically useful as herbicides for control of paddy weeds in rice.
    Type: Application
    Filed: March 6, 2003
    Publication date: February 5, 2004
    Inventors: Eung-Kul Ryu, Hyoung-Rae Kim, Dong-Ju Jeon, Jong-Whan Song, Kyoung-Mahn Kim, Jung-No Lee, Hyoung-cheul Kim, Kyung-Sik Hong
  • Publication number: 20040023806
    Abstract: The invention relates to novel compounds of the formula I 1
    Type: Application
    Filed: September 5, 2002
    Publication date: February 5, 2004
    Inventors: Hugo Ziegler, Saleem Farooq, Rene Zurflh
  • Patent number: 6667333
    Abstract: 3-(4,5-Dihydroisoxazol-3-yl)-substituted benzoylcyclohexenone derivatives of the formula I in which the substituents A and R1 to R12 are as defined in the description and their agriculturally useful salts are described. The compounds have herbicidal action.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: December 23, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Steffen Kudis, Ernst Baumann, Wolfgang von Deyn, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Karl-Otto Westphalen, Helmut Walter
  • Publication number: 20030228983
    Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) 1
    Type: Application
    Filed: April 23, 2003
    Publication date: December 11, 2003
    Inventors: Klaus-Helmut Muller, Stefan Lehr, Otto Schallner, Hans-Georg Schwarz, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen
  • Patent number: 6660692
    Abstract: This invention provides a method for controlling the growth of weeds (i.e. undesired vegetation) at a locus which comprises applying to the locus a herbicidally effective amount of: (a) picolinfen, a phenoxypicolinamide derivative of formula (I); and (b) a partner herbicide, selected from isoxazole, dione, urea and hydroxybenzonitrile herbicide.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: December 9, 2003
    Assignee: Aventis CropScience S.A.
    Inventor: Richard Henry Hewett
  • Patent number: 6660691
    Abstract: There are described herbicidal compositions comprising herbicidal compounds of the formula I and a safener-active compound of the formula II or III In formulae I, II and III, the symbols R1 to R10 are hydrogen, halogen and various organic radicals.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: December 9, 2003
    Assignee: Aventis CropScience GmbH
    Inventors: Frank Ziemer, Andreas van Almsick, Arnim Köhn, Lothar Willms, Hans-Joachim Zeiss, Hermann Bieringer, Erwin Hacker
  • Patent number: 6645919
    Abstract: 3-(4,5-Dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I in which the variables have the following meanings: R1, R2 are hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl or C1-C6-haloalkylsulfonyl; R3 is hydrogen, halogen or alkyl; R4 is hydrogen or alkyl; R5, R6 are hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, dialkylamino, phenyl, benzyl or carbonyl, it being possible for the 7 last-mentioned radicals to be substituted; R11 is unsubstituted or substituted cyclohexenone which is linked in position 2 and has attached to it in position 1 a hydroxyl radical or derivatives thereof; and their agriculturally useful salts, processes for the preparation of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones, compositions comprising them, and the use of these derivatives or of compositions comprising them for controlling undesired plants.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: November 11, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Ernst Baumann, Wolfgang von Deyn, Steffen Kudis, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Helmut Walter, Cyrill Zagar, Matthias Witschel
  • Patent number: 6642176
    Abstract: The invention concerns a novel composition comprising a herbicide of the glyphosate family, a herbicide of the isoxazole family and a biological activator, wherein the herbicide of the glyphosate family is selected among N-phosphomethylglycine (glyphosate acid), N-phosphomethylglycine alkaline metal salts, N-phosphomethylglycine ammonium salts and N-phosphomethylglycine trimethyisulphonium salts (sulphosate), and wherein the biological activator consists essentially of an ammonium sulphate. The invention also concerns a method for agronomic treatment of plants tolerant to glyphosate family herbicides and to isoxazole family herbicides to eliminate weeds which consists in applying in a field containing said tolerant plants an appropriate amount of the inventive composition.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: November 4, 2003
    Assignee: Bayer CropScience S.A.
    Inventors: Gilbert Antoine Perez, Louis Pillet, Jean-Claude Febvre, Sylvie Lavault
  • Patent number: 6627581
    Abstract: Cyclopropyl-fused 3-(4,5-dihydroisoxazol-3-yl)-substituted benzoylpyrazoles of the formula I in which the variables are as defined in the description, and their agriculturally useful salts are described. The compounds have herbicidal action.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: September 30, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Steffen Kudis, Ernst Baumann, Wolfgang von Deyn, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Karl-Otto Westphalen, Helmut Walter
  • Publication number: 20030171220
    Abstract: This invention provides for, inter alia, a herbicidal composition comprising a mixture of:
    Type: Application
    Filed: October 7, 2002
    Publication date: September 11, 2003
    Inventors: Frank Ziemer, Lothar Willms, Hermann Bieringer, Erwin Hacker
  • Patent number: 6613719
    Abstract: 3-(4,5-Dihydroisoxazol-3-yl)-substituted benzoylpyrazoles of the formula I in which R4 is C1-C4-haloalkyl and R1 to R3 and R5 to R10 are as defined in the description are described. The compounds have herbicidal activity.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: September 2, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Steffen Kudis, Ernst Baumann, Wolfgang von Deyn, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Karl-Otto Westphalen, Helmut Walter
  • Publication number: 20030153465
    Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) 1
    Type: Application
    Filed: July 15, 2002
    Publication date: August 14, 2003
    Inventors: Otto Schallner, Stefan Lehr, Hans-Georg Schwarz, Klaus-Helmut Muller, Dorothee Hoischen, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto
  • Patent number: 6599860
    Abstract: Herbicidally active haloalkyl-substituted 3-(4,5-dihydroisoxazol-3-yl)benzoylcyclohexenones of the formula I in which R1 to R3 and R5 to R14 are as defined in the description and R4 is C1-C4-haloalkyl are described.
    Type: Grant
    Filed: May 16, 2002
    Date of Patent: July 29, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Steffen Kudis, Ernst Baumann, Wolfgang von Deyn, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6586369
    Abstract: Agrochemical compositions having fungicidal action and comprising as active compounds compounds of the formula I where R1 is hydrogen, C1-C6-alkyl, C1-C6-alkylcarbonyl, formyl or C1-C6-haloalkylcarbonyl; R2 is halogen, C1-C6-alkylthio, C1-C6-alkoxy, C3-C6-cycloalkyl-C1-C6-alkoxy, C1-C6-alkoxy-C1-C6-alkyl, halo-C1-C6-alkoxy, C1-C6-alkylsulfonyl, C1-C6-alkylsulfinyl, halo-C1-C6-alkylsulfonyl, cyano or a radical NR13R14; R3-R12 are hydrogen, halogen, C1-C8-cycloalkyl, C1-C6-alkyl, halo-C1-C6-alkyl, C1-C6-alkoxy, halo-C1-C6-alkoxy, C1-C6-alkylsulfonyl, halo-C1-C6-alkylsulfonyl, formyl, C1-C6-alkylcarbonyl, cyano, C1-C6-alkylthio or phenyl, which may be unsubstituted or substituted by halogen, C1-C6-alkyl or halo-C1-C6-alkyl, R13 is hydrogen, C1-C6-alkyl, R14 is C1-C6-alkyl, C1-C8-cycloalkyl or, together with R13 and the nitrogen atom to which they are attached, a saturated or unsaturated heterocyclic five- or six-membered ring which contains one or two heteroatoms selected from the group co
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: July 1, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Joachim Rheinheimer, Karl Eicken, Ingo Rose, Thomas Grote, Eberhard Ammermann, John-Bryan Speakman, Siegfried Strathmann, Gisela Lorenz
  • Patent number: 6583089
    Abstract: Tricyclic benzoylcyclohexanedione derivatives of the formula I where X, Y, R1, R2, R3, R4, R5, R9, and m are defined herein, and their agriculturally useful salts. Process for preparing the tricyclic benzoylcyclohexanedione derivatives; compositions comprising them and the use of these derivatives or of the compositions comprising them for controlling undesirable plants are described.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: June 24, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Witschel, Steffen Kudis, Klaus Langemann, Ernst Baumann, Wolfgang von Deyn, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6576593
    Abstract: Described are herbicidal compositions comprising A) at least one compound from the benzoylcyclohexanedione group and B) at least one compound from the group of the herbicides which act selectively against monocotyledonous and/or dicotyledonous harmful plants in maize. These compositions have a superior action compared with the herbicides employed individually.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: June 10, 2003
    Assignee: Aventis CropScience GmbH
    Inventors: Andreas van Almsick, Lothar Willms, Erwin Hacker, Hermann Bieringer
  • Publication number: 20030104946
    Abstract: Herbicidal mixture comprising a benzoyl derivative, a fertilizer containing nitrogen and an adjuvant.
    Type: Application
    Filed: May 14, 2002
    Publication date: June 5, 2003
    Inventors: Udo Bickers, Erwin Hacker, Frank Sixl, Thomas Auler
  • Publication number: 20030096705
    Abstract: The present invention relates to chemical compounds, pharmaceutical compositions comprising said compounds, uses of said compounds and compositions, methods of treatment employing said compounds and compositions, and processes for preparing said compounds. Specifically, this invention relates to novel compounds which are antagonists of MCP-1 function and are useful in the prevention or treatment of chronic or acute inflammatory or autoimmune diseases, especially those associated with aberrant lymphocyte or monocyte accumulation such as arthritis, asthma, atherosclerosis, diabetic nephropathy, inflammatory bowel disease, Crohn's disease, multiple sclerosis, nephritis, pancreatitis, pulmonary fibrosis, psoriasis, restenosis, and transplant rejection. More specifically, the invention is related to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases.
    Type: Application
    Filed: January 29, 2002
    Publication date: May 22, 2003
    Inventors: Edgardo Laborde, Louise Robinson, Fanying Meng, Brian T. Peterson, Hugo O. Villar, Steven E. Anuskiewicz, Yoshiro Ishiwata, Shoji Yokochi, Yukiharu Matsumoto, Takuji Kakigami, Hideaki Inagaki, Takahito Jomori, Kouji Matsushima
  • Publication number: 20030092576
    Abstract: 3-(4,5-Dihydroisoxazol-3-yl)-substituted benzoylcyclohexenone derivatives of the formula I 1
    Type: Application
    Filed: May 13, 2002
    Publication date: May 15, 2003
    Inventors: Steffen Kudis, Ernst Baumann, Wolfgang Von Deyn, Klaus Langemann, Guido Mayer, Ulf Misslitz, Ulf Neidlein, Matthias Witschel, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6559100
    Abstract: Substituted 2-benzoylcyclohexane-1,3-diones of the formula I where: R1 and R2 are each hydrogen, mercapto, nitro, halogen, cyano, thiocyanato, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, —OR3, —OCOR3, —OSO2R3, —S(O)nR3, —SO2OR3, —SO2N(R3)2, —NR3SO2R3 or —NR3COR3; R3 is hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, phenyl or phenyl-C1-C6-alkyl; where the abovementioned alkyl radicals may be partially or fully halogenated and/or may carry one to three of the following groups: hydroxyl, mercapto, amino, cyano, R3, —OR3, —SR3, —N(R3)2, ═NOR3, —OCOR3, —SCOR3, —NR3COR3, —CO2R3, —COSR3, —CON(R3)2, C1-C4-alkyliminooxy, C1-C4-alkoxyamino, C1-C4-alkylcarbonyl, C1-C4-alkoxy-C2-C6-alkoxycarbonyl, C1-C4-alkylsulfonyl, heterocyclyl, heterocyclyloxy, phenyl, benzyl, hetaryl, phenoxy, benzyloxy and hetaryloxy, where the eight last mentioned radic
    Type: Grant
    Filed: February 7, 2000
    Date of Patent: May 6, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Stefan Engel, Joachim Rheinheimer, Ernst Baumann, Wolfgang von Deyn, Regina Luise Hill, Guido Mayer, Ulf Misslitz, Oliver Wagner, Matthias Witschel, Martina Otten, Helmut Walter, Karl-Otto Westphalen
  • Publication number: 20030078167
    Abstract: Herbicidal compositions are described that comprise active substances from the group of the benzoylcyclohexanediones and also safeners. These herbicidal compositions are especially suitable for use against weed plants in crop plant cultures.
    Type: Application
    Filed: April 18, 2002
    Publication date: April 24, 2003
    Inventors: Frank Ziemer, Andreas van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Erwin Hacker, Christopher Rosinger
  • Patent number: 6514910
    Abstract: A herbicidal mixture, comprising a) a herbicidally effective amount of a benzoyl compound of formula I  where: R1, R2 are halogen, C1-C6-alkyl, C1-C6-alkylthio, C1-C6-alkyl-sulfinyl or C1-C6-alkylsulfonyl; R3 is hydrogen, halogen, C1-C6-alkyl; X is 4,5-dihydroisoxazolyl which is unsubstituted or mono- or polysubstituted by halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylthio; R4 is a pyrazole of the formula II  which is attached in the 4-position and where R5 is hydrogen, R6 is methyl, or an environmentally compatible salt thereof; b) an adjuvant comprising i) a C1-C5-alkyl C5-C22-alkanoate, ii) a C10-C20-carboxylic acid, iii) a partial phosphoric ester or a partial sulfuric ester of a monohydroxy-functional polyalkyl ether and iv) optionally an alkyl polyoxyalkylene polyether, wherein the compound of formula I and the adjuvat are present in synergistically effective amounts.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: February 4, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Bratz, Rainer Berghaus, Martina Otten, Bernd Sievernich, Elmar Kibler, Herve Vantieghem
  • Patent number: 6479437
    Abstract: A herbicidal mixture comprising a) a herbicidally active amount of a 3-heterocyclyl-substituted benzoyl derivative of the formula I  in which the variables have the following meanings: R1,R2 are hydrogen, halogen, C1-C6-alkyl, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy; R3 is hydrogen, halogen, C1-C6-alkyl; X is a heterocycle from amongst the group consisting of isoxazolyl, 4,5-dihydroisoxazolyl and thiazolyl, it being possible for the heterocycle to be optionally monosubstituted or polysubstituted by halogen, C1-C6-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-alkylthio; R5 is hydrogen or C1-C6-alkyl, R6 is C1-C6-alkyl, or their environmentally compatible salts; b) a nitrogenous fertilizer in a synergistically effective amount and c) an adjuvant in a synergistically effective amount.
    Type: Grant
    Filed: December 5, 2000
    Date of Patent: November 12, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Bratz, Rainer Berghaus, Martina Otten, Bernd Sievernich, Elmar Kibler
  • Patent number: 6440899
    Abstract: Cyclohexenonedioxothiochromanoyl derivatives of the formula I where X is oxygen, sulfur, S═O, S(═O)2, CR4R5, C═O or C═NR6, the other substituents are as defined in the specification, and and agriculturally useful salts thereof; processes for preparing the cyclohexenonedioxotheiochromanoyl derivatives; compositions comprising them, and the use of these derivatives or of compositions comprising them for controling undesirable piants.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: August 27, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Matthias Witschel, Klaus Langemann, Wolfgang von Deyn, Ulf Misslitz, Ernst Baumann, Stefan Engel, Guido Mayer, Ulf Neidlein, Oliver Wagner, Roland Götz, Martina Otten, Karl-Otto Westphalen, Helmut Walter
  • Patent number: 6383987
    Abstract: A substantially water-free formulation of crop protection agents, comprising essentially a) a cyclohexenone oxime ether of the formula I  where R1=ethyl, propyl; R2=hydrogen or an equivalent of an agriculturally useful cation; R3=2-(thioethyl)propyl, tetrahydrothiopyran-3-yl, tetrahydrothiopyran-4-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, 1-(methylthio)cyclopropyl, 5-(isopropyl)isoxazol-3-yl, 2,5-dimethylpyrazol-3-yl, 2,4,6-trimethylphenyl or 2,4,6-trimethyl-3-butyrylphenyl; R4, R5=H, CH3, CO—OCH3; Alk=CH2CH2, CH2CH(CH3), CH2CH═CH, CH2CH═C(Cl), CH2CH2CH═CH; R6=H, phenyl, halophenyl, dihalophenyl, phenoxy, halophenoxy, dihalophenoxy; b) N-phosphonamethylglycine, or an ester or salt thereof, DL-homoalanin-4-yl(methyl)phosphinic acid or its ammonium salt; c) from 20 to 80% by weight of an aprotic or weakly protic solvent in which the components a) and b) are suspended; d) if desired emulsifiers, surfactants, sur
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: May 7, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Jürgen von der Heyde, Reiner Kober, Matthias Bratz, Rainer Berghaus, Karl-Friedrich Jäger, Jürgen Fries, Adolf Parg
  • Patent number: 6376429
    Abstract: Benzoylcyclohexanediones of the formula (I), process for their preparation and their use as herbicides and plant growth regulators are described. In this formula (I), R11, R2, R3, R4, R5, R6 and R7 are various radicals, L is an alkylene chain, and Y and Z are a monoatomic bridge element.
    Type: Grant
    Filed: October 7, 1999
    Date of Patent: April 23, 2002
    Assignee: Hoechst Schering AgrEvo GmbH
    Inventors: Andreas Van Almsick, Lothar Willms, Thomas Auler, Hermann Bieringer, Christopher Rosinger
  • Publication number: 20020045551
    Abstract: 4-Benzoylisoxazole derivatives of formula (I), wherein R 1
    Type: Application
    Filed: September 28, 2001
    Publication date: April 18, 2002
    Inventors: Tibor Musil, Simon Neil Pettit, Philip Henry Gaunt Smith
  • Patent number: 6323155
    Abstract: 4-Benzoylisoxazole derivatives of the formula wherein R is H or an ester; R1 is alkyl, haloalkyl or optionally substituted cycloalkyl; R2 is halogen, optionally halogenated alkyl, alkenyl or alkynyl; alkyl substituted with one or more —OR5; —NO2, —CN, —CO2R5, —S(O)pR6, —O(CH2)mOR5, —COR5, —NR5R6, —N(R8)SOqR7, —CONR9R10 or —OR51; or optionally substituted phenyl; R3 is —S(O)qR7; X is —N(R8)—; n is 0, 1, 2, 3, or 4; R5, R51 and R6 are independently H; optionally halogenated alkyl, alkenyl or alkynyl; optionally substituted phenyl; or cycloalkyl; R7 is optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or optionally substituted amino; R8 is H; optionally halogenated alkyl, alkenyl or alkynyl; cycloalkyl; optionally substituted phenyl; or alkoxy; m is 1, 2 or 3; p is 0, 1 or 2; q is 0 or 2; and their use as herbicides are described.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: November 27, 2001
    Assignee: Rhone-Poulenc Agriculture Limited
    Inventors: Tibor Musil, Simon Neil Pettit, Philip Henry Gaunt Smith
  • Patent number: 6297198
    Abstract: Compounds defined by the generic formula or an agriculturally acceptable salt thereof, wherein the letter R represents a lower alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, or alkenyl, each of which is optionally substituted, the symbol R1 represents a lower alkyl, haloalkyl or phenyl group, optionally substituted, X and Y are each independently a hydrogen, hydroxyl, halogen, cyano, alkylsulfenyl, alkylsulfinyl, alkylsulfonyl, acyloxy, carbamoyloxy, alkylsulfonyloxy, amino, substituted amino, acylamino, sulfamoyloxy, sulfamyl, or X and Y can be combined to be ═O, —S(CH2)mS— and —O(CH2)mO—, in which m is 2 or 3, the symbol Ar represents an aromatic ring moiety optionally substituted with from one to four groups and wherein two substituents on adjacent positions of the aromatic ring may be taken together with the two atoms to which they are attached, to form a 5- to 7-membered ring optionally substituted, and the letter Z represents —S—, —SO— o
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: October 2, 2001
    Assignee: Syngenta Participations AG
    Inventor: Shy-Fuh Lee
  • Patent number: 6277790
    Abstract: Tetrazolinonecarboxamides of formula I wherein Het is oxetan-3-yl, thietan-3-yl, tetrahydrofuran-3-yl, furan-3-yl, tetrahydrothiophen-3-yl, thiophen-3-yl, tetrahydro-2H-pyran-3-yl, tetrahydro-2H-thiopyran-3-yl, tetrahydro-2H-pyran-4-yl or tetrahydro-2H-thiopyran-4-yl, in each case with or without substitution; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl, or 3- to 7-membered heterocyclyl; R2 is hydrogen, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, or is optionally substituted cycloalkyl, cycloalkylalkyl, phenyl, phenylalkyl, 3- to 7-membered heterocyclyl, or 3- to 7-membered heterocyclylalkyl, their preparation and herbicidal compositions comprising them.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: August 21, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Cyrill Zagar, Gerhard Hamprecht, Markus Menges, Olaf Menke, Robert Reinhard, Peter Schäfer, Karl-Otto Westphalen, Martina Otten, Helmut Walter
  • Patent number: 6268313
    Abstract: The dihalopropene compounds of the general formula [I] have excellent insecticidal/acaricidal activity, so that they are satisfactorily effective for the control of noxious insects, mites and ticks.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: July 31, 2001
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Noriyasu Sakamoto, Sanshiro Matsuo, Masaya Suzuki, Taro Hirose, Kazunori Tsushima, Kimitoshi Umeda
  • Patent number: RE38675
    Abstract: An herbicidal composition containing from 1 to 4 pounds of clomazone per gallon of formulation and having a clomazone volatility less than fifty percent of that of an emulsifiable concentrate containing four pounds of clomazone per gallon of formulation is prepared by the interfacial reaction of polymethylene polyphenyl isocyanate with a polyfunctional amine selected from ethylenediamine, diethylenetriamine, triethylenetetramine, 1,6-hexanediamine, and their mixtures in an aqueous phase optionally containing from 0.05 to 0.25 weight percent of a xanthan gum viscosity modified/stabilizer. Several such formulations and the method of their preparation are described.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: December 21, 2004
    Assignee: FMC Corporation
    Inventors: Fui-Tseng H. Lee, Paul Nicholson