Oxygen Bonded Directly To A Carbon Or Hydrogen And Wherein The Oxygen Is Not Bonded Directly To Phosphorus Patents (Class 514/129)
  • Patent number: 11344522
    Abstract: The present invention generally relates to the field of dietary therapies for treating disorders associated with mitochondrial dysfunction, including epilepsy.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: May 31, 2022
    Assignees: Vitaflow (International) Ltd, UCL Business PLC
    Inventors: Maura O'Donnell, Bridget Lambert, Patricia Wallis, Patricia Rutherford, Simon Heales, Sean-David Hughes, Helen Cross, Simon Eaton
  • Patent number: 11198763
    Abstract: Disclosed are oral care compositions of novel phosphono-phosphate and anionic group containing polymer compositions that have targeted uses with divalent cations and surfaces having divalent cations. These compounds can be used to deliver anionic character to surfaces such as calcium hydroxyapatite for use in oral care applications.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: December 14, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Ryan Michael West, Scott Leroy Cron, Yingkun Jin, William Michael Glandorf
  • Patent number: 10875888
    Abstract: The present invention relates to a compound represented by formula (I), a tautomer thereof or a pharmaceutically acceptable salt thereof, and relates to applications thereof in the preparation of drugs for treating FXR related diseases.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: December 29, 2020
    Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    Inventors: Haiying He, Hualing Xiao, Peng Li, Chunyan Du, Zhi Luo, Shuhui Chen
  • Patent number: 10836954
    Abstract: A well treatment fluid composition that includes a tetrakis(hydroxyorgano)phosphonium salt and at least one oxidizing viscosity breaker. Methods for preparing a microbial viscosity breaker composition and treating a subterranean formation are also presented.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: November 17, 2020
    Assignee: Solvay USA Inc.
    Inventors: Chris Jones, Jean Molina, Francis Smith, Henry Wiggins, Dru Bishop
  • Patent number: 10174239
    Abstract: Biofouling may be prevented or at least mitigated by employing a cinnamaldehyde additive to augment the affect of the conventional biocide. Exemplary cinnamaldehyde additives include, but are not limited to, cinnamaldehyde, cinnamic acid and cinnamyl alcohol. A cinnamaldehyde additive by itself, in some embodiments, may also inhibit biofouling.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: January 8, 2019
    Assignee: Baker Hughes, a GE company, LLC
    Inventors: Crystal Lee, Joseph E. Penkala, Kenneth G. Wunch
  • Patent number: 10064830
    Abstract: Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. 20-23.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: September 4, 2018
    Inventors: Stanley L. Hazen, Bruce Levison, Zeneng Wang
  • Patent number: 9399619
    Abstract: Pharmaceutical compositions of the invention comprise sulfamoylbenzamide derivative useful as pregenomic RNA encapsidation inhibitors, useful for the treatment of Hepatitis B virus (HBV) infection.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: July 26, 2016
    Assignees: Baruch S. Blumberg Institute, Drexel University
    Inventors: Ju-Tao Guo, Xiaodong Xu, Timothy M. Block
  • Patent number: 9290710
    Abstract: A synergistic antimicrobial composition having two components. The first component is a hydroxymethyl-substituted phosphorus compound. The second component is one of the following biocides: hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine, 2,6-dimethyl-1,3-dioxan-4-yl acetate or ortho-phenylphenol or its alkali metal or ammonium salts.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: March 22, 2016
    Assignee: Dow Global Technologies LLC
    Inventor: Bei Yin
  • Patent number: 9265704
    Abstract: The invention relates to a cosmetic composition comprising, in a physiologically acceptable aqueous medium, a cucurbic acid compound of formula (I) in which R1 represents a radical COOR3, where R3 denotes H or a C1-C4 alkyl radical, which is optionally substituted by one or more hydroxyl groups; R2 represents a hydrocarbon radical having from 1 to 18 carbon atoms; and a copolymer of 2-acrylamido-2-methylpropanesulphonic acid and hydroxylated C2-C4 alkyl(meth)acrylate. Application to the care and make-up of keratin materials.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: February 23, 2016
    Assignee: L'OREAL
    Inventor: Yael Charbit
  • Patent number: 9138389
    Abstract: The invention relates to a method for cosmetically treating oily skin, including the topical application onto the skin of a composition containing a jasmonic acid compound in a physiologically acceptable medium.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: September 22, 2015
    Assignee: L'OREAL
    Inventor: Maria Dalko
  • Patent number: 9114135
    Abstract: A salt compound, and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject using the salt compound are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic salt compound comprising a nitrate ester.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: August 25, 2015
    Assignee: SGC Pharma Inc.
    Inventors: Robert Bender, Ho-Lun Joseph Chau, Doug Cowart
  • Publication number: 20150141377
    Abstract: A synergistic composition comprising a THP salt and a biopenetrant, in which the biopenetrant comprises a polymer of an unsaturated carboxylic acid or a copolymer of an unsaturated carboxylic acid with a sulphonic acid, said polymer or copolymer being terminated by a mono- or diphosphonated unsaturated carboxylic acid group or having such monomers incorporated into the polymer backbone. This composition acts synergistically to enhance the biocidal efficacy of the THP salt against both planktonic (free-swimming) and sessile (attached) bacteria, and also acts synergistically to enhance the efficacy of the THP salt in the dissolution of iron sulphide scale.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Robert Eric TALBOT, Christopher Raymond JONES
  • Patent number: 9034820
    Abstract: The invention generally relates to compositions and methods of their use. More specifically, the invention relates to the use of a compound in modulating erythropoiesis in a subject by mediating the activity and/or quantity of a member present in the LPA3-mediated signaling pathway, such as lysophosphatidic acid receptor subtype 3 (LPA3).
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: May 19, 2015
    Inventor: Hsinyu Lee
  • Patent number: 9023835
    Abstract: The invention provides a method of ameliorating a blood-brain barrier disorder, as well as a method of treating a disease accompanied by a blood-brain barrier disorder and a method of treating a cerebral ischemic disease, by administering a prothymosin ?, or a protein or polypeptide possessing the same function as the prothymosin ?. The invention also provides polypeptides useful in the context of the aforesaid methods.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: May 5, 2015
    Assignee: Nagasaki University
    Inventor: Hiroshi Ueda
  • Patent number: 9006216
    Abstract: A combination biocide (Glutaraldehyde or OPA), quaternary phosphonium biocide (preferably TTPC), alcohol (preferably isopropyl alcohol), and functional excipients for the oil and gas recovery industry. The functional excipients for the oil and gas recovery industry are a cellulose type proppant, a poloxamer wetting agent, a friction-reducing pluronic block copolymer, a drag reducing agent such as polyethylene oxide, and a flocculating agent. The OPA may be of the dialdehyde C6H4(CHO)2 form, and the Glutaraldehyde of formula C5H8O2. Both will produce an inherent bacteriostatic effect and lower surface tension and thus aids in the spread of the TTPC on the biofilm covered surface where it is readily absorbed by the negative surfaces of proteins and bacteria. It thus serves as a binding agent between the TTPC and the application surface. The foregoing constituents are combined in preferred concentrations within acceptable ranges to provide a synergistic biological chemical complementarity system.
    Type: Grant
    Filed: December 6, 2011
    Date of Patent: April 14, 2015
    Inventor: Howard Martin
  • Publication number: 20150098928
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure.
    Type: Application
    Filed: January 6, 2014
    Publication date: April 9, 2015
    Applicant: E.I. du Pont de Nemours and Company
    Inventors: George Philip Lahm, Ty Wagerle, Ming Xu
  • Publication number: 20150086596
    Abstract: Embodiments of the invention involve treating skin afflictions by the topical or oral use of organophosphates. By effectively reducing or eliminating the population of Demodex mites in affected skin areas and areas where Demodex mites may exist, this treatment achieves a more complete remission of clinical signs and symptoms of the skin afflictions than any previously described method. Embodiments of the invention are useful for treating skin afflictions including common acne, seborrheic dermatitis, perioral dermatitis, an acneform rash, transient acantholytic dermatosis, acne necrotica milliaris, psoriasis, steroid induced dermatitis, primary irritation dermatitis, rosacea and for diagnositic methods thereof.
    Type: Application
    Filed: July 28, 2014
    Publication date: March 26, 2015
    Inventor: Frank Anthony SPALLITTA
  • Publication number: 20150038471
    Abstract: Biofouling may be prevented or at least mitigated by employing a cinnamaldehyde additive to augment the affect of the conventional biocide. Exemplary cinnamaldehyde additives include, but are not limited to, cinnamaldehyde, cinnamic acid and cinnamyl alcohol. A cinnamaldehyde additive by itself, in some embodiments, may also inhibit biofouling.
    Type: Application
    Filed: October 22, 2014
    Publication date: February 5, 2015
    Applicant: BAKER HUGHES INCORPORATED
    Inventors: Crystal Lee, Joseph E. Penkala, Kenneth G. Wunch
  • Publication number: 20150038470
    Abstract: Disclosed are biocide compositions. The compositions are useful in applications relating to the production, transportation, storage, and separation of crude oil and natural gas. Also disclosed are methods of using the compositions, particularly in applications relating to the production, transportation, storage, and separation of crude oil and natural gas.
    Type: Application
    Filed: July 31, 2014
    Publication date: February 5, 2015
    Inventors: Victor Keasler, Jeffery Caleb Clark, Carrie Keller-Schultz, Brian Bennett
  • Publication number: 20140363486
    Abstract: Glycerophosphate salts have been found to hasten the healing of wounds and minimize the formation of scars, particularly when it is first applied to a wound about 0 to about 7 days after the wound is inflicted. Methods and compositions are provided for treating wounds using a composition comprising an effective amount of glycerophosphate salt. In particular, methods are provided for treating wounds using calcium glycerophosphate (CGP), for accelerating the healing process, reducing pain and scar formation, and for the cosmetic reducing, excision, erasure and/or complete repair of scars (scar revision).
    Type: Application
    Filed: July 30, 2014
    Publication date: December 11, 2014
    Inventor: Alan E. KLIGERMAN
  • Publication number: 20140356814
    Abstract: The present invention relates to a dental implant having an enhanced early stability and a method for manufacturing same, and more specifically to a dental implant and a method for manufacturing same which assure early stability and fixation power of an implant by suppressing early osteolysis after an implant procedure, and allowing better bone coherence of the implant surface during an osteogenic period by controlling the speed of bone remodeling.
    Type: Application
    Filed: October 4, 2012
    Publication date: December 4, 2014
    Inventors: Su Kyoung Kim, Eun Jung Kang, Ju Dong Song, Tae Gwan Eom, Kyoo Ok Choi
  • Publication number: 20140349976
    Abstract: As disclosed herein, co-administration of pimavanserin with an agent that ameliorates one or more cholinergic abnormalities can have a synergistic effect on the efficacy of the agent. Disclosed herein are compositions which include pimavanserin in combination with an agent that ameliorates one or more cholinergic abnormalities. Also disclosed herein are methods for ameliorating or treating a disease condition characterized by one or more cholinergic abnormalities that can include administering pimavanserin in combination with an agent that ameliorates one or more cholinergic abnormalities.
    Type: Application
    Filed: May 28, 2014
    Publication date: November 27, 2014
    Applicant: Acadia Pharmaceuticals Inc.
    Inventors: Uli HACKSELL, Krista MCFARLAND
  • Publication number: 20140315864
    Abstract: The present disclosure relates to a cosmetic or dietary composition for combating human or animal hair loss and/or promoting hair growth and/or regrowth and/or enhancing the beauty thereof (shine, softness, strength) and/or enhancing scalp comfort, comprising at least miliacin in a proportion greater than 0.1% by mass with respect to the total mass of the composition and polar lipids in a proportion greater than 0.1% by mass with respect to the total mass of the composition, including sphingolipids, particularly ceramides and/or glycosylceramides, and/or phospholipids in a proportion greater than 0.1% by mass with respect to the total mass of the composition. The present disclosure further relates to the use of such a composition, and the method for preparing such a composition.
    Type: Application
    Filed: February 21, 2014
    Publication date: October 23, 2014
    Applicant: HITEX
    Inventors: Irene LAMOUR, Francois LAIMAY, Emmanuelle GAILLARD
  • Publication number: 20140256686
    Abstract: A composition for treating an inorganic slurry, the composition comprising: (a) a tetrakis (hydroxyorgano) phosphonium salt; and (b) a dispersant selected from the group consisting of (i) a phosphonated compound containing at least one tertiary nitrogen atom, (ii) a phosphonated oligomer of an unsaturated acid, (iii) a homopolymer of an unsaturated acid, and (iv) a polyphosphate.
    Type: Application
    Filed: May 23, 2014
    Publication date: September 11, 2014
    Applicant: RHODIA OPERATIONS
    Inventor: Christopher Raymond JONES
  • Publication number: 20140249114
    Abstract: Provided are biocidal compositions comprising: a hydroxymethyl-substituted phosphorus compound and an isothiazolinone compound selected from 1,2-benzisothiazolin-3-one, 2-methyl-1,2-benzisothiazolin-3-one, and mixtures thereof. The compositions are useful for controlling microorganisms in aqueous or water-containing systems.
    Type: Application
    Filed: October 9, 2012
    Publication date: September 4, 2014
    Inventors: Bei Yin, Michael V. Enzien, Donald J. Love, Emerentiana Sianawati
  • Publication number: 20140221318
    Abstract: Provided are biocidal compositions comprising: a hydroxymethyl-substituted phosphorus compound and a polymeric biguanide. The compositions are useful for controlling microorganisms in aqueous or water-containing systems.
    Type: Application
    Filed: May 8, 2012
    Publication date: August 7, 2014
    Inventor: Bei Yin
  • Publication number: 20140220094
    Abstract: Glycerophosphate salts have been found to drastically improve a laparoscopic surgery by reducing the inflammatory response inflicted by the surgery and enhancing wound healing. Methods and devices for improving the laparoscopic surgery using a composition comprising an effective amount of a glycerophosphate salt are described.
    Type: Application
    Filed: April 10, 2014
    Publication date: August 7, 2014
    Applicant: PRELIEF INC.
    Inventors: Alan E. KLIGERMAN, Joseph V. DITROLIO
  • Publication number: 20140206653
    Abstract: Cu(I) complexes of the type [Cu(thp)4]n[X]?n, wherein thp is a tris(hydroxymethyl)phosphine, X is a counteranion, n=1-4, for the use as antineoplistic agents against solid tumors in humans.
    Type: Application
    Filed: August 16, 2011
    Publication date: July 24, 2014
    Inventors: Cristina Marzano, Marina Porchia, Francesco Tisato, Valentina Gandin, Carlo Santini, Maura Pellei, Giancarlo Gioia Lobbia, Grazia Papini
  • Patent number: 8778914
    Abstract: The present invention relates to a prodrug, comprising a pharmaceutically and/or diagnostically active compound, and one or more bisphosphonate groups, to a process for producing such a prodrug, and to a pharmaceutical composition comprising said prodrug, to be used for the treatment of bone-related disorders such as bone cancer.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: July 15, 2014
    Assignee: KTB Tumorforschungsgesellschaft mbH
    Inventors: Felix Kratz, Katrin Hochdoerffer
  • Patent number: 8765691
    Abstract: The present invention relates to the use of osmolytes for treating allergic or viral respiratory diseases, e.g. allergic rhinitis (hay fever) as well as rhinovirus and/or adenovirus infections. The invention also relates to a medicament preparation containing one or more compounds from the group of osmolytes. The group of osmolytes used in the invention comprises various low-molecular substances, more specifically ectoine, 4,5,6,7-tetrahydro-2-methyl-1H-[1,3]-diazepine-4-S-carboxylic acid (homoectoine), hydroxyectoine, di-myo-inositol-phosphate (DIP), to cyclic 2,3-diphosphoglycerate (cDPG), 1,1-diglycerol phosphate (DGP), ?-mannosylglycerate (firoin), ?-mannosylglyceramide (firoin-A), dimannosyl-diinositol phosphate (DMIP), glucosylglycerol, taurine, betaine, citrulline, and/or a derivative, e.g. an acid, salt, or ester of said compounds.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: July 1, 2014
    Assignee: Bitop AG
    Inventors: Jean Krutmann, Georg Lentzen, Thomas Schwarz
  • Publication number: 20140127165
    Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A is a 6-membered aromatic ring containing carbon atoms and 0-3 nitrogen atoms as ring members, said ring optionally substituted with 1-5 substituents independently selected from R2; R1 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C4-C7 alkylcycloalkyl or C4-C7 cycloalkylalkyl, each optionally substituted with one or more substituents independently selected from R21; R21 is independently H, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 alkylthio, C1-C6 haloalkylthio, C1-C6 alkylsulfinyl, C1-C6 haloalkylsulfinyl, C1-C6 alkylsulfonyl, C1-C6 haloalkylsulfonyl, CN or NO2; and Q is as defined in the disclosure.
    Type: Application
    Filed: January 6, 2014
    Publication date: May 8, 2014
    Applicant: E.I. du Pont de Nemours and Company
    Inventors: George Philip Lahm, Ty Wagerle, Ming Xu
  • Patent number: 8709454
    Abstract: At least one phytosphingosine salicylate derivative and at least one lysate of at least one microorganism of the genus Bifidobacterium. Composition, combination. Use, including cosmetic use for reinforcing the repair and regeneration capacity of an epithelium, especially an epidermis, in particular an aged epidermis.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: April 29, 2014
    Assignee: L'Oreal
    Inventors: David Amar, Bruno Bernard, Dominique Bernard, Isabelle Castiel
  • Publication number: 20140099268
    Abstract: A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. Compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives can also be used to lower intraocular pressure and treat bone disorders.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 10, 2014
    Applicant: Duke University
    Inventors: Mitchell A. deLong, John M. McIver, Robert S. Youngquist
  • Publication number: 20140080792
    Abstract: A method for reducing the effects of biological contamination in a hydrocarbon-containing system comprising the steps of continuously adding a formulation comprising tris(hydroxymethyl)phosphine or a tetrakis(hydroxymethyl)phosphonium salt to the system for one day or more; monitoring the efficacy of the continuous treatment by an assessment of the extent to which there is any effect on the environment that is attributable to metabolic activity of active microbes present in the system; wherein the tris(hydroxymethyl)phosphine or tetrakis(hydroxymethyl)phosphonium salt is added at a concentration of from 1 to 30 ppm based on the total volume of aqueous fluid added to the system, and wherein the formulation is added to the system at a stage to minimize incompatibility with any other chemicals that are added to the aqueous fluid.
    Type: Application
    Filed: February 29, 2012
    Publication date: March 20, 2014
    Applicant: RHODIA OPERATIONS
    Inventors: Chris Jones, Stephanie Edmunds, Gareth Collins
  • Publication number: 20140080793
    Abstract: The present invention is related to pharmaceutical compositions that include a phosphonium antimicrobial agent. In a preferred embodiment, the present invention relates to an otic, nasal or ophthalmic composition (e.g., an aqueous ophthalmic solution) that includes a phosphonium salt compound as an antimicrobial agent. The compositions typically possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements and/or similar preservative standards (e.g., EP and JP).
    Type: Application
    Filed: November 20, 2013
    Publication date: March 20, 2014
    Applicant: Alcon Research, Ltd.
    Inventors: Masood A. Chowhan, Wesley Wehsin Han, L. Wayne Schneider
  • Patent number: 8613941
    Abstract: A synergistic antimicrobial composition comprising: (a) a hydroxymethyl-substituted phosphorus compound selected from the group consisting of tetrakis(hydroxymethyl)phosphonium salts and tris(hydroxymethyl)phosphine; and (b) tris(hydroxymethyl)nitromethane.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: December 24, 2013
    Assignee: Dow Global Technologies LLC
    Inventor: Bei Yin
  • Patent number: 8598147
    Abstract: A synergistic antimicrobial composition having two components. The first component is a hydroxymethyl-substituted phosphorus compound. The second component is cis-1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride.
    Type: Grant
    Filed: September 13, 2010
    Date of Patent: December 3, 2013
    Assignee: Dow Global Technologies LLC
    Inventor: Bei Yin
  • Patent number: 8557266
    Abstract: A synergistic antimicrobial composition comprising: (a) a hydroxymethyl-substituted phosphorus compound selected from the group consisting of tetrakis(hydroxymethyl)phoshponium salts and tris(hydroxymethyl)phosphine; and (b) tris(hydroxymethyl)nitromethane.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: October 15, 2013
    Assignee: Dow Global Technologies LLC
    Inventor: Bei Yin
  • Patent number: 8551518
    Abstract: An anti-stick agent that may be incorporated into an aqueous medium to assist in the prevention of soils and bodily exudates adhering to the skin. A substrate may be utilized to assist in delivering the anti-stick agent to the skin.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: October 8, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Randall Glenn Marsh, Philip Andrew Sawin, Randall Alan Watson
  • Publication number: 20130244984
    Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
    Type: Application
    Filed: April 25, 2013
    Publication date: September 19, 2013
    Applicant: Kao Corporation
    Inventors: Yoshiya SUGAI, Hiroshi HASHIMOTO, Shinya AMANO, Shotaro ITO, Yoshie SHIMOTOYODOME, Yoriko NAKAGIRI
  • Publication number: 20130230463
    Abstract: The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an ?-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.
    Type: Application
    Filed: March 2, 2012
    Publication date: September 5, 2013
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Bruce Allan HAY, Daniel Eugene MEYER, Brian Christopher BALES, Michael Todd LUTTRELL
  • Publication number: 20130225531
    Abstract: A composition and method of treating Alzheimer's disease or a dementia of vascular origin are disclosed. The composition and method utilize an endothelin antagonist as the active agent to treat Alzheimer's disease or a dementia of vascular origin in mammals, including humans.
    Type: Application
    Filed: December 19, 2012
    Publication date: August 29, 2013
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventor: The Board Of Trustees Of The University of Illinois
  • Publication number: 20130225534
    Abstract: A method for treating an inorganic slurry to preserve the slurry against bacterial contamination, including (I) providing a slurry in a substantially homogeneous phase, and then (II) adding to the slurry an effective amount of a composition containing: (a) a tetrakis (hydroxyorgano) phosphonium salt selected from the group consisting of tetrakis (hydroxymethyl) phosphonium sulphate, tetrakis (hydroxymethyl) phosphonium chloride, tetrakis (hydroxymethyl) phosphonium phosphate, tetrakis (hydroxymethyl) phosphonium nitrate and tetrakis (hydroxymethyl) phosphonium oxalate; and (b) a dispersant selected from the group consisting of (i) a phosphonated compound containing at least one tertiary nitrogen atom and (ii) a homopolymer of an unsaturated acid; and (III) preserving the slurry against bacterial contamination, whilst avoiding instantaneous heterogeneous thickening of the slurry due to the tetrakis (hydroxyorgano) phosphonium salt.
    Type: Application
    Filed: April 3, 2013
    Publication date: August 29, 2013
    Applicant: Rhodia Operations
    Inventor: Rhodia Operations
  • Patent number: 8518915
    Abstract: The invention relates to pharmacology and medicine, in particular to a class of mitochondrially-addressed compounds which can be used in the pharmaceutical compositions of medicinal agents (preparations) for preventing and treating cardiovascular diseases and diseases and pathological conditions caused by disturbed blood circulation or oxygen supply to tissues and organs.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: August 27, 2013
    Assignee: Mitotech SA
    Inventors: Maxim Vladimirovich Skulachev, Vladimir Petrovich Skulachev
  • Patent number: 8501242
    Abstract: The present invention relates to compounds as novel thymidylate synthase inhibitors, novel strategies to treat or prevent neoplasia in a subject, methods and compositions thereof.
    Type: Grant
    Filed: May 29, 2010
    Date of Patent: August 6, 2013
    Assignee: University of Florida Research Foundation
    Inventors: David A. Ostrov, Carmen J. Allegra
  • Publication number: 20130171269
    Abstract: The present invention discloses pharmaceutical/nutritional compositions and methods for alleviating symptoms associated with premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). The pharmaceutical/nutritional compositions include at least 2% (w/w) phosphatidyl-L-serine, or salts thereof, out of a total effective composition, as a first effective ingredient; and a suitable amount of at least one bio-available form of magnesium as a second effective ingredient. Preferably, the bio-available form of magnesium is magnesium oxide, magnesium citrate, magnesium hydroxide, magnesium stearate, or a magnesium salt of the phosphatidyl-L-serine. Preferably, the composition further includes a pharmaceutical or nutritional excipient. Preferably, the total effective composition is administrable in a multi-part regimen. Preferably, the total effective composition is administrable by intravenous or oral delivery.
    Type: Application
    Filed: February 22, 2013
    Publication date: July 4, 2013
    Applicant: Lipogen Ltd.
    Inventor: Lipogen Ltd.
  • Publication number: 20130156816
    Abstract: The invention features compositions, methods, and kits for the administration of an oxidatively transformed carotenoid, or a fractionated component thereof, for use in aquaculture.
    Type: Application
    Filed: February 18, 2011
    Publication date: June 20, 2013
    Applicant: Chemaphor Inc.
    Inventors: Larry Arthur Stobbs, James Gary Nickerson, Clayton Paul Dick
  • Publication number: 20130131020
    Abstract: A synergistic composition comprising a THP salt and a biopenetrant, in which the biopenetrant comprises a polymer of an unsaturated carboxylic acid or a copolymer of an unsaturated carboxylic acid with a sulphonic acid, said polymer or copolymer being terminated by a mono- or diphosphonated unsaturated carboxylic acid group or having such monomers incorporated into the polymer backbone. This composition acts synergistically to enhance the biocidal efficacy of the THP salt against both planktonic (free-swimming) and sessile (attached) bacteria, and also acts synergistically to enhance the efficacy of the THP salt in the dissolution of iron sulphide scale.
    Type: Application
    Filed: January 18, 2013
    Publication date: May 23, 2013
    Applicant: Rhodia UK Limited
    Inventors: Robert Eric TALBOT, Christopher Raymond Jones
  • Patent number: 8440645
    Abstract: Provided are a drug, a cosmetic, etc. for promoting production of ceramide. Provided is a ceramide production promoter including a compound represented by the formula (1) or salts thereof as an active ingredient (in the formula, R1 represents a phosphono group or a hydrogen atom, R2 represents an alkyl group having 8 to 24 carbon atoms or an acyl group having 8 to 24 carbon atoms, and R3 represents an alkyl group having 1 to 24 carbon atoms when R1 represents a phosphono group or represents a phosphono group when R1 represents a hydrogen atom, or a salt thereof as an active ingredient.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: May 14, 2013
    Assignee: Kao Corporation
    Inventors: Yoshiya Sugai, Hiroshi Hashimoto, Shinya Amano, Shotaro Ito, Yoshie Shimotoyodome, Yoriko Nakagiri
  • Patent number: 8404181
    Abstract: The present invention relates to a method of preventing or alleviating the problems associated with corrosion and to novel formulations for use in such a method.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: March 26, 2013
    Assignee: Rhodia UK Limited
    Inventors: Chris Jones, Julie Hardy