The Hetero Ring Is Five-membered Patents (Class 514/158)
  • Patent number: 4981873
    Abstract: The present invention concerns compounds of the formula: ##STR1## where R.sub.1 is an alkyl or alkenyl radical containing up to 6 carbon atoms, a cycloalkyl radical containing 3 to 7 carbon atoms, an aralkyl, aralkenyl or aryl radical in which the aryl radical or moiety can be substituted one or more times by halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, hydroxyl, trifluoromethyl, cyano, nitro, amino, C.sub.1 -C.sub.6 -alkylamino, C.sub.2 -C.sub.12 -dialkylamino, C.sub.1 -C.sub.6 -acylamino, C.sub.1 -C.sub.16 -acyl, C.sub.1 -C.sub.6 -alkylsulphenyl, -sulphinyl or -sulphonyl or by azido, R.sub.2 is hydrogen atom or a C.sub.1 -C.sub.6 -alkyl, aralkyl, aralkenyl or acyl radical, A and B are saturated or unsaturated alkylene chains containing up to 10 carbon atoms which can be substituted one or more times by C.sub.1 -C.sub.
    Type: Grant
    Filed: June 23, 1989
    Date of Patent: January 1, 1991
    Assignee: Boehringer Mannheim GmbH
    Inventors: Ernst-Christian Witte, Karlheinz Stegmeier, Liesel Doerge, Robert A. Slater
  • Patent number: 4971989
    Abstract: Substituted 1-arylpyrazoles useful in combating insects having the arachnida and nematodes of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents alkyl or halogenoalkyl,R.sup.3 represents hydrogen or alkanoyl,R.sup.4 represents hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, halogenoalkyl, alkenyl, halogenoalkenyl or alkinyl, in each case optionally substituted cycloalkyl, aralkyl or aryl, or, when X represents oxygen or sulphur, R.sup.4 can represent a cation equivalent which is bonded in a salt-like manner,A represents a double-linked alkylene radical,X represents oxygen, sulphur or a radical ##STR2## Ar represents optionally substituted phenyl, pyridyl and n represents a number 0, 1 or 2, where R.sup.5 represents hydrogen, alkyl, hydroxylalkyl, alkoxyalkyl, alylthioalkyl, halogenoalkyl, alkenyl, halogenoalkenyl or alkinyl, or represents optionally substituted cycloalkyl, aralkyl or aryl.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: November 20, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uta Jensen-Korte, Schallner, Otto, Benedikt Becker, Jurgen Hartwig, Wilhelm Stendel
  • Patent number: 4965258
    Abstract: Cycloalkano[1,2-b]indole-sulphonamides of the formula ##STR1## where appropriate in an isomeric form, and their salts are disclosed. These compounds are useful to inhibit platelet aggregation and to antoganize thromboxane A.sub.2.
    Type: Grant
    Filed: November 28, 1989
    Date of Patent: October 23, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Rosentreter, Folker Lieb, Hermann Oediger, Friedel Seuter, Elisabeth Perzborn, Volker-Bernd Fiedler
  • Patent number: 4954486
    Abstract: Tinnitus symptoms were treated with furosemide, a loop diuretic, and reductions in tinnitus symptoms were observed.
    Type: Grant
    Filed: December 20, 1989
    Date of Patent: September 4, 1990
    Assignee: Tulane Educational Fund
    Inventor: Paul S. Guth
  • Patent number: 4888327
    Abstract: Disclosed are antibiotic compositions for topical administration comprising an aminoglycoside, a benzylpyrimidine and a sulfonamide.
    Type: Grant
    Filed: August 4, 1988
    Date of Patent: December 19, 1989
    Assignee: Alcon Laboratories, Inc.
    Inventor: John G. Edwards
  • Patent number: 4833132
    Abstract: There is disclosed a process for treating a warm-blooded animal wherein there is administered to the warm-blooded animal a therapeutically effective amount of composition selected from the group consisting of 5-methyl-3-sulfanilamidoisoxazole, a salt of 5-methyl-3-sulfanilamidoisoxazole with a pharmaceutically acceptable base, 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine, a salt of 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine with a pharmaceutically acceptable acid and mixtures thereof. The composition is useful to treat a fibrosarcoma (SAD.sub.2) tumor in warm-blooded animals.
    Type: Grant
    Filed: March 23, 1987
    Date of Patent: May 23, 1989
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Charles R. Spillert, Corinne Devereux, Eric J. Lazaro
  • Patent number: 4818753
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is H, methyl, ethyl, or chloro and R.sup.2 is hydrocarbyl of 1-12 C are useful as antifungal agents. Compounds of this series wherein R.sup.2 is 7-12 C are novel. A new synthetic method for the compounds is also described.
    Type: Grant
    Filed: September 18, 1987
    Date of Patent: April 4, 1989
    Assignee: SRI International
    Inventors: William T. Colwell, Joseph I. DeGraw
  • Patent number: 4781920
    Abstract: The invention provides physically stable anthelmintic paste compositions containing resinates of d1-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole and other anthelmintic compounds in combination with a wide variety of therapeutic agents such as antibiotics, vitamins, vaccines, or mineral supplements.
    Type: Grant
    Filed: September 3, 1985
    Date of Patent: November 1, 1988
    Assignee: American Cyanamid Company
    Inventor: James M. Quinlan
  • Patent number: 4735959
    Abstract: There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula Ia as well as the compounds of Formula I possess blood-sugar lowering properties.
    Type: Grant
    Filed: May 14, 1985
    Date of Patent: April 5, 1988
    Assignee: Dr. Karl Thomae GmbH
    Inventors: Wolfgang Grell, Gerhart Griss, Robert Sauter, Rudolf Hurnaus, Eckhard Rupprecht, Nikolaus Kaubisch, Joachim Kahling, Bernhard Eisele
  • Patent number: 4708952
    Abstract: A composition adapted to prolong the residence time of sulfa and cinchona alkaloid drugs in the circulating plasma of mammals including humans comprising hexanoic acid, potassium hydrogen tartrate, tannic acid, pectin and riboflavin, with the further presence of glutamic acid in the case of sulfa drugs and L-tyrosine in the case of the cinchona alkaloids.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: November 24, 1987
    Inventor: Aida Salatinjants
  • Patent number: 4698335
    Abstract: There is disclosed a process for treating a warm-blooded animal to be subjected to radiotherapy or chemotherapy wherein there is administered to the warm-blooded animal a therapeutically effective amount of a composition selected from the group consisting of 5-methyl-3-sulfanilamidoisoxazole, a salt of 5-methyl-3-sulfanilamidoisoxazole with a pharmaceutically acceptable base, 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine, a salt of 2,4-diamino-5-(3,4,5-trimethoxybenzene) pyrimidine with a pharmaceutically acceptable acid and mixtures thereof.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: October 6, 1987
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: Charles R. Spillert, Corinne Devereux, Eric J. Lazaro
  • Patent number: 4661478
    Abstract: There is disclosed a process for treating a warm-blooded animal subjected to barbituate anesthesia to potentiate effects thereof wherein there is administered to the warm-blooded animal a therapeutically effective amount of a composition selected from the group consisting of 5-methyl-3-sulfanilamidoisoxazole, a salt of 5-methyl-3-sulfanilamidoisoxazole with a pharmaceutically acceptable base, 2,4-diamino-5-3-(3,4,5-trimethoxybenzyl) pyrimidine, a salt of 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine with a pharmaceutically acceptable acid and mixtures thereof.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: April 28, 1987
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Charles R. Spillert, Corinne Devereux, Eric J. Lazaro
  • Patent number: 4632919
    Abstract: There is disclosed a process for prolonging recalcification, prothrombin and thrombin times of human plasma which comprises administering to a warm-blooded animal a composition selected from the group consisting of 5-methyl-3-sulfanilamidoisoxazole, a salt of 5-methyl-3-sulfanilamidoisoxazole with a pharmaceutically acceptable base, 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine, a salt of 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine with a pharmaceutically acceptable acid and mixtures thereof.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: December 30, 1986
    Assignee: University of Medicine & Dentistry of N.J.
    Inventors: Charles R. Spillert, Corinne Devereux, Eric J. Lazaro
  • Patent number: 4632920
    Abstract: There is disclosed a process for treating a warm-blooded animal following burn injury wherein there is administered to the warm-blooded animal a therapeutically effect amount of a composition selected from the group consisting of 5-methyl-3-sulfanilamidoisoxazole, a salt of 5-methyl-3-sulfanilamidoisoxazole with a pharmaceutically acceptable base, 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine, a salt of 2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrmidine with a pharmaceutically acceptable acid and mixtures thereof.
    Type: Grant
    Filed: September 27, 1984
    Date of Patent: December 30, 1986
    Assignee: University of Medicine & Dentistry of New Jersey
    Inventors: Charles R. Spillert, Corinne Devereux, Eric J. Lazaro
  • Patent number: 4610981
    Abstract: This invention concerns novel N-[(1H-imidazol-1-yl), (1H-1,2,4-triazol-1-yl) and (3-pyridyl)alkyl]benzenesulfonamides which are useful as inhibitors of thromboxane synthetase enzyme and/or as antihypertensive agents.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: September 9, 1986
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Marsico, Jr., William B. Wright, Jr.