5 Or 6 Amino Acid Residues In The Peptide Chain Patents (Class 514/21.8)
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Publication number: 20130203686Abstract: An azapeptide compound of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b—B??I.Type: ApplicationFiled: March 14, 2013Publication date: August 8, 2013Inventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
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Patent number: 8497248Abstract: Antifungal and antibacterial peptides, polypeptides and proteins as antifungal additives for paint and other coatings are disclosed, along with antifungal compositions, and coated surfaces with antifungal properties. Methods of using the coatings for treating and/or inhibiting growth of mold, mildew and other fungi and bacteria on objects such as building materials that are susceptible to such infestation are also disclosed.Type: GrantFiled: April 19, 2011Date of Patent: July 30, 2013Assignee: Reactive Surfaces, Ltd. LLPInventor: C. Steven McDaniel
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Patent number: 8492349Abstract: A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[X1X2X3? . . . X43X44X45]nValAlaX48GlyLeu[X51X52X53 . . . X94X95X96]m—Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.Type: GrantFiled: February 29, 2012Date of Patent: July 23, 2013Assignee: Pain Therapeutics, Inc.Inventors: Hoau-Yan Wang, Lindsay Burns Barbier, Jian Wang
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Publication number: 20130183358Abstract: Liposomes with cosmetic and/or dermopharmaceutical ingredients for the care of the skin, scalp and/or hair and their use in washing agents and/or sprays for the treatment of textile materials.Type: ApplicationFiled: August 17, 2012Publication date: July 18, 2013Applicant: LIPOTEC, S.A.Inventors: Alfonso Fernandez Botello, Joseph-Lluis Viladot Petit, Raquel Delgado Gonzalez
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Publication number: 20130184219Abstract: The invention relates to isolated peptides derived from Oryza sativa Japonica Group, pharmaceutical compositions comprising same, and uses thereof for treating, preventing, ameliorating, and/or delaying the onset of inflammatory and/or neuroinflammatory and/or autoimmune diseases or conditions and in particular multiple sclerosis. The invention further relates to extracts from Oryza sativa Japonica Group and use thereof as a dietary supplement or in a pharmaceutical composition for treating, preventing, ameliorating, and/or delaying the onset of inflammatory, and/or inflammatory, neuroinflammatory and/or autoimmune diseases or conditions. The peptides and the extract of the invention may be used for treating, ameliorating, and/or delaying the onset or preventing multiple sclerosis.Type: ApplicationFiled: June 29, 2010Publication date: July 18, 2013Inventor: Uri Wormser
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Publication number: 20130177523Abstract: Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein.Type: ApplicationFiled: July 13, 2011Publication date: July 11, 2013Applicant: University of Utah Research FoundationInventors: Hamid Ghandehari, Adam Gormley, Abhijit Ray, Nate Larson
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Patent number: 8481494Abstract: The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.Type: GrantFiled: January 26, 2010Date of Patent: July 9, 2013Inventors: Thomas Schrader, Katrin Hochdörffer, Julia März-Berberich, Luitgard Nagel-Steger, Gal Bitan, Sharmistha Sinha
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Publication number: 20130172266Abstract: There is described herein compounds comprising a mitochondrial penetrating peptide (MPP) conjugated to an anti-cancer compound, and their method of use.Type: ApplicationFiled: May 27, 2011Publication date: July 4, 2013Applicant: The Governing Council of the University of TorontoInventors: Shana Kelley, Mark Pereira, Sonali Fonseca
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Publication number: 20130172276Abstract: The invention relates to compounds and processes useful for the preparation of protease inhibitors, particularly serine protease inhibitors. The protease inhibitors are useful for treatment of HCV infections.Type: ApplicationFiled: February 14, 2013Publication date: July 4, 2013Applicant: VERTEX PHARMACEUTICALS INCORPORATEDInventor: VERTEX PHARMACEUTICALS INCORPORATED
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Publication number: 20130157960Abstract: The present application relates to novel derivatives of monomethylauristatin F, to processes for preparing these derivatives, to the use of these derivatives for treating and/or preventing diseases, and also to the use of these derivatives for preparing medicaments for treating and/or preventing diseases, more particularly hyperproliferative and/or angiogenic disorders such as, for example, cancerous disorders. Such treatments may be practised as a monotherapy or else in combination with other medicaments or further therapeutic measures.Type: ApplicationFiled: June 6, 2011Publication date: June 20, 2013Applicant: Seattle Genetics, Inc.Inventors: Hans-Georg Lerchen, Beatrix Stelte-Ludwig, Sven Golfier, Joachim Schuhmacher, Ursula Krenz
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Publication number: 20130149248Abstract: AV?6 peptide ligands, functional variants thereof and their nucleic acids encoding them are disclosed with their uses in the treatment and imaging of AV?6 mediated diseases.Type: ApplicationFiled: January 17, 2013Publication date: June 13, 2013Applicant: CANCER RESEARCH TECHNOLOGY LIMITEDInventor: CANCER RESEARCH TECHNOLOGY LIMITED
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Publication number: 20130150300Abstract: The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.Type: ApplicationFiled: February 19, 2013Publication date: June 13, 2013Applicant: The Texas A&M University SystemInventor: The Texas A&M University System
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Publication number: 20130149318Abstract: A PEG based hydrogel and a procedure for its topical application to the surface of the pia mater of the spinal cord that can be used for intrathecal delivery of diverse drug and biomolecular therapies for the treatment of traumatic central nervous system injuries and disorders including spinal cord injury (SCI), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are provided. This “painting of the pia” with biofunctionalized hydrogel material may be used as a prelude strategy in the therapeutic management of these CNS disorders. The strategy may be designed to create a microenvironment within the damaged regions of the spinal cord that is more conducive to the successful application of subsequent regeneration based treatments such as cell replacement therapies or endogenous regeneration and plasticity stimulation via application of growth factors or gene therapy.Type: ApplicationFiled: December 13, 2012Publication date: June 13, 2013Applicant: INVIVO THERAPEUTICS CORPORATIONInventor: InVivo Therapeutics Corporation
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Publication number: 20130150297Abstract: Compounds having activity for lowering parathyroid hormone levels are described. In one embodiment, the compounds are comprised of a contiguous sequence of subunits, X1-X2-X3-X4-X5-X6-X7, wherein the X1 subunit comprises a thiol-containing moiety and the distribution of charge on the X2-X7 subunits provides the desired activity. Methods of using the compounds for treating hyperparathyroidism, bone disease and/or hypercalcemic disorders are also described, and in particular, methods for lowering plasma PTH and serum calcium are provided. The compounds can be used to treat subjects having, for example: primary, secondary or tertiary hyperparathyroidism; hypercalcemia of malignancy; metastatic bone disease; or osteoporosis.Type: ApplicationFiled: February 18, 2013Publication date: June 13, 2013Applicant: KAI PHARMACEUTICALS, INC.Inventor: KAI PHARMACEUTICALS, INC.
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Patent number: 8460697Abstract: This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.Type: GrantFiled: June 25, 2010Date of Patent: June 11, 2013Assignee: Susavion Biosciences, Inc.Inventors: Laura L. Eggink, J. Kenneth Hoober
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Publication number: 20130143825Abstract: Compounds to be used in the treatment of diseases based on the expression of toxic transcripts. The present invention relates to peptide molecules, specifically hexapeptides, designed for the prevention and/or treatment of diseases the etiology whereof is based on the presence of toxic transcripts that comprise CUG, CCUG, CGG, CAG and AAG repeats, preferably: DM1 SCA8, DM2, FXTAS, HD and FA.Type: ApplicationFiled: March 9, 2011Publication date: June 6, 2013Applicants: UNIVERSITAT DE VALENCIA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS, FUNDACIÓN DE LA COMUNIDAD VALENCIANA CENTRO DE INVESTIGACION PRINCIPE FELIPEInventors: Ruben Darío Artero Allepuz, Amparo Garcia López, Maria Del Mar Orzáez Calatayud, Maria Beatriz Llamusí Troisi, Enrique Pérez Payá, Manuel Pérez Alonso
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Patent number: 8455616Abstract: The present invention provides a peptide comprising amino acid sequences R I, F I and R I G C and containing 25 or fewer amino acid residues, and capable of transporting a functional molecule into a cell, and also into a nucleus, more efficiently than a previous PTD.Type: GrantFiled: March 6, 2008Date of Patent: June 4, 2013Assignee: National Center for Global Health and MedicineInventors: Yukihito Ishizaka, Masakatsu Hasegawa, Satoshi Nohara
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Publication number: 20130129621Abstract: Compounds comprising R-G-Cysteic Acid (i.e., R-G-NH—CH(CH2—SO3H)COOH or Arg-Gly-NH—CH(CH2—SO3H)COOH) and derivatives thereof, including pharmaceutically acceptable salts, hydrates, stereoisomers, multimers, cyclic forms, linear forms, drug-conjugates, pro-drugs and their derivatives. Also disclosed are methods for making and using such compounds including methods for inhibiting integrins including but not necessarily limited to ?5?1-Integrin, ?v?3-Integrin and ?v?5-Integrin, inhibiting cellular adhesion to RGD binding sites, preventing or treating viral or other microbial infections, inhibiting angiogenesis in tumors, retinal tissue or other tissues or delivering other diagnostic or therapeutic agents to RGD binding sites in human or animal subjects.Type: ApplicationFiled: May 9, 2012Publication date: May 23, 2013Applicant: ALLEGRO PHARMACEUTICALS, INC.Inventors: Michael John Mackel, John Y. Park, Hampar L. Karageozian, Vicken H. Karageozian
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Patent number: 8445636Abstract: The invention provides lipophilic conjugates comprising a peptide coupled to a fatty acid, the peptide comprising at least two positively charged amino acid residues, said peptide after conjugation to the fatty acid possessing antibacterial, antifungal, and/or anticancer activity higher than prior to conjugation. The lipophilic conjugates are suitable for treatment of infections caused by pathogenic organisms such as bacteria and fungi. The lipophilic conjugates are also suitable for sanitation, as disinfectants, or for food preservation.Type: GrantFiled: January 11, 2010Date of Patent: May 21, 2013Assignee: Yeda Research & Development Co. Ltd.Inventors: Yechiel Shai, Dorit Avrahami
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Publication number: 20130123190Abstract: The present invention provides methods for treating a subject that has suffered combined exposure to total body ionizing irradiation and burns.Type: ApplicationFiled: March 28, 2011Publication date: May 16, 2013Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: Kathleen E. Rodgers, Gere S. diZerega
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Patent number: 8440615Abstract: A cosmetic or pharmaceutical composition, and in particular a dermatological one, including, in a physiologically adapted medium, active principles capable of activating aconitase, and methods of using the composition for protection of mitochondria, the skin and the appendages from external aggressions and to combat cutaneous aging. These active principles may be composed of polypeptides or of peptides, used alone or in association with at least one other active principle.Type: GrantFiled: April 23, 2008Date of Patent: May 14, 2013Assignee: Societe d'Extraction des Principes Actifs (Vincience)Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
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Publication number: 20130115167Abstract: The invention provides methods of targeting atherosclerotic plaques using LyP-1 related peptides. The invention additionally provides methods of treating an inflammatory condition using LyP-1 related peptides.Type: ApplicationFiled: June 22, 2012Publication date: May 9, 2013Applicant: Sanford-Burnham Medical Research InstituteInventors: Erkki Ruoslahti, Juliana Hamzah
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Patent number: 8435941Abstract: Disclosed herein are peptides which exhibit hepcidin activity and methods of making and using thereof.Type: GrantFiled: December 4, 2009Date of Patent: May 7, 2013Assignee: The Regents of the University of CaliforniaInventors: Tomas Ganz, Elizabeta Nemeth, Gloria Preza, Piotr Pawel Ruchala
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Patent number: 8435541Abstract: A topical composition according to the present invention for use in a skin care regimen that provides matrix metalloprotease (MMP) inhibiting activity, tissue inhibitor of metalloprotease (TIMP) inducing activity, and immediate and delayed antioxidative activity. Preferably, the topical composition comprises at least one MMP inhibitor, a TIMP inducing agent, Tremella fuciformis (snow fungus) extract, Camellia sinensis (green tea) leaf extract, and Eugenia caryophyllus (clove) extract. The compositions are useful in anti-wrinkle and anti-aging products, providing elasticity, firmness, tone and texture to the skin, ameliorating fine lines and preventing skin damage.Type: GrantFiled: September 2, 2010Date of Patent: May 7, 2013Assignee: Bath & Body Works Brand Management, Inc.Inventors: Joseph D. Ceccoli, Brian Costello, James A. Hayward, Konstantinos M. Lahanas
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Patent number: 8435950Abstract: The present invention relates to peptide compounds of general formula (I) R1-X1-X2-Ser-Pro-Leu-Gln-X3-X4-R2. The present invention also relates, on the one hand, to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I) in a cosmetically or dermatologically acceptable medium, and on the other hand to its use in order to prevent or treat the cutaneous signs of aging and to protect the skin against the harmful effects caused by UV radiation. The invention lastly relates to a cosmetic treatment method for preventing and/or combatting cutaneous signs of aging and for protecting the skin against the harmful effects caused by UV radiation.Type: GrantFiled: January 7, 2010Date of Patent: May 7, 2013Assignee: ISP InvestmentsInventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto, Isabelle Imbert
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Patent number: 8435548Abstract: Disclosed are peptide derivatives, wherein glutathione-like peptides are connected to benzoic acid derivatives, and a cosmetic composition comprising the same. The peptide derivatives have excellent tyrosinase inhibition and anti-oxidative activities to show excellent skin whitening effect, biocompatibility without skin stimulation, and stability during long-term storage. Therefore, they can be effectively used for a cosmetic composition for skin whitening.Type: GrantFiled: December 23, 2009Date of Patent: May 7, 2013Assignee: Bio-FD&C Co., LtdInventors: Dai Hyun Jung, Sang Hyun Moh, Jung Hun Lee, Su Jung Kim, Hyung Sik Kim, Hyo Hyun Seo, Yeon Ja Bae
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Patent number: 8435954Abstract: An azapeptide derivative of growth hormone releasing peptide (GHRP) of Formula I: A-(Xaa)a-N(RA)—N(RB)—C(O)-(Xaa?)b-B which binds to CD 36.Type: GrantFiled: June 18, 2008Date of Patent: May 7, 2013Assignees: Valorisation-Recherche, Limited Partnership, Valorisation HSJ, Limited PartnershipInventors: Huy Ong, Sylvain Chemtob, William Lubell, Florian Sennlaub, Damien Boeglin, Caroline Proulx, Zohreh Sajjadi, David Sabatino
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Publication number: 20130109619Abstract: A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.Type: ApplicationFiled: May 11, 2011Publication date: May 2, 2013Applicant: The United States of America, as represented by the Secretary, Department of Health and Human ServInventors: Nadya I. Tarasova, Giorgio Trinchieri, Howard A. Young, C. Andrew Stewart, Marco A. Cardone, Alan O. Perantoni
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Publication number: 20130102522Abstract: Compounds that are capable of inhibiting the activity of one or more protein kinases are provided. The compounds are short, predominantly basic peptidic compounds comprising between about 5 and about 20 amino acids, and can optionally comprise an ATP mimetic moiety. The protein kinase inhibiting compounds can be used to inhibit the activity of one or more protein kinases in vitro or in vivo. Also provided are methods of inhibiting a protein kinase in a subject by administration of an effective amount of a protein kinase inhibiting compound and the use of the protein kinase inhibiting compounds, alone or in combination with other chemotherapeutic agents, in the treatment of protein kinase mediated diseases and disorders.Type: ApplicationFiled: March 15, 2012Publication date: April 25, 2013Applicant: PHARMAGAP INC.Inventors: Raphael Terreux, Jenny Phipps
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Publication number: 20130102542Abstract: The invention is related to isoforms of components of transcription factor complexes that are specifically expressed in cancer cells. These isoforms can be used as biomarkers for detection, diagnosis, prognosis and monitoring of treatments of cancer, and as drug targets of pharmaceutical compositions for the treatment of various cancers expressing the targeted isoforms. Methods, molecules, materials and kits for these uses are disclosed.Type: ApplicationFiled: October 17, 2012Publication date: April 25, 2013Applicant: ONCOTX, INC.Inventor: Oncotx, Inc.
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Patent number: 8426364Abstract: Methods are described for slowing or inhibiting the progression of heart failure in a mammalian subject suffering from chronic hypertension. The methods involve administering an ?PKC, ?1PKC, or ?IIPKC peptide inhibitor, examples of which are provided.Type: GrantFiled: May 5, 2010Date of Patent: April 23, 2013Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Daria D. Mochly-Rosen, Koichi K. Inagaki
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Publication number: 20130096074Abstract: Disclosed is a protein hydrolysate having DPP-IV inhibiting activity, the hydrolysate being enriched in peptides having a length of 2-8 amino acids comprising at least one proline residue, an isolated peptide derivable from such a protein hydrolysate, or a mixture thereof, and the use of such protein hydrolysate or isolated peptide for the manufacture of a medicament, food supplement, beverage or food product for prophylaxis and/or treatment of a DPP-IV mediated condition, in particular chosen from the group of obesity, type 2 diabetes mellitus and an immunological disorder.Type: ApplicationFiled: September 14, 2012Publication date: April 18, 2013Inventor: Jan-Willem Pieter BOOTS
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Publication number: 20130096072Abstract: Provided herein are zymogen activating molecules such as zymogen activating peptides, and methods of identifying and using these zymogen activating molecules such as zymogen activating peptides.Type: ApplicationFiled: October 12, 2012Publication date: April 18, 2013Applicant: GENENTECH, INC.Inventor: Genentech, Inc.
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Publication number: 20130096073Abstract: Biologically active peptides that are derived from or are similar to sequences identical with the N-terminus of the ?S1 fraction of milk casein. These peptides are capable of stimulating and enhancing immune response, protecting against viral infection, normalizing serum cholesterol levels, and stimulating hematopoiesis. The casein-derived peptides are non-toxic and can be used to treat and prevent immune pathologies, hypercholesterolemia, hematological disorders and viral-related diseases, alone or in combination with other peptides or blood cell stimulating factors.Type: ApplicationFiled: September 5, 2012Publication date: April 18, 2013Inventor: Zvi SIDELMAN
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Patent number: 8420605Abstract: Hydrogel compositions comprise an aqueous dispersion phase and a plurality of peptides, or derivatives, or analogues thereof. Each peptide comprises at least two amino acid residues and an aromatic stacking ligand and the hydrogel is formed by self-assembly of said peptides in said aqueous dispersion medium. The aqueous dispersion phase is physiologically acceptable and may have a pH of 6 to 8, as may the hydrogel itself. The hydrogel may be used for cell culture or for treatment of medical conditions characterized by tissue loss/damage.Type: GrantFiled: September 7, 2006Date of Patent: April 16, 2013Assignee: The University of StrathclydeInventors: Rein Vincent Ulijn, Vineetha Jayawarna, Andrew Smith, Julie Elizabeth Gough
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Patent number: 8415292Abstract: The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.Type: GrantFiled: October 20, 2009Date of Patent: April 9, 2013Assignee: Trustees of Dartmouth CollegeInventors: Dean Madden, Patrick R. Cushing, Prisca Boinguérin, Rudolf Volkmer, Lars Vouilleme
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Patent number: 8404646Abstract: The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.Type: GrantFiled: September 28, 2011Date of Patent: March 26, 2013Assignees: Cornell Research Foundation, Inc., Institut de Recherches Cliniques de MontrealInventors: Peter W. Schiller, Hazel H. Szeto, Kesheng Zhao
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Publication number: 20130065841Abstract: The invention described herein pertains to an improved process for preparing the folate-targeted conjugate EC 145 and to the conjugate EC 145 prepared using the improved process, as well as to a pharmaceutical composition comprising the conjugate EC 145 prepared using the improved process.Type: ApplicationFiled: May 19, 2011Publication date: March 14, 2013Applicant: ENDOCYTE, INC.Inventors: Daniel S. Reno, Katheryn Marie Stanford, Iontcho Radoslavov Vlahov
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Publication number: 20130059773Abstract: The present invention concerns compounds modulating apoptosis of neutrophil cells. In particular, the invention concerns compounds inhibiting an interaction between Proliferating Cell Nuclear Antigen (PCNA) and proteins binding to cytoplasmic PCNA in neutrophil cells, for use in the treatment of a disease involving a neutrophil-dependent inflammatory process. The invention also relates to a method for the identification of a compound for use in the treatment of a neutrophil-dependent inflammatory process. The invention further relates to peptides for use in the treatment of neutropenia.Type: ApplicationFiled: February 24, 2011Publication date: March 7, 2013Inventor: Veronique Witko-Sarsat
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Patent number: 8383594Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin.Type: GrantFiled: August 7, 2007Date of Patent: February 26, 2013Assignee: Sami Labs LimitedInventors: Muhammed Majeed, Renukeshwar H Chandramouli, Kalyanam Nagabhushanam, Rattan Sood, Subbalakshmi Prakash, Susmitha Anand
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Patent number: 8383591Abstract: The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.Type: GrantFiled: December 21, 2010Date of Patent: February 26, 2013Assignee: Gene Signal International S.A.Inventors: Salman Al-Mahmood, Sylvie Colin
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Patent number: 8377883Abstract: The present invention relates to a peptide for anti-angiogenesis and use thereof, in particular, to a peptide useful for treating angiogenesis diseases; a polynucleotide coding the peptide; a vector and a cell comprising the polynucleotide; a pharmaceutical composition comprising the peptide, the fused peptide or the fused protein, the polynucleotide, the vector and/or the cell. The peptide, the fused peptide or the fused protein, the polynucleotide, the vector, the cell and/or the pharmaceutical composition can be used for treatment of associated diseases such as tumor by anti-angiogenesis.Type: GrantFiled: September 29, 2007Date of Patent: February 19, 2013Assignee: Beijing Institute for Cancer ResearchInventors: Chengchao Shou, Yahui Su, Qin Feng
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Patent number: 8377890Abstract: A hair treatment agent having advantageous properties is provided. The hair treatment agent contains, based on weight of the agent, 0.00001 to <0.05% by weight of at least one oligopeptide having at least one amino acid sequence Glu-Glu-Glu (formula (A)), wherein the amino group may be present in a free or protonated manner, and the carboxy groups may be present in a free or deprotonated manner.Type: GrantFiled: March 3, 2011Date of Patent: February 19, 2013Assignee: Henkel AG & Co. KGaAInventors: Erik Schulze Zur Wiesche, Petra Westphal, Elisabeth Poppe
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Patent number: 8378072Abstract: The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the modulation of unwanted immune responses, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use.Type: GrantFiled: April 13, 2007Date of Patent: February 19, 2013Assignee: Declion Pharmaceuticals, Inc.Inventor: Dustan Bonnin
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Publication number: 20130034590Abstract: Compositions comprising a lipophilic derivative of a hydrophilic drug and an amphiphile compound for use in therapy of the human or animal body are provided. Methods of medical treatment, wherein a composition according to the invention is administered to a human or animal body also form part of the invention. It is preferred that the drug is delivered to the brain.Type: ApplicationFiled: August 31, 2012Publication date: February 7, 2013Inventors: Ijeoma Uchegbu, Aikaterini Lalatsa, Andreas Schatzlein
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Publication number: 20130035291Abstract: The present invention relates to the production of bioactive products from raw plant matter, namely cocoa extracts. The said products have one or more biopeptides with prolyl endopeptidase (PEP) enzyme inhibitory activity in vitro and/or antioxidant and/or antineurodegenerative capacity in vivo and can be used in dietetics and in the food and pharmaceutical industries.Type: ApplicationFiled: December 23, 2009Publication date: February 7, 2013Applicants: NATRACEUTICAL INDUSTRIAL S.L.U., BIOPOLIS, S.L.Inventors: Esther Bataller Leiva, Salvador Genoves Martinez, Patricia Martorell Guerola, Daniel Ramon Vidal, Aida Ibañnez Lopez, Silvia Llopis Pla, Nuria Gonzalez Martinez, Honorato Monzo Oltra, Begoña Muguerza Marquinez
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Publication number: 20130036481Abstract: The application reports that perlecan domain V (DV) or the LG3 domain thereof reduces deposition and toxicity of A? peptide, the major component of plaques in Alzheimer's disease. Methods of using DV, LG3 and related molecules in treatment of amyloidogenic diseases, particularly Alzheimer's disease, are provided.Type: ApplicationFiled: January 6, 2011Publication date: February 7, 2013Applicant: THE TEXAS A&M UNIVERSITY SYSTEMInventors: Gregory J. Bix, Sarah Wright, Irene Griswold-Prenner
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Publication number: 20130034568Abstract: The present disclosure describes methods for preventing or treating periodontitis or diseases associated with periodontitis. The present disclosure also describes methods of screening for compounds that can be used to prevent or treat periodontitis or diseases associated with periodontitis.Type: ApplicationFiled: January 24, 2011Publication date: February 7, 2013Inventors: Georgios Hajishengallis, John D. Lambris
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Publication number: 20130029921Abstract: The present invention relates to polypeptides fragments derived from the protein TLT-1 and their uses for the treatment of inflammatory conditions and more particularly for the treatment of sepsis.Type: ApplicationFiled: April 8, 2011Publication date: January 31, 2013Inventors: Sebastien Gibot, Marc Derive
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Publication number: 20130022660Abstract: The present invention relates to the treatment and prevention of vasospasm. The present invention provides a system for treating a cerebral vasospasm in a human utilizing a pharmaceutical composition and administrating a therapeutically effective amount of the pharmaceutical composition to a predetermined location in close proximity to a cerebral artery within a subarachnoid space wherein the pharmaceutical composition produces a localized pharmacologic effect thereby treating the cerebral vasospasm.Type: ApplicationFiled: July 22, 2012Publication date: January 24, 2013Applicant: EDGE THERAPEUTICS, INC.Inventors: R. Loch Macdonald, Brian A. Leuthner