Parasite (e.g., Tapeworm, Roundworm, Nematode, Etc.) Destroying Or Inhibiting Patents (Class 514/4.6)
  • Patent number: 10993988
    Abstract: The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: May 4, 2021
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Brenda Bondesen, Lance Hammerland
  • Patent number: 10793604
    Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: October 6, 2020
    Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.
    Inventors: Loic Le Hir de Fallois, Greg Pacofsky, Alan Long, Charles Meng, Hyoung Ik Lee, Cyprian O. Ogbu
  • Patent number: 9856288
    Abstract: Disclosed are a tripeptide epoxyketone compound, a preparation method thereof, and a use thereof in the preparation of anti-tumor drugs.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: January 2, 2018
    Assignees: ZHEJIANG UNIVERSITY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
    Inventors: Yongzhou Hu, Jia Li, Tao Liu, Jiankang Zhang, Yubo Zhou, Bo Yang, Qiaojun He, Lei Xu, Xiaobei Hu
  • Publication number: 20150147283
    Abstract: The present invention provides methods for limiting development of skin wounds, and also for treatment of one or more of erythemas, blisters, rashes, pruritis, contact dermatitis, psoriasis, eczema, acne, and athlete's foot.
    Type: Application
    Filed: March 14, 2013
    Publication date: May 28, 2015
    Inventors: Kathleen E. Rodgers, Gere S. diZerega
  • Publication number: 20150133367
    Abstract: The present invention includes a novel class of highly specific protease inhibitors. In one embodiment, the inhibitors of the invention are ?-helical in structure. In another embodiment, the present invention represents the first demonstration of a highly specific cysteine protease inhibitor.
    Type: Application
    Filed: April 26, 2013
    Publication date: May 14, 2015
    Inventor: Doron C. Greenbaum
  • Publication number: 20150051138
    Abstract: Disclosed herein are Furin/PC inhibitors for inhibiting Furin and other Propprotein Convertases. Method of making the Furin/PC inhibitors, chemical and biological characterization of the Furin/PC inhibitors, and the use of the Furin/PC inhibitors to treat infectious diseases, cancers, and inflammatory/autoimmune disorders, are also disclosed.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 19, 2015
    Applicant: Sanford-Burnham Medical Research Institute
    Inventors: Alex Strongin, Maurizio Pellecchia, Elisa Barile
  • Publication number: 20150037281
    Abstract: The present invention relates to novel Prothymosin Alpha (ProT?) variants that are capable of inducing cell-mediated immune responses. These variants lack a nuclear localization signal and the proliferative oncogenic activity previously attributed to ProT?. The variants of the invention are used in methods of treating, for example, viral infections, bacterial infections, fungal infections, cancer, ischemia and myeloproliferative blood disorders. Administration of a ProT? variant to a subject in a therapeutically effective amount treats the infection or disease.
    Type: Application
    Filed: March 1, 2013
    Publication date: February 5, 2015
    Applicant: Icahn School of Medicine at Mount Sinai
    Inventors: Arevik Mosoian, Avelino Teixeira
  • Publication number: 20150011389
    Abstract: The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram and (B) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
    Type: Application
    Filed: January 22, 2013
    Publication date: January 8, 2015
    Inventor: Elke Hellwege
  • Publication number: 20150004165
    Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
    Type: Application
    Filed: September 8, 2014
    Publication date: January 1, 2015
    Applicant: INCYTE CORPORATION
    Inventors: Henry Yue, Monique G. Yao, Ameena R. Gandhi, Mariah R. Baughn, Anita Swarnakar, Narinder Walia, Madhusudan M. Sanjanwala, Michael Thorton, Vicki S. Kaulback, Yan Lu, Kimberly J. Gietzen, Neil Burford, Li Ding, April J.A. Hafalia, Y. Tom Tang, Olga Bandman, Bridget A. Warren, Cynthia D. Honchell, Dyung Aina M. Lu, Kavitha Thangaveln, Sally Lee, Yuming Xu, Junming Yang, Preeti G. Lal, Bao M. Tran, Craig H. Ison, Brendan M. Duggan, Stephanie Kareht
  • Publication number: 20140380521
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2 or 3, or the nucleotide sequence set forth in SEQ ID NO:1, as well as variants and fragments thereof.
    Type: Application
    Filed: June 29, 2012
    Publication date: December 25, 2014
    Applicant: Athenix Corp.
    Inventors: Candace Poutre, Theodore Kahn, Alissa Anthony
  • Publication number: 20140371139
    Abstract: The invention relates to preparations comprising amorphous emodepside in a polyvinylpyrrolidone matrix, pharmaceuticals comprising such preparations, and their use against endoparasites in animals or humans.
    Type: Application
    Filed: December 18, 2012
    Publication date: December 18, 2014
    Inventors: Venkatu-Rangarao Kanikanti, Petra Lange, Hans-Juergen Hamann, Peter Kleinebudde
  • Publication number: 20140325696
    Abstract: The invention relates to methods and compositions for increasing resistance or tolerance to a nematode plant pest in a plant or part thereof. Nucleotide sequences that confer resistance or tolerance to nematode plant pests when expressed in a plant are provided as well as compositions comprising the polypeptides encoded by the nucleotide sequences, and transgenic plants and parts thereof comprising the nucleotide sequences.
    Type: Application
    Filed: November 20, 2012
    Publication date: October 30, 2014
    Applicants: Syngenta Participations AG, Evogene Ltd.
    Inventors: Dror Shalitin, Hagai Karchi, Xiang Huang
  • Publication number: 20140315794
    Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.
    Type: Application
    Filed: November 21, 2013
    Publication date: October 23, 2014
    Applicant: MERIAL LIMITED
    Inventors: Loic Patrick Le Hir de Fallois, Hyoung Ik Lee, Douglas Edward Wilkinson, Brent Christopher Beck
  • Publication number: 20140308318
    Abstract: The present invention relates to a multi-functional protease inhibitor, which may be conjugated to various molecules. The present invention also relates to uses of the protease inhibitor and conjugates thereof.
    Type: Application
    Filed: August 15, 2012
    Publication date: October 16, 2014
    Inventors: Colin Watts, Sander Van Kasteren
  • Publication number: 20140296138
    Abstract: Transgenic plants expressing a Vip3 protein have been found to be efficacious against plant-infesting nematodes. Disclosed are methods of controlling nematode populations using transgenic plants expressing Vip3 protein.
    Type: Application
    Filed: July 11, 2012
    Publication date: October 2, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Xiang Huang, Jeng Shong Chen
  • Publication number: 20140296137
    Abstract: Described herein are compositions and methods for controlling, inhibiting, reducing and/or preventing rotifer growth with antimicrobial peptides. Methods for removing and/or preventing rotifer infestations in algae cultivations by controlling, inhibiting, reducing and/or preventing rotifer growth with an antimicrobial peptide (AMP) are further provided. Also described are transgenic algae comprising an expression vector comprising a nucleic acid sequence encoding an AMP. In some instances, the nucleic acid sequence encoding the AMP is codon-optimized for expression in algae.
    Type: Application
    Filed: March 31, 2014
    Publication date: October 2, 2014
    Inventors: Sathish Rajamani, Richard T. Sayre
  • Patent number: 8809268
    Abstract: Pharmaceutical compositions having at least one crystal protein and a nicotinic acetylcholine receptor agonist in amounts effective to inhibit a parasitic worm or helminth infection in a vertebrate or mammal are described. Methods for treating a parasitic worm or helminth infection in a subject are also described. The methods include administering to the subject a therapeutically effective amount of the at least one crystal protein and a nicotinic acetylcholine receptor agonist. The crystal proteins can be isolated from Bacillus thuringiensis and include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The nicotinic acetylcholine receptor agonist can be from the levamisole family, which include levamisole, pyrantel, and tribendimidine.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: August 19, 2014
    Assignee: The Regents of The University of California
    Inventors: Raffi V. Aroian, Yan Hu
  • Publication number: 20140223598
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:3-5, or the nucleotide sequence set forth in SEQ ID NO:2, as well as variants and fragments thereof.
    Type: Application
    Filed: July 27, 2012
    Publication date: August 7, 2014
    Applicant: Athenix Corp.
    Inventors: Kimberly S. Sampson, Duane A. Lehtinen
  • Publication number: 20140221207
    Abstract: A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, algae, arachnids, insects, fungi, weeds and nematodes) as well as methods for controlling algae using said species of Burkholderia. Also provided are natural products derived from a culture of said species and methods of controlling algae and/or arachnids using said natural products.
    Type: Application
    Filed: August 14, 2012
    Publication date: August 7, 2014
    Applicant: MARRONE BIO INNOVATIONS, INC.
    Inventors: Ratnakar Asolkar, Marja Koivunen, Pamela Marrone
  • Publication number: 20140194345
    Abstract: The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.
    Type: Application
    Filed: December 3, 2013
    Publication date: July 10, 2014
    Inventors: Aaron J. Peoples, Dallas Hughes, Losee Lucy Ling, William Millett, Anthony Nitti, Amy Spoering, Victoria Alexandra Steadman, Jean-Yves Christophe Chiva, Linos Lazarides, Michael Kenyon Jones, Karine Gaelle Poullenec, Kim Lewis
  • Patent number: 8759281
    Abstract: The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: June 24, 2014
    Assignee: Immune Targeting Systems Ltd.
    Inventors: Dominique Bonnet, Carlton B. Brown, Bertrand Georges, Philip J. Sizer
  • Publication number: 20140170124
    Abstract: The present disclosure provides a modified cecropin protein comprising a cecropin or a variant thereof fused to a hydrophilic tail lacking a C-terminal glycine. The present disclosure also provides pharmaceutical compositions, methods and uses of the modified cecropin protein or nucleic acid for treating or preventing endoparasites, such as Plasmodium, and bacteria.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 19, 2014
    Applicant: SOLARVEST BIOENERGY INC.
    Inventors: Subrata Chowdhury, Michael Thomas Horne
  • Patent number: 8734807
    Abstract: Schistosomiasis mansoni is caused by flukes called Schistosoma(es) that enters the human body through the skin in Schistosoma infested waters. The Schistosomes travel from the skin into human blood vessels where they mate, produce antigen containing eggs that travel from the blood vessels into the small intestines, where they are released in the human feces. Male and female Schistosome mates in human blood vessels, male Schistosomes secrete a protein called TGR ? protein to the Trk receptor sites on the females Schistosomes membranes. The process stimulates the formation of chemical SmInAct in female Schistosomes, a chemical necessary for the female Schistosomes to produce eggs. This novel technique describes new methods to inhibit Trk receptor sites on female Schistosome membranes using Trk inhibitor agent to prevent TGR ? proteins from binding to the Trk receptor sites. Thus, preventing SmInAct from being created in female Schistosomes, preventing production of eggs and Schistosomiasis.
    Type: Grant
    Filed: April 6, 2013
    Date of Patent: May 27, 2014
    Inventor: Gabriel Langlois-Rahme
  • Publication number: 20140080755
    Abstract: The invention provides methods for selecting nucleotide sequences that yield dsRNA-mediated gene suppression in a target organism and enable their uptake by the target organism. The invention further provides expression constructs that confer stabilized expression of such sequences in a transgenic host cell, and methods for their use. Also provided are organisms, cells and tissues prepared by a method of the invention.
    Type: Application
    Filed: August 6, 2013
    Publication date: March 20, 2014
    Applicant: Monsanto Technology LLC
    Inventors: Gregory R. Heck, Tichafa R.I. Munyikwa, Jean C. Goley, James K. Roberts, Scott C. Johnson, Ty T. Vaughn
  • Publication number: 20140056906
    Abstract: The invention provides human secreted proteins (SECP) and polynucleotides which identify and encode SECP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of SECP.
    Type: Application
    Filed: October 8, 2013
    Publication date: February 27, 2014
    Applicant: INCYTE CORPORATION
    Inventors: Henry Yue, Monique G. Yao, Ameena R. Gandhi, Mariah R. Baughn, Anita Swarnakar, Narinder Walia, Madhusudan M. Sanjanwala, Michael Thorton, Vicki S. Elliott, Yan Lu, Kimberly J. Gietzen, Neil Burford, Li Ding, April J. A. Hafalia, Y. Tom Tang, Olga Bandman, Bridget A. Warren, Cynthia D. Honchell, Dyung Aina M. Lu, Kavitha Thangaveln, Sally Lee, Yuming Xu, Junming Yang, Preeti G. Lal, Bao Tran, Craig H. Ison, Brendan M. Duggan, Stephanie Sapperstein
  • Publication number: 20140030218
    Abstract: A method of treating a patient having an autoimmune disease or a Th1 polarising infection or a condition associated with inflammation other than asthma or allergy, the method comprising administering to the patient a therapeutically effective amount of an inhibitor of Interferon Regulatory Factor 5 (IRF5).
    Type: Application
    Filed: January 5, 2012
    Publication date: January 30, 2014
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Irina Alexandrovna Udalova, Thomas Krausgruber, Marc Feldmann, David Saliba, Hayley Eames
  • Publication number: 20140033363
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2-5, or the nucleotide sequence set forth in SEQ ID NO: 1, as well as variants and fragments thereof.
    Type: Application
    Filed: March 29, 2012
    Publication date: January 30, 2014
    Applicant: ATHENIX CORP.
    Inventor: Kimberly Sampson
  • Patent number: 8609610
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: December 17, 2013
    Assignees: Trustees of Dartmouth College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Publication number: 20130303441
    Abstract: Novel peptide inhibitors of GSK-3, compositions containing same and uses thereof are disclosed. The novel peptide inhibitors are substrate-competitive inhibitors and have an amino acid sequence designed so as to bind to a defined binding site subunit in GSK-3.
    Type: Application
    Filed: January 26, 2012
    Publication date: November 14, 2013
    Applicants: Yeda Research and Development Co. Ltd., Ramot at Tel-Aviv University Ltd.
    Inventors: Hagit Eldar-Finkelman, Miriam Eisenstein
  • Publication number: 20130303440
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:28-62, or the nucleotide sequence set forth in SEQ ID NO:1-27, as well as variants and fragments thereof.
    Type: Application
    Filed: May 14, 2013
    Publication date: November 14, 2013
    Inventors: Kimberly S. Sampson, Daniel J. Tomso, Rong Guo
  • Publication number: 20130296230
    Abstract: A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from an intracellular organelle of the malaria parasite to an outside of the intracellular organelle and/or calcium ion entry from an outside of a cell of the malaria parasite into the cell.
    Type: Application
    Filed: October 27, 2011
    Publication date: November 7, 2013
    Applicant: RIKEN
    Inventors: Katsuhiko Mikoshiba, Masahiro Enomoto, Shin-Ichiro Kawazu
  • Publication number: 20130280297
    Abstract: The invention provides immunomodulatory proteins, e.g., useful to prevent, inhibit or treat microbial infection.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 24, 2013
    Inventors: Lori Neal, Laura Knoll, Erik Settles, Lindsey Anne Moser
  • Publication number: 20130237475
    Abstract: The present invention pertains to the field of production of recombinant proteins, using a synthetic gene for increased expression of the protein in Pichia pastoris. More specifically, the invention describes the production of a recombinant Sm14 protein of Schistosoma mansoni, by providing a synthetic gene for increased production of Sm14 protein, producing said gene and genetically manipulating the Pichia pastoris strain with said gene in order to produce a vaccine effectively. Improved methods are also provided for producing and purifying this protein from P. pastoris cells, which can be scaled for industrial production.
    Type: Application
    Filed: September 13, 2011
    Publication date: September 12, 2013
    Applicants: ALVOS - CONSULTORIA, DESENVOLVIMENTO E COMERCIALIZAÇÃO DE PRODUTOS BIOTECNOLÓGICOS S/A, FUNDAÇÃO OSWALDO CRUZ
    Inventors: Miriam Tendler, Celso Raul Romero Ramos, Andrew J.G. Simpson
  • Publication number: 20130217616
    Abstract: The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.
    Type: Application
    Filed: March 4, 2011
    Publication date: August 22, 2013
    Inventors: Peter Garred, Tina Hummelshøj Glue, Mikkel-Ole Skjødt
  • Publication number: 20130210712
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a delta-endotoxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated delta-endotoxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:13-24 or the nucleotide sequence set forth in SEQ ID NO:1-12 and 25-44, as well as variants and fragments thereof.
    Type: Application
    Filed: April 16, 2013
    Publication date: August 15, 2013
    Applicant: Athenix Corporation
    Inventor: Athenix Corporation
  • Publication number: 20130156697
    Abstract: The invention in suitable embodiments is directed to an isolated protein comprising one or more amino acid sequences, each amino acid sequence capable of being functionalized and/or attached in whole and/or in part to one or more or a plurality of elements of one or more types including to cargo elements, forming a composition of elements suitable for use as an in vivo and/or in vitro medicament to treat one or more biological species.
    Type: Application
    Filed: December 21, 2012
    Publication date: June 20, 2013
    Inventors: FRANCO VITALIANO, GORDANA DRAGAN VITALIANO
  • Publication number: 20130150289
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
    Type: Application
    Filed: February 1, 2013
    Publication date: June 13, 2013
    Applicant: Onyx Therapeutics, Inc.
    Inventor: Onyx Therapeutics, Inc.
  • Publication number: 20130150290
    Abstract: The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
    Type: Application
    Filed: February 1, 2013
    Publication date: June 13, 2013
    Applicant: Onyx Therapeutics, Inc.
    Inventor: Onyx Therapeutics, Inc.
  • Patent number: 8455431
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: June 4, 2013
    Assignees: Trustees of Dartmout College, Leiden University
    Inventors: Alexei Kisselev, Dmitry V. Filippov, Herman Overkleeft
  • Publication number: 20130133107
    Abstract: Compositions and methods for conferring nematicidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for nematicidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated nematicidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 8, 9, 13, 14, 47, 48, or 49, the nucleotide sequence set forth in SEQ ID NO:1, 2, 3, 6, 7, 10, 11, 12, 15, 45, or 46, as well as variants and fragments thereof.
    Type: Application
    Filed: January 23, 2013
    Publication date: May 23, 2013
    Applicant: ATHENIX CORPORATION
    Inventor: Athenix Corporation
  • Patent number: 8440612
    Abstract: The present invention relates to the use of nifurtimox for the treatment of giardiosis, in particular in dogs and cats.
    Type: Grant
    Filed: June 20, 2009
    Date of Patent: May 14, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Gisela Greif, Achim Harder, Thomas Bach, Gabriele Petry, Eva-Maria Kruedewagen
  • Patent number: 8440613
    Abstract: The present invention relates to the use of nifurtimox for the treatment of diseases caused by trichomonads, such as, for example, histomoniasis, in particular in turkeys.
    Type: Grant
    Filed: June 20, 2009
    Date of Patent: May 14, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Achim Harder, Gisela Greif, Robrecht Froyman
  • Publication number: 20130109619
    Abstract: A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.
    Type: Application
    Filed: May 11, 2011
    Publication date: May 2, 2013
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Nadya I. Tarasova, Giorgio Trinchieri, Howard A. Young, C. Andrew Stewart, Marco A. Cardone, Alan O. Perantoni
  • Publication number: 20130102527
    Abstract: The present invention is an inhibitor of the trypsin-like ?2/?2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the ?2/?2i site of a proteasome and treat a proteasome-mediated disease or condition are also described.
    Type: Application
    Filed: December 21, 2012
    Publication date: April 25, 2013
    Applicants: LEIDEN UNIVERSITY, TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Trustees Of Dartmouth College, Leiden University
  • Publication number: 20130097728
    Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be used in DNA constructs or expression cassettes for expression in plants and bacteria. Compositions include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, polynucleotide sequences and the toxin proteins encoded thereby are provided. Also provided are antibodies specifically binding to those amino acid sequences. In particular, the invention encompasses nucleotide sequences encoding fusion proteins, as well as biologically active variants and fragments thereof, wherein the fusion protein contains the C-terminal portion of SEQ ID NO:43. The fusion protein may also contain the N-terminal portion of SEQ ID NO:45.
    Type: Application
    Filed: April 4, 2012
    Publication date: April 18, 2013
    Inventors: Volker Heinrichs, Duane Lehtinen
  • Publication number: 20130096051
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and re-search use. In particular, the present invention provides antiviral and antimicrobial lectin compounds (BanLec) isolated from bananas. These compounds have low mitogenicity and pro-inflammatory activity whilst maintaining anti-HIV-1 activity.
    Type: Application
    Filed: April 11, 2011
    Publication date: April 18, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David Markovitz, Michael Swanson, Irwin Goldstein, Harry Winter
  • Patent number: 8415317
    Abstract: The invention provides adjuvants, immunogenic compositions, and methods useful for polynucleotide-based vaccination and immune response. In particular, the invention provides an adjuvant of cytofectin:co-lipid mixture wherein cytofectin is GAP-DMORIE.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: April 9, 2013
    Assignee: Vical Incorporated
    Inventor: Carl J. Wheeler
  • Patent number: 8404934
    Abstract: Compositions and methods for conferring nematicidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for nematicidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also include transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated nematicidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for isolated nucleic acid molecules including nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4, 5, 8, 9, 13, 14, 47, 48, or 49, the nucleotide sequence set forth in SEQ ID NO:1, 2, 3, 6, 7, 10, 11, 12, 15, 45, or 46, as well as variants and fragments thereof.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: March 26, 2013
    Assignee: Athenix Corporation
    Inventors: Cheryl L. Peters, Brian Vande Berg, Brian Carr, Julia T. Daum, Vadim Beilinson, Sandra Volrath, Candace Poutre, Kimberly Sampson
  • Patent number: 8377867
    Abstract: Treatments of trichomonas, propionibacterium, or yeast infection using an epinecidin-1 peptide or an anti-lipopolysaccharide factor peptide.
    Type: Grant
    Filed: January 11, 2010
    Date of Patent: February 19, 2013
    Assignee: Academia Sinica
    Inventors: Jyh-Yih Chen, Chia-Yu Pan
  • Publication number: 20130029844
    Abstract: The invention provides novel cyclotide polypeptides, and variants and fragments thereof, obtained from Butterfly pea and having pesticidal activity against nematodes. Particular embodiments of the invention provide isolated nucleic acids encoding pesticidal proteins, biopesticide compositions, expression cassettes, and transformed microorganisms and plants comprising a nucleic acid of the invention. These compositions find use in methods for controlling pests, especially plant-parasitic pests such as nematodes and insects.
    Type: Application
    Filed: April 4, 2012
    Publication date: January 31, 2013
    Applicant: PIONEER HI BRED INTERNATIONAL INC.
    Inventors: Daniel J. Altier, Xuehua Hu, Daniel L. Siehl, Jun-Zhi Wei, Gusui Wu