Alkyne Patents (Class 514/135)
  • Patent number: 8658425
    Abstract: The present invention relates to a composition for promoting differentiation of pluripotent stem cells into cardiac muscle cells, and a method for inducing differentiation of pluripotent stem cells into cardiac muscle cells and a method for preparing cardiac muscle cells.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: February 25, 2014
    Assignee: Kyoto University
    Inventors: Norio Nakatsuji, Motonari Uesugi, Kouhei Yamada, Itsunari Minami, Tomomi Otsuji
  • Patent number: 6919322
    Abstract: Novel FBPase inhibitors of the formula I are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: July 19, 2005
    Assignee: Metabasis Therapeutics, Inc.
    Inventors: Brett C. Bookser, Qun Dang, K. Raja Reddy
  • Patent number: 6566304
    Abstract: The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling plant-parasitic soil nematodes by strengthening the correspondingly antagonistic soil potential, more particularly by strengthening the growth of antagonistic and/or nematicidal rhizosphere bacteria and/or corresponding mycorrhiza strains—and at the same time strengthening the growth of cultivated plants in soil. The multicomponent mixtures which strengthen bacterial growth are preferably introduced into the region of the plant roots in the form of an aqueous preparation using plant-compatible emulsifiers before and/or during plant growth. Components (a) and (b) are used in such quantity ratios that the ratio by weight of C to N is no higher than 6:1 and preferably no higher than 5:1.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: May 20, 2003
    Assignee: Cognis Deutschland GmbH
    Inventors: Doris Bell, Bettina Kopp-Holtwiesche, Stephan Von Tapavicza
  • Patent number: 6096330
    Abstract: A method for controlling pests comprising administering to them a compound of the formula (i) R-PH-R', wherein R is a C.sub.1 -C.sub.6 aliphatic hydrocarbyl group and R' is H or a C.sub.1 -C.sub.6 aliphatic hydrocarbyl group. Either hydrocarbyl group may be optionally substituted. Preferably, the compound of formula (i) is metliylphosphiine. The method has particular utility against insects which are resistant to phosphine. Also disclosed are pesticidal compositions of compounds of formula (i), and methods and compositions combining these compounds with phosphine.
    Type: Grant
    Filed: May 19, 1998
    Date of Patent: August 1, 2000
    Assignee: The Secretary of State for Minister of Agriculture Fisheries & Food in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Mohammad Oasim Chaudhry, Alan Donald Macnicoll, Nicholas Raymond Price
  • Patent number: 5541221
    Abstract: 3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05 to 100 mg per kilogram, body weight, per day, for the purpose of influencing the balance between bone production and bone resorption, and particularly for treating osteoporosis.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: July 30, 1996
    Assignee: Allergan
    Inventor: Michael E. Garst
  • Patent number: 5242908
    Abstract: The use of a compound of the formula I ##STR1## in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R.sup.1 and R.sup.2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R.sup.1 and R.sup.2 together form a cyclic diester, R.sup.3 and R.sup.4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
    Type: Grant
    Filed: February 1, 1991
    Date of Patent: September 7, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Anuschirwan Peyman, Eugen Uhlmann, Karlheinz Budt, Jochen Knolle, Irvin Winkler, Matthias Helsberg
  • Patent number: 5015635
    Abstract: Pesticidal S-(halogenoalkyl)-dithiophosphoric (phosphonic) acid esters of the formula ##STR1## in which R.sup.1 represents an optionally substituted radical from the group consisting of alkyl, alkenyl, alkoxy, alkenyloxy and alkinyloxy,R.sup.2 represents an optionally substituted radical from the group consisting of alkyl, cycloalkyl, alkenyl, alkinyl and aryl,X and Y are identical or different and independently of one another represent hydrogen, halogen or alkyl, andZ represents hydrogen, halogen or alkyl.
    Type: Grant
    Filed: July 26, 1989
    Date of Patent: May 14, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Herbert Sommer, Jurgen Hartwig, Hans-Detlef Matthaei
  • Patent number: 4935410
    Abstract: This present invention relates to fungicidal compositions comprising an aqueous solution of an aluminum salt of alkyl phosphonates stabilized with the salt of a weak acid and a strong base. The stabilized aqueous solution can be used to prevent or treat fungal diseases in plants by spraying, soaking the roots or injecting into the trunks of shrubs or trees.
    Type: Grant
    Filed: July 29, 1986
    Date of Patent: June 19, 1990
    Assignee: Rhone-Poulenc Agrochimie S.A.
    Inventor: Denis Barlet
  • Patent number: 4839390
    Abstract: A method of combating arthropods and nematodes which comprises applying thereto, to a habitat thereof or to an area from which they are to be excluded an arthropodicidally or nematocidally effective amount of at least one long-chain halogenoolefine of the formula (I) ##STR1## in which R represents a straight-chain or branched alkyl radical with 8 to 25 carbon atoms in the straight chain, the alkyl radical optionally being interrupted once or several times by a --C.tbd.C-- and/or ##STR2## in which Z and Z.sup.1 are identical or different and represent hydrogen or methyl andR.sup.1 represents hydrogen, alkyl or halogen.Those compounds are new wherein R has at least 12 carbon atoms in the straight chain.
    Type: Grant
    Filed: May 8, 1987
    Date of Patent: June 13, 1989
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Naumann, Benedikt Becker, Wolfgang Behrenz, Bernhard Homeyer, Wilhelm Stendel
  • Patent number: 4614735
    Abstract: Compounds having the formula ##STR1## in which R.sub.1 is methyl or ethyl and R.sub.2 is ethyl or a C.sub.3 -C.sub.5 branched alkyl group other than 1,2-dimethylpropyl, are effective soil insecticides.
    Type: Grant
    Filed: December 24, 1984
    Date of Patent: September 30, 1986
    Assignee: Stauffer Chemical Company
    Inventor: Alexandra B. Shortt