Plasma Protein Affecting Or Utilizing Patents (Class 514/15.3)
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Patent number: 10232022Abstract: Long-term stable pharmaceutical formulations of lyophilized recombinant von-Willebrand Factor (rVWF) and methods for making and administering said formulations are described.Type: GrantFiled: November 12, 2015Date of Patent: March 19, 2019Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Kurt Schnecker, Eva Haidweger, Peter Turecek
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Patent number: 10183976Abstract: The present disclosure provides, among other aspects, improved methods for the manufacture of Factor H compositions from plasma precipitation fractions. In some aspects, the methods include an improved process step for extracting Factor H from a plasma precipitate fraction with reduced co-extraction of amidolytic activities. In other aspects, the methods include a heat treatment step for reducing impurities, such as amidolytic enzymes, from a Factor H composition. In yet other aspects, the methods include improved anion exchange, heparin affinity, and/or mixed mode chromatographic enrichment of Factor H. In still other aspects, the improved methods include a combination of the individual improved process steps disclosed herein.Type: GrantFiled: March 14, 2014Date of Patent: January 22, 2019Assignees: Baxalta Incorporated, Baxalta GmbHInventors: Ruth Madlener, Wolfgang Teschner, Hans-Peter Schwarz, Sonja Svatos, Azra Pljevljakovic, Lena Nitsch
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Patent number: 9655945Abstract: A method for treating ascites patients by administering the peptide drug terlipressin by continuous infusion. The patients include those whose ascites condition has not progressed to hepatorenal syndrome (HRS). Administration may be accomplished with a continuous infusion pump.Type: GrantFiled: June 30, 2016Date of Patent: May 23, 2017Assignee: BIOVIE, Inc.Inventors: Paolo Angeli, Penelope Markham, Jonathan Adams
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Patent number: 9248162Abstract: The present invention provides a method for preventing or inhibiting allograft rejection by a recipient of that allograft by treating the recipient with a composition comprising Factor H (FH). The invention also encompasses methods in which the recipient is also administered one or more immunosuppressants in addition to the Factor H.Type: GrantFiled: March 13, 2014Date of Patent: February 2, 2016Assignees: Baxalta Incorporated, Baxalta GmbHInventor: Richard Johnson
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Publication number: 20150079194Abstract: Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (A2M) from whole blood and or recombinant A2M are provided. Also provided are methods of treating wounds with A2M. Methods for utilizing A2M in combination with other treatments (e.g., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or carriers. Also provided is a method of producing recombinant A2M wild type or variants thereof where the bait region was modified to enhance the inhibition characteristics of A2M and/or to prolong the half-life of the protein for treating wounds.Type: ApplicationFiled: August 28, 2014Publication date: March 19, 2015Inventors: Lewis HANNA, John David LAUGHLIN, Shawn Robert BROWNING
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Publication number: 20150056271Abstract: Factor VIII variants and methods of use thereof are disclosed.Type: ApplicationFiled: August 25, 2014Publication date: February 26, 2015Inventors: Valder Arruda, Rodney Camire, Nicholas Iacobelli
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Publication number: 20150038420Abstract: The present invention relates to methods for treating or preventing a properd related disease or disorder in a subject in need thereof, or for reducing mortality of a subject suffering from a properdin-related disease or disorder, comprising administering to the subject an effective amount of a pharmaceutical composition comprising a properdin protein. Also provided are related medicaments, pharmaceutical compositions, and methods for preparing the medicaments.Type: ApplicationFiled: August 31, 2012Publication date: February 5, 2015Applicant: THE MEDICINES COMPANYInventors: Hans-Wilhelm Schwaeble, Mohammed Youssif Ibrahim Ali, Dimitrios Gkountis
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Publication number: 20150031621Abstract: A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of caprylate ions to fractions of blood or plasma, comprising the steps of: a) providing a Factor H containing source, in particular reconstitution of caprylate precipitate to provide a complement Factor H containing solution; b) performing a cation exchange chromatography in particular as first chromatographic step; c) performing an anion exchange chromatography; d) performing a hydroxyl apatite chromatography; e) followed by ultra/diafiltration to obtain a complement Factor H concentrate.Type: ApplicationFiled: July 9, 2014Publication date: January 29, 2015Inventors: Hubert Brandstaetter, Petra Schulz, Juergen Roemisch
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Patent number: 8911789Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: March 11, 2013Date of Patent: December 16, 2014Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute, Carmell Therapeutics CorporationInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Publication number: 20140349940Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: ApplicationFiled: April 28, 2014Publication date: November 27, 2014Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams
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Publication number: 20140348810Abstract: An in situ gel-forming composition is disclosed. The in situ gel-forming composition comprises one or more absorbable polymers, solvents such as N-methyl-2-pyrrolidone, polyethylene glycol or DMSO, and optionally one or more bioactive agent. The composition forms a hydrogel or semi-solid mass on contact with an aqueous environment. The method of using in situ gel-forming composition for various applications is also disclosed.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Applicant: POLY-MED, INC.Inventor: Shalaby W. Shalaby
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Publication number: 20140336122Abstract: The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.Type: ApplicationFiled: June 4, 2014Publication date: November 13, 2014Inventors: Wolfgang Teschner, Hans-Peter Schwarz, Ruth Madlener, Sonja Svatos, Azra Pljevljakovic, Alfred Weber
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Publication number: 20140336121Abstract: The present invention provides a method for preventing or inhibiting allograft rejection by a recipient of that allograft by treating the recipient with a composition comprising Factor H (FH). The invention also encompasses methods in which the recipient is also administered one or more immunosuppressants in addition to the Factor H.Type: ApplicationFiled: March 13, 2014Publication date: November 13, 2014Applicants: Baxter Healthcare SA, Baxter International Inc.Inventor: Richard Johnson
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Publication number: 20140288001Abstract: Methods, kits and compositions are described that include a non-naturally occurring kallikrein inhibitor and an anti-thrombolytic agent, e.g., an anti-fibrinolytic agent, for preventing or reducing blood loss and/or ischemia, e.g., ischemia associated with perioperative blood loss and cerebral ischemia, the onset of systemic inflammatory response, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia or a focal brain ischemia, e.g., in patients subjected to invasive surgical procedures, especially procedures requiring cardiopulmonary bypass.Type: ApplicationFiled: May 6, 2014Publication date: September 25, 2014Applicant: DYAX CORP.Inventors: Henry Blair, Thomas Beck, Robert Charles Ladner
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Publication number: 20140286929Abstract: Provided herein are novel biomarkers for the identification, prediction or monitoring of fibrotic pulmonary diseases (e.g. idiopathic pulmonary fibrosis (IPF)). The biomarkers provided herein may further be used for therapeutic treatment of IPF.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Applicant: Intermune, Inc.Inventors: Karl Kossen, Xiaoli Qin, Sharlene R. Lim, Scott S. Seiwert, Donald Ruhrmund
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Publication number: 20140249087Abstract: The invention relates to use of hemopexin (Hx) to sequester extravascular hemoglobin and thereby reduce or prevent inflammation of non-infectious etiology in a subject (e.g., a human).Type: ApplicationFiled: September 27, 2012Publication date: September 4, 2014Inventor: H. Shaw Warren
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Publication number: 20140227296Abstract: The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of NKT cells. The compositions and methods of the present invention are useful for the prevention and treatment of diseases.Type: ApplicationFiled: March 14, 2013Publication date: August 14, 2014Inventors: Steven A. Porcelli, Maurice Zauderer
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Publication number: 20140205588Abstract: The invention relates to variants of plasminogen and plasmin comprising one or more point mutations in the catalytic domain which reduce or prevent autocatalytic destruction of the protease activity of plasmin. Compositions, uses and methods of using said variants of plasminogen and plasmin are also disclosed.Type: ApplicationFiled: August 13, 2012Publication date: July 24, 2014Applicant: THROMBOGENICS NVInventor: Richard Reinier Zwaal
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Patent number: 8772240Abstract: Methods of preparing alpha-1-antiproteinase inhibitor and controlling the amount of des-lys alpha-1-antiproteinase inhibitor in the preparation, and compositions comprising the same, as well as methods of treatment using the same are provided.Type: GrantFiled: May 17, 2007Date of Patent: July 8, 2014Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Peter Matthiessen, Alfred Weber, Peter Turecek, Hans-Peter Schwarz
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Publication number: 20140161786Abstract: The present invention generally relates to therapeutic compositions for the treatment of mammalian disease and related methods. It more specifically relates to compositions comprising peptides for the treatment of inflammation and methods for delivering the peptides. In one composition aspect, the composition comprises a peptide, and the peptide comprises one or more hexapeptides that are capable of forming fibrils.Type: ApplicationFiled: August 29, 2013Publication date: June 12, 2014Inventors: Jonathan B. Rothbard, Lawrence Steinman, Michael P. Kurnellas
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Patent number: 8741846Abstract: Method for the production of a fibrinogen solution from an aqueous solution that contains functionally intact fibrinogen and is contaminated with profibrin and/or fibrin monomers and/or fibrin monomer complexes and/or fibrin split products, characterized in that the contaminations are precipitated using a non-denaturing precipitating agent at a temperature ranging from ?4° to +4° and calcium ion activity not exceeding that of a 1,000 ?M CaCl2 solution and are separated from the solution by means of filtering or centrifugation process.Type: GrantFiled: June 22, 2009Date of Patent: June 3, 2014Assignee: Bio-Products & Bio-Engineering AGInventor: Johann Eibl
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Patent number: 8722624Abstract: A streamlined method for purifying alpha-1-antitrypsin (AAT) from an AAT-containing protein mixture, such as a Cohn fraction IV precipitate, is provided. In the method of the invention, contaminating proteins are destabilized by cleavage of disulfide bonds with a reducing reagent, such as a dithiol, which does not affect AAT. The destabilized proteins are then preferentially adsorbed on a solid protein-adsorbing material, without the addition of a salt as a precipitant. Separation of the solid adsorbent from the solution leaves a purified AAT solution that is directly suitable for chromatographic purification, without the need for extensive desalting as in prior art processes. A process incorporating this method, which provides pharmaceutical grade AAT in high yield on a commercial scale, is also described.Type: GrantFiled: February 28, 2012Date of Patent: May 13, 2014Assignee: CSL Behring LLCInventors: Scott M Kee, Paul I Cook, James R Smith, Robert Kling, Scott A Fowler, David Weber
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Patent number: 8722019Abstract: The present invention is related to fragments of human melanotransferrin (p97). In particular, this invention relates to treatment of diseases through the introduction of the melanotransferrin fragment conjugated to a therapeutic or diagnostic agent to a subject.Type: GrantFiled: August 3, 2012Date of Patent: May 13, 2014Assignee: biOasis Technologies, Inc.Inventors: Wilfred Jefferies, Mei Mei Tian, Timothy Vitalis
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Publication number: 20140128327Abstract: The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.Type: ApplicationFiled: December 16, 2013Publication date: May 8, 2014Applicant: The Regents of the University of MichiganInventors: James R. Baker, JR., Xue-min Cheng, Abraham F.L. Van Der Spek, Baohua Mark Huang, Thommey P. Thomas
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Patent number: 8715654Abstract: The current invention is directed to methods of inducing migration of an immune cell toward a cancer cell comprising inhibiting the activity of a chemorepellant released from the cancer cell.Type: GrantFiled: October 2, 2009Date of Patent: May 6, 2014Assignee: Celtaxsys, Inc.Inventors: Surendra Chavan, Jonathan L. Moon, Lopa Bhatt
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Patent number: 8710007Abstract: Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.Type: GrantFiled: November 22, 2010Date of Patent: April 29, 2014Assignee: Dyax Corp.Inventors: Robert C. Ladner, Arthur C. Ley, Shirish Hirani, Anthony Williams
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Publication number: 20140105824Abstract: Provided herein are diagnostic methods for identifying subjects susceptible to treatment with a hypoxia-activated agent, and related methods. Also provided herein are methods of monitoring treatments with anti-hyaluronan agents, and related methods.Type: ApplicationFiled: October 16, 2013Publication date: April 17, 2014Inventors: H. Michael Shepard, Xiaoming Li, Curtis Thompson
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Publication number: 20140094411Abstract: The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.Type: ApplicationFiled: March 14, 2013Publication date: April 3, 2014Applicant: CSL Behring LLCInventor: CSL Behring LLC
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Patent number: 8680052Abstract: Methods of treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing percutaneous coronary intervention (PCI), comprising administering to the patient a pharmaceutical composition comprising cangrelor. The method may further comprise administering an additional therapeutic agent to the patient, the additional therapeutic agent comprising a P2Y12 inhibitor. Pharmaceutical compositions useful for treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing PCI. The pharmaceutical compositions comprise cangrelor. Methods of preparing a pharmaceutical composition for treating, reducing the incidence of, and/or preventing an ischemic event in a patient undergoing PCI, comprising admixing cangrelor with one or more pharmaceutically acceptable excipients. An ischemic event may include stent thrombosis, myocardial infarction, ischemia-driven revascularization, and mortality.Type: GrantFiled: May 29, 2013Date of Patent: March 25, 2014Assignee: The Medicines CompanyInventors: Clive Arthur Arculus-Meanwell, Simona Skerjanec, Jayne Prats, David J. Schneider
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Publication number: 20140031294Abstract: The present invention provides a recombinant protein comprising the sequence of a transferrin mutant, wherein Ser415 is mutated to an amino acid which does not allow glycosylation at Asn413 and/or wherein Thr613 is mutated to an amino acid which does not allow glycosylation as Asn611. It also provides polynucleotides encoding the same and methods of making and using said recombinant protein.Type: ApplicationFiled: July 29, 2013Publication date: January 30, 2014Applicant: Novozymes Biopharma DK A/SInventors: Christopher John Arthur Finnis, Darrell Sleep, Joanna Hay
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Publication number: 20130310305Abstract: The present invention provides the use of recombinant plasminogen activator inhibitor-1 (PAI-1) isoform 23 in methods of increasing plasmin activity, inhibiting angiogenic vasa vasorum, promoting plaque regression and treating atherosclerosis by administering to a subject in need of treatment an effective amount of recombinant plasminogen activator inhibitor type isoform 23 (rPAI-123). In some embodiments, rPAI-123 is set forth in SEQ ID NOs:5-8. In other embodiments, rPAI-123 is administered at a dose in the range of approximately 2.5 ?g/kg/day to 20 ?g/kg/day. In further embodiments, the effective amount achieves a ratio of rPAI-123 to PAI-1 is in the range of approximately 1:2 to 3:1.Type: ApplicationFiled: February 3, 2012Publication date: November 21, 2013Applicant: TRUSTEES OF DARTMOUTH COLLEGEInventor: Mary Jo Mulligan-Kehoe
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Publication number: 20130287817Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.Type: ApplicationFiled: April 27, 2012Publication date: October 31, 2013Applicant: Warsaw Orthopedic, Inc.Inventors: Susan J. Drapeau, Daniel A. Shimko
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Patent number: 8569238Abstract: The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences.Type: GrantFiled: March 18, 2013Date of Patent: October 29, 2013Assignees: The Chemo-Sero-Therapeutic Research Institute, Ginkyo Academy Kumamoto Health Science University, National University Corporation Kumamoto UniversityInventors: Shintaro Kamei, Asami Shindome, Takayoshi Hamamoto, Hiroaki Maeda, Masaki Hirashima, Sachio Okuda, Misako Umehashi, Sachie Ogawa, Megumi Imuta, Norio Akaike, Kazuo Takahama, Ryoko Wada
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Patent number: 8557535Abstract: A method of preparing a fibrinogen rich composition is disclosed. One embodiment of the method involves contacting plasma with a hydrogel capable of increasing in mass upon contact with said plasma; maintaining said contact for a period of time sufficient for said hydrogel to absorb a substantial amount of at least the water from said plasma to produce a swollen hydrogel and a fibrinogen rich phase; and separating said fibrinogen rich phase from said swollen hydrogel; whereby said fibrinogen rich composition is produced.Type: GrantFiled: September 9, 2009Date of Patent: October 15, 2013Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
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Patent number: 8551953Abstract: The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising certain diketopiperazines. The invention further provides methods of making improved pharmaceutical compositions of proteins and peptides by either increasing or decreasing the content of diketopiperazines in the compositions and the resultant improved pharmaceutical compositions.Type: GrantFiled: November 14, 2012Date of Patent: October 8, 2013Assignee: DMI Acquisition Corp.Inventors: David Bar-Or, Raphael Bar-Or, Richard Shimonkevitz
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Publication number: 20130244941Abstract: The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke.Type: ApplicationFiled: February 25, 2013Publication date: September 19, 2013Applicant: PHARMING INTELLECTUAL PROPERTY B.V.Inventors: Maurice Mannesse, Johannes Henricus Nuijens, Frank Pieper, Maria Grazia De Simoni, Gijsbertus Johannes Ziere
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Patent number: 8529958Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: July 6, 2011Date of Patent: September 10, 2013Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon UniversityInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Patent number: 8529960Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: July 6, 2011Date of Patent: September 10, 2013Assignees: Carnell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon UniversityInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Patent number: 8529961Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: July 6, 2011Date of Patent: September 10, 2013Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon UniversityInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Patent number: 8529959Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: July 6, 2011Date of Patent: September 10, 2013Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon UniversityInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Patent number: 8529956Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.Type: GrantFiled: April 17, 2008Date of Patent: September 10, 2013Assignees: Carnell Therapeutics Corporation, Carnegie Mellon University, Allegheny-Singer Research InstituteInventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
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Publication number: 20130217616Abstract: The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.Type: ApplicationFiled: March 4, 2011Publication date: August 22, 2013Inventors: Peter Garred, Tina Hummelshøj Glue, Mikkel-Ole Skjødt
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Publication number: 20130165382Abstract: The present invention relates to the formation of conjugates (e.g., protein-protein dimers) using a-halo-acetophenones, benzylic halides, quinones, and related compounds as a conjugating system. The invention also features compositions that include the conjugates described herein, as well as uses of these conjugates in methods of medical treatment.Type: ApplicationFiled: June 1, 2011Publication date: June 27, 2013Applicant: ADVANCED PROTEOME THERAPEUTICS INC.Inventors: Alexander Krantz, Peng Yu
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Publication number: 20130150304Abstract: Treatment of a disease associated with retinal degenerative disorder. The present invention relates to human Transferrin or an active fragment thereof for use in the treatment of a disease associated with retinal degenerative disorder.Type: ApplicationFiled: July 11, 2011Publication date: June 13, 2013Applicant: Institut National de la Sante et de la Recherche Medicale (Inserm)Inventors: Yves Courtois, Jean-Claude Jeanny, Emilie Picard, Francine Behar-Cohen
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Publication number: 20130129693Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor X and factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of reversing anticoagulation, stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.Type: ApplicationFiled: August 21, 2012Publication date: May 23, 2013Inventors: Uma Sinha, Genmin Lu, Pamela B. Conley
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Publication number: 20130129814Abstract: The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.Type: ApplicationFiled: December 21, 2012Publication date: May 23, 2013Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventor: ABBOTT CARDIOVASCULAR SYSTEMS INC.
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Publication number: 20130123184Abstract: The invention provides methods for increasing the level of human fetal hemoglobin in a subject or cell in need thereof. The methods can be used with subjects suffering from a ?-chain hemoglobinopathy including thalassemia (e.g., ?-thalassemia) or sickle cell anemia.Type: ApplicationFiled: December 20, 2012Publication date: May 16, 2013Applicants: National Institutes of Health, Celgene CorporationInventors: Mitchell KEEGAN, Janelle R. KEYS, Richard L. PIEKARZ, Susan E. BATES
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Publication number: 20130123182Abstract: The invention relates to a new polynucleotide which encodes a polypeptide expressed in the salivary glands of ticks, more particularly the Ixodes ricinus arthropod tick, during the slow-feeding phase of the blood meal have, said polynucleotide and related polypeptide may be used in different constructions and for different applications which are also included in the present invention.Type: ApplicationFiled: October 1, 2012Publication date: May 16, 2013Applicant: HENOGEN S.A.Inventor: HENOGEN S.A.
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Publication number: 20130123185Abstract: In certain embodiments, the disclosure relates to methods of treating or preventing organ inflammation or failure such as pulmonary inflammation comprising administering a heme scavenger such as hemopexin to a subject in need thereof. The subject may be diagnosed with higher than normal levels of protein-free plasma heme or a hemolytic disorder such as sickle cell disease, autoimmune hemolytic anemia, or paroxysmal nocturnal hemoglobinuria or acute lung injury or acute chest syndrome. Typically, the hemopexin is recombinant human hemopexin.Type: ApplicationFiled: August 5, 2011Publication date: May 16, 2013Applicant: EMORY UNIVERSITYInventors: Solomon Ofori-Acquah, Samit Ghosh
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Publication number: 20130102537Abstract: The present invention provides compositions and pharmaceutical formulations of Factor H derived from plasma. Also provided are methods for the manufacture of the Factor H compositions and formulations, as well as methods for the treatment of diseases associated with Factor H dysfunction.Type: ApplicationFiled: October 1, 2012Publication date: April 25, 2013Applicants: Baxter International Inc.Inventors: Baxter International Inc., Baxter Healthcare S.A.