N-c(=x)-x-n Containing Patents (Class 514/477)
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Patent number: 11414396Abstract: Disclosed herein is a process of making a compound of formula I The compound of formula I is an inhibitor of MEK and thus can be used to treat cancer.Type: GrantFiled: August 26, 2020Date of Patent: August 16, 2022Assignees: Exelixis, Inc., Genentech, Inc.Inventors: Sriram Naganathan, Nathan Guz, Matthew Pfeiffer, C. Gregory Sowell, Tracy Bostick, Jason Yang, Amit Srivastava, Neel Kumar Anand
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Patent number: 11173120Abstract: The present invention related to aqueous lipid and/or liposome formulations with an increased chemical stability, to methods of preparing such aqueous formulations as well as to kits comprising them. The present invention further relates to methods of preparing lipid-based pharmaceutical compositions, to pharmaceutical compositions prepared by such methods and to methods of chemically stabilizing aqueous lipid and/or liposome formulations.Type: GrantFiled: September 17, 2015Date of Patent: November 16, 2021Assignee: BioNTech RNA Pharmaceuticals GmbHInventors: Heinrich Haas, Isaac Hernan Esparza Borquez
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Patent number: 8957060Abstract: Disclosed herein are solutions and kits for tumescent antibiotic delivery. Embodiments of the solution comprise an antibiotic component, an anesthetic component and a vasoconstrictor component. In addition, a method of use is disclosed comprising subcutaneous delivery of the solution. The disclosed solution, kit and method of subcutaneous delivery can be used for a variety of surgical procedures including liposuction, mastectomy and others. The tumescent antibiotic solution can be administered to a patient in situations where establishing IV access is difficult, impossible, or undesirable. A variety of delivery methods appropriate for surgical settings, as well as for use by first responders are likewise disclosed.Type: GrantFiled: May 30, 2012Date of Patent: February 17, 2015Inventor: Jeffrey Alan Klein
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Publication number: 20150033418Abstract: A first aspect of the invention is an agricultural composition comprising nanoparticles, an agrochemical active ingredient in the nanoparticles, and optionally (but in some embodiments preferably) a carrier for the nanoparticles. In some embodiments, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids. In some embodiments, the carrier comprises an inert or biodegradable carrier (e.g., a solid carrier) to which the nanoparticles are bound or in which the nanoparticles are suspended. In some embodiments, the carrier comprises inert or biodegradable polymer fibers.Type: ApplicationFiled: April 16, 2013Publication date: January 29, 2015Inventors: Steven A. Lommel, Julie Willoughby, Richard Guenther
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Patent number: 8916500Abstract: Active compound combinations are disclosed which comprise (A) a dithiino-tetracarboximide of formula (I) and a further insecticidally active compound (B). Methods for controlling animal pests such as insects and/or unwanted acarids and for curatively or preventively controlling the phytopathogenic fungi of plants or crops are also disclosed as well as the use of a composition according to the invention for the treatment of seed, to a method for protecting a seed and to the treated seed.Type: GrantFiled: April 17, 2013Date of Patent: December 23, 2014Assignee: Bayer Intellectual Property GmbHInventors: Thomas Seitz, Ulrike Wachendorff-Neumann, Heike Hungenberg, Peter Dahmen
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Patent number: 8846567Abstract: The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which R1 and A have the meanings given in the description and, secondly, at least one further known active compound from the class of the organophosphates or carbamates, which combinations are highly suitable for controlling animal pests such as insects and unwanted acarids.Type: GrantFiled: March 25, 2009Date of Patent: September 30, 2014Assignee: Bayer CropScience AGInventors: Heike Hungenberg, Peter Jeschke, Robert Velten, Wolfgang Thielert
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Publication number: 20140274685Abstract: The disclosure provides for methods for reducing dust by treating a seed with a dust reducing composition described herein. The disclosure also provides for methods of reducing exposure to vacuum planter dust released during seed planting by applying a composition described herein to a seed. Methods for increasing seed lubricity by coating a seed with a composition described herein are also provided for. Compositions and seeds useful in these methods are also described.Type: ApplicationFiled: March 5, 2014Publication date: September 18, 2014Applicant: BAYER CROPSCIENCE LPInventors: Yaodong HUANG, William HANSON, Philip M. Mathew, Smita PATEL, Justin ELDRIDGE
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Publication number: 20130178490Abstract: The present invention provides a composition having an excellent controlling activity on a pest. The composition comprising a compound represented by Formula (1) and one or more carbamate compound(s) selected from Group (A) shows an excellent controlling activity on a pest.Type: ApplicationFiled: October 13, 2011Publication date: July 11, 2013Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventors: So Kiguchi, Soichi Tanaka
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Patent number: 8398759Abstract: An ecologically compatible anti-microbial-adhesion agent is described, which is particularly suitable for use in anti-fouling paints, preferably for boats, characterized in that it comprises a compound selected from eugenol, vanillin, benzaldehyde substituted with one or two substituents selected from the groups —OH (hydroxy) and —OCH3 (methoxy), or any combination thereof. An anti-fouling paint is also described, particularly for boats, comprising the anti-microbial-adhesion agent mentioned above and other components selected from conventional biocides, solvents, resins, pigments, charges and fillings, and combinations thereof.Type: GrantFiled: May 12, 2009Date of Patent: March 19, 2013Assignee: Biopaint S.R.L.Inventors: Cecilia Calisti, Giulio Zanaroli, Fabio Fava, Alessandra Bontempi Di Roccaspada, Maurizio Ruzzi
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Publication number: 20120283095Abstract: The present invention relates to synergistic mixtures comprising, as active components, one insecticidal compound I selected from the group consisting of carbamates; and one fungicidal compound II selected from the group of strobilurines in synergistic effective amounts.Type: ApplicationFiled: November 29, 2010Publication date: November 8, 2012Applicant: BASF SEInventors: Markus Gewehr, Egon Haden, Lutz Brahm
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Publication number: 20110311503Abstract: The novel active ingredient combinations which consist of the compounds of the formula (I) in combination with further active insecticidal ingredients (II) are very suitable for control of animal pests such as insects and/or unwanted acarids.Type: ApplicationFiled: June 16, 2011Publication date: December 22, 2011Applicant: BAYER CROPSCIENCE AGInventors: Christian FUNKE, Heike HUNGENBERG, Rüdiger FISCHER
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Patent number: 8003119Abstract: The use of the polyamine known as spermidine, i.e., N-(3-aminopropyl)tetraminethylenediamine, as an active principle in the preparation of a composition for pharmaceutical or dietetic use in man for combating hair loss is disclosed.Type: GrantFiled: June 2, 2006Date of Patent: August 23, 2011Assignee: Giuliani S.p.A.Inventors: Fabio Rinaldi, Elisabetta Sorbellini, Valter Gatti, Danila Ingrid Marchioretto
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Patent number: 7999006Abstract: The present invention provides methods of treating cancer by administering a compound of Formula I, or a pharmaceutically acceptable salt or solvate thereof, in combination with other cancer treatments.Type: GrantFiled: December 14, 2007Date of Patent: August 16, 2011Assignee: Exelixis, Inc.Inventor: Peter Lamb
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Publication number: 20110160251Abstract: The present invention provides an animal ectoparasite control composition containing an insecticidal component and an adipate, and a method of controlling an animal ectoparasite which comprises administering an effective amount of the animal ectoparasite control composition to an animal.Type: ApplicationFiled: December 22, 2010Publication date: June 30, 2011Inventors: Naonobu NISHIGUCHI, Takahisa Hirayama, Kaori Ikari
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Patent number: 7935727Abstract: Compounds having a biphenyl group substituted with a phenyl or heteroaromatic group, as shown in Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:Type: GrantFiled: October 13, 2006Date of Patent: May 3, 2011Assignee: Merck Sharp & Dohme Corp.Inventors: Yi-Heng Chen, Zhijian Lu, Peter J. Sinclair
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Publication number: 20100255997Abstract: Compositions useful in the field of agricultural chemistry and methods for making and using the compositions are provided. Methods of improving the degree of efficacy of an active component or speed of action of an active component are also provided.Type: ApplicationFiled: June 18, 2010Publication date: October 7, 2010Applicant: CJB IndustriesInventor: David Miles
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Patent number: 7803839Abstract: Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.Type: GrantFiled: October 5, 2006Date of Patent: September 28, 2010Assignee: Exelixis, Inc.Inventors: Naing Aay, Neel Kumar Anand, Charles M. Blazey, Owen Joseph Bowles, Joerg Bussenius, Simona Costanzo, Jeffry Kimo Curtis, Steven Charles DeFina, Larisa Dubenko, Anagha Abhijit Joshi, Abigail R. Kennedy, Angie Inyoung Kim, Elena S. Koltun, Jean-Claire Limun Manalo, Csaba J. Peto, Kenneth D. Rice, Tsze H. Tsang
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Publication number: 20100113268Abstract: The invention relates to active compound combinations of chloronicotinyls with oxamyl and to the use of these mixtures for controlling animal pests.Type: ApplicationFiled: December 12, 2007Publication date: May 6, 2010Applicant: Bayer CropScience AGInventors: Wolfram Andersch, Heike Hungenberg, Roland Gallow
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Publication number: 20090099135Abstract: Embodiments of the present invention provide compositions for controlling a target pest including a pest control product and at least one active agent, wherein: the active agent can be capable of interacting with a receptor in the target pest; the pest control product can have a first activity against the target pest when applied without the active agent and the compositions can have a second activity against the target pest; and the second activity can be greater than the first activity.Type: ApplicationFiled: January 16, 2008Publication date: April 16, 2009Applicant: TyraTech, Inc.Inventor: Essam Enan
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Publication number: 20090099127Abstract: A nematicidal composition includes (a) at least one carbamate and (b) at least one neonicotinoid and/or chloronicotinyle. In one exemplary embodiment, the carbamate can be an oxime carbamate, such as thiodicarb and the neonicotinoid can be a nitroguanidine. In one specific embodiment, the nitroguanidine includes imidacloprid and/or clothianidin. An exemplary method of the invention includes applying a composition of the invention to either soil or a plant (e.g., seeds or foliarly) to combat nematode damage and/or increase crop yield.Type: ApplicationFiled: October 31, 2006Publication date: April 16, 2009Applicant: BAYER CROPSCIENCE LPInventors: Michael R. Schwarz, John E. Curtis
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Publication number: 20080306026Abstract: An encapsulated composition of (a) a pesticide at least active via ingestion that is photolabile, and (b) at least one photoprotectant, wherein the encapsulating polymeric barrier is base triggerable is disclosed. A method for controlling damage of a material by a pest by the use of such encapsulated compositions is likewise disclosed. The composition as disclosed gives protection for beneficial arthropods and reduces workers exposure.Type: ApplicationFiled: February 23, 2006Publication date: December 11, 2008Inventors: Ian Malcolm Shirley, Tanya Wright, Robert Michael Perrin, Patrick Mulqueen, Anne Waller, Andy Pierce
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Publication number: 20080287534Abstract: Disclosed is a method for protecting a plant planted in a growing medium from foliar insect pests comprising applying an insecticidally effective amount of a mixture comprising methomyl and oxamyl to the growing medium.Type: ApplicationFiled: February 14, 2006Publication date: November 20, 2008Inventors: Jon Stuart Claus, Gale Edwin Drake, Robert Mark Leighty, Frederick Walters Marmor
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Publication number: 20080101409Abstract: A method and apparatus analyze a compressed image code stream to determine logical boundaries of segments and parse the data stream into packets, wherein the packets are configured to reduce a number of partial logical segments in individual packetsType: ApplicationFiled: October 26, 2006Publication date: May 1, 2008Inventors: Matthew J. West, Paul S. Everest, John G. Apostolopoulos, Susie J. Wee
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Patent number: 7312244Abstract: Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided.Type: GrantFiled: November 8, 2001Date of Patent: December 25, 2007Assignee: Cellgate, Inc.Inventors: Linda Clifford, legal representative, Laurence J. Marton, Aldonia L. Valasinas, Venodhar K. Reddy, Benjamin Frydman, deceased
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Patent number: 6949574Abstract: The present invention relates to novel oxime carbamyl derivatives and pharmaceutical compositions comprising said derivatives which inhibit fatty acid amide hydrolase. These pharmaceutical compositions are useful for the treatment of conditions which can be effected by inhibiting fatty acid amide hydrolase including, but not limited to, neuropathic pain, emesis, anxiety, altering feeding behaviors, movement disorders, glaucoma, brain injury, and cardiovascular disease.Type: GrantFiled: February 4, 2003Date of Patent: September 27, 2005Assignee: Bristol-Myers Squibb CompanyInventors: Sing-Yuen Sit, Kai Xie, Hongfeng Deng
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Patent number: 6825014Abstract: The present invention relates to the preparation of compounds of formula (I): from the corresponding hydantoins by means of an enzymatic process. The L-compound is preferably formed.Type: GrantFiled: July 30, 2001Date of Patent: November 30, 2004Assignee: Degussa AGInventors: Hans-Peter Krimmer, Oliver May, Ingo Klement, Karlheinz Drauz, Dietmar Reichert
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Patent number: 6692754Abstract: The present invention relates to skin aging inhibitors and/or skin quality-improving agents comprising hydroxyproline, its N-acyl derivatives or salts thereof, and cosmetic compositions for inhibiting skin aging and/or improving skin quality comprising said skin aging inhibitors and/or skin quality-improving agents.Type: GrantFiled: August 30, 2001Date of Patent: February 17, 2004Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Makimoto, Asako Kobayashi, Toshihiro Sakakibara, Chiemi Takaboshi, Ayako Kamimura, Tomoya Takahashi, Minako Tajima, Yoichiro Takekoshi
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Publication number: 20030220352Abstract: The present invention is directed to a method for reducing the emetogenic effects of PDE inhibitors, and more particularly is directed to compounds having PDE4 inhibition activity with little or no emetogenic side-effects, and chemical methods including benzylation for preparing such compounds. A benzyl group may be attached to either a carbon or nitrogen atom of a PDE4 inhibitor. Suitable benzylation chemistry is to extract a hydrogen from a PDE4 inhibitor, preferably with a base, and then react the resulting nucleophilic PDE4 inhibitor with a benzylating agent, e.g., benzyl bromide or a derivative thereof.Type: ApplicationFiled: March 18, 2003Publication date: November 27, 2003Applicant: Inflazyme Pharmaceuticals Ltd.Inventors: Ronald W. Lauener, David L. Burgoyne, Patrick J. Rebstein, Lloyd F. MacKenzie, Yuanlin Zhou, Yaping Shen
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Patent number: 6593362Abstract: This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promoting hair growth, in treating infections with filarial and helmintic parasites, and in treating and preventing infections with the human immunodeficiency virus.Type: GrantFiled: May 21, 2001Date of Patent: July 15, 2003Assignee: Guilford Pharmaceuticals Inc.Inventors: Joseph P. Steiner, Gregory S. Hamilton
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Publication number: 20020091150Abstract: The present invention is a compound of formula 1Type: ApplicationFiled: December 10, 2001Publication date: July 11, 2002Inventors: Konrad Bleicher, Vincent Mutel, Eric Vieira, Jurgen Wichmann, Thomas Johannes Woltering
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Patent number: 6414031Abstract: There are disclosed bisoxime ether derivatives of the formula I in which the variables have the following meanings: R1 is halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy; n is 1 to 5, it being possible for the radicals R1 to be different if n is other than 1; R2 is C1-C4-alkyl, C3-C6-alkenyl or C3-C6-alkynyl, it being possible for these groups to be partially or fully halogenated; Q is C(═CHOCH3)—COOCH3, C(═CHCH3)—COOCH3, C(═NOCH3)—COOCH3 or C(═NOCH3)13 CONHCH3; and salts thereof, processes and intermediates for the preparation of these compounds, and their use for controlling animal pests and harmful fungi.Type: GrantFiled: November 2, 2000Date of Patent: July 2, 2002Assignee: BASF AktiengesellschaftInventors: Herbert Bayer, Roland Götz, Michael Keil, Hubert Sauter, Oliver Cullmann, Markus Gewehr, Wassilios Grammenos, Andreas Gypser, Bernd Müller, Arne Ptock, Eberhard Ammermann, Thomas Grote, Gisela Lorenz, Siegfried Strathmann, Volker Harries
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Patent number: 6290992Abstract: A method of termite control consists of injecting a foam formulation above ground into the walls of a structure infested with termites or other undesirable pests. The inner spaces of affected walls are flooded at and above ground level to ensure that the foam formulation reaches all passages open to the soil under the structure and establishes an above-ground layer of pest-control chemicals. The foam penetrates all porous material exposed to the injection and impregnates it with active ingredients that remain embedded in the material long after the foam disappears, thereby retaining the insecticidal, repellant and preservative properties of the active agents for a long time without exposure to normal degrading forces. The pest-control formulation preferably comprises pesticide, repellant and preservative components, and a foaming agent in a liquid carrier.Type: GrantFiled: July 10, 1998Date of Patent: September 18, 2001Inventor: Shelby J. Magnuson-Hawkins
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Patent number: 6235729Abstract: The present invention provides a method of inhibiting tumor progression in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Also provided is a method of inhibiting metastasis in an individual in need of such treatment, comprising the step of administering to said individual a pharmacologically effective dose of a phospholipase C inhibitor. Further provided are pharmaceutical compositions, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis and a pharmaceutically acceptable carrier and a pharmaceutical composition, comprising a phospholipase C inhibitor of tumor invasiveness and metastasis, a antineoplastic agent and a pharmaceutically acceptable carrier.Type: GrantFiled: March 25, 1997Date of Patent: May 22, 2001Assignee: UAB Research FoundationInventors: Philip Chen, Timothy Turner, Alan Wells
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Patent number: 6221885Abstract: Pesticidal compositions containing as active ingredients 3,5-dichloro-1-(3,3-dichloro-2-propenyloxy)-4-[3-(5-trifluoromethylpyridin-2-yloxy)pro poxy]benzene of the formula: and at least one carbamate compound selected from thiodicarb, methomyl and alanycarb have excellent pesticidal activity by their synergistic cooperative action.Type: GrantFiled: August 23, 1999Date of Patent: April 24, 2001Assignee: Sumitomo Chemical Company, LimitedInventor: Shigeru Saito
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Patent number: 6150406Abstract: A method for suppressing plant damage by nematodes which comprises the concurrent administration, to the locus, soil or seeds of plants in need of such treatment, of (a) a metabolite of the fungus Myrothecium verrucaria and (b) a chemical pesticide, as well as synergistic nematocidal compositions useful therein.Type: GrantFiled: April 17, 2000Date of Patent: November 21, 2000Assignee: Valent BioSciences, Inc.Inventors: Prem Warrior, Daniel F. Heiman, Linda A. Rehberger
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Patent number: 6114285Abstract: A method of chemically suckering trees of the families Musaceae (banana) and Plantaginaceae (plantains) which comprises introducing into a mother tree an amount of a composition effective to arrest apical dominance in the mother tree.A method of protection of two or more trees of the families Musaceae (banana) and Plantaginaceae (plantains) which share a common root system.Type: GrantFiled: February 18, 1999Date of Patent: September 5, 2000Assignee: Rhone Poulenc AgroInventors: Marvin Donaldo Mora Padilla, Juan Bocanegra, Jorge Cepeda
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Patent number: 6034137Abstract: This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.Type: GrantFiled: October 20, 1997Date of Patent: March 7, 2000Assignee: Syntex (U.S.A.) Inc.Inventors: Paula N. Belloni, Donald R. Hirschfeld, John O. Link, John J. Nestor, Jr., Gary A. Peltz
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Patent number: 5952316Abstract: 2-Amino-1,3-propanediol compounds of the formula (I) ##STR1## wherein R is an optionally substituted straight- or branched carbon chain, an optionally substituted aryl, an optionally substituted cycloalkyl or the like, and R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different and each is a hydrogen, an alkyl, an aralkyl, an acyl or an alkoxycarbonyl, pharmaceutically acceptable salts thereof and immunosuppressants comprising these compounds as active ingredients.The 2-amino-1,3-propanediol compounds of the present invention show immunosuppressive action and are useful for suppressing rejection in organ or bone marrow tranplantation, prevention and treatment of autoimmune diseases or as reagents for use in medicinal and pharmaceutical fields.Type: GrantFiled: August 14, 1997Date of Patent: September 14, 1999Assignees: Yoshitomi Pharmaceutical Industries, Ltd., Taito Co., Ltd.Inventors: Tetsuro Fujita, Shigeo Sasaki, Masahiko Yoneta, Tadashi Mishina, Kunitomo Adachi, Kenji Chiba
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Patent number: 5910323Abstract: This invention provides a novel aqueous pesticide formulation having a fungicidal bicarbonate-containing inorganic salt ingredient which enhances the efficacy of an insecticidal ingredient for treatment of cultivated crops. An invention pesticide formulation also contains a water-soluble organic compound which functions as a compatibility enhancing ingredient in the aqueous pesticide formulation, and improves the spreadability and adhesiveness of the composition ingredients when applied to foliage.Type: GrantFiled: October 21, 1993Date of Patent: June 8, 1999Assignee: Church & Dwight Co., Inc.Inventors: M. Stephen Lajoie, Amy L. Joseph, Keith A. Jones, Anthony E. Winston
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Patent number: 5889059Abstract: Phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is oxygen or sulfur;R is hydrogen or alkyl;R.sup.1 is hydrogen or alkyl;R.sup.2 is cyano, nitro, trifluoromethyl, halogen, alkyl or alkoxy;m is 0, 1 or 2, it being possible for the R.sup.2 radicals to be different if m is 2;R.sup.3 is hydrogen, cyano, nitro, hydroxyl, amino, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, alkylamino or dialkylamino;R.sub.Type: GrantFiled: August 5, 1996Date of Patent: March 30, 1999Assignee: BASF AktiengesellschaftInventors: Herbert Bayer, Hubert Sauter, Ruth Muller, Wassilios Grammenos, Albrecht Harreus, Reinhard Kirstgen, Franz Rohl, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5851988Abstract: Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## whereineach A is independently a proton-accepting substituent;each R is independently a noninterfering substituent;n is 0, 1, or 2; andeach linker is independently an isostere of --NHCONH-- or of --N.dbd.N-- or of --NHCO--.Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.Type: GrantFiled: January 15, 1997Date of Patent: December 22, 1998Assignee: Terrapin Technologies, Inc.Inventors: Richard Sportsman, Hugo O. Villar, Lawrence M. Kauvar, Wayne R. Spevak
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Patent number: 5821260Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignee: Emory UniversityInventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
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Patent number: 5807884Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: October 4, 1994Date of Patent: September 15, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5783596Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: June 7, 1995Date of Patent: July 21, 1998Assignee: Emory UniversityInventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
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Patent number: 5750351Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5747514Abstract: The present invention relates to therapeutically active hydroxamic acid and carboxylic acid derivatives, to processes for their preparation, to pharmaceutical compositions containing them, and to the use of such compounds in medicine. In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation, and in addition are inhibitors of the release of tumor necrosis factor from cells.Type: GrantFiled: July 19, 1996Date of Patent: May 5, 1998Assignee: British Biotech Pharmaceuticals LimitedInventors: Raymond Paul Beckett, Mark Whittaker, Andrew Miller, Fionna Mitchell Martin
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Patent number: 5723490Abstract: The present invention relates to a class of THF-containing sulfonamides which are aspartyl protease inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention.Type: GrantFiled: April 19, 1995Date of Patent: March 3, 1998Assignee: Vertex Pharmaceuticals IncorporatedInventor: Roger D. Tung
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Patent number: 5716979Abstract: The invention concerns tachykinin antagonists. The compounds are nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma and rheumatoid arthritis.Type: GrantFiled: October 8, 1996Date of Patent: February 10, 1998Assignee: Warner-Lambert CompanyInventors: David Christopher Horwell, William Howson, Martyn Clive Pritchard, Edward Roberts, David Charles Rees
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Patent number: 5599803Abstract: Insecticidal compositions, comprising normally-employed insecticides but comprising also an effective activity-enhancing amount of capsaicin or other capsaicinoid, especially in the form of capsicum, exhibit synergistic effects against numerous insects, including especially bud worms, boll worms, cabbage loopers, army worms, beet army worms, and beetles, and are especially effective on cotton, soybeans, common garden vegetables, and flowers, when sprayed on the insect or its habitat, especially as an aqueous solution, suspension, or emulsion. Larger crop stands may be effectively treated by aerial spraying from the usual crop-dusting airplane.Type: GrantFiled: September 29, 1995Date of Patent: February 4, 1997Assignee: Kalamazoo Holdings, Inc.Inventors: Gary C. Hainrihar, James G. Dubberly, John T. Greenlee
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Patent number: RE38915Abstract: Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula wherein each A is independently a proton-accepting substituent; each R is independently a noninterfering substituent; n is 0, 1, or 2; and each linker is independently an isostere of —NHCONH— or of —N?N— or of —NHCO—. Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.Type: GrantFiled: December 21, 2000Date of Patent: December 6, 2005Assignee: Telik, Inc.Inventors: Richard Sportsman, Hugo O. Villar, Lawrence M. Kauvar, Wayne R. Spevak