Oxygen Single Bonded To A Ring Carbon Of The Cyclopentanohydrophenanthrene Ring System Patents (Class 514/182)
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Publication number: 20140194401Abstract: Disclosed herein are methods of treating cancer and/or reducing cellular proliferation in a patient, comprising identifying a patient in need of treatment and administering a therapeutically effective amount of at least one cationic steroid antimicrobial (CSA), or a pharmaceutically acceptable salt thereof. Kits comprising such compositions and instructions on such methods are also contemplated herein.Type: ApplicationFiled: January 7, 2014Publication date: July 10, 2014Applicant: BRIGHAM YOUNG UNIVERSITYInventors: Carl Genberg, Paul B. Savage
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Publication number: 20140187855Abstract: In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto tissue, including supporting tissues (e.g., ligaments, connective tissue, muscles, etc.) for pelvic organs, among other tissues. In other aspects, the present disclosure pertains to compositions that are useful for performing such procedures. In still other aspects, the present disclosure pertains to kits that are useful for performing such procedures.Type: ApplicationFiled: December 23, 2013Publication date: July 3, 2014Applicant: Boston Scientific Scimed, Inc.Inventors: Sandra Nagale, Mark W. Boden, Andrew Dolan
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Publication number: 20140186417Abstract: An aliphatic polyester polymer for stent coating is described.Type: ApplicationFiled: February 20, 2014Publication date: July 3, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: O. Mikael Trollsas, Lothar W. Kleiner, Syed F.A. Hossainy
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Publication number: 20140186278Abstract: An anhydrous multiphase gel system consisting of an outer lipid matrix and an inner phase gelled by means of a polymer is described, which can be obtained by a) Melting the lipid phase with the formation of a liquid lipid phase, b) Mixing and homogenizing polymers or polymer blends capable of swelling with the formation of a polymer phase to be dispersed, c) Combining the polymer phase with the liquid lipid phase and homogenizing the phases, and d) Cold stirring the phase mixture until a solid gel-like mixed structure of the entire system is formed. The anhydrous multiphase gel system is particularly suitable for taking up difficulty soluble active substances in high concentration and for providing topical and transdermal applications. The described system is called an EDRS, “Entrapped Drug Reservoir System”.Type: ApplicationFiled: September 19, 2013Publication date: July 3, 2014Inventor: Patrick Franke
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Patent number: 8765164Abstract: The invention provides high molecular weight, crystalline or semi crystalline biodegradable and biocompatible poly(ester urea) (PEU) polymers useful for making vascular stents and hard tissue replacement implants, such as bone substitutes. The PEU polymers are based on ? amino acids and are made by a polycondensation reaction. PEU polymer compositions can contain a therapeutic diol incorporated into the polymer backbone that is released from such an implant in situ. Bioactive agents, such as analgesics, antibiotics, and the like, can also be covalently attached to certain PEU polymers for release into tissue surrounding an implant during biodegradation of the polymer.Type: GrantFiled: October 19, 2006Date of Patent: July 1, 2014Inventors: Ramaz Katsarava, David Tugushi, Zaza D. Gomurashvili
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Publication number: 20140179656Abstract: Provided herein are methods for detecting and/or confirming the neurogenesis effect of cholesterol and/or oxysterol utilizing adipose-derived stem cells (ADSCs). Further provided are methods of promoting neurogenesis in ADSCs. Also provided are methods for the use of cholesterol and/or oxysterol for the production of a neurologic component that may be incorporated into a nutritional composition for promoting neurogenesis in a pediatric subject.Type: ApplicationFiled: October 3, 2013Publication date: June 26, 2014Inventors: Chenzhong Kuang, Yan Xiao, Dirk Hondmann, Eduard Poels, Zeina Jouni
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Publication number: 20140179658Abstract: Methods and pharmaceutical compositions are provided for enhancing or stimulating regeneration of a tissue in a subject. In one aspect, the invention provides a method including administering to a subject in need thereof a therapeutically effective amount of an aminosterol or a pharmaceutically acceptable salt thereof to stimulate or enhance regeneration of a tissue. In another aspect, the invention provides a method including administering to a subject a therapeutically effective amount of an aminosterol or a pharmaceutically acceptable salt thereof to stimulate or enhance regeneration of a tissue to treat or prevent a disease, disorder, trauma, or condition resulting from an injury of the tissue. In an additional aspect, the invention provides a pharmaceutical composition comprising a therapeutically effective amount of an aminosterol to stimulate or enhance regeneration of a tissue.Type: ApplicationFiled: December 20, 2013Publication date: June 26, 2014Inventors: Michael Alan Zasloff, Viravuth Pho Yin
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Publication number: 20140179657Abstract: The present invention provides an efficient method for industrially producing a naturally-derived carotenoid composition with a large amount of a carotenoid such as astaxanthin from a culture of a yeast of the genus Xanthophyllomyces without requiring any special extraction equipment and any complicated refinement process and without any need for organic solvents harmful to humans. Provided is a method for producing a carotenoid composition, including the steps of washing a carotenoid-containing yeast of the genus Xanthophyllomyces with an organic solvent (A) at 30° C. or lower, and extracting a carotenoid from the washed yeast with an organic solvent (B) at 10° C. to 70° C.Type: ApplicationFiled: June 29, 2012Publication date: June 26, 2014Applicant: KANEKA CORPORATIONInventors: Kento Kanaya, Koichi Kinoshita, Masaru Hirano
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Publication number: 20140171490Abstract: Disclosed is the use of a mist of a pharmaceutical composition for ophthalmic delivery of a protein or peptide active pharmaceutical ingredient, a related method of treatment and a device useful in implementing the use and method. Disclosed is also the use of a mist for ophthalmic delivery of a pharmaceutical composition including a highly irritating penetration enhancer and an ophthalmically acceptable carrier, a related method of treatment and a device useful in implementing the use and method. Disclosed is also a device for ophthalmic administration configured to direct a mist of a pharmaceutical composition to the eye only when the eye is open. Disclosed is also a self-sterlizing device for ophthalmic administration. Disclosed is also a device and a method for increasing the bioavailability of an ophthalmically administered API in a pharmaceutical composition.Type: ApplicationFiled: August 9, 2013Publication date: June 19, 2014Applicant: PHARMALINGT INC.Inventors: Yossi Gross, Rafi Herzog, Steven B. Koevary
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Patent number: 8754069Abstract: Compounds of Formula I: that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.Type: GrantFiled: September 20, 2012Date of Patent: June 17, 2014Assignee: Bristol-Myers Squibb CompanyInventors: Zheng Liu, Nicholas A. Meanwell, Alicia Regueiro-Ren
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Patent number: 8754068Abstract: Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 betulinic acid and other structurally related natural products derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.Type: GrantFiled: June 2, 2011Date of Patent: June 17, 2014Assignee: Bristol-Myers Squibb CompanyInventors: Alicia Regueiro-Ren, Jacob Swidorski, Zheng Liu, Nicholas A. Meanwell, Sing-Yuen Sit, Jie Chen, Ny Sin
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Publication number: 20140162962Abstract: The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: AXOLABS GMBHInventors: Rainer CONSTIEN, Anke Geick, Philipp Hadwiger, Torsten Haneke, Ludger Markus Ickenstein, Carla Alexandra Hernandez Prata, Andrea Schuster, Timo Weide
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Publication number: 20140155364Abstract: The present application is directed to an aqueous pharmaceutical formulation comprising less than about 5% w/v sodium deoxycholate maintained at a pH sufficient to substantially inhibit precipitation of the sodium deoxycholate. Also disclosed herein, are methods for inhibiting precipitation of sodium deoxycholate in an aqueous solution comprising less than about 5% w/v of sodium deoxycholate, said method comprising maintaining pH of the solution of from at least about 8.0 to about 8.5.Type: ApplicationFiled: February 7, 2014Publication date: June 5, 2014Applicant: Kythera Biopharmaceuticals, Inc.Inventors: Robert Emil Hodge, Jeffrey Douglas Webster
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Publication number: 20140154309Abstract: In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicant: Marinus PharmaceuticalsInventors: Kenneth Shaw, Mingbao Zhang
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Patent number: 8741882Abstract: The preset invention relates to a new oral anti-diabetic compound prepared by synthesizing a steroid and a guanide or biguanide, which is eliminated via the hepatic route, instead of the renal route, to avoid adverse effects of administering metformin in diabetic patients with renal dysfunction. A pharmaceutical composition comprising the compound of the invention and the method for treating diabetes using the compound are also provided.Type: GrantFiled: January 20, 2012Date of Patent: June 3, 2014Assignee: Sen Capital, LLC.Inventor: John Soong
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Patent number: 8741880Abstract: This invention pertains to the discovery that agents which inhibit the binding of cortisol to its receptors can be used in methods for preventing neurological damage associated with glucocorticoid therapy in ventilator-dependent low birth weight preterm infants. Mifepristone, a potent glucocorticoid receptor antagonist, can be used in these methods.Type: GrantFiled: February 24, 2011Date of Patent: June 3, 2014Assignee: Corcept Therapeutics, Inc.Inventor: Joseph K. Belanoff
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Publication number: 20140148429Abstract: The present application is directed to an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid, wherein the composition is maintained at a pH from about 8.1 to about 8.5 such that the composition is stabilized against precipitation. Also disclosed herein, are methods for stabilizing an aqueous pharmaceutical composition comprising from about 0.4% w/v to less than about 2% w/v of a salt of deoxycholic acid against precipitation, said method comprising maintaining pH of the solution from about 8.1 to about 8.5.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Inventors: Robert Emil Hodge, Jeffrey Douglas Webster, Robert M. Moriarty
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Publication number: 20140148428Abstract: The present invention relates to methods of treating, reducing the risk of preventing, or alleviating a symptom of a pulmonary disease or condition, reducing or suppressing inflammation in the lung, and promoting lung repair, by using a compound of formula A: or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Inventors: Mark Pruzanski, Luciano Adorini
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Publication number: 20140148427Abstract: In one aspect, the present invention provides neuroactive steroids for use in the treatment of nervous system disorders, degenerative brain diseases and congenital storage diseases. In a second aspect, the invention provides neuroactive steroids in combination with a Liver X Receptor (LXR) ligand to effect treatment of a nervous system condition.Type: ApplicationFiled: October 24, 2013Publication date: May 29, 2014Inventor: Synthia MELLON
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Publication number: 20140142076Abstract: This invention relates to dosage forms for the delivery of drugs across the oral mucosa having improved transmucosal permeability. More specifically, the invention relates to an oral transmucosal dosage form comprising a primary vehicle comprising a crystallization inhibition agent (CIA) system and a drug, and a secondary vehicle. It also relates to methods of designing and making this dosage form, methods of administering this dosage form and methods of packaging the dosage forms.Type: ApplicationFiled: November 14, 2013Publication date: May 22, 2014Applicant: ABON PHARMACEUTICALS, LLCInventors: Salah U. AHMED, Yanming ZU, Karunakar NEELAM, Saad MUNTAZIM, Tahseen A. CHOWDHURY, Shiying TIAN
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Publication number: 20140142071Abstract: Some embodiments of the present invention provide pharmaceutical formulations, for treating atherosclerosis in a mammal, including a bile acid and/or a terpene atherosclerotic plaque emulsifier. Some embodiments provide methods for administering such pharmaceutical formulations. In some embodiments, pharmaceutical formulations include a combination of a bile acid and a terpene in amounts effective to result in plaque regression, and the amount of each individual emulsifier in the combination can be lower than an amount that is effective to result in plaque regression when the emulsifier is administered alone. In some embodiments, a statin can be administered simultaneously or sequentially with the pharmaceutical formulation.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicant: ATHERONOVA OPERATIONS, INC.Inventors: Filiberto Zadini, Giorgio Zadini
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Patent number: 8729058Abstract: A method of treating or preventing a systemic viral infection in a mammal by administering a pharmaceutically acceptable composition selected from the group consisting of squalamine, an active isomer thereof, and an active analogue thereof, via a dosing regimen that delivers effective antiviral concentrations of squalamine. Also compositions for achieving the systemic antiviral effect.Type: GrantFiled: October 27, 2010Date of Patent: May 20, 2014Inventor: Michael Zasloff
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Patent number: 8716270Abstract: The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.Type: GrantFiled: June 23, 2011Date of Patent: May 6, 2014Assignee: OHR Pharmaceutical Inc.Inventors: Eric Chellquist, Mary Doubleday, Charles W. Gilbert, Xuehai Zhang, Michael McLane, Kyle Armbruster, Roy C. Levitt
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Patent number: 8716268Abstract: The present invention relates to the diuretic effects of nitrate esters of corticoid compounds. A patient in heart failure may be treated by administering a therapeutically effective dosage of a pharmaceutical composition comprising a nitrate ester of corticoid compound as a diuretic having the general formula B—X1—NO2. A method of improving kidney function by administering a therapeutically effective dosage of a pharmaceutical composition having a nitrate ester of corticoid compound of the same formula is also described.Type: GrantFiled: June 2, 2011Date of Patent: May 6, 2014Inventors: Chao Liu, Kunshen Liu
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Publication number: 20140121190Abstract: The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of 3-alpha-androstanediol, preferably in combination with a type 5 phosphodiesterase (PDE5) inhibitor.Type: ApplicationFiled: January 3, 2014Publication date: May 1, 2014Applicant: EMOTIONAL BRAIN B.V.Inventors: Jan Johan Adriaan TUITEN, Johannes Martinus Maria BLOEMERS, Robertus Petrus Johannes DE LANGE
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Publication number: 20140121189Abstract: The invention relates to the field of male and/or female sexual dysfunction. The invention specifically relates to the use of 3-alpha-androstanediol, preferably in combination with a 5-HT1A agonist. Optionally, said 3-alpha-androstanediol and said 5HT1a agonist are further combined with a type 5 phosphodiesterase (PDE5) inhibitor.Type: ApplicationFiled: January 3, 2014Publication date: May 1, 2014Applicant: EMOTIONAL BRAIN B.V.Inventors: Jan Johan Adriaan TUITEN, Johannes Martinus Maria BLOEMERS, Robertus Petrus Johannes DE LANGE
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Patent number: 8703751Abstract: The present invention provides methods of determining whether a female patient will benefit from hormone replacement therapy.Type: GrantFiled: November 9, 2010Date of Patent: April 22, 2014Assignees: The Regents of the University of California, The Regents of the University of MichiganInventors: William L. Lasley, Daniel S. McConnell, Nancy A. Gee, Jiangang Chen
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Patent number: 8703169Abstract: The present invention provides an implantable device having a coating including a slow dissolving polymer or material and the methods of making and using the same.Type: GrantFiled: August 8, 2007Date of Patent: April 22, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventor: Jeong Lee
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Publication number: 20140107090Abstract: Treating and Preventing mastitis employing cationic steroidal antimicrobials (CSAs). Treating or preventing clinical mastitis in a mammal includes administering a cationic steroidal anti-microbial compound (CSA) formulation to the intra-mammary organ of a mammal (e.g., a dairy cow), such as by injection into the mammary organ (e.g., through the teat of the mammary organ), and/or topical application. The dairy cow can be lactating and have a somatic cell count (SCC) less than or equal to 500,000 cells/mL at the time of administering the CSA formulation. Alternatively, the dairy cow can be lactating and have a somatic cell count (SCC) greater than 500,000 cells/mL at the time of administering the CSA formulation. The dairy cow can be taken out of production during the administration of the CSA formulation for a period of time of about 3 days or less, 2 days or less, or 1 day or less.Type: ApplicationFiled: October 17, 2013Publication date: April 17, 2014Applicant: Brigham Young UniversityInventors: Chad S. Beus, Paul B. Savage
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Publication number: 20140107091Abstract: The present invention relates to a process for the preparation of a compound of formula (I) comprising the steps of a) reacting a compound of formula (II) with a silylating or an acylating agent to produce compound of formula (III), wherein P1 is a protecting group selected from R2Si—R3R4 or R1CO—, R1 is a group selected from C1-6alkyl or C3-6cycloalkyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl; R2, R3 and R4 are each independently a group selected from C1-6alkyl or phenyl, each group being optionally substituted by one or more substituents independently selected from fluoro or C1-4alkyl; b) halogenation or sulfinylation of the compound of formula (III) to produce a compound of formula (IV); wherein X is halo, or —O—SO—R5, and R5 is a group selected from C6-10aryl or heteroaryl, each group being optionally substituted by one or more substituents independently selected from chloro or C1-4alkyl; c) dehalogenation or desulfinylation of thType: ApplicationFiled: June 1, 2012Publication date: April 17, 2014Applicant: ESTETRA S.A.Inventor: Jean-Claude Pascal
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Publication number: 20140099281Abstract: This invention relates to stable aminosterol phosphate compositions. The aminosterol phosphate compositions permit administration without associated tissue damage and achieve a sustained release effect.Type: ApplicationFiled: December 12, 2013Publication date: April 10, 2014Inventor: Michael Zasloff
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Publication number: 20140100209Abstract: The invention relates to compounds of Formula A: or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease.Type: ApplicationFiled: April 26, 2013Publication date: April 10, 2014Applicant: INTERCEPT PHARMACEUTICALS, INC.Inventor: Intercept Pharmaceuticals, Inc.
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Publication number: 20140100175Abstract: The present invention provides insecticidal lipids and lipid fractions from fungi of the phylum Ascomycota, together with compositions comprising such lipids and lipid fractions and methods of preparing same. Methods for the biological control of insects, such as phytopathogenic insects, using the lipids and lipid fractions or compositions comprising said lipids optionally together with one or more insecticidal or entomopathogenic agents including entomopathogenic fungi, are also provided.Type: ApplicationFiled: March 26, 2012Publication date: April 10, 2014Applicant: BIOTELLIGA HOLDINGS LIMITEDInventors: Stephen Reynold Ford, Travis Robert Glare
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Patent number: 8691252Abstract: Storage-stable, anti-microbial compositions and products include a carrier and a ceragenin compound suspended in the carrier. Ceragenin compounds suspended in the carrier include a sterol backbone and a number of cationic groups attached to the sterol backbone via hydrolysable linkages. The carrier has a pH of 5.5 or less, which acts to stabilize the hydrolysable linkages and increase the shelf-life of the anti-microbial compositions and anti-microbial products. Nevertheless, the ceragenin compounds described herein are designed to break down relatively quickly (e.g., within about 5 days) if the pH environment of the ceragenin compounds is raised to about pH 6.5 or greater.Type: GrantFiled: November 3, 2011Date of Patent: April 8, 2014Assignee: Brigham Young UniversityInventor: Paul B. Savage
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Publication number: 20140094443Abstract: The invention relates to compounds of Formula A: or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including obesity, insulin sensitivity, inflammation, cholestasis, and bile desaturation.Type: ApplicationFiled: April 1, 2013Publication date: April 3, 2014Applicant: INTERCEPT PHARMACEUTICALS, INC.Inventor: Intercept Pharmaceuticals, Inc.
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Patent number: 8685433Abstract: The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.Type: GrantFiled: March 31, 2010Date of Patent: April 1, 2014Assignee: Abbott Cardiovascular Systems Inc.Inventors: Lothar W. Kleiner, Syed F. A. Hossainy, Mikael Trollsas, Stephen D. Pacetti
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Publication number: 20140088053Abstract: The present application discloses 17? hydroxy steroid dehydrogenase (17? HSD) type 1, 3, 10 inhibitors and use thereof (alone and in combination) in the treatment of cancer and other afflictions. 17? HSD1 inhibitors include estradiol derivatives with a nieta-carbamoylbenzyl substituent at C 16. 17? HSD3/HSD10 inhibitors include androsterone derivatives substituted at the C3 position with a sulfonamide piperazine. Also disclosed are compounds that are inhibitors of both 17? HSD1 and 17? HSD3 that have a spiro-morpholine substituent at C20.Type: ApplicationFiled: March 26, 2012Publication date: March 27, 2014Applicant: UNIVERSITÉ LAVALInventors: Donald Poirier, René Maltais, Jenny Roy
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Publication number: 20140088060Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicant: University of ChicagoInventors: Ching Song, Shutsung Liao, Qing Dai
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Publication number: 20140088059Abstract: The invention provides compositions and methods for the prevention, diagnosis, or treatment of conditions affecting breast tissue. The compositions can include one or more therapeutic agents or diagnostic agents, and an effective carrier. The composition can be specifically adapted for transdermal permeation through the mammary papilla, areola, or a combination thereof, and into underlying breast tissue.Type: ApplicationFiled: July 15, 2013Publication date: March 27, 2014Inventors: Omathanu P Perumal, Kaushalkumar Dave, Chandradhar Dwivedi, Sreevidy Santha
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Publication number: 20140088061Abstract: The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention also relates to a method for preparing said composition and a kit including the composition.Type: ApplicationFiled: April 23, 2012Publication date: March 27, 2014Applicant: Capital, Business Y Gestion De Finanzas S.L.Inventors: Jose Castillo, Jose B. Iturraspe, Jose L. Nunez
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Publication number: 20140088062Abstract: Described are solid pharmaceutical compositions of fusidic acid, and pharmaceutically acceptable salts thereof, dosage units of the pharmaceutical compositions, and packages for pharmaceutical compositions of fusidic acid, and pharmaceutically acceptable salts thereof, which increase stability against the degradation of the fusidic acid, and pharmaceutically acceptable salts thereof. Also described are uses of the pharmaceutical compositions and dosage units in treating diseases.Type: ApplicationFiled: May 23, 2012Publication date: March 27, 2014Applicant: CEM-102 PHARMACEUTICALS, INC.Inventor: David E. Pereira
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Patent number: 8680084Abstract: This invention relates to a method of preventing pregnancy and treating PMS including PMDD. More particularly, the invention relates to a method, which involves administering one of several combination oral contraceptive regimens in combination with an antidepressant and a kit containing the same.Type: GrantFiled: August 30, 2012Date of Patent: March 25, 2014Assignee: Teva Women's Health, Inc.Inventors: Robert G. Bell, Carole Ben-Maimon, Beata Iskold
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Patent number: 8679545Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.Type: GrantFiled: November 12, 2008Date of Patent: March 25, 2014Assignees: The Regents of the University of California, Meritage Pharma, Inc.Inventors: Ranjan Dohil, John Bastian, Seema Aceves
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Patent number: 8680085Abstract: The present invention relates to a method of treating an incretin related disease such as diabetes, obesity and the like by delivery of butyric acid, bile acid, long chain fatty acid, or glutamine to the colon by bypassing the upper digestive tract.Type: GrantFiled: October 8, 2012Date of Patent: March 25, 2014Assignee: Biokier Inc.Inventor: Jerzy Ryszard Szewczyk
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Publication number: 20140079642Abstract: The present invention relates to a poly(lactic glycolic) acid (PLGA) nanoparticle associated with therapeutic agents for a variety of therapeutic applications.Type: ApplicationFiled: January 24, 2012Publication date: March 20, 2014Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem LTDInventors: Simon Benita, Taher Nasser, Nour Karra, Amit Badihi
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Publication number: 20140073615Abstract: A lipid layer forming composition for topical treatment of psoriasis comprises volatile silicone oil, polar lipid, C2-C4 aliphatic alcohol, and a pharmacologically effective amount of an agent for the treatment of psoriasis, wherein the silicone oil has a boiling point above 180° C., in particular above 200° C. The composition does not comprise polymer silicone. Also disclosed are corresponding methods of treatment and of manufacture of the composition.Type: ApplicationFiled: April 30, 2012Publication date: March 13, 2014Applicant: LIPIDOR ABInventors: Anders Carlsson, Bengt Herslöf, Jan Holmbäck
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Publication number: 20140072536Abstract: Disclosed herein are ?7?1 integrin modulatory agents and methods of using such to treat conditions associated with decreased ?7?1 integrin expression or activity, including muscular dystrophy. In one example, methods for treating a subject with muscular dystrophy are disclosed. The methods include administering an effective amount of an ?7?1 integrin modulatory agent to the subject with muscular dystrophy, wherein the ?7?1 integrin modulatory agent increases ?7?1 integrin expression or activity as compared to ?7?1 integrin expression or activity prior to treatment, thereby treating the subject with muscular dystrophy. Also disclosed are methods of enhancing muscle regeneration, repair, or maintenance in a subject and methods of enhancing ?7?1 integrin expression by use of the disclosed ?7?1 integrin modulatory agents. Methods of prospectively preventing or reducing muscle injury or damage in a subject are also disclosed.Type: ApplicationFiled: March 15, 2013Publication date: March 13, 2014Applicant: Board of Regents of the Nevada System of Higher Education On Behalf of the University of NevadaInventors: Ryan Wuebbles, Dean Burkin
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Patent number: 8669244Abstract: Disclosed is a cucurbitane-triterpenoid compound for activating estrogen receptor activity, and a pharmaceutical composition, use and preparation method thereof. The cucurbitane-triterpenoid compound is presented as formula (I): wherein a single bond or a double bond is formed between C5 and C10, and a single bond or a double bond is fromed between C8 and C9; when a single bond is formed between C5 and C10, the R1 is oxygen; while a single bond is formed between C8 and C9, R2 is carbonyl group (—C?O), methyl hydroxyl group (—CH(OH)), methyl ketone or methyl dimethoxy group (—CH(OCH3)2); and wherein while R1 is oxygen (—O—) and R2 is carbonyl group (—C?O) or methyl hydroxyl group (—CH(OH)), a single bond is formed between R1 (—O—) and C19 of R2 such that R1 and R2 are formed tetrahydro-2H-pyran-2-one or hemiacetal ring.Type: GrantFiled: June 30, 2011Date of Patent: March 11, 2014Assignee: National Taiwan UniversityInventors: Ching-Jang Huang, Yueh-Hsiung Kuo, Chin Hsu
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Publication number: 20140066417Abstract: The present invention relates generally to the field of drug delivery systems for neuroactive steroid anaesthetic agents. More particularly, anaesthetic and sedative formulations are provided in the form of host/guest preparations comprising one or more neuroactive steroid anaesthetics and a cyclodextrin. Particular cyclodextrins contemplated include sulfoalkyl ether cyclodextrins and modified forms thereof.Type: ApplicationFiled: November 1, 2013Publication date: March 6, 2014Applicant: DRAWBRIDGE PHARMACEUTICALS PTY LTDInventors: JULIET MARGUERITE GOODCHILD, COLIN STANLEY GOODCHILD, BENJAMIN JAMES BOYD
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Patent number: 8664210Abstract: New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.Type: GrantFiled: September 18, 2008Date of Patent: March 4, 2014Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Alberto Cerri, Giuseppe Bianchi, Giorgio Fedrizzi, Patrizia Ferrari, Mauro Gobbini, Marco Torri, Giuseppe Marazzi, Walter Cabri