Abstract: Disclosed are substituted fused pyrazoles, for example substituted indazoles, that inhibit LRRK2 kinase activity, pharmaceutical compositions containing them and their use in the treatment of Parkinson's disease.
Type:
Grant
Filed:
July 22, 2016
Date of Patent:
April 13, 2021
Assignee:
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Abstract: The invention provides effervescent composition comprising a bisphosphonate, an acidic compound, an alkaline effervescing component, and optionally an anti-ulcer agent and methods of treating osteoporosis in a mammal using the effervescent compositions.
Abstract: The invention relates to N-phenylphosphoric acid triamides of general formula (I) to a method for the production thereof and to their use as agents for regulating or inhibiting enzymatic urea hydrolysis.
Abstract: The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.
Type:
Application
Filed:
March 26, 2010
Publication date:
September 23, 2010
Applicants:
University of Orago, Medical Research Council
Inventors:
Robin Andrew James Smith, Michael Patrick Murphy
Abstract: Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.
Abstract: The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.
Type:
Application
Filed:
March 27, 2009
Publication date:
September 17, 2009
Applicants:
University of Otago, Medical Research Council
Inventors:
Robin Andrew James Smith, Michael Patrick Murphy
Abstract: A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 &mgr;m and contain at least 80% by weight of metoprolol.
Type:
Application
Filed:
September 5, 2003
Publication date:
June 17, 2004
Inventors:
Alf Djurle, Mikael Hansson, Malin Soderbom
Abstract: A method of producing betulinic acid from the bark of plane trees by fractional extraction with a solvent of medium polarity and subsequent recrystallization out of methanol.
Type:
Application
Filed:
November 30, 2000
Publication date:
November 8, 2001
Inventors:
Birgit Draeger, Tino Galgon, Reinhard Neubert, Wolfgang Wohlrab
Abstract: A lawn colorant composition having rearing effects contains a pigment and an adhesive for the pigment. The pigment comprises a blue pigment composed as a primary component of a compound represented by the following formula: MFe[Fe(CN)6] wherein M represents an alkali metal atom or an ammonium group, one of the two Fe atoms is a divalent ion, and the other Fe atom is a trivalent ion. The adhesive comprises a water-dispersed polymer and a water-soluble polymer having compatibility with said water-dispersed polymer.
Type:
Application
Filed:
January 21, 2000
Publication date:
November 8, 2001
Inventors:
Ken Okura, Toshio Hattori, Masayoshi Sakakibara, Shigeo Ssasaki
Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
Abstract: Phosphonic acid agents are synthesized and characterized which are potent inhibitors of angiogenesis, tumorigenesis and metalloproteinase activity. Their method of use for the inhibition of angiogenesis and metalloproteinase and the treatment of tumors is also shown.
Type:
Grant
Filed:
July 23, 1998
Date of Patent:
August 1, 2000
Assignee:
University of Kentucky Research Foundation
Inventors:
Delwood C. Collins, Antonio R. Gagliardi, Peter Nickel
Abstract: The invention provides fungicidal compositions containing benzyl-tris(aryl)-phosphonium salts of the general formula ##STR1## in which R.sup.1 represents an optionally substituted alkyl or alkoxy group; R.sup.2 represents a hydrogen atom or an optionally substituted alkyl group; R.sup.3, R.sup.4 and R.sup.5 independently represent a hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group; and A.sup.- represents an anion processes for the preparation of such compounds. Certain of the compounds of formula I are novel and the invention therefore also provides processes for the preparation of such compounds and their use as fungicides.
Abstract: The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as antibiotics, vitamins, vaccines, or mineral supplements.
Abstract: The invention relates to novel urease inhibited fertilizer compositions containing urea and a urease inhibiting amount of one or more diaminophosphinyl compounds having oxidized sulfur functions, and methods and composition for inhibiting the activity of urease through use of such compounds.
Type:
Grant
Filed:
December 20, 1983
Date of Patent:
December 16, 1986
Assignee:
Allied Corporation
Inventors:
Michael D. Swerdloff, Milorad M. Rogic, Larry L. Hendrickson