Plural N-c(=x)-x Groups Patents (Class 514/483)
-
Patent number: 6436421Abstract: The present invention relates to pesticide compositions. In particular, the present invention relates to pesticide compositions comprising a pesticide and a redispersible polymer and to a method for controlling agricultural pests by applying to the pest or the locus of the pest a pesticide composition comprising a pesticide and a redispersible polymer.Type: GrantFiled: February 27, 1998Date of Patent: August 20, 2002Assignee: ?Rohm and Haas CompanyInventors: Frederick James Schindler, Yili Guo, Gregory C. Pierce, James Allen Quinn
-
Publication number: 20020091146Abstract: Compositions and methods comprising an agent that reduces proteinuria in an individual are disclosed. Compositions and methods comprise an agent that reduces availability of a catalytic iron source in glomeruli. Agents of the invention include inhibitors of members of the cytochrome P450 (CYP) superfamily. In a particularly preferred embodiment, compositions and methods comprise an agent that inhibits ability of a CYP superfamily member to serve as a glomerular catalytic iron source, thereby reducing proteinuria in an individual afflicted with a glomerular disease.Type: ApplicationFiled: January 29, 2002Publication date: July 11, 2002Inventors: Sudhir V. Shah, Radhakrishna Ballga
-
Patent number: 6416789Abstract: A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mold and mildew when wood is treated with this combination. Also provided is wood treated by this combination, and a method of treatment for composite wood.Type: GrantFiled: January 5, 2001Date of Patent: July 9, 2002Assignee: Kop-Coat, Inc.Inventors: Brian Marks, Alan S. Ross, Hans A. Ward
-
Publication number: 20020045573Abstract: In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in accordance with the present invention, dithiocarbamates are linked to the surface of a non-immunogenic, non-targeting macromolecule other than an antibody (e.g., albumin protein) either by using cross-linking reagents or by nonspecific binding to produce polydithiocarbamate-macromolecule-containing compositions, which represent a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. In accordance with another aspect of the present invention, combinational therapeutic methods have been developed for the in vivo inactivation or inhibition of formation (either directly or indirectly) of species which induce the expression of inducible nitric oxide synthase, as well as reducing nitric oxide levels produced as a result of .NO synthase expression.Type: ApplicationFiled: October 1, 1999Publication date: April 18, 2002Inventor: CHING-SAN LAI
-
Patent number: 6331542Abstract: The present invention provides compounds which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease, comprising inhibiting said bone loss or excessive cartilage or matrix degradation by administering to a patient in need thereof a compound of the present invention.Type: GrantFiled: April 19, 2000Date of Patent: December 18, 2001Assignee: SmithKline Beecham CorporationInventors: Thomas Joseph Carr, Renee Louise Desjarlais, Timothy Francis Gallagher, Stacie Marie Halbert, Hye-Ja Oh, Scott Kevin Thompson, Daniel Frank Veber, Dennis Shinji Yamashita, Jack Hwekwo Yen
-
Patent number: 6319949Abstract: A method for preventing fungal diseases in crops which comprises the steps of: (a) applying to a crop an aqueous or a non-aqueous spray composition which includes a pesticide and a spray adjuvant including a solvent and an emulsifier, wherein the solvent is a mixture of aliphatic hydrocarbons having a distillation range of about 520 to 600° F. and an aromatic content of about 1% or less, or the solvent is a single or combination of C6-C18 fatty alcohol(s); and (b) applying chlorothalonil to the crop previously to, simultaneously with, or subsequently to the application of the aqueous spray composition, wherein phytotoxicity associated with the application of chlorothalonil is reduced or eliminated.Type: GrantFiled: November 4, 1996Date of Patent: November 20, 2001Assignee: Syngenta LimitedInventors: Jeffrey R. Schussler, Robert E. Moser, Kevin E. Crosby, John R. Washington
-
Patent number: 6315991Abstract: The present invention is directed to monomeric and polymeric compositions based upon polymeric urethane surfactants which are derived from linear, branched, or aromatic compounds of synthetic or natural origin, preferably from tertiary amines and diisocyanate compounds. The urethane polymers of the present invention may be in the form of betaines, quaternium salts, tertiary amine salts or N-oxides. The compounds of the present invention may be incorporated into personal care formulations such as cosmetics, dental care products and toiletries to improve at least one and preferably two or more characteristics of such formulations.Type: GrantFiled: March 24, 1999Date of Patent: November 13, 2001Assignee: Fleet Bank, National AssociationInventors: Albert Zofchak, Madeline Kenney, John Obeji, Michael Mosquera
-
Publication number: 20010034365Abstract: Enantiomeric forms of monocarbamates of halogenated 2-pheny-1,2 -ethanediol and dicarbamates of halogenated 2-pheny-1,2-ethanediol have been found to be effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents.Type: ApplicationFiled: January 31, 2001Publication date: October 25, 2001Inventors: Yong Moon Choi, Min Woo Kim, Jeonghan Park
-
Patent number: 6290992Abstract: A method of termite control consists of injecting a foam formulation above ground into the walls of a structure infested with termites or other undesirable pests. The inner spaces of affected walls are flooded at and above ground level to ensure that the foam formulation reaches all passages open to the soil under the structure and establishes an above-ground layer of pest-control chemicals. The foam penetrates all porous material exposed to the injection and impregnates it with active ingredients that remain embedded in the material long after the foam disappears, thereby retaining the insecticidal, repellant and preservative properties of the active agents for a long time without exposure to normal degrading forces. The pest-control formulation preferably comprises pesticide, repellant and preservative components, and a foaming agent in a liquid carrier.Type: GrantFiled: July 10, 1998Date of Patent: September 18, 2001Inventor: Shelby J. Magnuson-Hawkins
-
Publication number: 20010021378Abstract: There are described a flowable composition for controlling harmful insects and representatives of the order Acarina, comprising at least one pesticidally active compound, one or more signal substances selected from the group consisting of pheromones, kairomones and attractants, a UV absorber or a UV absorber mixture and, if appropriate, one or more additives selected from the group consisting of viscosity-regulating thickeners, fillers, solvents and other formulation auxiliaries,Type: ApplicationFiled: February 22, 2001Publication date: September 13, 2001Inventors: Dieter Hofer, Max Angst, Pierre-Joseph Charmillot
-
Patent number: 6288110Abstract: Disulfiram (tetraethylthiuram disulfide) is shown to inhibit angiogenesis and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and to prevent cell hyperproliferation and formation of clots along or around medical devices.Type: GrantFiled: July 10, 2000Date of Patent: September 11, 2001Assignee: Yeda Research and Development Co Ltd.Inventor: Moshe Marikovsky
-
Patent number: 6225345Abstract: The invention relates to compounds of formula (I): wherein R1 and R10 are each independently of the other lower alkoxycarbonyl; either R2, R3 and R4 are each independently of the other C1-C4alkyl and R7, R8 and R9 are each selected from hydrogen and C1-C4alkyl, with not more than 2 of the radicals being hydrogen; or R7, R8 and R9 are each independently of the other C1-C4alkyl and R2, R3 and R4 are each selected from hydrogen and C1-C4alkyl, with 1 or 2 of the radicals being hydrogen; R5 is phenyl or cyclohexyl; and R6 is phenyl or cyanophenyl; or salts thereof; those compounds are inhibitors of retroviral aspartate proteases and are effective, for example, against HIV.Type: GrantFiled: May 21, 1998Date of Patent: May 1, 2001Assignee: Novartis AGInventors: Alexander Fässler, Guido Bold, Hans-Georg Capraro, Marc Lang
-
Patent number: 6221896Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more compounds selected from the group consisting of benzoepin, nereistoxin-type insecticidal agents and diafenthiuron.Type: GrantFiled: May 24, 1999Date of Patent: April 24, 2001Assignee: American Cyanamid Co.Inventor: Toshiki Fukuchi
-
Patent number: 6177067Abstract: Disclosed is a hair revitalizing tonic composition containing a dimethylpropanediol derivative of the formula: wherein R1 and R2 are each independently a C1-30 hydrocarbon group which may be substituted, or a five- or six-membered heterocyclic group which contains 1 to 4 heteroatoms selected from oxygen, sulfur and nitrogen atoms and which may be substituted, R3 is hydrogen atom, an alkyl group which may be substituted, an acyl group, an alkoxycarbonyl group, a phenoxycarbonyl group, or a carbamoyl group which may be substituted, and a and b are each 0 or 1, as well as a method for effecting hair growth promotion, hair growth stimulation, or hair loss prevention in mammals by using such a hair revitalizing tonic composition. Also disclosed is the use of a compound of formula (I) in the preparation of a hair revitalizing tonic composition. Thus, this invention can provide an excellent means of hair revitalization or hair loss prevention in mammals.Type: GrantFiled: October 13, 1998Date of Patent: January 23, 2001Assignees: Shiseido Company, Ltd., Takeda Chemical Industries, Ltd.Inventors: Tsunao Magara, Yoshiharu Tsuji, Masahiro Tajima, Koji Kobayashi, Hirotada Fukunishi, Masazumi Watanabe
-
Patent number: 6130209Abstract: A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelles is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.Type: GrantFiled: April 24, 1998Date of Patent: October 10, 2000Assignee: University of South FloridaInventors: George R. Newkome, Charles N. Moorefield, Gregory Baker
-
Patent number: 6127412Abstract: The optically pure forms of monocarbamates of halogenated 2-phenyl-1,2-ethanediol and dicarbamates of 2-phenyl-1,2-ethanediol have been found to be effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents.Type: GrantFiled: July 8, 1999Date of Patent: October 3, 2000Assignee: SK CorporationInventors: Yong Moon Choi, Min Woo Kim, Jeonghan Park
-
Patent number: 6103768Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.Type: GrantFiled: September 8, 1997Date of Patent: August 15, 2000Assignee: Mycogen CorporationInventors: Steven D. Savage, Steven L. Evans, Robert A. Haygood, Paul S. Zorner, Keith Jones
-
Patent number: 6066656Abstract: The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to treat retroviral, specifically HIV and more specifically HIV-1 and HIV-2, infections in mammals, particularly humans, a method of synthesizing asymmetric DAD isosteres comprising benzamide, sulfonamide and anthranilamide subunits, and a method of using such compounds to assay new compounds for antiretroviral activity.Type: GrantFiled: March 16, 1998Date of Patent: May 23, 2000Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Ramnarayan S. Randad, John W. Erickson
-
Patent number: 6034117Abstract: This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl choline esterase inhibitor (CEI) such as pyridostigmine or a pharmaceutically acceptable salt thereof.Type: GrantFiled: September 21, 1998Date of Patent: March 7, 2000Inventors: Jan Hedner, Holger Kraiczi
-
Patent number: 6034123Abstract: Use of bambuterol or a pharmaceutically acceptable salt thereof for the manufacture of a pharmaceutical preparation with lipid lowering effect.Type: GrantFiled: November 17, 1998Date of Patent: March 7, 2000Assignee: Astra AktiebolagInventors: Carl-Axel Wilhelm Edvard Bauer, Leif .ANG.ke Svensson
-
Patent number: 6005002Abstract: The invention provides compounds of formula (I) and (II) wherein X and Y are independently chlorine, bromine, iodine, a mesyl group CH.sub.3 SO.sub.3 or a tosyl group OSO.sub.2 phenyl (wherein phenyl is optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from C.sub.1-4 alkyl, halogen, cyano or nitro; R.sup.1 and R.sup.2 are independently 1 to 4 optional substituents; Z.sup.1 and Z.sup.2 are each independently --O-- or --NH--; R.sup.3 is hydrogen, t-butyl or allyl; Z.sup.3 is a hydrocarbyl group such as carboxyethyl, optionally containing heteroatoms, and physiologically acceptable derivatives thereof. The compounds can be converted in situ into nitrogen mustard agents by the actions of enzymes such as carboxypeptidase or nitroreductase and are useful for the treatment of cancer.Type: GrantFiled: July 16, 1997Date of Patent: December 21, 1999Assignee: Cancer Research Campaign Technology LimitedInventors: Caroline Joy Springer, Ion Niculescu-Duvaz
-
Patent number: 5973000Abstract: The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, and a and b are 0 or 1, as well as its use. Thus, there is provided a hair revitalizing tonic composition having an excellent hair loss prevention and hair revitalizing effect and, moreover, an excellent dandruff and itchy scalp prevention effect.Type: GrantFiled: June 3, 1997Date of Patent: October 26, 1999Assignees: Shiseido Company, Ltd., Takeda Chemical Industries, Ltd.Inventors: Tsunao Magara, Yoshiharu Tsuji, Chika Hamada, Yosuke Nakazawa, Eriko Takeoka, Masahiro Tajima, Masazumi Watanabe
-
Patent number: 5942540Abstract: Methods are disclosed for prophylactically and chronically preventing symptomatic depression, neuronal cell injury and cell death in systemic and neurological conditions, populations with cerebrovascular risk factors, and invasive vascular procedures, employing a glycine-site antagonist at the NMDA (N-methyl-D-aspartate) complex e.g., 2-phenyl-1,3-propanediol dicarbamate (felbamate).Type: GrantFiled: October 10, 1997Date of Patent: August 24, 1999Inventor: Walter E. Kozachuk
-
Patent number: 5854283Abstract: The optically pure forms of monoocarbamates of halogenated 2-phenyl-1,2-ethanediol and dicarbamates of 2-phenly-1,2-ethaniediol have been found to be effective in the treatment of disorders of the central nervous system, especially as anti-convulsive or anti-epileptic agents.Type: GrantFiled: January 9, 1997Date of Patent: December 29, 1998Assignee: Yukong LimitedInventors: Yong Moon Choi, Min Woo Kim, Jeonghan Park
-
Patent number: 5851988Abstract: Modulation of the activity of the insulin receptor, enhancement of glucose uptake by cells, and other effects significant in the control and management of diabetes are accomplished using compounds of the formula ##STR1## whereineach A is independently a proton-accepting substituent;each R is independently a noninterfering substituent;n is 0, 1, or 2; andeach linker is independently an isostere of --NHCONH-- or of --N.dbd.N-- or of --NHCO--.Compounds in the genus of Formula (1) can also be used for structure activity studies to identify features responsible for the relevant activities.Type: GrantFiled: January 15, 1997Date of Patent: December 22, 1998Assignee: Terrapin Technologies, Inc.Inventors: Richard Sportsman, Hugo O. Villar, Lawrence M. Kauvar, Wayne R. Spevak
-
Patent number: 5837727Abstract: Use of bambuterol or a pharmaceutically acceptable salt thereof for the manufacture of a pharmaceutical preparation with lipid lowering effect.Type: GrantFiled: March 15, 1991Date of Patent: November 17, 1998Assignee: Astra AktiebolagInventors: Carl-Axel Wilhelm Edvard Bauer, Leif .ANG.ke Svensson
-
Patent number: 5773469Abstract: The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.Type: GrantFiled: June 18, 1996Date of Patent: June 30, 1998Assignee: Ortho Pharmaceutical CorporationInventors: Ramesh M. Kanojia, James P. Demers, Dennis J. Hlasta, Sigmond G. Johnson, Dieter H. Klaubert
-
Patent number: 5763364Abstract: The invention relates to thixotropic aqueous suspension concentrates of plant protection agents. The invention furthermore relates to the use of these agents in plant protection and the use of saponites as auxiliaries in the preparation of plant protection agent suspensions by wet grinding of the solid constituents.Type: GrantFiled: September 19, 1995Date of Patent: June 9, 1998Assignee: Hoechst Schering AgrEvo GmbHInventors: Gerhard Frisch, Thomas Maier
-
Patent number: 5728728Abstract: Novel methods are disclosed for treating acute and chronic neurological disease and attenuating further neuronal cell death in neurological diseases, employing a glycine site antagonist at the NMDA (N-methyl-D-aspartate) complex, e.g., 2-phenyl-1,3-propanediol dicarbamate (felbamate).Type: GrantFiled: April 10, 1996Date of Patent: March 17, 1998Inventor: Walter E. Kozachuk
-
Patent number: 5716968Abstract: Compositions having anti-inflammatory, antiviral and other activities are disclosed. The compositions are derived from phorboids of the diaminobenzyl alcohol- and diacylglycerol-classes.Type: GrantFiled: June 7, 1995Date of Patent: February 10, 1998Assignee: Procyon Pharmaceuticals, Inc.Inventors: Paul E. Driedger, James Quick
-
Patent number: 5709890Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 20, 1997Date of Patent: January 20, 1998Assignee: Donlar CorporationInventor: J. Larry Sanders
-
Patent number: 5698588Abstract: The pure enantiomeric forms, as well as enantiomeric mixtures excluding the racemic mixture of monocarbamates of 2-phenyl-1,2-ethanediol substituted with more than one halogen atom on the phenyl ring and dicarbamates of 2-phenyl-1,2-ethanediol substituted with more than one halogen atom on the phenyl ring have been found to be effective in the treatment of disorders of the central nervous system.Type: GrantFiled: January 16, 1996Date of Patent: December 16, 1997Assignee: Yukong LimitedInventors: Yong Moon Choi, Min Woo Kim
-
Patent number: 5656660Abstract: The present invention describes compounds, methods and compositions effective to treat mast cell mediated inflammatory conditions, such as conjunctivitis, asthma and allergic rhinitis. The compounds of the invention comprise novel mono- and di-aminomethylbenzyl, aminobenzyl, guanidylbenzyl and benzyl tryptase inhibitors. The compositions for treating mast cell mediated inflammatory conditions include oral, inhalant and topical preparations as well as devices comprising such preparations.Type: GrantFiled: May 31, 1995Date of Patent: August 12, 1997Assignee: Arris Pharmaceutical CorporationInventors: Robert T. Lum, Heinz W. Gschwend, Barr E. Bauer, Elaine Kuo, Ken Rice
-
Patent number: 5646133Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 14, 1996Date of Patent: July 8, 1997Assignee: Donlar CorporationInventor: J. Larry Sanders
-
Patent number: 5500446Abstract: A fungicidal mixture containinga) the oxime ether carboxamide of the formula I ##STR1## b) a dithiocarbamate (II) selected from the group - manganese ethylenebis(dithiocarbamate) (zinc complex) (IIa),- manganese ethylenebis(dithiocarbamate) (IIb),- zinc ammoniate ethylenebis(dithiocarbamate) (IIc) and- zinc ethylenebis(dithiocarbamate) (IId)in a synergistically active amount is described.Type: GrantFiled: September 15, 1994Date of Patent: March 19, 1996Assignee: BASF AktiengesellschaftInventors: Horst Wingert, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz, Reinhold Saur, Klaus Schelberger, Manfred Hampel
-
Patent number: 5462966Abstract: Methods for protecting warm-blooded animals against the formation of myocardial infarct through the administration of 2-phenyl-1,3-propanediol dicarbamate are disclosed.Type: GrantFiled: October 15, 1993Date of Patent: October 31, 1995Assignee: Carter-Wallace Inc.Inventor: Robert D. Sofia
-
Patent number: 5389674Abstract: Novel and improved fungicidal dithiocarbamate particulate compositions comprising one or more components selected from dithiocarbamates and bisdithiocarbamoyl disulfides and an effective amount of moisture content to significantly enhance the flowability of the particulate composition, reduce the dustiness of the composition, increase the bulk density of the composition and/or reduce the ethylenethiourea content of the composition. Methods for producing such particulate compositions are presented wherein controlled slurry production and spray-drying are effective in producing such compositions.Type: GrantFiled: July 12, 1993Date of Patent: February 14, 1995Assignee: Rohm and Haas CompanyInventor: Yili Guo
-
Patent number: 5373021Abstract: This invention discloses a rapid-diffusion injectable formulation, comprising disulfiram or a suitable salt or analog of disulfiram. Unlike slow-release injectable formulations designed to ensure that chronic alcoholics have significant quantities of disulfiram in their blood at all time, the rapid-diffusion injectable formulation disclosed herein is designed to reduce the hypoxic or ischemic damage caused by crisis events such as stroke, heart attack, cardiac arrest, or asphyxiation. A rapid-diffusion injectable formulation can contain disulfiram mixed with water, an organic compound having a plurality of hydroxyl groups (such as pharmaceutically acceptable glycols or polysaccharides; propylene glycol, dextrans, and cyclodextrins are often used for such purposes), and a buffer.Type: GrantFiled: April 26, 1993Date of Patent: December 13, 1994Assignee: Cypros Pharmaceutical CorporationInventor: Paul J. Marangos
-
Patent number: 5356931Abstract: Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1;m is 0, 1, 2, 3 or 4;R.sup.1 is cyano, cyanato, thiocyanato, nitro, hydroxyl, carboxyl, haloalkyl, haloalkoxy, unsubstituted or substituted cycloalkyl, cycloalkenyl, cycloalkadienyl, alkenyl, alkynyl or amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, unsubstituted or substituted benzyloxycarbonyl, benzoyl, phenylalkyl, phenylalkoxy or phenoxyalkyl,or R.sup.1 together with one of the radicals R.sup.2 forms an unsubstituted or substituted 1,3-butadiene-1,4-diyl group or an unsubstituted or substituted chain consisting of carbon members and an oxygen member, andR.sup.2 is halogen, unsubstituted or substituted alkyl, alkoxy, alkenyloxy, alkynyloxy, alkadienyloxy, benzyloxy or benzylthio, are used for controlling pests.Type: GrantFiled: January 4, 1993Date of Patent: October 18, 1994Assignee: BASF AktiengesellschaftInventors: Reinhard Kirstgen, Rainer Otter, Christoph Kuenast, Uwe Kardorff, Wolfgang Steglich, Gunda Bertram
-
Patent number: 5290808Abstract: Novel methods and compositions for the suppression of the desire for food consumption in warm-blooded animals consisting essentially of the administration of 2-phenyl-1,3-propanediol dicarbamate are disclosed.Type: GrantFiled: November 6, 1992Date of Patent: March 1, 1994Assignee: Carter-Wallace, Inc.Inventor: Robert D. Sofia
-
Patent number: 5256690Abstract: A method for treating and controlling the symptoms of neuropsychopharmacological disorders and neurodegenerative diseases associated with or resulting from excessive activation of the N-methyl-D-aspartate receptor complex which comprises administering to warm-blooded animals in need of such treatment, 2-phenyl-1,3-propanediol dicarbamate, the neuroprotective effects of which are at least partially mediated through a strychnine-insensitive glycine receptor mechanism is disclosed.Type: GrantFiled: October 26, 1992Date of Patent: October 26, 1993Assignee: Carter-Wallace, Inc.Inventor: Robert D. Sofia
-
Patent number: 5208236Abstract: Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: R.sup.1 and R.sup.3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino;R.sup.2 is H or hydroxy;R.sup.4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl;R.sup.6 is H or R.sup.7 --(CH.sub.2).sub.3 --, wherein R.sup.7 is amino or (aryllower alkoxy)carbonylamino;Q is --C(O)-- or --SO.sub.2 --;Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of the formula ##STR2## wherein A is a bond, --N(R.sup.5)--, or --O--; and R.sup.5 is H or lower alkyl;B is H or Z--(CH.sub.2).sub.m --Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, 1-pyrrolidino or 1-piperidino;m=1,2,3,4 or 5; and n=1,2 or 3; oror a pharmaceutically acceptable addition salt thereof; useful in the treatment of cardiovascular disorders, are disclosed.Type: GrantFiled: September 23, 1992Date of Patent: May 4, 1993Assignee: Schering CorporationInventor: Bernard R. Neustadt
-
Patent number: 5206264Abstract: A method is disclosed for reducing cardiovascular damage caused by hypoxic or ischemic events such as heart attack and cardiac arrest. This method involves the administration of disulfiram, or a suitable salt or analog of disulfiram, to a mammal in need of such treatment. Disulfiram can inhibit enzymes such as xanthine oxidase which would otherwise generate oxygenated free radicals, which are highly reactive chemical compounds that non-specifically attack and damage essential molecules and cells. It can also chelate copper and iron, thereby suppressing lipid peroxidation and protecting cell membranes from destruction. It also generates metabolites such as tryptophol which reduce the rate of metabolic activity in neurons and affected tissue, which can be useful during cytotoxic events. This invention also discloses injectable formulations that rapidly release disulfiram into the circulating blood.Type: GrantFiled: November 4, 1991Date of Patent: April 27, 1993Assignee: Cypros Pharmaceutical CorporationInventor: Paul J. Marangos
-
Patent number: 5189058Abstract: The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R.sub.1 and R.sub.2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, aralkyl, a hydrocarbon chain, a hetero group, or a heteroalkyl group, and the compounds are useful in treating atherosclerosis.Type: GrantFiled: April 9, 1991Date of Patent: February 23, 1993Assignee: Warner-Lambert CompanyInventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
-
Patent number: 5140044Abstract: A UCN-1028D derivative represented by the formula: ##STR1## has protein kinase C inhibitory activity and is expected to be used as an active ingredient in anti-tumor agents, etc.Type: GrantFiled: March 27, 1990Date of Patent: August 18, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Teruo Kishi, Hiromitsu Saito, Hiroshi Sano, Isami Takahashi, Tatsuya Tamaoki
-
Patent number: 5063241Abstract: A fungicidal composition comprising a fungicidally effective amount of (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which A is --CH.sub.2 Ch.sub.2 -- or --CH.dbd.CH--,or an addition product thereof with an acid or metal salt, and (ii) at least one member selected from the group consisting ofA) wettable sulphur,B) a polyhalogenoalkylthio derivative,C) a quanidine derivative,D) an aromatic carboxylic acid derivative,E) a dithiocarbamate,F) a benzimidazole derivative,G) an imidazole or triazole derivative,H) a phosphoric acid ester,I) a tetrahydroquinoline derivative,J) an S,N-heterocyclene compound,K) a urea derivative,L) a sulphonamide derivative,M) a polyhydroxy ether derivative,N) a triazine derivative,O) a copper complex salt,P) an N-formyl derivative,Q) a morpholine derivative,R) a quinoxaline derivative, andS) a dicarboximide derivative.Type: GrantFiled: August 14, 1990Date of Patent: November 5, 1991Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Gerd Hanssler, Paul Reinecke, Hans Scheinpflug, Graham Holmwood
-
Patent number: 5055489Abstract: A method for the prevention and control of hypoxic damage resulting from stroke or other cerebral ischemic event which comprises administering pharmaceutical compositions containing 2-phenyl-1, 3-propanediol dicarbamate as an active ingredient.Type: GrantFiled: May 4, 1990Date of Patent: October 8, 1991Assignee: Carter-Wallace, Inc.Inventor: Robert D. Sofia
-
Patent number: 5035878Abstract: Various types of biological treatments, including antineoplastic treatments with antineoplastic drugs, can result in damage to the blood-forming function of the bone marrow. This damage can be reversed, at least to some degree, with an effective amount (preferably an extremely low dose) of a pharmaceutically acceptable dithiocarbamic compound, including a compound of the formula R.sub.1 R.sub.2 NCSSM or R.sub.1 R.sub.2 NCSS-SCSNR.sup.3 R.sup.4, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different aliphatic or cycloaliphatic or heterocycloaliphatic groups, unsubstituted or substituted by hydroxyl, or one of R.sup.1 and R.sup.2 and one of R.sup.3 and R.sup.4 can be H, or R.sup.1 and R.sup.2 or R.sup.3 and R.sup.Type: GrantFiled: October 10, 1989Date of Patent: July 30, 1991Assignee: University of RochesterInventors: Richard F. Borch, Therese K. Schmalbach
-
Patent number: 4987130Abstract: Substituted amino derivatives represented by the formula: ##STR1## wherein R.sup.1 and R.sup.2 each stand for an acyclic hydrocarbon residue or an alicyclic hydrocarbon residue; R.sup.3 and R.sup.4 each stand for hydrogen or a hydrocarbon residue optionally containing hetero-atom(s); A stands for a carbon chain having two or more carbon atoms optionally containing ether linkage or sulfide linkage, which may be substituted and which may per se form a ring; X.sup.1 and X.sup.2 each stand for oxygen atom or sulfur atom; and Y stands for amino group or an organic residue bonded through nitrogen atom, which may form a ring by combining with a carbon atom constituting A; and their salts have anti-arrhythmic activity and are useful for prevention and treatment of a variety of arrhythmias.Type: GrantFiled: December 22, 1989Date of Patent: January 22, 1991Assignee: Takeda Chemical Industries, Ltd.Inventors: Susumu Tsushima, Muneo Takatani, Minoru Hirata
-
Patent number: 4976769Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl, phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.Type: GrantFiled: October 18, 1989Date of Patent: December 11, 1990Assignee: Kao CorporationInventor: Tetsuji Iwasaki