Oxygen Bonded Directly To A Carbon Or Hydrogen And Wherein The Oxygen Is Not Bonded Directly To Phosphorus Patents (Class 514/129)
  • Patent number: 5015635
    Abstract: Pesticidal S-(halogenoalkyl)-dithiophosphoric (phosphonic) acid esters of the formula ##STR1## in which R.sup.1 represents an optionally substituted radical from the group consisting of alkyl, alkenyl, alkoxy, alkenyloxy and alkinyloxy,R.sup.2 represents an optionally substituted radical from the group consisting of alkyl, cycloalkyl, alkenyl, alkinyl and aryl,X and Y are identical or different and independently of one another represent hydrogen, halogen or alkyl, andZ represents hydrogen, halogen or alkyl.
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: May 14, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Sommer, Jurgen Hartwig, Hans-Detlef Matthaei
  • Patent number: 4992429
    Abstract: Disclosed are novel substituted cyclohexenyl phosphinylhydroxybutyrates as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula: ##STR1## and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 24, 1989
    Date of Patent: February 12, 1991
    Assignee: Rhone-Poulenc Rorer Pharmaceuticals Inc.
    Inventors: John W. Ullrich, Kent W. Neuenschwander, John R. Regan
  • Patent number: 4962097
    Abstract: Dipeptide mimics which contain phosphorus and their pharmaceutical use and preparation are disclosed. The compounds have dehydropeptidase (DHP) enzyme inhibitor activity.
    Type: Grant
    Filed: August 17, 1989
    Date of Patent: October 9, 1990
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, ARthur A. Patchett
  • Patent number: 4962207
    Abstract: The present application discloses novel potassium salts of particular tellurium and selenium compounds which are useful for the stimulation of the production of cytokines.
    Type: Grant
    Filed: October 9, 1987
    Date of Patent: October 9, 1990
    Assignee: Bar-Ilan University
    Inventors: Michael Albeck, Benjamin Sredni
  • Patent number: 4950658
    Abstract: This invention relates to a method for improving memory and accompanying symptoms in patients with Alzheimer's disease and related disorders of memory. The method includes the steps of dosing a patient with 2,2-dichlorovinyl dimethyl phosphate sometimes referred to as dichlorvos or DDVP, or a precursor thereof maintaining said dosage at a level and over a period of time sufficient to create a concentration of DDVP in the brain whereby memory improvement occurs. A satisfactory precursor for this method is 2,2,2-trichloro-1-hydroxyethyl dimethyl phosphate sometimes referred to as metrifonate and 1,2-dibromo, 2-dichlorvoethyl dimethyl phosphate sometimes referred to as naled. Other precursors are also useful.
    Type: Grant
    Filed: December 6, 1988
    Date of Patent: August 21, 1990
    Assignee: Board of Trustees of Southern Illinois Univ.
    Inventors: Robert E. Becker, Ezio Giacobini
  • Patent number: 4891362
    Abstract: Novel substituted N-alkyl-N-alkoxyamidophosphonates or -thiophosphonates and N-alkyl-N-alkoxyamidophosphates or -thiophosphates of formula ##STR1## wherein R is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy,R.sub.1 and R.sub.3 are each independently of the other C.sub.1 -C.sub.4 alkyl,R.sub.2 is hydrogen, C.sub.4 -C.sub.4 alkyl, or when taken together with R.sub.1, forms the radical --(CH.sub.2).sub.4 --; andX and Y are each independently of the other oxygen or sulfur, with the proviso that at least one of X or Y is sulfur if R.sub.2 is hydrogen.The preparation of these compounds is described, as well as the use thereof in pest control, especially for controlling insects and representatives of the order Acarina.
    Type: Grant
    Filed: June 27, 1988
    Date of Patent: January 2, 1990
    Assignee: Ciba-Geigy Corporation
    Inventor: Odd Kristiansen
  • Patent number: 4874526
    Abstract: A process for treating water which comprises adding to the water (a) from 1 to 50 ppm of a phosphonium compound of the formula: ##STR1## in which R represents C.sub.1 -C.sub.6 groups which are unsubstituted or substituted by a cyano, hydroxy, esterified hydroxy or aryl group, R.sub.1 represents a C.sub.8 -C.sub.18 alkyl group and X represents chlorine or bromine, and optionally (b) from 0.1 to 100 ppm of an anionic water treatment agent such as a scale or corrosion inhibiting agent.
    Type: Grant
    Filed: May 26, 1988
    Date of Patent: October 17, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Reinhardt Grade, Brien M. Thomas
  • Patent number: 4791139
    Abstract: A compound of formula: ##STR1## wherein W represents one or more substituents selected from halo, alkyl, alkoxy, alkoxyalkyl, haloalkyl and haloalkoxy or W represents a bidentate group linking adjacent carbon atoms selected from alkylene and alkylenedioxy; Y is a group of formula ##STR2## wherein X is a group of formula --(CF.sub.2).sub.n R.sup.3, where R.sup.3 is selected from hydrogen, chloro and fluoro, and n is one or two, R.sup.1 is selected from hydrogen, chloro, fluoro and hydroxy and R.sup.2 is selected from methyl, cyano, ethynyl and hydrogen; Q is selected from carbon bearing a hydrogen atom and nitrogen; and Z represents one or more substituents selected from fluoro, benzyl, phenoxy, chlorophenoxy, fluorophenoxy and bromophenoxy, or any isomer thereof. Processes for preparing these compounds and intermediates for use therein, insecticidal compositions containing these compounds and the use thereof are also disclosed.
    Type: Grant
    Filed: February 25, 1987
    Date of Patent: December 13, 1988
    Assignee: Imperial Chemical Industries PLC
    Inventors: Michael J. Bushell, Robin A. E. Carr
  • Patent number: 4781920
    Abstract: The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as antibiotics, vitamins, vaccines, or mineral supplements.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: November 1, 1988
    Assignee: American Cyanamid Company
    Inventor: James M. Quinlan
  • Patent number: 4775407
    Abstract: A method of treating surfaces colonized or colonizable by bryophites or lichens which comprises applying thereto sufficient of a water soluble tetrakis (hydroxymethyl) phosphonium salt to kill, or inhibit the growth thereon of said bryophytes or lichens.
    Type: Grant
    Filed: November 12, 1986
    Date of Patent: October 4, 1988
    Assignee: Albright & Wilson Limited
    Inventors: Robert E. Talbot, Kenneth G. Cooper
  • Patent number: 4752614
    Abstract: Certain tellurium compounds have been found to have the ability to stimulate the in vivo and in vitro production of cytokines and their receptors. These compounds may be utilized in the treatment of certain tumors, autoimmune diseases, immune diseases and infectious diseases.
    Type: Grant
    Filed: June 3, 1987
    Date of Patent: June 21, 1988
    Assignee: Bar-Ilan University
    Inventors: Michael Albeck, Benjamin Sredni
  • Patent number: 4731240
    Abstract: The present invention relates to the art of veterinary science. The preparation for prevention and treatment of myiases of animals comprises the following components, percent by mass:an insecticide exhibiting a larvicidal effect: 1.4 to 2.3a 5-10% ethanolic solution of polyvinylbutyral and a resol-type phenolformaldehyde resin taken in a ratio of 1:10-45: 16 to 35.0a plastifying agent improving elasticity of the resulting polymeric film: 1.0 to 20.0an antibiotic: 0.1 to 0.7an organic solvent: the balance.
    Type: Grant
    Filed: June 5, 1986
    Date of Patent: March 15, 1988
    Inventors: Alexandr A. Zakomyrdin, Mark A. Simetsky, Elena I. Pilipets, Vladimir M. Repin, Vitaly I. Ilyaschenko, Dmitry G. Klientovsky, Ljudmila I. Golik, Viktor A. Samkin, Nina P. Kuznetsova
  • Patent number: 4715994
    Abstract: New 3-(1-aminoalkylphosphinyl)-(2-substituted)propionic acids are described which display antibacterial activity and potentiate carbapenem antibiotics.
    Type: Grant
    Filed: November 5, 1986
    Date of Patent: December 29, 1987
    Assignee: Merck & Co., Inc.
    Inventors: William H. Parsons, William R. Schoen, Arthur A. Patchett, Masao Taniguchi
  • Patent number: 4701447
    Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.
    Type: Grant
    Filed: September 23, 1983
    Date of Patent: October 20, 1987
    Assignee: Schering Corporation
    Inventors: Dhiru B. Vashi, Jeffrey N. Clark, Neil A. Lindo
  • Patent number: 4692436
    Abstract: Novel phosphoroimidates of the formula ##STR1## wherein R represents n-propyl or sec.-butyl,R.sup.1 represents methyl or ethyl,R.sup.2 represents methyl or ethyl, andR.sup.3 represents alkyl having from 3 to 4 carbon atoms,and the use of the new compounds as insecticides, acaricides and nematicides.
    Type: Grant
    Filed: May 9, 1986
    Date of Patent: September 8, 1987
    Assignee: Nihon Tokushu Noyaku Seizo K.K.
    Inventors: Toyohiko Kume, Shinichi Tsuboi, Kunihiro Isono
  • Patent number: 4673509
    Abstract: The growth of microbiological contaminants in industrial cooling and process waters and in aqueous based products, susceptible to microbiological spoilage on storage, is inhibited by the presence of a phosphorus compound having a hydroxy alkyl group directly attached to the phosphorus atom, such as tetrakis hydroxy methyl phosphonium sulphate.
    Type: Grant
    Filed: August 27, 1984
    Date of Patent: June 16, 1987
    Assignee: Albright & Wilson Limited
    Inventors: Keith P. Davis, Robert E. Talbot
  • Patent number: 4639438
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2 which may be identical to or different from each other, are each straight or branched alkyl of 1 to 3 carbon atoms;R.sub.3 is alkyl of 1 to 8 carbon atoms;X is sulfur or oxygen;Y is chlorine, bromine or fluorine; andn is 1 or 2.The compounds are useful as pesticides.
    Type: Grant
    Filed: March 12, 1986
    Date of Patent: January 27, 1987
    Assignee: Celamerck GmbH & Co. KG
    Inventors: Richard Sehring, Wolfgang Buck, Ricarda Prokic-Immel, Sigmund Lust
  • Patent number: 4585762
    Abstract: New phospholipid derivatives represented by the formula: ##STR1## wherein R.sup.1 is alkyl, alkoxy, alkylthio or alkylsulfonyl;R.sup.2 is hydrogen, hydroxy, alkoxy, lower alkanoyloxy or lower alkylcarbamoyloxy;n is 0 or 1;R.sup.3 is hydroxy or protected hydroxy; andR.sup.4 is lower alkoxy or lower alicyclic-oxy group which is substituted with 2 or more hydroxy or protected hydroxy groups, and may be substituted with lower alkoxy or another alicyclic-oxy group having two or more hydroxy or protected hydroxy groups, in which the alicyclic ring may contain an oxygen atom;and pharmaceutically acceptable salt thereof, which exhibit antitumor activity.
    Type: Grant
    Filed: July 13, 1983
    Date of Patent: April 29, 1986
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Tsutomu Teraji, Eishiro Todo, Norihiko Shimazaki, Teruo Oku, Takayuki Namiki
  • Patent number: 4565809
    Abstract: Compounds having the formula ##STR1## in which R.sub.1 is C.sub.1 -C.sub.3 alkyl; R.sub.2 is C.sub.3 -C.sub.6 alkyl; R.sub.3 is hydrogen, halo, trifluoromethyl, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, phenoxy, cyano, nitro or C.sub.2 -C.sub.5 carboalkoxy; n is an integer from 1 to 5; --A-- is ##STR2## R.sub.4 is hydrogen, C.sub.1 -C.sub.4 alkyl, or --CH.sub.2 Y; m is 0 or 1; and Y is halo, are insecticides.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: January 21, 1986
    Assignee: Stauffer Chemical Co.
    Inventors: Charles G. Chavdarian, David B. Kanne
  • Patent number: 4544652
    Abstract: A compound of the formula: ##STR1## wherein X is a hydrogen atom, a chlorine atom or a bromine atom and R is an alkyl group, a lower haloalkyl group, a lower cycloalkyl group, a lower alkoxy(lower)alkyl group, a lower alkylthio(lower)alkyl group, a phenoxy(lower)alkyl group, a phenylthio(lower)alkyl group, a phenyl(lower)alkoxy(lower)alkyl group, a phenyl(lower)alkylthio(lower)alkyl group, a lower cycloalkyl(lower)alkyl group, a lower alkyl(lower)cycloalkyl group, a halo(lower)cycloalkyl group, a lower alkylthio(lower)cycloalkyl group, a lower alkoxy(lower)cycloalkyl group, a lower cycloalkyl(lower)cycloalkyl group, a lower alkoxy(lower)alkoxy(lower)alkyl group, a phenyl(lower)alkyl group, a halophenyl(lower)alkyl group, a lower alkylphenyl(lower)alkyl group, a lower alkoxyphenyl(lower)alkyl group, a phenoxyphenyl(lower)alkyl group, a phenylphenyl(lower)alkyl group, a dihalophenyl(lower)alkyl group, a di(lower)alkylphenyl(lower)alkyl group, a di(lower)alkoxyphenyl(lower)alkyl group, a tri(lower)alkoxyphenyl(l
    Type: Grant
    Filed: April 22, 1983
    Date of Patent: October 1, 1985
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Mitsuru Sasaki, Yukio Ishiguri
  • Patent number: 4537884
    Abstract: 2-Trifluoromethylphenyl (di)thiophosphates of the formula ##STR1## where R.sup.1 is alkyl of 1 to 3 carbon atoms, R.sup.2 is alkyl of 1 to 5 carbon atoms, alkoxyalkyl or alkylthioalkyl of 2 to 8 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, R.sup.3, R.sup.4 and R.sup.5 independently of one another are each hydrogen, cyano, halogen, alkoxy, alkylthio, each of 1 to 4 carbon atoms, or alkyl of 1 to 4 carbon atoms, which may be substituted by halogen or cyano, and X is oxygen or sulfur, are used for pest control.
    Type: Grant
    Filed: January 11, 1983
    Date of Patent: August 27, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Walter Seufert, Juergen Varwig, Wolfgang Seppelt, Heinrich Adolphi
  • Patent number: 4522817
    Abstract: A fungicidal composition which comprises as an active ingredient a fungicidally effective amount of a phosphoramidothionate of the formula: ##STR1## wherein R.sub.1 is a lower alkyl group, a lower alkenyl group, a lower alkynyl group, a lower cycloalkyl group, a lower cycloalkyl(lower)alkyl group, a halogen atom-substituted lower alkyl group, a lower alkoxy(lower)alkyl group, a di(lower)alkoxy(lower)alkyl group, a cyano group-substituted lower alkyl group, a lower alkylthio(lower)alkyl group, a lower dioxothiacycloalkyl group, a lower thiacycloalkyl group, a lower oxacycloalkyl group, a furanyl(lower)alkyl group or a thiophenyl(lower)alkyl group, R.sub.2 is a lower alkyl group and R.sub.3 is a lower alkyl group or a lower alkoxy group, and an inert carrier or diluent.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: June 11, 1985
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hideo Kohsaka, Mitsuru Sasaki, Yukio Ishiguri
  • Patent number: H303
    Abstract: This invention describes a composition of matter and a method of treating agricultural substrates in which an active ingredient selected from the group consisting of fungicides, bactericides, insecticides, insect repellents, herbicides and plant growth regulators and mixtures thereof is utilized in conjunction with an amount of a glycoside dispersing agent selected from the group consisting of fructoside, glucoside, mannoside, galactoside, taloside, guloside, alloside, altroside, idoside, arabinsode, xyloside, lyxoside and riboside and mixtures thereof which is sufficient to form an emulsion or dispersion of the active ingredient.
    Type: Grant
    Filed: October 22, 1986
    Date of Patent: July 7, 1987
    Assignee: A. E. Staley Manufacturing Company
    Inventors: Arshad H. Malik, Arno Cahn