3,10-dihydroxy-2-naphthacene Carboxamide Or Derivative (e.g., Tetracycline, Etc.) Doai Patents (Class 514/152)
With stabilizer or preservative (Class 514/153)
With an additional active ingredient (excludes reaction product or complex) (Class 514/154)
  • SILVER/WATER, SILVER GELS AND SILVER-BASED COMPOSITIONS; AND METHODS FOR MAKING AND USING THE SAME
    Publication number: 20110262556
    Abstract: We disclose a colorless composition comprising metal particles (e.g., silver nanoparticles) and water, wherein said particles comprise an interior of elemental metal (e.g., silver) and an exterior of metal oxide (e.g., one or more silver oxide(s)), wherein the metal nanoparticles are present in the water at a level of about 5-40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described. The composition can be incorporated into a hydrogel with essentially no loss of antimicrobial properties. Various metal-containing compositions with unexpected biological efficacy are also disclosed.
    Type: Application
    Filed: December 30, 2005
    Publication date: October 27, 2011
    Applicant: AMERICAN SILVER, LLC
    Inventors: Robert J. Holladay, William Moeller, Dillip Mehta, Rustum Roy, Julian H.J. Brooks, Mark G. Mortenson
  • Controlled Delivery of Tetracycline Compounds and Tetracycline Derivatives
    Publication number: 20110262542
    Abstract: A composition is provided for delivering a tetracycline compound to a mammal. The composition includes an antibiotic tetracycline compound and a controlled-release agent having at least one controlled-release agent. The tetracycline compound is associated with the controlled-release matrix to provide a release profile whereby the mammal is treated substantially without antibiotic activity. Methods for treating a mammal with a tetracycline compound and a dosage unit are also provided utilizing the controlled-release tetracycline composition.
    Type: Application
    Filed: July 6, 2011
    Publication date: October 27, 2011
    Applicant: GALDERMA LABORATORIES INC.
    Inventor: Robert A. Ashley
  • POROUS CERAMIC SCAFFOLD HAVING AN ORGANIC/INORGANIC HYBRID COATING LAYER CONTAINING BIOACTIVE FACTOR AND METHOD THEREOF
    Publication number: 20110256203
    Abstract: A method for manufacturing a porous ceramic scaffold having an organic/inorganic hybrid composite coating layer containing a bioactive factor is disclosed. The method includes; forming a porous ceramic scaffold, mixing a silica xerogel and a physiologically active organic substance to prepare an organic/inorganic hybrid composite, adding a bioactive factor to the organic/inorganic hybrid composite, and filling the organic/inorganic composite containing the bioactive factor into a pore structure of the porous ceramic scaffold, thereby coating the porous ceramic scaffold. In accordance with the method, the porous ceramic scaffold may be uniformly coated with the organic/inorganic hybrid composite while maintaining an open pore structure, and stably discharge the bioactive factor over a long period of time.
    Type: Application
    Filed: April 15, 2011
    Publication date: October 20, 2011
    Inventors: Hyoun-Ee KIM, Shin-Hee JUN, Eun-Jung LEE
  • MULTIPLICATION OF THE EFFICACY OF ANTI-INFECTIOUS AGENTS BY A COMPOSITION COMPRISING AN EXTRACT MADE FROM DEHYDRATED AND PARTIALLY SODIUM-FREE SEAWATER
    Publication number: 20110244062
    Abstract: The present invention relates to a composition inhibiting or destroying at least one living or unicellular organism, which comprises at least one anti-infectious agent and one activating agent, which consists of an extract made from dehydrated and partially sodium-free seawater or an extract made from a dried fossil sea with a similar composition. The present invention also relates to the utilization of such a composition.
    Type: Application
    Filed: February 14, 2011
    Publication date: October 6, 2011
    Applicant: AROMAPHARM IRELAND LTD.
    Inventors: Pierre LAGNY, Jean-Jacques HERAULT
  • Compounds and methods for the treatment of pain and other diseases
    Publication number: 20110230452
    Abstract: The present invention relates generally to pharmaceutical agents, and in particular, to metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of dual acting MMP-2 and MMP-9 inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP-2 and MMP-9 inhibitors for the treatment of pain and other diseases. Additionally, the present invention relates to methods for treating pain, addiction and/or withdrawal symptoms in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.
    Type: Application
    Filed: September 23, 2010
    Publication date: September 22, 2011
    Inventor: Irving Sucholeiki
  • CALCIUM CARBONATE MICROSTRUCTURES USEFUL IN ENCAPSULATION APPLICATIONS AND A PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20110223111
    Abstract: A facile method to synthesize stable calcium carbonate microstructures is demonstrated which allows in situ encapsulation of sensitive molecules like drugs. The methodology involves a macromolecular assembly of anionic polypeptide with cationic peptide oligomer to concurrently template and hold to stabilize the mineralized structure. The heterogeneously distributed mixture of anionic and cationic residues in the macromolecular assembly, similar to that is found in natural systems assists in recognizing and coassembling Ca2+ and CO32? ionic clusters, especially for formation of a disordered precursor phase such as amorphous calcium carbonate (ACC) and further crystallization to form a metastable vaterite phase. The assembly also facilitates encapsulation of a guest molecule such as tetracycline at ambient conditions without affecting the mineralization process.
    Type: Application
    Filed: March 11, 2011
    Publication date: September 15, 2011
    Inventors: Rohit Kumar RANA, Gousia BEGUM
  • MUCOADHERENTS COMPOSITIONS AND THEIR USE
    Publication number: 20110218166
    Abstract: The present invention has as its objective to provide mucoadherent compositions with enhanced properties of bioadhesivity, consistency, stability and vaginal pH regulation. It can also be the carrier of an active principle for the treatment or prophylaxis of disturbances or diseases caused in mucosa, particularly in the vaginal tract, as well as their use.
    Type: Application
    Filed: August 14, 2009
    Publication date: September 8, 2011
    Applicant: Incrementha PD&I - Pesquisa, Desenvolvimento e Inovecao de Famacos e Medicamentos Ltda.
    Inventors: Haline Fernanda Santana Castanho, Lupércio Calefe
  • 7-N-substituted phenyl tetracycline compounds
    Patent number: 8012951
    Abstract: 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: September 6, 2011
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza
  • Method to diagnose and treat degenerative joint disease
    Patent number: 8012950
    Abstract: Disclosed are methods for detecting and treating joint disease. The methods of diagnosis include determining increased expression of enzymes that are upregulated during the progress of joint and ligament inflammation and degeneration. In addition, disclosed are methods of treating the disease including inhibiting the activity of responsible proteases.
    Type: Grant
    Filed: August 30, 2004
    Date of Patent: September 6, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peter Muir, Ray Vanderby, Jr., Paolo Pepe Provenzano
  • Methods for Treating Spinal Muscular Atrophy Using Tetracycline Compounds
    Publication number: 20110207706
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Application
    Filed: May 3, 2011
    Publication date: August 25, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • OVIEDOMYCIN DERIVATIVES, METHOD FOR OBTAINING SAME AND USE THEREOF
    Publication number: 20110207705
    Abstract: Oviedomycin derivatives, method for obtaining same and use thereof. This invention relates to oviedomycin derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and to produce the oviedomycin derivatives. The invention further relates to bacterial strains that can be used to produce oviedomycin derivatives. Finally, said oviedomycin derivatives are applicable in the field of the human health, specifically to produce drugs for the treatment of tumour diseases.
    Type: Application
    Filed: March 26, 2009
    Publication date: August 25, 2011
    Applicant: UNIVERSIDAD DE OVIEDO
    Inventors: Carmen Méndez Fernández, Felipe Lombó Brugos, Alfredo A. Fernández Braña, José Antonio Salas Fernández
  • METHODS OF TREATING AUTOIMMUNE DISEASES CAUSED BY SMALL INTESTINAL BACTERIAL OVERGROWTH
    Publication number: 20110171232
    Abstract: Disclosed is a method of diagnosing autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis an autoimmune disease. Also disclosed is a method of treating these autoimmune diseases, which involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of antimicrobial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. Also disclosed is a kit for the diagnosis or treatment of autoimmune diseases.
    Type: Application
    Filed: March 28, 2011
    Publication date: July 14, 2011
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Henry C. Lin, Mark Pimentel
  • 7-Pyrazolyl Tetracycline Compounds and Methods of Use Thereof
    Publication number: 20110160165
    Abstract: The present invention provides compounds of Formula (I) and related methods and formulations: wherein: A represents a pyrazole ring optionally substituted by one or more R groups.
    Type: Application
    Filed: March 1, 2011
    Publication date: June 30, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sophie Huss, Jose M. Bueno, Jose M. Fiandor, Roger Frechette
  • Pharmaceutical Composition for the Eradication of Helicobacter Pylori and Preparation Method Thereof
    Publication number: 20110160156
    Abstract: The present invention relates to a pharmaceutical composition and its preparation method for the eradication of Helicobacter pylorif in the forms of effervescent tablet, suspension or powder. The pharmaceutical composition comprises an effective dose of ?-lactam antibiotic, an effective dose of macrolide antibiotic, an effective dose of antacid such as proton pump inhibitor and H2 blocker, and a pharmaceutical acceptable carrier. An effective dose of alkaline substance such as carbonate or bicarbonate can be added to increase the pH of the stomach when the PPI antacid is used, which can protect the degradation of acid-labile antibiotics or PPI to further increase the bioavailability of the pharmaceutical composition for the purpose of Helicobacter pylori eradication.
    Type: Application
    Filed: June 16, 2010
    Publication date: June 30, 2011
    Applicants: SYNMOSA BIOPHARMA CORPORATION
    Inventors: Chih-Hui Lin, Jui-Ming Chou, Li-Heng Pao, Chia-Wen Chang, Chia-Yi Lin, An-Long Lee
  • Aqueous Formulations
    Publication number: 20110152212
    Abstract: A method of preparing an aqueous formulation of an active material and such a formulation per se are described, wherein the active material has a very low solubility in water. The method may involve contacting active material in solid form with an optionally cross-linked water soluble polymer. The water soluble polymer is preferably a polyvinyl polymer with polyvinylalcohol being preferred. The polymer is optionally cross-linked. The method and formulation may be of particular utility in delivery of anti-cancer drugs or drugs via a pulmonary route.
    Type: Application
    Filed: February 22, 2008
    Publication date: June 23, 2011
    Inventors: Nicholas John Crowther, Donald Eagland
  • SUSTAINED-RELEASE DRUG CARRIER COMPOSITION
    Publication number: 20110117197
    Abstract: The present invention provides compositions for extended release of an active ingredient, comprising a lipid-saturated matrix formed from a biodegradable polymer. The present invention also provides methods of producing the matrix compositions and methods for using the matrix compositions to provide controlled release of an active ingredient in the body of a subject in need thereof.
    Type: Application
    Filed: July 14, 2009
    Publication date: May 19, 2011
    Applicant: POLYPID LTD.
    Inventors: Noam Emanuel, Moshe Neuman, Shlomo Barak
  • 7,8 And 9-Substituted Tetracycline Compounds
    Publication number: 20110118215
    Abstract: 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Applicant: Trustees of Tufts College
    Inventors: Mark L. Nelson, Darrell J. Koza, Glen Rennie
  • Antimicrobial combination therapy
    Patent number: 7943600
    Abstract: This invention provides methods and pharmaceutical compositions for treating a subject having a condition associated with an antibiotic resistant bacterial infection. The invention includes administering to a subject a therapeutically effective combination of an antibiotic and a toxic compound (e.g., a nucleic acid damaging agent, an alkylating agent, or a heavy metal containing compound).
    Type: Grant
    Filed: December 20, 2005
    Date of Patent: May 17, 2011
    Assignees: Massachusetts Institute of Technology, University of Massachusetts
    Inventors: Doriana Froim, John M. Essigmann, Martin G. Marinus
  • COMPOSITION FOR TRANSDERMAL DELIVERY OF CATIONIC ACTIVE AGENTS
    Publication number: 20110111029
    Abstract: A composition for transdermal delivery, particularly iontophoretic transdermal delivery, having at least one cationic active agent or a salt thereof. The composition comprises at least one cationic active agent or a salt thereof, at least one polyamine and/or polyamine salt, water or an aqueous solvent mixture, and optionally one or more additives. Use of the composition as a component of a transdermal patch or of an iontophoretic transdermal patch is also provided, as well as the use of the composition in a method for transdermally or iontophoretically administering cationic active agents. A method for determining the in vitro skin permeation properties of an active agent-containing iontophoretic composition is also provided.
    Type: Application
    Filed: June 16, 2009
    Publication date: May 12, 2011
    Applicant: LTS Lohmann Therapie-Systeme AG
    Inventors: Christoph Schmitz, Mohammad Sameti, Andreas Koch, Michael Horstmann
  • Tetracycline derivatives as antibacterial agents
    Patent number: 7939513
    Abstract: In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm blooded animals employing these new compounds. wherein R1 is selected from optionally substituted alkyl.
    Type: Grant
    Filed: September 8, 2008
    Date of Patent: May 10, 2011
    Assignees: Dr. Reddy's Laboratories Limited, Dr. Reddy's Laboratories, Inc.
    Inventors: Mohamed Takhi, Natesan Selvakumar, Sreenivas Kandepu, Gavara Govinda Rajulu, Javed Iqbal
  • POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPOUND-INDUCED OTOTOXICITY
    Publication number: 20110104257
    Abstract: Methods of determining a subjects ototoxicity risk from administration of platinum-coordinating compounds having an ototoxicity risk, methods of administering a platinum-coordinating compound having an ototoxicity risk and oligonucleotides, peptide nucleic acids, arrays and addressable collections for performing embodiments of the methods are provided herein.
    Type: Application
    Filed: April 14, 2009
    Publication date: May 5, 2011
    Inventors: Michael R. Hayden, Bruce Carleton, Colin Ross
  • Methods for treating spinal muscular atrophy using tetracycline compounds
    Patent number: 7935687
    Abstract: Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: May 3, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Todd Bowser, Michael Draper, Stuart B. Levy, Mark L. Nelson
  • Methods and Devices for Correcting Spinal Deformity With Pharmaceutical-Eluting Pedicle Screws
    Publication number: 20110097377
    Abstract: A method of correcting spinal deformity, which includes locating pharmaceutical-loaded implants adjacent to targeted spinal growth plates, and then eluting the pharmaceutical onto the growth plates. Preferably, the method involves correcting spinal deformity by simply inserting a pharmaceutical-eluting pedicle screw onto the concave side of a scoliotic curve. In some embodiments, the screw has a cannulated internal reservoir that contains a growth-inhibiting pharmaceutical (such as a tetracycline) and at least one fenestration that allows the pharmaceutical to elute onto the vertebral body growth plate.
    Type: Application
    Filed: March 24, 2010
    Publication date: April 28, 2011
    Inventors: Hassan Serhan, Michael J. O'Neil, Sean Lilienfeld, Thomas M. DiMauro
  • 7-And 9-Carbamate, Urea, Thiourea, Thiocarbamate, And Heteroaryl-Amino Substituted Tetracycline Compounds
    Publication number: 20110092467
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicants: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • Tetracycline Compounds for Treatment of Cryptosporidium Parvum Related Disorders
    Publication number: 20110086821
    Abstract: Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 14, 2011
    Applicant: Trustees of Tufts College
    Inventors: Stuart B. Levy, Mark L. Nelson
  • Substituted Tetracycline Compounds
    Publication number: 20110086822
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 14, 2011
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Y. Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Reddy Nagavelli, Paul Sheahan, Atul K. Verma, Peter Viski, Tadeusz Warchol
  • Method for the treatment of acne
    Patent number: 7919483
    Abstract: A method for treatment of acne with tetracyclines is provided. A lower sustained dose and no loading dose is employed, with an optional once-a-day dosing regimen.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: April 5, 2011
    Assignee: Medicis Pharmaceutical Corporation
    Inventors: Mitchell Wortzman, R. Todd Plott, Kuljit Bhatia, Bhiku Patel
  • Biodegradable Absorbents and Methods of Preparation
    Publication number: 20110076250
    Abstract: A biodegradable microfiber absorbent comprises a substantially homogeneous mixture of at least one hydrophilic polymer and at least one biodegradable polymer. The absorbent can be prepared by an electro hydrodynamic spinning of a substantially homogeneous polymer mixture. Medical dressings for burns and wounds, cavity dressings, drug delivery patches, face masks, implants, drug carriers that comprises at least one microfiber electrospun from a polymer mixture are provided. The dressings can have variable water vapor penetration characteristics and variable biodegradation times.
    Type: Application
    Filed: December 7, 2010
    Publication date: March 31, 2011
    Inventors: Bronislava G. Belenkaya, Vyacheslav N. Polevov, Valentina I. Sakharova, Claudia Polevov
  • 4-Substituted Tetracyclines and Methods of Use Thereof
    Publication number: 20110077225
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: December 7, 2010
    Publication date: March 31, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Beena Bhatia, Mark Grier, Mark L. Nelson, Jingwen Pan
  • Method to reduce SLOSH energy absorption and its damaging effects through the reduction of inelastic collisions in an organism
    Publication number: 20110065637
    Abstract: A first embodiment can be a method to reduce SLOSH energy absorption within an organism by reducing the inelastic collisions. A fluid containing organism can utilize an embodiment of the method wherein one or more of reversibly increasing pressure within the organs or cells, reversibly increasing the volume within the organs or cells, reversibly altering vascular, molecular, or cell wall stiffness, or reversibly altering vascular, molecular, or cell wall configuration within said organism may reduce these collisions.
    Type: Application
    Filed: September 10, 2010
    Publication date: March 17, 2011
    Inventor: David William Smith
  • METHODS FOR IMPROVING LID MARGIN AND TEAR FILM FUNCTION AND TREATMENT OF LID MARGIN DISEASE USING TETRACYCLINE FAMILY ANTIBIOTICS
    Publication number: 20110059925
    Abstract: The present invention provides a mucoadhesive broad spectrum antibiotic with anti-inflammatory characteristics with strong tissue penetration for improving lid margin function and the treatment of diseases associated therewith. The present invention further provides compositions and methods for treating and/or preventing the signs and/or symptoms of blepharitis and dry eye disease.
    Type: Application
    Filed: March 26, 2009
    Publication date: March 10, 2011
    Inventor: Eric Donnenfeld
  • Cardioplegia Solution for Cardiac Surgery
    Publication number: 20110059177
    Abstract: The invention relates to improved cardioplegia solutions. The invention provides cardioplegia solutions and compositions that produce a readily reversible, rapid electrochemical arrest with minimal tissue ischaemia. The cardioplegia solutions and compositions are used for arresting, protecting and/or preserving organs, in particular the heart during open-heart surgery, transplanting, cardiovascular diagnosis or therapeutic intervention.
    Type: Application
    Filed: February 10, 2009
    Publication date: March 10, 2011
    Inventor: Hemant Thatte
  • 7-substituted fused ring tetracycline compounds
    Patent number: 7893282
    Abstract: 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: February 22, 2011
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Laura Honeyman
  • METHOD FOR TREATING MEIBOMIAN GLAND DISEASE
    Publication number: 20110039805
    Abstract: A method for treating a patient having meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion, is disclosed. Preferably, the method concerns treatment of a patient with topical tetracycline, a derivative or analogue of tetracycline, or a chemically modified tetracycline (CMT). Oral administration of a CMT is also disclosed as part of the method for treating meibomian gland disease, ocular irritation associated with delayed tear clearance, or recurrent corneal epithelial erosion.
    Type: Application
    Filed: July 21, 2010
    Publication date: February 17, 2011
    Applicant: The University of Miami
    Inventors: Stephen C. Pflugfelder, Balakrishna L. Lokeshwar, Marie Selzer
  • THERAPEUTIC COMPOSITION FOR BONE INFECTIOUS DISEASE
    Publication number: 20110039764
    Abstract: A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and/or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.
    Type: Application
    Filed: October 26, 2010
    Publication date: February 17, 2011
    Applicants: Denki Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hiroaki Matsuno, Masamichi Hashimoto, Yoshiaki Miyata, Teruzou Miyoshi
  • DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS
    Publication number: 20110034422
    Abstract: Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.
    Type: Application
    Filed: October 6, 2008
    Publication date: February 10, 2011
    Applicant: WAYNE STATE UNIVERSITY
    Inventors: Rangaramanujam Kannan, Raymond Iezzi, Bharath Rajaguru, Sujatha Kannan
  • DRESSING COMPOSITIONS AND METHODS
    Publication number: 20110033503
    Abstract: Described is a spray-on hydrogel comprising water-soluble PEG polymers that cross-link in situ to form a hydrogel such that the cross-links are reversible. The hydrogel can be useful as a drug delivery composition, wound dressing or surgery adjuvant. Polyethylene glycol polymer and cross-linker solutions are sprayed simultaneously through a common orifice. Cross-linking via formation of thioether or disulfide bonds is initiated upon mixing, providing rapid gelation. The hydrogel components can be derivatized with RGD peptides or analogs thereof to promote retention in/on a body compartment such as the skin, surface of the eye, or a mucosa such as the vaginal mucosa. The cross-links are reversed using a reducing solution enabling easy removal of the hydrogel by dissolution. Processes for preparation of the cross-linker, RGD derivatized PEG and RGD-linked agents are also disclosed.
    Type: Application
    Filed: April 23, 2008
    Publication date: February 10, 2011
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Patrick J. Sinko, Stanley Stein, Anupa R. Menjoge, Simi Gunaseelan, Siva Naga Sree priay Anumolu, Raghavandra Navath
  • Compositions and methods for the treatment of arthritis
    Patent number: 7884090
    Abstract: The present invention provides compositions, combination of medicaments, and methods for the treatment of certain conditions such as arthritis, and in particular, reactive arthritis, osteoarthritis, and bursitis, among others.
    Type: Grant
    Filed: December 7, 2005
    Date of Patent: February 8, 2011
    Inventors: Ernest L. Bonner, Jr., Robert Hines
  • Regression of Established Atherosclerotic Plaques, and Treating Sudden-Onset Asthma Attacks, using PARP Inhibitors
    Publication number: 20110028420
    Abstract: A method is disclosed for treating and inducing the regression of established atherosclerotic plaques. A method is disclosed for treating asthma, including treatment of an ongoing asthma attack. In both cases, treatment with PARP inhibitors, such as the PARP inhibitor TIQ-A (Thieno[2,3-c]isoquinolin-5-one), can lead to regression of existing disease and symptoms.
    Type: Application
    Filed: April 7, 2009
    Publication date: February 3, 2011
    Inventors: Hamid A. Boulares, Chetan P. Hans, Amarjit S. Naura
  • Low Viscosity Liquid Polymeric Delivery System
    Publication number: 20110027389
    Abstract: Low viscosity biodegradable polymer solutions of a liquid biodegradable polymer and biocompatible solvent and methods of using the compositions to form a biodegradable liquid polymer implant are provided.
    Type: Application
    Filed: January 13, 2009
    Publication date: February 3, 2011
    Inventor: Richard L. Dunn
  • Tigecycline crystalline forms and processes for preparation thereof
    Patent number: 7871993
    Abstract: The present invention relates to solid crystalline Tigecycline, and crystalline forms thereof.
    Type: Grant
    Filed: April 24, 2007
    Date of Patent: January 18, 2011
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Evgeny Tsiperman, Sigalit Levi, Judith Aronhime, Tamas Koltai
  • SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF
    Publication number: 20110009371
    Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
    Type: Application
    Filed: May 12, 2010
    Publication date: January 13, 2011
    Inventors: Andrew G. Myers, Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel
  • MINOCYCLINE ORAL DOSAGE FORMS FOR THE TREATMENT OF ACNE
    Publication number: 20100330131
    Abstract: Minocycline oral dosage forms containing a controlled release carrier are useful for the treatment of acne.
    Type: Application
    Filed: September 3, 2010
    Publication date: December 30, 2010
    Applicant: MEDICIS PHARMACEUTICAL CORPORATION
    Inventors: Mitchell Wortzman, R. Todd Plott, Kuljit Bhatia, Bhiku Patel
  • 4-substituted tetracyclines and methods of use thereof
    Patent number: 7858601
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: December 28, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Joel Berniac, Beena Bhatia, Mark Grier, Mark L. Nelson, Jingwen Pan
  • 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
    Patent number: 7858600
    Abstract: Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.
    Type: Grant
    Filed: February 24, 2004
    Date of Patent: December 28, 2010
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Stuart B. Levy, Roger Frechette, Todd Bowser, Mohamed Y. Ismail
  • 7-phenyl-substituted tetracycline compounds
    Patent number: 7851460
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: December 14, 2010
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza
  • Substituted Tetracycline Compounds
    Publication number: 20100305072
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 2, 2010
    Inventors: Oak K. Kim, Mark L. Nelson, Paul Abato, Haregewein Assefa, Joel Bernaiac, Mohamed Y. Ismail, Todd Bowser, Mark Grier, Beena Bhatia, Atul K. Verma, Laura Honeyman, Jingwen Pan
  • HYALURONIC ACID (HA) INJECTION VEHICLE
    Publication number: 20100291027
    Abstract: Disclosed herein are compositions that exhibit viscosities suitable for injectable formulations. The compositions comprise bioactive agent-loaded microparticles and hyaluronic acid or a salt thereof in a suitable liquid pharmaceutical carrier. Also disclosed are methods of making and using the compositions.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 18, 2010
    Inventor: Jason Campbell
  • TETRACYCLINE AND USES THEREOF
    Publication number: 20100292183
    Abstract: Provided herein are methods and compositions for the in vitro formation of tetracycline conjugates, for example, tetracycline conjugated to anti-coagulants. The present invention also provides methods for preventing or treating plaque-related diseases or disorders such as atherosclerosis using tetracycline alone, or the tetracycline conjugates of the present invention.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 18, 2010
    Inventor: Shanmugavel MADASAMY
  • RADIOPROTECTIVE DRUGS
    Publication number: 20100292193
    Abstract: Drugs and their compositions useful in preventing and treating negative side effects associated with radiation exposure or clinical radiotherapy are disclosed. More specifically, new compounds that can be administered systemically to patients exposed to radiation or undergoing radiotherapy and methods of using these formulations are disclosed.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 18, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: WILLIAM H. McBRIDE, KWANGHEE KIM, ROBERT D. DAMOISEAUX, ANDREW J. NORRIS