9-position Substituted Patents (Class 514/180)
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Publication number: 20110319377Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).Type: ApplicationFiled: July 25, 2011Publication date: December 29, 2011Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, OTONOMY, INC.Inventors: Jay Lichter, Benedikt Vollrath, Andrew M. Trammel, Sergio G. Durón, Fabrice Piu, Luis A. Dellamary, Qiang Ye, Carl Lebel, Michael Christopher Scaife, Jeffrey P. Harris
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Patent number: 8080263Abstract: Stabilized dispersions are provided for the delivery of a bioactive agent. The dispersions preferably comprise a plurality of perforated microstructures dispersed in a suspension medium that typically comprises a liquid fluorochemical. As density variations between the suspended particles and suspension medium are minimized and attractive forces between microstructures are attenuated, the disclosed dispersions are particularly resistant to degradation, such as by settling or flocculation. In particularly preferred embodiments the stabilized dispersions may be directly administered to the lung of a patient using an endotracheal tube or bronchoscope.Type: GrantFiled: May 27, 2008Date of Patent: December 20, 2011Assignee: Novartis AGInventors: Luis A. Dellamary, Thomas E. Tarara, Alexey Kabalnov, Jeffry G. Weers, Ernest G. Schutt
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Publication number: 20110305743Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.Type: ApplicationFiled: August 19, 2011Publication date: December 15, 2011Inventors: Jane-Guo SHIAH, Rahul BHAGAT, Wendy M. BLANDA, Thierry NIVAGGIOLI, Lin PENG, David CHOU, David A. WEBER
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Publication number: 20110301136Abstract: The present invention relates to the diuretic effects of nitrate esters of corticoid compounds. A patient in heart failure may be treated by administering a therapeutically effective dosage of a pharmaceutical composition comprising a nitrate ester of corticoid compound as a diuretic having the general formula B—X1—NO2. A method of improving kidney function by administering a therapeutically effective dosage of a pharmaceutical composition having a nitrate ester of corticoid compound of the same formula is also described.Type: ApplicationFiled: June 2, 2011Publication date: December 8, 2011Inventors: Chao Liu, Kunshen Liu
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Publication number: 20110301135Abstract: The invention relates to nonaqueous pharmaceutical preparations comprising a glucocorticoid ester and an acid, and to the stabilization of glucocorticoid esters in such preparations by acids.Type: ApplicationFiled: November 29, 2010Publication date: December 8, 2011Applicant: BAYER ANIMAL HEALTH GMBHInventors: DIRK MERTIN, Iris Heep, Georg Schulte, Ulrike Umgelder, Gert Daube, Ernst B+e,uml o+ee ttcher
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Publication number: 20110293689Abstract: The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.Type: ApplicationFiled: August 11, 2011Publication date: December 1, 2011Inventors: Robert L. Cleek, Michael D. Daly, Krzysztof R. Pietrzak
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Publication number: 20110294717Abstract: The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.Type: ApplicationFiled: December 15, 2010Publication date: December 1, 2011Inventors: Mir M. Ali, Abhimanyu Sabnis, David Dewitt, Greg Troiano, James Wright, Maria Figueiredo, Michael Figa, Tina Van Geen Hoven, Young-Ho Song, Jason Auer, Tarikh C. Campbell
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Publication number: 20110288062Abstract: A polymer system useful for in vivo delivery of a therapeutic agent is provided. The polymer system comprises a biocompatible biodegradable polymeric backbone that is capable of a reversible stimuli-induced transition from liquid to gel.Type: ApplicationFiled: April 22, 2011Publication date: November 24, 2011Inventors: Heather Sheardown, Scott Fitzpatrick, M.A. Jafar Mazumder
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Patent number: 8063031Abstract: Methods for treating inflammation-mediated conditions of the eye are described, comprising: implanting into the vitreous of the eye of an individual a bioerodible implant comprising a steroidal anti-inflammatory agent and a bioerodible polymer, wherein the implant delivers the agent to the vitreous in an amount sufficient to reach a concentration equivalent to at least about 0.05 ?g/ml dexamethasone within about 48 hours and maintains a concentration equivalent to at least about 0.03 ?g/ml dexamethasone for at least about three weeks.Type: GrantFiled: December 23, 2009Date of Patent: November 22, 2011Assignee: Allergan, Inc.Inventors: Vernon G. Wong, Mae W. L. Hu
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Publication number: 20110281834Abstract: The present invention provides pharmaceutical formulations suitable for iontophoresis that provide enhanced iontophoretic delivery of a corticosteroid to the skin.Type: ApplicationFiled: November 10, 2009Publication date: November 17, 2011Inventors: Phillip M. Friden, Hyun Kim, Bireswar Chakraborty
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Publication number: 20110274738Abstract: Provided herein are methods for functionalizing a polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.Type: ApplicationFiled: July 19, 2011Publication date: November 10, 2011Inventors: Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
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Publication number: 20110268781Abstract: The present invention relates to materials having therapeutic compositions releasably contained within the materials. The materials are configured to release therapeutic compositions at a desired rate. The present invention also relates to devices incorporating the materials.Type: ApplicationFiled: May 9, 2011Publication date: November 3, 2011Applicant: Gore Enterprise Holdings, Inc.Inventors: Robert L. Cleek, Edward H. Cully, Jeffrey B. Duncan, Theresa A. Holland, Thomas R. McDaniel, Christine M. Scotti
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Publication number: 20110263551Abstract: A method is provided for treating swimmer's ear and other types of otitis externa. The method comprises (a) diagnosing an instance of swimmer's ear in a patient; and (b) applying to the meatal tissues of the external ear of the patient, in a single application, a volume of a pharmaceutical composition preferably within the range of about 0.1 ml to about 1.5 ml. The pharmaceutical composition comprises a corticosteroid disposed in a viscous medium, and preferably also includes an antifungal agent. The corticosteroid is preferably betamethasone or a betamethasone derivative, and the concentration of the corticosteroid is preferably within the range of about 0.45 mg to about 0.9 mg per gram of the pharmaceutical composition.Type: ApplicationFiled: June 8, 2011Publication date: October 27, 2011Inventor: Patrick Slater
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Publication number: 20110262547Abstract: Carrier particles in which at least 60% of the surface is coated with magnesium stearate are useful for preparing dry powder formulations for inhalation.Type: ApplicationFiled: April 1, 2011Publication date: October 27, 2011Applicant: Chiesi Farmaceutici S.p.A.Inventors: Rossella Musa, Daniela Cocconi, Alain Chamayou, Laurence Galet
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Publication number: 20110251142Abstract: Use of triterpene and anthraquinone glycosides, as substances exerting hydragogue activity on mucosa of upper respiratory apparatus, for the treatment of the effects resulting from the upper respiratory tract diseases. The present invention concerns the use of triterpene and anthraquinone glycosides, as substances exerting hydragogue activity on mucosa of upper respiratory apparatus, for the treatment of the effects resulting from the upper respiratory tract diseases as for example, sinusitis, both acute or chronic, rhinosinusitis, rhinitis.Type: ApplicationFiled: March 18, 2011Publication date: October 13, 2011Inventor: Sandro Soriano
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Patent number: 8034370Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.Type: GrantFiled: October 31, 2007Date of Patent: October 11, 2011Assignee: Allergan, Inc.Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
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Patent number: 8034366Abstract: The invention provides biodegradable implants sized for implantation in an ocular region and methods for treating medical conditions of the eye. The implants are formed from a mixture of hydrophilic end and hydrophobic end PLGA, and deliver active agents into an ocular region without a high burst release.Type: GrantFiled: October 31, 2007Date of Patent: October 11, 2011Assignee: Allergan, Inc.Inventors: Jane-Guo Shiah, Rahul Bhagat, Wendy M. Blanda, Thierry Nivaggioli, Lin Peng, David Chou, David A. Weber
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Publication number: 20110244017Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.Type: ApplicationFiled: March 31, 2010Publication date: October 6, 2011Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Lothar W. Kleiner, Syed F.A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
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Publication number: 20110244043Abstract: A controlled releasing composition comprising a plurality of microparticles and a matrix as well as the preparation method thereof is disclosed. The plurality of microparticles comprise a first material and the matrix comprises a second material. The melting temperature of the first material is higher than the melting temperature of the second material.Type: ApplicationFiled: December 10, 2009Publication date: October 6, 2011Inventors: Jianjian Xu, Shiliang Wang, Manzhi Ding
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Publication number: 20110245217Abstract: The present invention relates to asthma. Particularly, the present invention relates to clinical screening, diagnosis, prognosis, therapy and prophylaxis, as well as for drug screening and drug development for the treatment of asthma. The present invention relates to a new paradigm in diagnosing, screening, and treating asthma by affecting airway epithelial synchronization.Type: ApplicationFiled: April 6, 2011Publication date: October 6, 2011Applicant: THE CHILDREN'S RESEARCH INSTITUTEInventors: Robert J. FREISHTAT, Eric P. Hoffman
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Patent number: 8030296Abstract: There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.Type: GrantFiled: March 3, 2006Date of Patent: October 4, 2011Assignee: Sterix LimitedInventors: Barry Victor Lloyd Potter, Michael John Reed, Lok Wai Lawrence Woo, Hatem Hejaz, Bertrand Leblond, Matthew Paul Leese, Atul Purohit
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Publication number: 20110238016Abstract: A drug delivery device may include a base to be percutaneously affixable in an attachment zone of a synovial joint and a sustained-release drug carrier coupled to the base. The drug delivery device may also include an access device to provide access to the attachment zone. The attachment zone may comprise a non-articulating portion of a bone and/or cartilage with the synovial joint and the drug carrier may elute the drug into the synovial fluid sufficient to sustain a therapeutically effective concentration of the drug in the synovial fluid for at least 8 hours.Type: ApplicationFiled: June 8, 2011Publication date: September 29, 2011Applicant: Hospital for Special SurgeryInventors: Robert N. HOTCHKISS, John A. Koski
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Publication number: 20110237563Abstract: The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition, leading to difficulties in swallowing oral medicine forms and thus difficulties in treating said illnesses. Particularly, the present invention discloses the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with dysphagia and/or odynophagia and/or aspiration risk. Another aspect of the present invention is the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for the treatment of dysphagia and/or odynophagia and/or aspiration risk.Type: ApplicationFiled: March 23, 2010Publication date: September 29, 2011Inventor: Dominique Costantini
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Patent number: 8026229Abstract: The present invention relates to the use of 2-alkoxyestrogen sulfamates of general formula I wherein R1 and R2 independently represent H, methyl, C1-C4 acyl, benzoyl R3 represents C1-C4 alkyl or a group of formula CnFmHo, wherein n=1, 2, 3, 4, 5 or 6, m>1, and m+o=2n+1, R4 and R5 in each case represent H or, together, a methylene group or an additional double bond, R6 represents H, R7 represents OH, OC1-C4-alkyl, OC1-C11-acyl or OSO2NR1R2, the dashed lines in the B and C rings of the steroid skeleton additionally representing up to two double bonds, for the production of a medical drug for the treatment of tumor diseases which can be affected positively by inhibiting the tubulin polymerization. The inventive compounds are distinguished by the 2-alkoxy substitution in conjunction with the 17-hydroxy substitution. They have a special effect with regard to inhibiting tubulin polymerization and can be used, for example, for the treatment of prostate cancers.Type: GrantFiled: August 13, 2002Date of Patent: September 27, 2011Assignee: Sterix LimitedInventors: Ina Scherlitz-Hofmann, Jens Hoffmann, Alexander Hillisch, Eberhard Unger, Tobias Neumann, Sigfrid Schwarz, Olaf Peters, Thomas Michel
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Publication number: 20110229580Abstract: Disclosed herein are compositions, methods and kits for a microsphere with one or more entrapped nanoparticles. The method of preparation comprises atomizing a suspension comprising a polysaccharide and one or more nanoparticles into a solution comprising a cross linking agent.Type: ApplicationFiled: March 22, 2010Publication date: September 22, 2011Inventors: Rohit SRIVASTAVA, Abhijeet Balwantrao Joshi, R. Keerthi PRASAD
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Publication number: 20110229551Abstract: Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prostheses, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, both non-biodegradable or biodegradable, and derived from synthetic or natural sources. The present invention discloses 1) the composition of fibrous articles and 2) methods for using these articles in medical applications. The biodegradable fibrous articles, which are preferably formed by electrospinning polymer solution of biodegradable fiberizable material with or in conjunction with medicinal agents and bioactive materials, comprise a composite (or asymmetric composite) of nanofibers with actives.Type: ApplicationFiled: March 17, 2010Publication date: September 22, 2011Applicant: NOTUS LABORATORIES, INC.Inventors: JAYESH N. DOSHI, LARRY RAYMOND DEBARGE
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Publication number: 20110224723Abstract: A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying a tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.Type: ApplicationFiled: November 14, 2007Publication date: September 15, 2011Inventors: Jeoung Soo Lee, Charles Kenneth Webb, Robert Ziummerman, Rafael Ruiz, SR.
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Publication number: 20110224176Abstract: Provided herein are lyophilized cake forms of fluticasone, salmeterol, or a pharmaceutically acceptable salt or a combination thereof which provides room temperature stability for an extended period of time. Upon reconstitution with an acceptable solvent (e.g., a carrier or diluent), the reconstituted pharmaceutical or cosmetic formulation provides a sterile, non-suspension form suitable for parenteral injectable administration, including subcutaneous injection.Type: ApplicationFiled: January 14, 2011Publication date: September 15, 2011Applicant: Lithera, Inc.Inventors: John Daniel Dobak, Chris Kemmerer, Kenneth Walter Locke
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Publication number: 20110212137Abstract: An inhalable pharmaceutical solution aerosol comprising beclometasone dipropionate, ethanol and a propellant selected from 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof, wherein the aerosol has a droplet size having a mass median aerodynamic diameter of 0.5-2.0 ?m, for maintaining lung function above 60% of baseline FEV1, or reducing the occurrences of lung function falling below 60% of baseline FEV1.Type: ApplicationFiled: February 15, 2011Publication date: September 1, 2011Applicant: TEVA BRANDED PHARMACEUTICAL PRODUCTS R&D, INC.Inventors: Paul Michael Dorinsky, David Price
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Publication number: 20110212053Abstract: Provided are compounds according to Formula (I): or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R1, R6, R7, and R8 are as defined, and which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PI3-kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.Type: ApplicationFiled: June 19, 2009Publication date: September 1, 2011Inventors: Dapeng QIAN, Amy Qi Han, Mark Hamilton, Eric Wang
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Patent number: 8007831Abstract: A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.Type: GrantFiled: February 9, 2007Date of Patent: August 30, 2011Assignee: Biocompatibles UK LimitedInventors: Andrew Lennard Lewis, Yiqing Tang, Maria Victoria Gonzalez Fajardo
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Publication number: 20110206773Abstract: Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye.Type: ApplicationFiled: November 12, 2010Publication date: August 25, 2011Inventors: Erin Lavik, James Bertram, Sandeep Saluja, Markus Kuehn, Young H. Kwon, Rebecca Robinson, John J. Huang
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Patent number: 8003127Abstract: Compositions comprising a nanoparticulate corticosteroid and an antihistamine are described. The compositions are useful in the prophylaxis and chronic treatment of asthma in adults and pediatric patients and for the relief of allergic conjunctivitis, symptoms of seasonal allergic rhinitis in adults and pediatric patients. Combining an antihistamine with a nanoparticulate corticosteroid in a single formulation results in improved efficacy.Type: GrantFiled: March 23, 2006Date of Patent: August 23, 2011Assignee: Elan Pharma International LimitedInventors: Gary Liversidge, Scott Jenkins, H. William Bosch, Christian F. Wertz
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Publication number: 20110200660Abstract: A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.Type: ApplicationFiled: February 28, 2011Publication date: August 18, 2011Applicant: Advanced Cardiovascular Systems, Inc.Inventors: Lothar Walter Kleiner, Jessica Reneé DesNoyer, Stephen Dirk Pacetti, Syed Faiyaz Ahmed Hossainy
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Publication number: 20110190250Abstract: The present invention aims to provide an eye drop for treating macular edema. The present invention provides an eye drop for treating macular edema, which contains difluprednate as an active ingredient. The eye drop can afford effects such as improvement of visual acuity and decreased foveal retinal thickness in macular edema.Type: ApplicationFiled: July 14, 2010Publication date: August 4, 2011Inventors: Hidetoshi Yamashita, Teiko Yamamoto, Sakiko Goto, Sachi Abe, Eriko Kirii, Atsushi Okumura
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Publication number: 20110182994Abstract: Methods and systems for preparing nanoparticles. A source of a carrier fluid is connected to an inlet of a flow conduit, such as an intravenous solution administration tube with injection ports, such that the carrier fluid flows through the conduit. A substance (e.g., a drug solution or other substance solution) is introduced into the conduit at a first location causing substance nanoparticles to form within and continue to flow thought he conduit. A stabilizer is introduced into the conduit at a second location to cause a stabilizing effect on the nanoparticles. In some embodiments, the stabilizer may limit or deter agglomeration or growth of the nanoparticles, thereby limiting the size of the nanaparticles produced.Type: ApplicationFiled: July 27, 2009Publication date: July 28, 2011Applicants: S.K. PHARMACEUTICALS, INC., THE CALIFORNIA INSTITUTE OF TECHNOLOGYInventors: Julia Ann Kornfield, Richard Charles Flagen, Bahar Bingol, John Yol Park
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Publication number: 20110177169Abstract: The eye is effectively treated by providing it with formulations including uncoated cationically charged microparticles of reversed cubic phase or reversed hexagonal phase material. The treatment methods are effective; for a variety of diseases and conditions including dry eye. The structure, charge and components of the microparticles in dispersion, with or without an active ingredient, provide mucoadhesion, layering, protection and prolonged duration of ophthalmic action.Type: ApplicationFiled: July 9, 2010Publication date: July 21, 2011Inventors: David Anderson, Vince Conklin, Benjamin Cameransi, David M. Kleinman, Eugene R. Cooper
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Publication number: 20110165176Abstract: Compositions and methods for inducing the deposition of elastin by administering compositions including a mineralocorticoid, such as, for example, aldosterone and, optionally, a secondary active agent for enhancing or modulating the effect of the mineralocorticoid are described herein.Type: ApplicationFiled: June 8, 2009Publication date: July 7, 2011Inventors: Aleksander Hinek, Thomas F. Mitts
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Publication number: 20110165251Abstract: The present invention relates to liquid dosage compositions of stable nanoparticulate active agents. The liquid dosage compositions of the invention include osmotically active crystal growth inhibitors that stabilize the nanoparticulate active agents against crystal and particle size growth of the active agent.Type: ApplicationFiled: March 9, 2011Publication date: July 7, 2011Inventors: H. William BOSCH, Matthew R. HILBORN, Douglas C. HOVEY, Laura J. KLINE, Robert W. LEE, John D. PRUITT, Niels P. RYDE, Tuula A. RYDE, Shuqian XU
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Patent number: 7972627Abstract: Nasal pharmaceutical formulations comprising a drug substance having a specific particle size distribution profile are disclosed herein. Such profile provides increased bioavailability, increased efficacy or prolonged therapeutic effect of the drug substance when administered intranasally. The formulations of the present invention may comprise one or more corticosteroids having a specific particle size distribution profile. In a preferred embodiment, the corticosteroid is beclomethasone or a pharmaceutically acceptable derivative thereof for the treatment of one or more symptoms of rhinitis. Preferably, the drug substance is beclomethasone dipropionate. The formulations herein may be provided as an aqueous suspension suitable for inhalation via the intranasal route.Type: GrantFiled: October 14, 2005Date of Patent: July 5, 2011Assignee: Merck Patent GmbHInventor: Imtiaz Chaudry
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Publication number: 20110152228Abstract: Anhydrous sprayable pharamecutical/dermatological compositions containing, as active pharmaceutical agent, a corticoid, preferably clobetasol propionate, and an oily phase, are formulated in a physiologically acceptable medium, and are useful for the treatment of a variety of conditions and afflictions, notably psoriasis.Type: ApplicationFiled: March 2, 2011Publication date: June 23, 2011Applicant: Galderma, S.A.Inventors: Nathalie Willcox, Sandrine Orsoni
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Patent number: 7960367Abstract: Steroid compounds processing a hydrogen donor in 3beta position, either in the form of a hydroxy- or a sulfate group, function as efficient blockers of the 3alpha-hydroxy-pregnan-steroid action and thus have utility as therapeutic substances for the prevention and/or treatment of steroid related CNS disorders. Treatment methods based on the administration of these substances are disclosed, and these substances either alone or in combination are also suggested for the manufacture of pharmaceuticals for the treatment of many specific steroid induced CNS disorders.Type: GrantFiled: December 20, 2002Date of Patent: June 14, 2011Assignee: Umecrine ABInventors: Torbjorn Backstrom, Per Lundgren, Ming-De Wang, Inga-Maj Johansson
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Patent number: 7960368Abstract: Described herein are bismethylene-17? carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of preparing and using these novel compounds.Type: GrantFiled: March 4, 2009Date of Patent: June 14, 2011Assignee: Everstra, Inc.Inventors: Klaus Nickisch, Pemmaranu N. Rao, James W. Cessac, Anne Marie Simmons
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Publication number: 20110130376Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful in the treatment of illnesses wherein the known steroid, parent or precursor steroid, is generally applied, with increased benefit in terms of pharmacological profile and fewer or milder side effects than those of the known steroids.Type: ApplicationFiled: July 24, 2009Publication date: June 2, 2011Applicant: NICOX S.A.Inventors: Francesca Benedini, Laura Carzaniga, Ennio Ongini, Stefamo Biondi
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Publication number: 20110130375Abstract: The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts or stereoisomers thereof The compounds are useful for treating diabetic macular edema, diabetic retinopathy, macular degeneration, age-related macular degeneration and other diseases of retina and macula lutea.Type: ApplicationFiled: July 24, 2009Publication date: June 2, 2011Applicant: NICOX S.A.Inventors: Francesca Benedini, Rebecca Steele, Valerio Chiroli, Stefano Biondi, Ennio Ongini
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Publication number: 20110123619Abstract: A buccal delivery system capable of being blended in a normal dry powder process and compressed using a standard tabletting machine, said buccal delivery system comprising a matrix of: (a) an effective amount of one or more active ingredients; (b) an amount of one or more polyethylene glycols or derivatives thereof having a molecular weight between 1000 to 8000 sufficient to provide the required hardness and time for dissolution of the matrix; (c) 0.05-2% by weight of the total matrix of one or more suspending agents; (d) 0.05-2% by weight of the total matrix of one or more flowing agents; and (e) 0.05-2% by weight of the total matrix of one or more sweeteners.Type: ApplicationFiled: February 4, 2011Publication date: May 26, 2011Applicant: OZPHARMA PTY. LTD.Inventors: Ernest Alan Hewitt, Richard James Stenlake
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Patent number: 7947744Abstract: Provided herein is a stable pharmaceutical product comprising a dry powder inhalation device, and a pharmaceutical composition that comprises R,R-Formoterol L-tartrate salt, in particular crystalline R,R-formoterol L-tartrate; and ciclesonide.Type: GrantFiled: January 5, 2006Date of Patent: May 24, 2011Assignee: Nycomed GmbHInventor: Ruth Margaret Wayland
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Publication number: 20110117189Abstract: New compositions for ophthalmic use for the prevention and therapy of pathologies of the posterior segment of the eye. These compositions utilize xanthan gum as an active principle carrier, and can be advantageously administered as liquid-gel eye drops on the surface of the eye and optionally used in combination with other therapies for the treatment of the same pathologies.Type: ApplicationFiled: July 8, 2008Publication date: May 19, 2011Applicant: S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A.Inventors: Maria Grazia Mazzone, Claudine Civiale, Francesco Cuffari
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Publication number: 20110111006Abstract: This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.Type: ApplicationFiled: January 14, 2011Publication date: May 12, 2011Applicant: RAMSCOR, INC.Inventors: Vernon G. WONG, Louis L. Wood
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Publication number: 20110105449Abstract: The invention provides dry powder pharmaceutical formulations comprising an ascorbic acid derivative that demonstrate good inhalation performance and dry powder inhalers containing them.Type: ApplicationFiled: November 6, 2008Publication date: May 5, 2011Applicant: ASTRAZENECA R&DInventor: Jan Trofast