3,10-dihydroxy-2-naphthacene Carboxamide Or Derivative (e.g., Tetracycline, Etc.) Doai Patents (Class 514/152)
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Patent number: 12226392Abstract: The present disclosure targets West Nile virus, Respiratory Syncytial Virus, and other disease-causing microbes, including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.Type: GrantFiled: January 12, 2023Date of Patent: February 18, 2025Inventor: Steven Baranowitz
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Patent number: 11944634Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.Type: GrantFiled: February 27, 2019Date of Patent: April 2, 2024Assignee: MELINTA SUBSIDIARY CORP.Inventors: David C. Griffith, Serge Boyer, Scott Hecker, Michael N. Dudley
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Patent number: 11781156Abstract: Provided herein are methods and compositions for plakophilin-2 gene therapy for treating heart diseases such as arrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy (ACM).Type: GrantFiled: July 30, 2021Date of Patent: October 10, 2023Assignee: TENAYA THERAPEUTICS, INC.Inventors: Zhihong Jane Yang, Jaclyn Ho, Chris Reid, Jin Yang
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Patent number: 11590099Abstract: The present disclosure targets the Zika virus and other disease-causing microbes including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.Type: GrantFiled: November 4, 2020Date of Patent: February 28, 2023Inventor: Steven Baranowitz
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Patent number: 11583521Abstract: Provided herein are the long-acting injection compositions of ?3 adrenoreceptor agonists like mirabegron or their pharmaceutically acceptable salts or esters thereof. The present invention also relates to methods for preparing long-acting injection compositions and methods of using these dosage forms for the treatment of obesity, metabolic diseases, and other diseases as described herein. The long-acting injection compositions as per the present invention have desirable pharmaceutical technical attributes.Type: GrantFiled: June 30, 2021Date of Patent: February 21, 2023Assignee: Jubilant Pharma Holdings Inc.Inventors: Indranil Nandi, Tusharmouli Mukherjee
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Patent number: 11369566Abstract: Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).Type: GrantFiled: September 20, 2017Date of Patent: June 28, 2022Assignees: ALK-ABELLÓ, INC., THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Jay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Patent number: 11364212Abstract: The present application relates to a method of treating an inflammatory skin condition by administering a pharmaceutical composition comprising a reduced dose of minocycline to a subject in need thereof, wherein said administration provides an effective plasma or interstitial fluid concentration of minocycline for treating the inflammatory skin condition.Type: GrantFiled: December 23, 2020Date of Patent: June 21, 2022Assignee: DR. REDDY'S LABORATORIES LTD.Inventors: Swati Kulkarni, Bijay Kumar Padhi, Shanvas Alikunju, Rajeev Singh Raghuvanshi, Srinivas Ramchandra Sidgiddi, Anirudh Gautam
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Patent number: 11260106Abstract: Disclosed are compositions and methods of treating a neurodegenerative disease in an individual. The methods disclose administration of an Integrin ?4?1, Very Late Antigen-4 positive neural precursor cell (“VLA4+ NPC”) transfected with a lentivirus overexpressing wild type GCase to an individual having a neurodegenerative disorder. The neurodegenerative disease may include lipid storage diseases, for example Gaucher disease, Parkinson's disease (PD), Dementia with Lewy bodies.Type: GrantFiled: April 28, 2020Date of Patent: March 1, 2022Assignee: Children's Hospital Medical CenterInventor: Ying Sun
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Patent number: 11224608Abstract: The present application provides, in some aspects, methods of treating cancers, such as homologous recombination (HR)-deficient cancers. In some embodiments, the disclosure provides a method for treating cancer by administering to a subject a compound of Formula (I):(I), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: October 16, 2018Date of Patent: January 18, 2022Assignee: Dana-Farber Cancer Institute, Inc.Inventors: Alan D'Andrea, Raphael Ceccaldi, Jia Zhou
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Patent number: 11197872Abstract: The present disclosure relates to compounds and methods of eradicating cancer stem cells by combining inhibitors of oxidative metabolism and glycolytic metabolism. Also described are compounds and methods of identifying a combination of inhibitors of oxidative metabolism and glycolytic metabolism to treat cancer stem cells.Type: GrantFiled: April 20, 2018Date of Patent: December 14, 2021Assignee: LUNELLA BIOTECH, INC.Inventors: Michael P. Lisanti, Federica Sotgia
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Patent number: 11191740Abstract: The present application relates to a method of treating an inflammatory skin condition by administering a pharmaceutical composition comprising a reduced dose of minocycline to a subject in need thereof, wherein said administration provides an effective plasma or interstitial fluid concentration of minocycline for treating the inflammatory skin condition.Type: GrantFiled: January 7, 2019Date of Patent: December 7, 2021Assignee: DR. REDDY'S LABORATORIES LTD.Inventors: Swati Kulkarni, Bijay Kumar Padhi, Shanvas Alikunju, Rajeev Singh Raghuvanshi, Srinivas Ramchandra Sidgiddi, Anirudh Gautam
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Patent number: 10883976Abstract: Methods of preparing compositions for preferential distribution of active agents to injury sites are provided. The compositions may comprise a polymer with hydrophilic properties and one or more active agents, such as compounds comprising hydrophilic metal ions. Because the delivery ligand and the active agent are specifically selected so the interactions between them are mainly of an ionic nature. Methods of identifying suitable components for such compositions are also disclosed.Type: GrantFiled: February 12, 2015Date of Patent: January 5, 2021Assignee: Warsaw Orthopedic, Inc.Inventors: Josee Roy, Victor Kelley, Roger E. Harrington
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Patent number: 10874632Abstract: The present disclosure targets the Zika virus and other disease-causing microbes including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.Type: GrantFiled: February 18, 2020Date of Patent: December 29, 2020Inventor: Steven Baranowitz
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Patent number: 10842802Abstract: The present disclosure provides novel controlled release pharmaceutical dosage form, methods of making the same, and methods of using the same to treat dermatological conditions.Type: GrantFiled: May 8, 2013Date of Patent: November 24, 2020Assignee: MEDICIS PHARMACEUTICAL CORPORATIONInventors: Sajeev Chandran, Shirishkumar Kulkarni, Pravin Meghrajji Bhutada, Ashish Ashokrao Deshmukh, Douglas Bakan, Mitchell Wortzman
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Patent number: 10835613Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.Type: GrantFiled: April 17, 2019Date of Patent: November 17, 2020Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
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Patent number: 10821187Abstract: The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.Type: GrantFiled: February 20, 2019Date of Patent: November 3, 2020Assignee: Foamix Pharmaceuticals Ltd.Inventors: Dov Tamarkin, Elana Gazal, Yohan Hazot, David Schuz, Irakliy Papiashvili
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Patent number: 10603299Abstract: The present disclosure targets the Zika virus and other disease-causing microbes including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.Type: GrantFiled: July 3, 2019Date of Patent: March 31, 2020Inventor: Steven Baranowitz
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Patent number: 10543298Abstract: A tetracycline salt comprising a tetracycline and an organic acid wherein the organic acid is oxalic acid or maleic acid is provided. The tetracycline is preferably doxycycline, minocycline, sancycline, lymecycline, tetracycline or demeclocycline, and preferred salts include oxycycline maleate, minocycline oxalate, tetracycline oxalate, demeclocycline maleate, demeclocycline oxalate, sancycline maleate, lymecycline maleate, or lymecycline oxalate. A pharmaceutical formulation comprising a tetracycline salt according to the invention is also provided, as is a medical device having coated thereon a salt or pharmaceutical formulation according to the invention. A salt of the invention, or a formulation of the invention are also provided for use as medicaments, particularly for use in the treatment or prevention of an inflammation and/or an infection.Type: GrantFiled: November 24, 2016Date of Patent: January 28, 2020Assignee: Hovione Scientia LimitedInventors: Luis Sobral, Livia Santana De Arruda, Margarida Figueiredo, Rafael Antunes, Ana Paula Filipe
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Patent number: 10493163Abstract: The present invention provides dendrimer conjugates. The present invention provides a composition comprising a dendrimer conjugate and a cell, such as a cell covered with dendrimer conjugates, in which dendrimer conjugates home the cell to a target tissue.Type: GrantFiled: June 30, 2017Date of Patent: December 3, 2019Assignee: UNIVERSITY OF MIAMIInventors: Omaida Velazquez, Sylvia Daunert, Pirouz Daftarian, Zhao-Jun Liu, Sapna Deo
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Patent number: 10383852Abstract: The present invention targets the Zika virus and other disease-causing microbes including viruses, bacteria, fungi, and parasites. It does this using agents and methods with little toxicity compared to existing therapies.Type: GrantFiled: November 27, 2018Date of Patent: August 20, 2019Inventor: Steven Baranowitz
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Patent number: 10385003Abstract: Disclosed herein is an ophthalmic formulation comprising a compound of formula (I): wherein R1 is a linear or branched C9-C33 alkyl or a linear or branched C9-C33 alkenyl with 1 to 4 double bonds; R2 is a linear or branched C9-C19 alkyl or a linear or branched C9-C19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.Type: GrantFiled: December 21, 2012Date of Patent: August 20, 2019Inventors: Thomas Millar, Burkhardt Schuett
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Patent number: 10383884Abstract: The invention disclosed herein provides a method for treating Community-Acquired Bacterial Pneumonia (CABP) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.Type: GrantFiled: October 31, 2017Date of Patent: August 20, 2019Assignee: Paratek Pharmaceuticals, Inc.Inventors: Evangelos L. Tzanis, Paul McGovern, Amy L. Manley, Lynne Garrity-Ryan, S. Ken Tanaka
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Patent number: 10314926Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.Type: GrantFiled: June 29, 2017Date of Patent: June 11, 2019Assignee: Intrexon CorporationInventors: Bethany Lynn Merenick, Robert P. Beech, Thomas D. Reed, Anna P. Tretiakova, Richard E. Peterson
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Patent number: 10314912Abstract: Described herein are coating compositions for consumer and/or medical products. The coating compositions can be used to confer desirable properties to the consumer and/or medical products.Type: GrantFiled: March 13, 2017Date of Patent: June 11, 2019Assignee: Ariste Medical, LLCInventors: Lisa Jennings, Jonathan McCanless, Brian Best, Timothy Fabian, Michael Cole
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Patent number: 10273468Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.Type: GrantFiled: June 26, 2017Date of Patent: April 30, 2019Assignee: Washington UniversityInventors: Niraj Tolia, Gautam Dantas, Timothy Wencewicz, Jooyoung Park, Andrew Gasparrini, Kevin Forsberg, Joseph Vogel, Margaret Ruth Reck, Chanez Tiffany Symister, Jana L. Markley
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Patent number: 10238670Abstract: The invention disclosed herein provides a method for treating urinary tract infection (UTI) using 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, in either oral or IV doses or a combination of both.Type: GrantFiled: May 2, 2017Date of Patent: March 26, 2019Assignee: Paratek Pharmaceuticals, Inc.Inventors: Amy L. Manley, Evangelos L. Tzanis, Lynne Garrity-Ryan, S. Ken Tanaka, Judith N. Steenbergen, Stephen Bai
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Patent number: 10159685Abstract: The invention relates to the use of a poly(ADP ribose) polymerase (PARP) inhibitor and/or a tetracycline, for treating, preventing or ameliorating medial vascular calcification, and to pharmaceutical compositions comprising PARP inhibitors or tetracycline.Type: GrantFiled: June 15, 2017Date of Patent: December 25, 2018Assignees: Cambridge Enterprise Limited, King's College LondonInventors: Melinda Duer, David Reid, Catherine Shanahan
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Patent number: 10124014Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.Type: GrantFiled: June 29, 2017Date of Patent: November 13, 2018Assignee: Paratek Pharmaceuticals, Inc.Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
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Patent number: 10124066Abstract: In one aspect, the invention provides a stabilized lipid-based glycopeptide antibiotic composition and a process for producing the same. In another aspect, the invention provides methods for treating a bacterial pulmonary infection by administering to a subject in need thereof a therapeutically effective amount of the stabilized lipid-based glycopeptide antibiotic composition.Type: GrantFiled: November 27, 2013Date of Patent: November 13, 2018Assignee: INSMED INCORPORATEDInventors: Walter Perkins, Vladimir Malinin
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Patent number: 10111890Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein the 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline is administered orally at a dose of about 450 mg per day for two consecutive days, then at a dose of about 300 mg per day for 5 or more days.Type: GrantFiled: August 3, 2017Date of Patent: October 30, 2018Assignee: Paratek Pharmaceuticals, Inc.Inventors: S. Ken Tanaka, Evangelos L. Tzanis, Lynne Garrity-Ryan, Amy L. Manley
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Patent number: 10065924Abstract: In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.Type: GrantFiled: July 22, 2015Date of Patent: September 4, 2018Assignee: WILLIAM MARSH RICE UNIVERSITYInventors: Kyriacos C Nicolaou, Christopher R. H. Hale, Christian Nilewski, Heraklidia Ioannidou, Abdellatif El Marrouni
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Patent number: 9775855Abstract: The present invention provides for methods, compositions, and kits pertaining to the treatment of various diseases associated with inflammation. In various aspects, the invention provides methods and compositions comprising an effective amount of a macrolide and an effective amount of a tetracycline.Type: GrantFiled: September 13, 2012Date of Patent: October 3, 2017Inventors: Thomas J. Lewis, Clement L. Trempe
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Patent number: 9724358Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.Type: GrantFiled: February 2, 2016Date of Patent: August 8, 2017Assignee: Paratek Pharmaceuticals, Inc.Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
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Patent number: 9724430Abstract: The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.Type: GrantFiled: September 24, 2015Date of Patent: August 8, 2017Assignee: Intrexon CorporationInventors: Bethany Lynn Merenick, Robert P. Beech, Thomas D. Reed, Anna P. Tretiakova, Richard E. Peterson
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Patent number: 9700574Abstract: The invention relates to the combination of secnidazole with an antibiotic of the macrolide family, preferably azithromycin 11, for oral treatment of dental infections, which enables a considerable reduction in the length of treatment and the doses administered in comparison with the conventional treatment.Type: GrantFiled: May 14, 2012Date of Patent: July 11, 2017Assignee: ATHENA PHARMACEUTIQUES SASInventor: Pierre-Marie Defrance
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Patent number: 9657090Abstract: The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.Type: GrantFiled: December 11, 2012Date of Patent: May 23, 2017Assignees: AMGEN INC., THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Hua Zhu Ke, Min Liu, William V. Giannobile
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Patent number: 9624166Abstract: The present invention is directed to a compound represented by Structural Formula (1): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (I) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (I) and its therapeutic use.Type: GrantFiled: August 27, 2010Date of Patent: April 18, 2017Assignee: Tetraphase Pharmaceuticals, Inc.Inventors: Yonghong Deng, Louis Plamondon, Cuixiang Sun, Xiao-Yi Xiao, Jingye Zhou, Joyce A. Sutcliffe, Magnus P. Ronn
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Patent number: 9605175Abstract: Described herein are coating compositions for consumer and/or medical products. The coating compositions can be used to confer desirable properties to the consumer and/or medical products.Type: GrantFiled: October 29, 2013Date of Patent: March 28, 2017Assignee: ARISTE MEDICAL, LLCInventors: Lisa Jennings, Jonathan McCanless, Brian Best, Timothy Fabian, Michael Cole
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Patent number: 9562003Abstract: A method for modulating RNA with tetracycline compounds is described.Type: GrantFiled: July 2, 2015Date of Patent: February 7, 2017Assignee: Paratek Pharmaceuticals, Inc.Inventors: Stuart B. Levy, Michael P. Draper, Mark L. Nelson, Graham Jones
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Patent number: 9532996Abstract: Doxycycline formulations with a reduced food effect are disclosed. Particularly disclosed are modified release formulations which can be administered once a day and exhibit a reduced food effect. Methods of treating inflammatory conductions such as rosacea or inflammatory symptoms such as the papules and pustules of rosacea or acne vulgaris are also disclosed.Type: GrantFiled: November 19, 2015Date of Patent: January 3, 2017Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Ankit Baheti, Bijay Kumar Padhi, Rajeev Singh Raghuvanshi
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Patent number: 9481639Abstract: Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described.Type: GrantFiled: August 19, 2013Date of Patent: November 1, 2016Assignee: Paratek Pharmaceuticals, Inc.Inventors: Haregewein Assefa, Beena Bhatia, Michael P. Draper, Laura Honeyman, Oak K. Kim, Dennis P. Molnar
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Patent number: 9365499Abstract: The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.Type: GrantFiled: July 26, 2012Date of Patent: June 14, 2016Assignee: KBP Biosciences Co., Ltd.Inventors: Hui Zhang, Yanyan Dong
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Patent number: 9365500Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: GrantFiled: June 27, 2014Date of Patent: June 14, 2016Assignee: PARATEK PHARMACEUTICALS, INC.Inventors: Mark L. Nelson, Roger Frechette, Mohamed Y. Ismail, Laura Honeyman, Todd Bowser, Beena Bhatia
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Patent number: 9333261Abstract: The present invention provides a novel therapeutic combination comprising one or more anti-androgen agents and one or more antibiotic/anti-inflammatory agents or pharmaceutically acceptable salts or hydrates thereof, useful for the treatment of a dermatological disorder.Type: GrantFiled: January 17, 2014Date of Patent: May 10, 2016Assignee: M. ALPHABET 1, LLCInventors: Howard Fein, Mindy B. Berlin
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Patent number: 9327015Abstract: A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.Type: GrantFiled: March 24, 2010Date of Patent: May 3, 2016Assignee: DePuy Synthes Products, Inc.Inventors: Hassan Serhan, Michael J. O'Neil, Sean Lilienfeld, Thomas M. DiMauro
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Patent number: 9278911Abstract: The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.Type: GrantFiled: February 10, 2014Date of Patent: March 8, 2016Assignee: Paratek Pharmaceuticals, Inc.Inventors: Mark L. Nelson, Kwasi Ohemeng
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Patent number: 9278105Abstract: The present invention relates to compositions, pharmaceutical compositions, and methods for preparing the same, comprising a tetracycline with improved stability and solubility. Some embodiments include a tetracycline with an excess of a divalent or trivalent cation.Type: GrantFiled: October 17, 2012Date of Patent: March 8, 2016Assignee: Rempex Pharmaceuticals, Inc.Inventors: David C. Griffith, Serge Boyer, Michael N. Dudley, Scott Hecker
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Patent number: 9278079Abstract: An ocular composition consisting essentially of purified water, PEG-80 sorbitan laurate, sodium trideceth sulfate, PEG-150 distearate, sodium lauroamphoacetate, cocamidopropyl hydroxysultaine, sodium laureth-13 carboxylate, sodium chloride, PEG-15 cocopolyamine, polyhexamethylene biguanide, potassium sorbate, 1,2 hexanediol, and caprylyl glycol. The composition can be applied to a fabric pad for use as an eyelid cleanser, where the fabric pad is pre-moistened with the composition and packaged for use. The composition may also be used in an eyelid treatment kit for convenient combination treatments to improve overall eyelid hygiene and adjunctive eyelid therapy.Type: GrantFiled: July 12, 2013Date of Patent: March 8, 2016Assignee: OCuSOFT, Inc.Inventors: Nat Adkins, Jr., Cynthia Barratt
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Patent number: 9265740Abstract: Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of MSSA, MRSA, B-streptococci, Viridans Streptococci, Enterococcus, or combinations thereof.Type: GrantFiled: April 22, 2014Date of Patent: February 23, 2016Assignee: Paratek Pharmaceuticals, Inc.-124418Inventors: Sean M. Johnston, Robert D. Arbeit, Thomas J. Bigger, Dennis P. Molnar, S. Ken Tanaka
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Patent number: 9260550Abstract: In an example, a process for the production of an acrylate polymer is disclosed. The process includes reacting lactide with a bromination material to form a brominated lactide. The process further includes reacting the brominated lactide with an elimination material to form an acrylic monomer, and polymerizing the acrylic monomer to form an acrylate polymer.Type: GrantFiled: January 27, 2015Date of Patent: February 16, 2016Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Dylan J. Boday, Timothy C. Mauldin