Diester Patents (Class 514/148)
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Patent number: 5597809Abstract: Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.Type: GrantFiled: June 23, 1994Date of Patent: January 28, 1997Assignee: Massachusetts Eye & Ear InfirmaryInventor: Evan B. Dreyer
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Patent number: 5508273Abstract: Compounds represented by the formula I: ##STR1## are disclosed as agents for use in treating bone wasting diseases.Type: GrantFiled: December 30, 1993Date of Patent: April 16, 1996Assignee: Ortho Pharmaceutical CorporationInventors: Scott Beers, Elizabeth A. Malloy, Charles Schwender
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Patent number: 5478815Abstract: A liver protectant comprising a phosphoric diester compound of the following formula (wherein R.sub.1 and R.sub.2 are the same or different and each represents hydrogen or methyl) or a pharmacologically acceptable salt thereof. ##STR1## The liver protectant composition of this invention effectively inhibits the elevation of GOT and GPT, among other parameters, so that it is useful for the prevention and therapy , of acute liver disorder, chronic liver disorder and fuminant liver disorder. It can also be used in cirrhosis of the liver with success. The liver protectant composition of this invention can be used with advantage in liver damage associated with alcohol intake and hepatic impairment due to acetaminophen and other drugs. Furthermore, the liver protectant composition of this invention is of value in acute intrahepatic cholestasis.Type: GrantFiled: November 30, 1994Date of Patent: December 26, 1995Assignee: Senji Pharmaceutical Co., Ltd.Inventors: Kazumi Ogata, Takahiro Sakaue, Sachiko Matsuura, Rie Nagao, Shinya Ogino
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Patent number: 5455249Abstract: Background of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, or ##STR2## R.sup.3 and R.sup.4 are each, independently, hydrogen, Ar, or --(CR.sup.6 R.sup.7).sub.a Y(CR.sup.8 R.sup.9).sub.b Z, or R.sup.3 and R.sup.4 may be taken together to form a 5-7 membered ring;R.sup.5 is hydrogen, alkyl, alkenyl, alkynyl, alkoxyalkyl, arylalkyl, cycloalkyl, or Ar;R.sup.6, R.sup.7, R.sup.8, and R.sup.9, are each, independently, hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylaminoalkyl, dialkylaminoalkyl, arylalkyl, cycloalkyl, --OR.sup.10, --SR.sup.10, halogen, --CN, --NO.sub.2, --CF.sub.3, --COR.sup.10, --CO.sub.2 R.sup.10, --CONHR.sup.10, --SO.sub.2 R.sup.10, --SO.sub.3 R.sup.10, --OSO.sub.3 R.sup.10, --NR.sup.10 R.sup.11, --NHCOR.sup.10, --NHCO.sub.2 R.sup.10, --NHSO.sub.2 R.sup.10, --NHSO.sub.3 R.sup.10, or Ar;X is O or NOR.sup.12 ;Y is --O--, --CH.sub.2 --, --NR.sup.13 --, --S--, --S(O)--, --S(O).sub.2 --, or --C(O)--;R.sup.10, R.sup.11, R.sup.Type: GrantFiled: October 21, 1994Date of Patent: October 3, 1995Inventors: Jerauld S. Skotnicki, Andri L. Smith
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Patent number: 5451573Abstract: Substituted cyclohexane derivatives for the treatment of diseases Esters of cyclohexane derivatives of the formula I ##STR1## in which A--B, R.sup.3, R.sup.4, R.sup.5, Y and Z have the meanings indicated, for use as inhibitors of the glucose-6-phosphatase system of the liver in mammals are described. The compounds are suitable for the production of pharmaceutical preparations.Type: GrantFiled: September 7, 1993Date of Patent: September 19, 1995Assignee: Hoechst AktiengesellschaftInventors: Horst Hemmerle, Peter Schindler, Roland Utz, Robert Rippel, Andreas Herling
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Patent number: 5447923Abstract: Methods for the treatment of a human or lower animal subject having an H. pylori-mediated upper gastrointestinal disorder comprising administering to said subject a safe and effective amount of a diphenyl ether phosphate ester of the following formula: ##STR1## wherein n is an integer from 0 to 3, or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: October 11, 1994Date of Patent: September 5, 1995Assignee: The Proctor & Gamble CompanyInventors: Carl E. Catrenich, Dennis G. A. Nelson
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Patent number: 5182271Abstract: The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.Type: GrantFiled: August 30, 1991Date of Patent: January 26, 1993Assignee: Sandoz Ltd.Inventor: William J. Houlihan
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Patent number: 5116992Abstract: The invention relates to glycerol derivatives of general formulae Ia, Ib and Ic ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, A and Y stand for various substituents, to a preparation process of said compounds and to therapeutical compositions containing the same.Type: GrantFiled: December 19, 1990Date of Patent: May 26, 1992Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Pierre Braquet, Colette Broquet, Benedicte Vandamme, Paola Principe-Nicolas
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Patent number: 5057541Abstract: An emulsion-like or creamy composition for external application is disclosed. The composition is prepared by applying a shear force to an aqueous suspension comprising 0.1 to 20% by weight of one or more specific types of polyvalent metal alkyl phosphates. This composition has a gloss and a beautiful outward appearance, in which a powdery polyvalent metal alkyl phosphate is dispersed in an aqueous medium. The composition exhibits favorable characteristics inherent to a powder such as excellent extendability, good smoothness, stickilessness, slipperiness as well as superior freshness.Type: GrantFiled: December 9, 1988Date of Patent: October 15, 1991Assignee: Kao CorporationInventors: Tomohiko Sano, Yuji Suzuki, Kayoto Iwata
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Patent number: 5053222Abstract: A hair cosmetic composition containing, as an active component, a diester of phosphoric acid with ascorbic acid and tocopherol, having the formula (I), and/or a salt thereof: ##STR1## wherein R.sub.1 represents H or CH.sub.3 and R.sub.2 represents H or CH.sub.3.Type: GrantFiled: June 7, 1989Date of Patent: October 1, 1991Assignees: Shiseido Company Ltd., Senju Pharmaceutical Co., Ltd.Inventors: Emiko Takasu, Kazumi Ogata, Yoshihisa Sato
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Patent number: 4948787Abstract: Mercaptan odors in a thiophosphate compound or formulation are suppressed by treatment of the compound during preparation of the formulation with treatment agents selected from iodine, and alkali and alkaline earth metal hydroxides, hypochlorites and iodates. Depending on the particular agent and method of treatment used, the agent and any reaction products resulting from the treatment may be either removed from the thiophosphate or retained with it in the final formulation. Formulations of particular interest are granular formulations for field application.Type: GrantFiled: January 4, 1989Date of Patent: August 14, 1990Assignee: Imperial Chemical Industries PLCInventors: Chia-Chung Chen, Richard H. Rider, Ray J. Lo
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Patent number: 4938797Abstract: The invention relates to a process for the preparation of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide. The process comprises first dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide, in the presence of an anionic dispersant and at least one nonionic protective colloid and/or a nonionic surfactant, and subsequently reacting the dispersion with a polyamine, to give a stable aqueous suspension of microcapsules which can be used either direct or after dilution with water as pesticidal composition.Type: GrantFiled: June 7, 1988Date of Patent: July 3, 1990Assignee: Ciba-Geigy CorporationInventors: Hans W. Hasslin, Michael J. Hopkinson
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Patent number: 4828844Abstract: A pulmonary surfactant for the treatment of dyspnea syndromes, containing dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) in a ratio of from 9:1 to 8:2 and a sugar, in the form of a redispersable powder, which is obtained by dissolving the phospholipids in glacial acetic acid, adding the sugar, and finally freeze-drying of the mixture. The lyophilisate is redispersed in a suitable buffer solution for application.Type: GrantFiled: August 4, 1983Date of Patent: May 9, 1989Inventors: Renate Rontgen-Odenthal, Manfred Durr, Ekkehard Harhausen
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Patent number: 4686211Abstract: A medical composition for external application comprises a dialkyl phosphate represented by the formula: ##STR1## wherein R.sub.1 and R.sub.2 independently represent a hydrocarbon group having from 6 to 24 carbon atoms, R.sub.3 and R.sub.4 independently represent hydrocarbon group having from 2 to 6 carbon atoms, m and n independently represent a value of from 0 to 20, and x represents a hydrogen atom or a salt of an alkali metal and the like.In the presence of the dialkyl phosphate, percutaneous intake of medically active ingredients is highly enhanced. Examples of the medically active ingredients directed to in the invention include antiinflammatory agents such as ethyl aminobenzoate; adrenocortical hormones such as hydrocortisone; etc.The inventive composition is highly safe without giving any stimulation to the skin.Type: GrantFiled: September 20, 1985Date of Patent: August 11, 1987Assignee: Kao CorporationInventors: Kenji Hara, Hiromichi Takahashi, Tetsuro Kamiya, Kaoru Tsujii
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Patent number: 4536519Abstract: Disclosed herein is an emulsifying agent comprising (a) a partially or completely neutralized product, with a basic substance, of a phosphoric acid ester which contains a phosphoric acid monoester represented by the general formula (I) and a phosphoric acid diester represented by the general formula (II) from 100:0 to 70:30 molar ratio: ##STR1## wherein R.sub.1 and R.sub.4 represent individually a linear alkyl group or a linear alkenyl group of 10-22 carbon atoms or a branched alkyl group of 12-24 carbon atoms, R.sub.2 and R.sub.3 represent individually an ethylene group or a propylene group, and m and n represent individually a number of 0-30, and (b) a nonionic surfactant with HLB of 6 or less. Emulsified cosmetics comprising (a) the neutralized product of the phosphoric acid ester, (b) a nonionic surfactant with HLB of 6 or less, (c) an oily substrate, and (d) water is also disclosed.Type: GrantFiled: June 9, 1982Date of Patent: August 20, 1985Assignee: Kao Soap Co., Ltd.Inventors: Toshiyuki Suzuki, Tohru Nakamura, Hisao Tsutsumi
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Patent number: 4514392Abstract: Novel, aryl N-(alkylthio-phosphorothio)acyl carbamates represented by structure: ##STR1## wherein the R groups represent various alkyl substituents, and Ar represents an aryl radical with various organic substituents, which exhibit superior insecticidal and miticidal activity.Type: GrantFiled: June 30, 1983Date of Patent: April 30, 1985Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: H303Abstract: This invention describes a composition of matter and a method of treating agricultural substrates in which an active ingredient selected from the group consisting of fungicides, bactericides, insecticides, insect repellents, herbicides and plant growth regulators and mixtures thereof is utilized in conjunction with an amount of a glycoside dispersing agent selected from the group consisting of fructoside, glucoside, mannoside, galactoside, taloside, guloside, alloside, altroside, idoside, arabinsode, xyloside, lyxoside and riboside and mixtures thereof which is sufficient to form an emulsion or dispersion of the active ingredient.Type: GrantFiled: October 22, 1986Date of Patent: July 7, 1987Assignee: A. E. Staley Manufacturing CompanyInventors: Arshad H. Malik, Arno Cahn