Sulfur Single Bonded Directly To Nitrogen Patents (Class 514/116)
  • Patent number: 10975081
    Abstract: Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: April 13, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
    Inventors: Xiao Ding, Yun Jin, Qian Liu, Feng Ren, Yingxia Sang, Luigi Piero Stasi, Zehong Wan, Hailong Wang, Weiqiang Xing, Yang Zhan, Baowei Zhao
  • Patent number: 8449906
    Abstract: The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: May 28, 2013
    Assignee: EffRx Pharmaceuticals, S.A.
    Inventor: Christer Rosen
  • Patent number: 8236958
    Abstract: Two new crystalline monohydrates and two new crystalline anhydrates of gaboxadol are disclosed together with methods for preparing them.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: August 7, 2012
    Assignee: H. Lundbeck A/S
    Inventor: Vincent Brett Cooper
  • Patent number: 7855189
    Abstract: The invention relates to N-phenylphosphoric acid triamides of general formula (I) to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: December 21, 2010
    Assignee: SKW Stickstoffwerke Piesteritz GmbH
    Inventors: André Hucke, Hans-Joachim Niclas, Hartmut Wozniak, Hans-Jürgen Michel, Carola Schuster
  • Publication number: 20100240615
    Abstract: The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 23, 2010
    Applicants: University of Orago, Medical Research Council
    Inventors: Robin Andrew James Smith, Michael Patrick Murphy
  • Patent number: 7799824
    Abstract: Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: September 21, 2010
    Assignee: OraPharma, Inc.
    Inventors: Bharat Lagu, Michael Wachter
  • Publication number: 20090233873
    Abstract: The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.
    Type: Application
    Filed: March 27, 2009
    Publication date: September 17, 2009
    Applicants: University of Otago, Medical Research Council
    Inventors: Robin Andrew James Smith, Michael Patrick Murphy
  • Publication number: 20040116392
    Abstract: A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 &mgr;m and contain at least 80% by weight of metoprolol.
    Type: Application
    Filed: September 5, 2003
    Publication date: June 17, 2004
    Inventors: Alf Djurle, Mikael Hansson, Malin Soderbom
  • Patent number: 6498160
    Abstract: Phthalazine compounds having formula I wherein , A, B, R, R1, R2 and R3 are as defined herein, useful as phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: December 24, 2002
    Assignee: Zambon Group S.p.A.
    Inventors: Mauro Napoletano, Gabriele Norcini, Giancarlo Grancini, Franco Pellacini, Gabriele Morazzoni
  • Publication number: 20020156053
    Abstract: Novel compounds of formula I, with the exception of
    Type: Application
    Filed: March 1, 2001
    Publication date: October 24, 2002
    Inventors: Thomas Elebring, Peter Guzzo, Anders aq Holmen, Thomas Olsson, Marianne Swanson, Sverker Von Unge
  • Publication number: 20010038864
    Abstract: A method of producing betulinic acid from the bark of plane trees by fractional extraction with a solvent of medium polarity and subsequent recrystallization out of methanol.
    Type: Application
    Filed: November 30, 2000
    Publication date: November 8, 2001
    Inventors: Birgit Draeger, Tino Galgon, Reinhard Neubert, Wolfgang Wohlrab
  • Publication number: 20010039267
    Abstract: A lawn colorant composition having rearing effects contains a pigment and an adhesive for the pigment. The pigment comprises a blue pigment composed as a primary component of a compound represented by the following formula: MFe[Fe(CN)6] wherein M represents an alkali metal atom or an ammonium group, one of the two Fe atoms is a divalent ion, and the other Fe atom is a trivalent ion. The adhesive comprises a water-dispersed polymer and a water-soluble polymer having compatibility with said water-dispersed polymer.
    Type: Application
    Filed: January 21, 2000
    Publication date: November 8, 2001
    Inventors: Ken Okura, Toshio Hattori, Masayoshi Sakakibara, Shigeo Ssasaki
  • Publication number: 20010018430
    Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
    Type: Application
    Filed: February 7, 2001
    Publication date: August 30, 2001
    Applicant: Tularik, Inc.
    Inventor: Jonathan B. Houze
  • Patent number: 6096730
    Abstract: Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: August 1, 2000
    Assignee: University of Kentucky Research Foundation
    Inventors: Delwood C. Collins, Antonio R. Gagliardi, Peter Nickel
  • Patent number: 5441959
    Abstract: Novel substituted quinazolinones of the formula (I) are useful as angiotensin II antagonists.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: August 15, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Prasun K. Chakravarty, Stephen E. de Laszlo, Tomasz W. Glinka, William J. Greenlee, Nathan B. Mantlo, Arthur A. Patchett
  • Patent number: 5336671
    Abstract: The invention provides fungicidal compositions containing benzyl-tris(aryl)-phosphonium salts of the general formula ##STR1## in which R.sup.1 represents an optionally substituted alkyl or alkoxy group; R.sup.2 represents a hydrogen atom or an optionally substituted alkyl group; R.sup.3, R.sup.4 and R.sup.5 independently represent a hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group; and A.sup.- represents an anion processes for the preparation of such compounds. Certain of the compounds of formula I are novel and the invention therefore also provides processes for the preparation of such compounds and their use as fungicides.
    Type: Grant
    Filed: October 18, 1991
    Date of Patent: August 9, 1994
    Assignee: Shell Research Limited
    Inventors: Heinz-Manfred Becher, Guido Albert, Jurgen Curtze
  • Patent number: 4781920
    Abstract: The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as antibiotics, vitamins, vaccines, or mineral supplements.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: November 1, 1988
    Assignee: American Cyanamid Company
    Inventor: James M. Quinlan
  • Patent number: 4686209
    Abstract: Compounds of the formula ##STR1## wherein the symbols have assigned meanings, and their use for controlling insects and mites.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: August 11, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Mohamed A. H. Fahmy
  • Patent number: 4629491
    Abstract: The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of urease through use of such compounds.
    Type: Grant
    Filed: December 20, 1983
    Date of Patent: December 16, 1986
    Assignee: Allied Corporation
    Inventors: Michael D. Swerdloff, Milorad M. Rogic, Larry L. Hendrickson