Oxygen Of The Saccharide Radical Bonded Directly To A Polycyclo Ring System Of Four Carbocyclic Rings (e.g., Daunomycin, Etc.) Patents (Class 514/34)
  • Patent number: 11311537
    Abstract: The present disclosure relates, in general, a method of diagnosing and treatment of lymphoproliferative disorders.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: April 26, 2022
    Assignee: UNIVERSITY OF MIAMI
    Inventors: Izidore Lossos, Ramiro E. Verdun
  • Patent number: 11312984
    Abstract: Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and M are described. The methods include utilizing recombinant microorganisms for converting various staring compositions to target steviol glycosides. In addition, novel steviol glycosides reb D2 and reb M2 are disclosed, as are methods of preparing the same. The highly purified rebaudiosides are useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 26, 2022
    Assignee: PURECIRCLE SDN BHD
    Inventors: Indra Prakash, Cynthia Bunders, Pankaj Soni, Avetik Markosyan, Jarrin Cyrille, Aurelien Badie, Rober Ter Halle
  • Patent number: 11305017
    Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: April 19, 2022
    Assignee: The General Hospital Corporation
    Inventors: Mark C. Poznansky, Patrick Reeves
  • Patent number: 11308360
    Abstract: A computer system selects a kernel and kernel parameters for a first Support Vector Machine (SVM) model, testing the SVM model on a feature matrix T of n feature vectors of length m to produce false positive (FP) data set and false negative (FN) data set by a computer processor, wherein n and m are integer numbers, copies the feature matrix T to produce a feature matrix T_best, and checking if a ratio (T_best sample number)/(SVM support vector number) is above a threshold for the SVM model on T_best. If the ratio is above the threshold, SVM predictions are performed using the SVM model on the feature matrix T_best. The first SVM model can be used classify the faces or the objects in the images. An image-product design can be created based on the faces or the objects in the images classified by the first SVM model using the feature matrix T_best.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: April 19, 2022
    Assignee: Shutterfly, LLC
    Inventor: Omer Moshe Moussaffi
  • Patent number: 11262362
    Abstract: The present invention provides biomarkers for sensitive, specific, accurate and quantitative diagnosis and assessment of chronic hypoxia. In particular, the present invention provides 2-hydroxyglutarate as a biomarker that is differentially produced in chronic hypoxia. Furthermore, embodiments of the invention are able to differentiate between chronic and acute hypoxia. Assays for levels of 2-hydroxyglutarate may be used alone or in conjunction with additional biomarkers of hypoxia to increase the precision of analysis. In particular embodiments of the invention, the level of 2-hydroxyglutarate and at least one second biomarker may be assayed to generate a hypoxic profile that can be compared to a reference or control profile, thereby diagnosing a subject as normoxic, chronically hypoxic, or acutely hypoxic.
    Type: Grant
    Filed: November 18, 2012
    Date of Patent: March 1, 2022
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: David R. Wise, Patrick S. Ward, Craig B. Thompson
  • Patent number: 11242568
    Abstract: The present subject matter provides, inter alia, a method of diagnosing invasive ductal cancer or detecting invasive ductal cancer risk in a subject who has ductal carcinoma in situ, a method of treating breast cancer in a subject detected to have invasive ductal cancer or determined to be at risk of invasive ductal cancer, compositions for detecting invasive presence or potential in ductal carcinoma in situ in a subject, and kits including reagents and composition for detecting invasive presence or potential in ductal carcinoma in situ in a subject.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: February 8, 2022
    Assignee: City of Hope
    Inventors: Maria A. Hahn, John H. Yim, Yuman Fong, Arthur X. Li, Xiwei Wu, Sun-Wing T. R. Tong
  • Patent number: 11241421
    Abstract: This invention relates to methods and compositions for treatment of inv(16) leukemia and particularly to treatment of acute myeloid leukemia. Disclosed is a method of treating inv(16) leukemia comprising the step of administering to a subject in need thereof a therapeutically effective combination of a) a compound of the formula (1) and b) a chemotherapeutic agent selected from the group consisting of pirarubicin, aclarubicin, mitoxantrone, doxorubicin, daunorubicin, idarubicin, epirubicin, cytarabine, pharmaceutically acceptable salts and mixtures thereof. The therapeutically effective combination synergistically inhibits proliferation of inv(16) leukemia cells. This invention also relates to pharmaceutical compositions comprising a therapeutically effective combination of the compound of formula (1) and the chemotherapeutic agent and a pharmaceutically acceptable excipient.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: February 8, 2022
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: John H. Bushweller, Anuradha Illendula
  • Patent number: 11191728
    Abstract: A method of preparing degradable and environment responsive composite microgels, belonging to polymer material synthesis and biomaterial technology fields. Firstly, a copolymer of L-malic acid and 6-hydroxyhexanoate is prepared; then, N,N,N?,N?-tetramethyl cystamine is prepared. The copolymer and N,N,N?,N?-tetramethyl cystamine are mixed in an organic solvent to form a mixed solution which is added into excess distilled water to produce composite microgels. The microgels have advantages of mild preparing conditions, fast reaction speed without catalysts, no impurity remained, and controllable degradation rate. The microgels can load anticancer drug doxorubicin hydrochloride, showing environment responsive controlled release due to introduction of carboxyl groups and disulfide bonds.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: December 7, 2021
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Caihua Ni, Zhenle Tian, Gang Wang, Liping Zhang, Ren Liu
  • Patent number: 11180615
    Abstract: The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: November 23, 2021
    Assignee: CNPHARM CO. LTD.
    Inventors: Youn Soo Sohn, Yong Joo Jun, Prakash Gouda Avaji
  • Patent number: 11123387
    Abstract: A method of treating viral infection, such as viral infection caused by a virus of the Filoviridae family, Flaviviridae family (Flavivirus genus), Deltaretrovirus genus, or Togaviriade family is provided. A composition having at least one cardiac glycoside is used to treat viral infection. The composition can further include at least one triterpene. Alternatively, the composition comprises at least one, at least two, or at least three triterpenes.
    Type: Grant
    Filed: February 27, 2020
    Date of Patent: September 21, 2021
    Assignee: PHOENIX BIOTECHNOLOGY, INC.
    Inventors: Robert A. Newman, Otis C. Addington
  • Patent number: 11078541
    Abstract: The present invention includes methods for treating a FLT3 mutated proliferative disorder comprising: measuring expression of a mutated FLT3 and one or more genetic abnormalities in a sample obtained from a tumor sample obtained from the patient, wherein the presence of the one or more genetic abnormalities indicates that the patient has a poor prognosis; and administering to the patient a therapeutically effective amount of crenolanib or a pharmaceutically acceptable salt thereof, wherein the crenolanib increases a chance of survival of the patient having both the mutated FLT3 and the one or more genetic abnormalities, wherein the crenolanib, as shown below, is administered to a subject suffering from said disorder:
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: August 3, 2021
    Assignee: AROG PHARMACEUTICALS, INC.
    Inventor: Vinay K. Jain
  • Patent number: 11052157
    Abstract: Enhanced loading of small molecule compounds into intact, bacterially derived vesicles provides operational and therapeutic advantages.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: July 6, 2021
    Assignee: ENGENEIC MOLECULAR DELIVERY PTY LTD.
    Inventors: Himanshu Brahmbhatt, Jennifer MacDiarmid
  • Patent number: 11007194
    Abstract: The present invention relates to a method of treating a patient with a serine/threonine kinase inhibitor wherein resistance to the treatment with a serine/threonine kinase inhibitor is suppressed by administering the serine/threonine kinase inhibitor on an intermittent dosing schedule.
    Type: Grant
    Filed: November 9, 2012
    Date of Patent: May 18, 2021
    Assignee: Array BioPharma Inc.
    Inventors: Darrin Stuart, Meghna Das Thakur
  • Patent number: 10907145
    Abstract: Ligands and methods for selectively binding hypermethylated DNA from a sample. The ligands include a CG-region binding molecule-conjugated resin derived from the aminoglycoside antibiotic amikacin. Furthermore, the CG-region binding molecule may be conjugated to the resin with a crosslinker and/or may be modified with one or more of long chain and short chain alkyl, aryl, piperazinyl, piperidyl, and pyrrolidyl groups. Such ligands are used in methods for contacting a sample to thereby selectively bind hypermethylated DNA.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: February 2, 2021
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Kaushal Rege, Kevin Lin, Sudhakar Godeshala, Taraka Sai Pavan Grandhi
  • Patent number: 10899781
    Abstract: A platinum complex includes a structure of Formula (I). A method for treating a subject suffering from cancer includes a step of administering an effective amount of the platinum complex to the subject. A method for inhibiting the growth of cancer cells includes the step of contacting a population of cancer cells with an effective amount of the platinum complex. The platinum complexes are particularly suitable for treatment of cancer through, in particular, photodynamic therapy.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: January 26, 2021
    Assignee: City University of Hong Kong
    Inventors: Guangyu Zhu, Zhigang Wang, Zoufeng Xu
  • Patent number: 10898577
    Abstract: The present invention relates to a conjugate of ginsenoside compound K and glycol chitosan, a method for preparing the conjugate, and a pharmaceutical composition for treating cancer including the conjugate in a pharmaceutically acceptable carrier. The conjugate of ginsenoside compound K and glycol chitosan of the present invention has cancer cell-specific anticancer activity because of increased water solubility relative to ginsenoside compound K, formation of nanosized self-aggregates in an aqueous solution, stability at neutral pH and release of the ginsenoside compound K at acidic pH due to pH sensitivity, thus having excellent effects as a composition for treating cancer.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: January 26, 2021
    Assignee: UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY
    Inventors: Deok Chun Yang, Yeon Ju Kim, Mathiyalagan Ramya
  • Patent number: 10792483
    Abstract: The present invention relates to a vaccine composed of at least one immune stimulant and radiofrequency waves using capacitive coupling and to a method, especially an in-situ and in vivo vaccination method for treatment of primary cancer and its metastases even in disseminated cell-states, which cannot be detected by presently available imaging methods or for prevention of relapse of the cancer disease, and especially for enabling and supporting the patient's own immune system to recognize and kill the cancer cells and to build up a memory to prevent relapse of a cancer disease.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: October 6, 2020
    Assignee: XAX KFT.
    Inventors: Gabor Andocs, Oliver Szasz, Andras Szasz, Nora Iluri
  • Patent number: 10683552
    Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: June 16, 2020
    Assignees: Presidents and Fellows of Harvard College, The Broad Institute, Inc.
    Inventors: Steven Andrew McCarroll, Giulio Genovese
  • Patent number: 10675270
    Abstract: The present invention relates to the use of chondroitin as a transdermal carrier and slow-release system for active ingredients in pharmaceutical and cosmeceutical compositions.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: June 9, 2020
    Assignee: Altergon S.A.
    Inventors: Mario De Rosa, Chiara Schiraldi
  • Patent number: 10668166
    Abstract: The present invention relates to novel anthracycline derivatives comprising two oxazolidine cycles and the preparation of said anthracycline derivatives. Furthermore, antibody-drug conjugates (ADCs) comprising the novel anthracycline derivatives and the use of such ADCs in the prevention and treatment of cancer are disclosed.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: June 2, 2020
    Assignee: Toxinvent Ou
    Inventors: Ain Uustare, Ivan Ogibalov, Olga T{hacek over (s)}ubrik, Andrus Tasa, Uno Mäeorg, Ago Rinken
  • Patent number: 10646540
    Abstract: The disclosure provides, inter alia, compositions comprising TWIST peptide inhibitors and optionally one or more anti-cancer agents, and methods of using the compositions for the treatment of cancer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: May 12, 2020
    Assignee: City of Hope
    Inventor: Carlotta A. Glackin
  • Patent number: 10624949
    Abstract: The present invention relates to methods for treating a disease, in which the disease arises from dysregulation of the Wnt signaling pathway. In some instances, the disease can be treated by administering a Wnt pathway inhibitory compound. In other instances, the method optionally includes conducting a genome-wide screening to determine one or more genes resulting in a reduced disease state and then identifying the gene(s) as being involved in the Wnt signaling pathway.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: April 21, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Oscar A. Negrete, Brooke Nicole Harmon
  • Patent number: 10463685
    Abstract: Methods for treating a telomerase-expressing cell characterized by an over-activation of telomerase in a subject in need thereof comprising administering a pharmaceutical composition comprising a first amount of a 6-mercaptopurine analog, and a second amount of a telomerase inhibitor, wherein the first amount and the second amount together comprises an amount effective to reduce stability of telomere length and to induce cell death in the telomerase-expressing cell are provided. The methods can be used to treat patients with lung cancer, colon cancer, or cervical cancer.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 5, 2019
    Assignee: The Board of Regents of the University of Texas System
    Inventors: Jerry W. Shay, Sergei M. Gryaznov
  • Patent number: 10426841
    Abstract: The present invention relates to a composition and a combination comprising at least one first drug and at least one protein-binding prodrug, wherein the protein-binding prodrug comprises a protein-binding group, a second drug, and a linker that can be cleaved hydrolytically, enzymatically, or in a pH-dependent manner in the body, as well as to a kit and a pharmaceutical composition comprising said composition or combination.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: October 1, 2019
    Assignee: Vergell Medical S.A.
    Inventor: Felix Kratz
  • Patent number: 10391112
    Abstract: A method for treating a biological cell is disclosed. The method administers a mixture of a chemotherapeutic drug and a co-drug that facilitates delivery of the chemotherapeutic drug to the nucleus of the cell. Examples of co-drugs include cationic polymers, cationic lipids and cationic proteins. Cationic polymers include a polyethyleneimine (PEI), polylysine, a polybetaaminoester (PBAE), an ?-polylysine (EPL) including ?-poly-L-lysine (e-PLL), a polyarginine peptide, chitosan, a polyamidoamine dendrimer (PAMAM). Cationic lipids include 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). Cationic proteins include protamine.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: August 27, 2019
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Debra Auguste, Daxing Liu
  • Patent number: 10328153
    Abstract: There is provided a complex comprising rifaximin and a complexing agent, wherein the complexing agent is a polyvinyl pyrrolidone (PVP) or a cyclodextrin. There is also provided a process for preparing the complex, a pharmaceutical composition including the complex and therapeutic uses of the complex.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: June 25, 2019
    Assignee: Cipla Limited
    Inventors: Maruti Ganpati Ghagare, Sunilkumar Parasnath Saroj, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
  • Patent number: 10301662
    Abstract: Provided is a method for preparing rebaudioside M by using an enzyme method. In the method, rebaudioside A or rebaudioside D is used as a substrate; and in the existence of a glucosyl donor, rebaudioside M is generated by means of reaction of the substrate under the catalysis of UDP-glucosyl transferase and/or recombinant cells containing the UDP-glucosyl transferase.
    Type: Grant
    Filed: September 29, 2013
    Date of Patent: May 28, 2019
    Assignee: PepsiCo, Inc.
    Inventors: Junhua Tao, Guoqing Li, Xiaoliang Liang, Andrew Tao
  • Patent number: 10201523
    Abstract: The invention provides compositions comprising wilforlide A for overcoming drug resistance in cancer therapy, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods and compositions for treating a cancer are disclosed. The method administers to a patient in need thereof a combination of wilforlide A and a chemotherapeutic drug. Wilforlide A and chemotherapeutic drug are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug alone.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: February 12, 2019
    Assignee: WESTERN UNIVERSITY OF HEALTH SCIENCES
    Inventors: Moses Sing Sum Chow, Ying Huang, Zhi Jun Wang
  • Patent number: 10196687
    Abstract: Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample at the protein or nucleic level. The expression of the gene or biomarker can be indicative of the lung tumor subtype as well as prognostic and predictive for therapeutic response. The compositions and methods provided herein are suited for analysis of gene or biomarker expression at the protein or nucleic acid level in paraffin-embedded tissues.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: February 5, 2019
    Assignee: University of North Carolina at Chapel Hill
    Inventors: David N. Hayes, Charles M. Perou, Philip Bernard
  • Patent number: 10144753
    Abstract: The invention relates to anthracycline derivative compounds for treating tumor diseases, and related methods, compositions, and kits.
    Type: Grant
    Filed: October 15, 2013
    Date of Patent: December 4, 2018
    Assignee: Produkem Molekulares Design GMBH
    Inventors: Christian R. Noe, Michael Sonntagbauer, Sébastien Queva, Ernst Urban
  • Patent number: 10100372
    Abstract: An RSV reporter strain that can be used for high-throughput drug discovery is disclosed. Also disclosed is a recombinant RSV vector that contains an RSV genome encoding the disclosed RSV reporter strain operably linked to an expression control sequence. Also disclosed is an infectious RSV virion produce by expression of the disclosed recombinant RSV vector in a host cell. Also disclosed is a recombinant nucleic acid that comprises an RSV F protein having an escape mutation operably linked to a heterologous expression control sequence. Also disclosed are methods of screening for antiviral agents using the disclosed RSV reporter strains.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: October 16, 2018
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Richard K. Plemper, Dan Yan
  • Patent number: 10098962
    Abstract: The present invention provides a glycosaminoglycan derivative in which a group derived from glycosaminoglycan and a group derived from a physiologically active substance having at least one of a carboxy group and a hydroxy group are coupled by covalent bond with a spacer therebetween, in which the spacer is selected in accordance with the decomposition rate of the covalent bond to the group derived from the physiologically active substance.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: October 16, 2018
    Assignee: Seikagaku Corporation
    Inventors: Kenji Miyamoto, Yosuke Yasuda, Hisayuki Takeuchi, Keiji Yoshioka
  • Patent number: 10091998
    Abstract: A tetrazolinone compound represented by formula (1): wherein R1 represents a C1-C6 alkyl group; R2, R3, and R4 are the same or different and represent a hydrogen atom; R5 represents a C1-C3 alkyl group optionally having one or more halogen atoms; Y represents #—C(RA 1 RA 2)—Z— in which left end and Q are bound to each other, and RA 1 and RA 2 each represents a hydrogen atom; Q represents a divalent C3-C10 carbocyclic group; X represents an oxygen atom; and A represents a C6-C10 aryl group, has excellent control activity against pests.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: October 9, 2018
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Koichiro Dota
  • Patent number: 10064883
    Abstract: The present invention relates to a pharmaceutical composition including Lipiodol and a molecule with anti-tumor activity and secondarily a hydroxyethyl starch. The present invention also relates to the use of the compositions according to the invention for treating cancer. According to one embodiment, the pharmaceutical composition according to the invention has between 0.004% and 0.2% by weight of idarubicin, between 0.38% and 2.25% by weight of hydroxyethyl starch and secondarily between 60% and 68% by weight of Lipiodol, and water for injection (or even physiological saline) in a quantity sufficient (q.s.) for 100%.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: September 4, 2018
    Assignee: GUERBET
    Inventors: Boris Guiu, Mathieu Boulin, Jean-Pierre Cercueil
  • Patent number: 10045951
    Abstract: The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of flaxseed lignans.
    Type: Grant
    Filed: April 11, 2011
    Date of Patent: August 14, 2018
    Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventor: Melpo Christofidou-Solomidou
  • Patent number: 9968570
    Abstract: The present invention provides, in part, compositions and methods for treating cancer using a combination of C6-ceramide and other anti-cancer agents in certain vesicles.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: May 15, 2018
    Assignee: Chemo-Enhanced LLC
    Inventor: Harold J. Wanebo
  • Patent number: 9931313
    Abstract: The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing proliferative disorders, such as cancel-, that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include monotherapy with malate, or a derivative thereof, as well as combination therapy, such as malate, or a derivative thereof, combined with another therapeutic agent, such as a malic enzyme 2 inhibitor, an antineoplastic agent, a glycolysis inhibitor, an antiangiogenic agent, an immunomodulatory agent, an antibody, or a cytokine.
    Type: Grant
    Filed: April 4, 2013
    Date of Patent: April 3, 2018
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Vikas P. Sukhatme, Jian-Guo Ren
  • Patent number: 9895385
    Abstract: Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and/or NTM culture conversion to negative during or after the administration period.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: February 20, 2018
    Assignee: INSMED INCORPORATED
    Inventors: Gina Eagle, Renu Gupta
  • Patent number: 9839634
    Abstract: It has been determined that co-administration of a rifamycin and a switch-region inhibitor 1) results in synergistic antibacterial effects, enabling efficacy at low, subtoxic doses, and/or 2) results in a low spontaneous resistance frequency, enabling treatment of high-titer infections without treatment failure due to spontaneous resistance. Accordingly, certain embodiments provide a composition comprising a rifamycin and a switch region inhibitor, as well as methods of use thereof.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: December 12, 2017
    Assignee: Rutgers, The State University of New Jersey
    Inventor: Richard H. Ebright
  • Patent number: 9801922
    Abstract: The invention provides compositions and methods to treat cancer with an agent that increases reactive oxygen species (ROS) levels in cancer cell mitochondria (“an XTPP agent”) or a pharmaceutically acceptable salt thereof, an inhibitor of hydroperoxide metabolism and a pharmaceutically acceptable diluent or carrier.
    Type: Grant
    Filed: August 2, 2012
    Date of Patent: October 31, 2017
    Assignees: UNIVERSITY OF IOWA RESEARCH FOUNDATION, REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Douglas R. Spitz, Michael K. Schultz, Kyle Kloepping, Yueming Zhu, Nukhet Aykin-Burns, Max S. Wicha
  • Patent number: 9657047
    Abstract: A crystalline epirubicin hydrochloride and a method for its production are provided. The method for producing the crystalline epirubicin hydrochloride includes the steps: (a) providing epirubicin hydrochloride, (b) producing a mixture containing the provided epirubicin hydrochloride and at least one alcohol selected from the group 1-butanol, 2-butanol, and 1-pentanol, and (c) crystallizing epirubicin hydrochloride from this mixture.
    Type: Grant
    Filed: May 15, 2012
    Date of Patent: May 23, 2017
    Assignee: MEDAC GESELLSCHAFT FÜR KLINISCHE SPEZIALPRÄPARATE MBH
    Inventor: Tero Kunnari
  • Patent number: 9585855
    Abstract: The present invention relates to methods of treating the side effects of a toxic medical therapy using nitrated lipids. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: March 7, 2017
    Assignee: The University of Utah Research Foundation
    Inventor: Tianxin Yang
  • Patent number: 9566333
    Abstract: An isolated DNA molecule comprising a fragment of the gene encoding the feline NIS is disclosed as well as methods of use thereof. Also provided are methods for rational diet design of food composition suitable for administration to feline companion animals afflicted with hyperthyroidism, comprising (a) accessing at least one database that comprises a first data set relating functional gene profile of a biofluid or tissue sample from an animal to physiological condition of the animal, where the functional gene profile is that of the feline NIS gene; (b) accessing at least one database that comprises a second data set relating effects of bioactive dietary components on the functional gene profile; (c) using an algorithm drawing on these data sets, processing input data defining physiological condition to derive a nutritional formula promoting wellness of a feline companion animal afflicted with hyperthyroidism; and (d) preparing a food composition based on the nutritional formula.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: February 14, 2017
    Assignee: Hill's Pet Nutrition, Inc.
    Inventors: Samer Al-Murrani, Jeffrey Brockman
  • Patent number: 9527880
    Abstract: Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five ?-D-glucosyl units connected to the aglycone steviol. Also disclosed are methods for producing rebaudioside D3, a UDP-glycosyltransferase fusion enzyme, and methods for producing rebaudioside D and rebaudioside E.
    Type: Grant
    Filed: February 5, 2016
    Date of Patent: December 27, 2016
    Assignee: Conagen Inc.
    Inventors: Guohong Mao, Venkata Sai Prakash Chaturvedula, Oliver Yu
  • Patent number: 9486466
    Abstract: The invention relates to a method for the treatment of triple negative breast cancer in a subject, comprising administering to the subject an effective amount of 2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide, or a pharmaceutically acceptable salt thereof, and an effective amount of carboplatin, in combination with standard of care.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: November 8, 2016
    Assignee: AbbVie Inc.
    Inventor: Gary Gordon
  • Patent number: 9267934
    Abstract: Embodiments of the present invention include methods and compositions for ameliorating cancer. Some embodiments include methods and compositions for ameliorating pancreatic cancer targeting the CXCR4 receptor and the CXCL12 ligand.
    Type: Grant
    Filed: October 25, 2011
    Date of Patent: February 23, 2016
    Assignee: University of South Alabama
    Inventors: Seema Singh, Ajay P. Singh
  • Patent number: 9220720
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual in need thereof.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: December 29, 2015
    Assignees: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Patent number: 9211301
    Abstract: A method for reducing arrhythmic risk associated with cardiomyopathy by improving conduction velocity, includes administering a composition containing NAD+ or a mitochondrial targeted antioxidant to an individual or person in need thereof.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: December 15, 2015
    Assignees: U.S. DEPARTMENT OF VETERANS AFFAIRS, THE BOARD OF TRUSTEES OF THE UNIV. OF ILLINOIS
    Inventor: Samuel C. Dudley, Jr.
  • Patent number: 9207243
    Abstract: Methods of treating cancer comprising administering inhibitors of glucose transporters (GLUTs) are provided. Methods of predicting whether a cancer will respond to treatment with a GLUT inhibitor also are provided.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: December 8, 2015
    Assignee: Northwestern University
    Inventors: Malathy Shanmugam, Samuel K. McBrayer, Steven T. Rosen
  • Patent number: 9192677
    Abstract: The present invention relates in general to the field of targeted drug delivery of anti-cancer drugs. More precisely, the present invention concerns polymer drug conjugates, namely, conjugates of poly(organo)phosphazenes and anti-cancer drugs, wherein the conjugates are suitable to selectively release anti-cancer drugs in tumor tissue. In addition, the present invention relates to a method for manufacturing such poly(organo)phosphazene molecule conjugates, to poly(organo)phosphazene molecule conjugates for use in medicine, in particular, to poly(organo)phosphazene molecule conjugates for use in the treatment of cancer, and to pharmaceutical compositions comprising such poly(organo)phosphazene molecule conjugates.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: November 24, 2015
    Assignee: JOHANNES KEPLER UNIVERSITÄT LINZ
    Inventors: Ian P. Teasdale, Ivo Nischanga, Oliver Brüggemann, Sandra Wilfert