Abstract: A fluidic nano/micro array chipset comprises a microarray filling chip and a nano/micro array stamping chip. There are a plurality of sample containers and a plurality of nano/micro channels on the top of the microarray filling chip, and a plurality of nano/micro-scaled micro filling holes on the bottom of the microarray filling chip. Each nano/micro channel is connected to one of the sample containers and leads the sample solution in that sample container to the corresponding micro filling hole. The nano/micro array stamp chip comprises a plurality of stamping heads arranged in an array pattern, with a body part of the stamp chip and a plurality of space channels forming hydrophobic areas. Each sample solution is stored in the body of the stamp chip, and is transported by the corresponding stamping head to the stamping part of this stamping head.

Abstract: An apparatus is disclosed for use in solid-phase chemical synthesis procedures. The apparatus allows the separation of a cleaved product from the solid-phase used to make the product, and subsequent removal of the solid-phase from the apparatus. The apparatus allows the cleaved product to be concentrated within the apparatus without transfer to another device.

Abstract: A system and method for synthesizing a peptide, a nucleic acid sequence, an oligonucleotide, a DNA sequence, an RNA sequence, or the like, inside an array of capillary tubes, is provided. The system can comprise an array of capillary tubes. Each of the capillary tubes in the array of capillary tubes can comprise a first end, a second end, an inner wall, and a sequence linker bonded to the inner wall. The system can comprise a pressure control source that can be in fluid communication with each of the first ends of the array of capillary tubes. The system can comprise a reagent container support, wherein the second end of each of the capillary tubes can be adapted to move towards and/or away from the reagent container support.

Abstract: An interactive method of providing an array of nucleic acid sequences in which a remote user enters a query to generate a listing of desired sequence probes, which are then selected and returned to the host for use in producing a custom microarray designed by a remote user.

Abstract: The invention relates to a device for applying a plurality of microdroplets to a substrate (65) comprising a plate (50) provided with a plurality of bore holes (51) and a bottom (52) which is connected to said plate (50), and is provided with a plurality of channels (53). The device is characterized in that each bore (51) of the plate (50) is assigned to a single channel (53) of the bottom (52). The invention also relates to a method for producing this device, the use of this device for applying a plurality of microdroplets to a substrate (65), as well as a method for applying a plurality of microdroplets to a substrate (65).

Abstract: Novel and improved systems and methods for high speed arraying, hybridization, quantitative development and/or assaying are provided. Some embodiments provide a web based arraying format. Some other embodiments provide a sheet based arraying format. Some embodiments use a drop on drop assaying or hybridization mode. In some embodiments, a substantially inert substrate is utilized. In some other embodiments, an interactive substrate is utilized.

Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.

Abstract: Embodiments of this invention include application of new inferential methods to analysis of complex biological information, including gene networks. New methods include modifications of Bayesian inferential methods and application of those methods to determining cause and effect relationships between expressed genes, and in some embodiments, for determining upstream effectors of regulated genes. Additional modifications of Bayesian methods include use of time course data and use of gene disruption data to infer causal relationships between expressed genes. Other embodiments include the use of bootstrapping methods and determination of edge effects to more accurately provide network information between expressed genes. Information about gene networks can be stored in a memory device and can be transmitted to an output device, or can be transmitted to remote location.

Abstract: The present invention discloses micro-stamp array supported on a substrate comprising a plurality of micro-stamp sticks. Each of the micro-stamp sticks includes a micro-stamp-stick head having a channel opened through a central portion in each of the micro-stamp sticks. Each of the micro-stamp-stick heads is attached to a tapered guide tube surrounded by tapered guide-tube walls wherein the tapered guide tube is in hydraulic communication with the micro-stamp-head channel. The micro-stamp array further includes a filler chip that includes a filler reservoirs disposing on top of the tapered guide tubes, each of the filler reservoirs having a refill channel opened to the tapered guide tube for refilling the tapered guide tube and the channels.

Abstract: The present invention provides a hybridization method suited for using a signal probe. An array of the present invention comprises: a substrate; a nucleic acid probe that is fixed to the substrate and is hybridized with a sample to have a signal change; and at least one cavity that is filled with a specific liquid containing the sample and causing the hybridization of the nucleic acid probe with the sample. The array in this arrangement effectively enhances the reproducibility and the efficiency of hybridization with the signal probe.

Abstract: This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided.

Abstract: A photolabile compound, an oligomer probe array, and a substrate for oligomer probe array comprising the same, and a manufacturing method of the same are disclosed.

Abstract: Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying.

Abstract: A micro channel for recovering nucleic acid from a biological sample treated with a chaptropic ion, include an integrated portion composed of silica micro beads having a pore size of from 6 to 29 nm is formed in the channel.

Abstract: The present invention provides a substrate, system and method for synthesizing chain molecules in parallel using light-directed chemistry by imaging a selected pattern of light onto a dense array of microwells extending into a substrate surface, wherein the microwells are packed with high-surface-area carrier particles on which the chain molecules are grown in a series of sequential photoinitiated chemical steps.

Abstract: A high throughput preparation of a plurality of different lubricating oil compositions for combinatorial libraries and subsequent high throughput screening for lubricant performance is provided. The methods can advantageously be optimized using combinatorial chemistry, in which a database of combinations of lubricating oil compositions are generated. As market conditions vary and/or product requirements or customer specifications change, conditions suitable for forming desired products can be identified with little or no downtime.

Abstract: A nucleic acid amplifier including at least one flow channel in which a reaction solution made up of at least a nucleic acid template, a nucleic acid primer, a phosphate compound, and a metal ion, is caused to flow through the flow channel and to thereby perform nucleic acid amplification in the flow channel; and a method of amplifying a nucleic acid.

Abstract: A microarray disc characterized in that a substrate is provided with a pregroove and a thin film with an excellent adherence to a probe DNA or protein is disposed at least on the pregroove, and that a liquid drop containing the probe DNA or protein is arranged on a convex part or concave part of the pregroove so that the liquid drop expands in the tangential direction of the pregroove due to the surface tension of the liquid drop and/or in the instance of concave part, due to the restriction by the concave groove wall with any expansion in the direction perpendicular to the groove, and that in the above condition, the probe DNA or protein is immobilized on the substrate.

Abstract: The present invention relates to a microfluid reaction carrier intended for the purely fluid or light-controlled synthesis or analysis of oligomers or polymers. The reaction carrier comprises a structure of flow channels for the fluids, while supply channels and discharge channels parallel to the latter form an angle relative to the plane of the structure of the flow channels (reaction areas).

Abstract: Multiplexed affinity purification and thermal dissociation prior to biochip hybridization simplifies uncharacterized sample admixtures, thereby minimizing or eliminating sample interferents, improving hybridization specificity on a microarray detector, and minimizing or eliminating the need for post-hybridization thermal dissociation analysis. An integrated thermo-affinity sample preparation sub-circuit for sample purification and enrichment is described that is consistent with a field-portable form factor and analytical processes. Thermo-affinity sample preparation on model admixtures of varying complexity was efficacious.

Abstract: A method of electrochemically treating a substrate is provided comprising the steps of: (a) providing an electrolyte in contact with the substrate; (b) providing a device which faces the substrate and is in contact with the electrolyte, the device having: (i) a common first electrode arranged to define cells therein; and (ii) a plurality of individually addressable second electrodes, wherein a plurality of the cells contain individually addressable second electrodes; and (c) altering the potential of at least one of the second electrodes relative to the common first electrode so that: (i) the common first electrode generates a first redox product; and (ii) the at least one of the second electrodes generate a second redox product which is able to modify a region of the substrate facing the at least one electrodes, wherein the electrolyte is such that the second redox product is quenchable by the first redox product.

Abstract: The present invention relates to methods and apparatus for synthesizing combinatorial materials libraries using pyrolysis techniques. In certain embodiments, the methods involve varying the precursors and/or reactant gases in an operating pyrolysis unit to continuously vary the resulting nanoparticle composition and collecting different nanoparticles at different locations on a substrate using a spatially addressable particle collector.

Abstract: Biocompatible polyarylates of tyrosine-derived diphenol compounds and poly(alkylene oxide) dicarboxylic acids, articles formed therefrom and therapeutic uses are disclosed.

Abstract: A dye mordant composition comprises the reaction product of (1) a vinyl copolymer derived from ethylenically unsaturated monomers comprising first and second repeating units wherein at least one third of the units are first repeating units represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 are hydrogen or alkyl and R.sup.2 may be a group containing at least one aromatic nucleus; Q is a divalent radical, R.sup.3, R.sup.4 and R.sup.5 are alkyl or aryl and R.sup.3 and R.sup.4 along with the nitrogen atom and Q may form a quaternized heterocyclic ring, and X.sup.- is an anion and the second repeating units are free of acidic carboxyl groups; and (2) a vinyl polymer crosslinking agent for the copolymer comprising a bisalkane sulfonate or bisarene sulfonate. These compositions are useful as dye mordants in photographic elements.