Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.

Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.

Abstract: Patients can be helped to break free of addictive or habit-forming narcotics and anti-depressants, by treatment using two drugs. One drug is dextromethorphan (DM), which has been used for decades as an anti-tussive (cough-suppressing) drug in cough syrups. The other drug is an oxidase inhibitor which suppresses activity of a liver enzyme called cytochrome P450-2D6 (also called debrisoquin hydroxylase, sparteine monooxygenase, cytochrome P450-DB, and CYP2D6). In most patients, this oxidase enzyme rapidly degrades DM and converts it into a metabolite called dextrorphan. An oxidase inhibitor (such as quinidine) which suppresses cytochrome P450-2D6 activity increases the half-life and concentration of DM in the circulating blood. When this combined treatment was administered orally to patients who had become dependent on morphine and anti-depressant drugs because of chronic intractable pain, it initially helped the patients reduce their dosages of morphine and other drugs, including anti-depressants.

Abstract: A composition comprising effective amounts of a) a carbamate of the formula I where X is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, and b) a dithiocarbamate (II) selected from the group consisting of manganese ethylenebis(dithiocarbamate) (zinc complex) (IIa), manganese ethylenebis(dithiocarbamate) (IIb), zinc ammoniate ethylenebis(dithiocarbamate) (IIc) and zinc ethylenebis(dithiocarbamate) (IId) and optionally c) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (III) H3CCH2—NHCONH—CO—C(CN)═NOCH3  (III) which exhibits a synergistically enhanced fungicidal effect is described.

Abstract: A method for combatting plant fungi in a plant, which comprises applying to the seeds or tubers of the plant, an effective amount of a fungicidal composition comprising a fungicidally effective amount of a 2-alkoxyiminoacetamide compound, optionally in admixture with one or both of an alkylene bis-dithiocarbamate complex salt and a thiophanate compound. Fungicidal compositions comprising a fungicidally effective amount of a 2-alkoxyimino-acetamide compound, an alkylene bis-dithiocarbamate complex salt, and a thiophanate compound, are also described.

Abstract: A fungicidal mixture comprisinga) an oxime ether of the formula I ##STR1## where the substituents have the following meaning: X is oxygen or amino (NH);Y is CH or N;Z is oxygen, sulfur, amino (NH) or C.sub.1 -C.sub.4 -alkylamino (N--C.sub.1 -C.sub.4 -alkyl);R' is C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -haloalkyl, C.sub.3 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -haloalkenyl, C.sub.3 -C.sub.6 -alkynyl, C.sub.3 -C.sub.6 -haloalkynyl, C.sub.3 -C.sub.6 -cycloalkylmethyl, or benzyl which may be partially or fully halogenated and/or may carry one to three of the following radicals: cyano, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkoxy and C.sub.1 -C.sub.

Abstract: The invention described here concerns the unique utility of fatty acids and their derivatives to eradicate existing fungal and bacterial infections in plants. Also, described herein are combination treatments whereby fatty acids are used to enhance or augment the activity of fungicides, bactericides, and biological control agents.

Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description,with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.

Abstract: There are described new active compound combinations of a compound of the formula (I) ##STR1## with known fungicidal active compounds, and their use for combating phytopathogenic fungi.

Abstract: This invention is directed towards stabilizing the biocidal activity of an alkyd composition containing a halopropargyl compound and a transition metal drier by use of a chelating agent.

Abstract: A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharmaceutically acceptable acid or a combination of pharmaceutically acceptable acids. The solution can optionally be encapsulated in hard gelatin capsules or soft elastic gelatin capsules. The solution can optionally be granulated with a pharmaceutically acceptable granulating agent.

Abstract: A fungicidal mixture comprisesa) an oxime ether carboxamide of the formula I ##STR1## where R is hydrogen or halogen andb) a dithiocarbamate (II) selected from the group consisting ofmanganese ethylenebis(dithiocarbamate) (zinc complex) (IIa),manganese ethylenebis(dithiocarbamate) (IIb),zinc ammoniate ethylenebis(dithiocarbamate) (IIc) andzinc ethylenebis(dithiocarbamate) (IId)in a synergistically active amount.

Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates along with a chemotherapeutic agent and optionally a potentiator. A composition for treating viral infections in animals or humans comprising a safe and effective amount of N-chlorophenylcarbamates and the N-chlorophenylthiocarbamates and a potentiator is also disclosed.

Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.

Abstract: A fungicidal mixture comprisinga) the oxime ether carboxylic ester of the formula I ##STR1## and b) a dithiocarbamate (II) selected from the group consisting ofmanganese ethylenebis(dithiocarbamate) (zinc complex) (IIa),manganese ethylenebis(dithiocarbamate) (IIb),zinc ammoniate ethylenebis(dithiocarbamate) (IIc) andzinc ethylenebis(dithiocarbamate) (IId)in a synergistically effective amount.

Abstract: Fungicidal mixtures comprisinga) the oxime ether carboxylic ester of the formula I ##STR1## and b) 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (II)H.sub.3 CCH.sub.2 --NHCONH--C (CN).dbd.NOCH.sub.3 IIin a synergistically effective amount.

Abstract: Methods are disclosed for increasing the effectiveness of dextromethorphan in treating chronic or intractable pain, for treating tinnitus and for treating sexual dysfunction comprising administering dextromethorphan in combination with a therapeutically effective dosage of a debrisoquin hydroxylase inhibitor. A preferred combination is dextromethorphan and the oxidative inhibitor quinidine.

Abstract: In accordance with the present invention, there are provided in vivo methods for the reduction of cyanide levels. The present invention employs a scavenging approach whereby cyanide is bound in vivo to a suitable scavenger. The resulting complex renders the cyanide harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods.

Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of nitric oxide levels in a mammalian subject. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function of the enzymes responsible for nitric oxide production is inhibited), the present invention employs a scavenging approach whereby overproduced nitric oxide is bound in vivo to a suitable nitric oxide scavenger. The resulting complex renders the nitric oxide harmless, and is eventually excreted in the urine of the host. An exemplary nitric oxide scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-ferrous iron complex. This complex binds to .NO, forming a stable, water-soluble NO-containing complex having a characteristic three-line spectrum (indicative of a mononitrosyl-Fe complex) which can readily be detected at ambient temperatures by electron paramagnetic resonance (EPR) spectroscopy.

Abstract: The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.

Abstract: In accordance with the present invention, there are provided combinational therapeutic methods for the in vivo inactivation or inhibition of formation (either directly or indirectly) of species which induce the expression of nitric oxide synthase, as well as reducing nitric oxide levels produced as a result of .NO synthase expression. In contrast to the inhibitory approach described in the prior art (i.e., wherein the function of the enzymes responsible for nitric oxide production is inhibited), the present invention employs a combination of inactivation (or inhibition) and scavenging approach whereby the stimulus of nitric oxide synthase expression is inactivated, or the production thereof is inhibited, and overproduced nitric oxide is bound in vivo to a suitable nitric oxide scavenger. The resulting complexes render the stimulus of nitric oxide synthase expression inactive (or inhibit the production thereof), and nitric oxide harmless.

Abstract: A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharmaceutically acceptable acid or a combination of pharmaceutically acceptable acids. The solution can optionally be encapsulated in hard gelatin capsules or soft elastic gelatin capsules. The solution can optionally be granulated with a pharmaceutically acceptable granulating agent.

Abstract: A method for controlling phytopathogenic fungi comprises applying a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of manganese-zinc ethylenebis(dithiocarbamate), manganese ethylenebis(dithiocarbamate), zinc ammoniate ethylenebis(dithiocarbamate), zinc ethylenebis(dithiocarbamate), 2-cyano-N-((ethylamino)carbonyl)-2-(methoxyimino)acetamide, and (E,Z) 4-(3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl)morpholine to plant seed, to plant foliage or to a plant growth medium and provides higher fungicidal activity than separate use of the same compounds.

Abstract: Fungicidal compositions for the protection of turfgrass against crown and root rot are disclosed. The compositions comprise, as the active material, a mixture of (a) a monoester salt of a phosphorous acid (preferably aluminum ethyl phosphite), and (b) an ethylene bisdithiocarbamate contact fungicide (preferably manganese-zinc ethylene bisdithiocarbamate). Preferred compsitions comprise one part by weight of the monosester salt to two parts by weight of the ethylene bisdithiocarbamate.

Abstract: When used in admixture with mancozeb, chlorothalonil, a copper salt, folpet, fluazinam or cymoxanil (it being possible for the latter to be used also together with one of the other five components), metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly increased fungicidal action against plant diseases as compared with a similar mixture in which metalaxyl is used in the form of the racemate.

Abstract: Fungicidal compositions for the protection of turfgrass against crown and root rot are disclosed. The compositions comprise, as the active material, (a) a monoester salt of a phosphorous acid (preferably aluminum ethyl phosphite), (b) an ethylene bisdithiocarbamate contact fungicide (preferably manganese-zinc ethylene bisdithiocarbamate), and (c) a benzoporphyrin compound. Preferred compositions comprise 1 part by weight of the monoester salt, 2 parts by weight of the ethylene bisdithiocarbamate, and between about 0.01 and about 0.1 parts by weight of the benzoporphyrin compound.

Abstract: The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.

Abstract: Synergistic mixtures which include dimethomorph and cymoxonil in a fungicidially effective aggregate amount, and the use of such mixtures in the control of plant diseases. In certain embodiments, a contact fungicide is included, along with the dimethomorph and cymoxonil in suitable ratios.

Abstract: A vitamin C supplement comprising ascorbic acid, ascorbyl palmitate, niacinamide ascorbate, calcium ascorbate, magnesium ascorbate, potassium ascorbate, and sodium ascorbate which together can be administered to a human to avoid the transitory initial suppression of human NK cell activity which is present when ascorbic acid alone is administered. Also included is xylitol, lysine acetate, tetrasodium pyrophosphate, ribose, cysteine, and hesperidin which further prolongs the biological activity of ascorbic acid and promotes the uptake of ascorbic acid by human tissue.

Abstract: The present invention relates to novel substituted benzothiazepines and benzoxazepines of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.7, R.sup.8, R.sup.9 and X are as defined below, and to novel intermediates used in the synthesis of such compounds.Such compounds are useful in the treatment and prevention of gastrointestinal disorders, pain and anxiety disorders.

Abstract: This invention provides a dry blend pesticide composition which contains a fungicidal bicarbonate salt ingredient, and a spreader-sticker ingredient which is a crystalline clathrate complex of a urea constituent and a normally liquid spreader sticker constituent such as a nonionic surfactant. In a preferred embodiment all of the composition ingredients are water-soluble, and the composition is readily dispersible in an aqueous medium to form a sprayable pesticide solution.

Abstract: The invention provides fungicidal combinations comprising:(a) a compound of formula A ##STR1## wherein each of R.sub.1 and R.sub.2, which are identical or different, is H, Hal or optionally halogenated lower alkyl, and each of R.sub.3 and R.sub.4, which are identical or different, is (C.sub.1 -C.sub.4) alkyl, and(b) at least one compound B selected from the group consisting of maneb, mancozeb, folpet, a copper derivative, phosethyl-Al or phosphorous acid or one of its alkali metal or alkaline-earth metal salts, chlorothalonil, fluazinam, an acylalanine, an acetamide, a methoxyacrylate or a methoxyiminoacetate.Fungicidal compositions comprising the combination and methods for curatively and preventatively treating plants against fungal disease are also provided.

Abstract: The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.

Abstract: A method of controlling the attachment of organisms to an underwater surface is disclosed. The method comprises contacting the organisms with a compound of Formula I ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each independently hydrogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, halogen, or hydroxyl. Antifouling coatings and cementitious compositions containing a compound of Formula I are also disclosed.

Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.

Abstract: This invention provides a fungicide composition which is capable of in situ generation of ammonium bicarbonate when applied to plant foliage in the form of an aqueous dispersion. The constituents include (1) an ingredient such as urea which slow-releases ammonia under aqueous alkaline pH conditions; and (2) an alkali metal bicarbonate ingredient which imparts alkalinity to the aqueous dispersion, and provides bicarbonate ions for combination with the released ammonium ions. A spreader-sticker ingredient is included to maintain the ingredients in contact with plant foliage over an extended period after application.

Abstract: Fungicidal compositions for the protection of turfgrass against crown and root rot are disclosed. The compositions comprise, as the active material, a mixture of (a) a monoester salt of a phosphorous acid (preferably aluminum ethyl phosphite), and (b) an ethylene bisdithiocarbamate contact fungicide (preferably manganese-zinc ethylene bisdithiocarbamate). Preferred compositions comprise one part by weight of the monosester salt to two parts by weight of the ethylene bisdithiocarbamate.

Abstract: The present invention relates to a process for the control of fungal disease of plants by applying to the leaves of the plants:a) 2-(4-chlorobenzylidene)-5,5-diemethyl-1-(1H-1,2,4-triazol-1-ylmethyl)-1-cy clopentanol;b) one or more fungicides suitable for protecting against the said fungal diseases and to compositions which may be used in the process.

Abstract: Fungicidal compositions comprise a combination of two fungicides, one of which is a quinoline or cinnoline compound of the formula (1) ##STR1## the substituents being as described in the specification.

Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.

Abstract: The invention relates to a lipid compound of formula (I): ##STR1## where R.sub.1 denotes a C.sub.11 to C.sub.21 alkyl or alkenyl radical and R.sub.2 denotes a linear or branched C.sub.8 to C.sub.30 hydrocarbon radical, saturated or bearing one or more ethylenically unsaturated bonds, and also to a process for preparing it and to compositions for cosmetic use or pharmaceutical use for skin conditions containing this compound.

Abstract: A pharmaceutical composition is used to treat and prevent a diabetes-dependent type of autoimmune diseases, said pharmaceutical composition comprising a therapeutically effective amount of 3-oxygermylpropionic acid represented by the following formula:[(O.sub.1/2).sub.3 GeCH.sub.2 CH.sub.2 CO.sub.2 H].sub.nwherein n stands for an integer of 1 or more, optionally with an activating carrier.

Abstract: A novel composition and/or method for the treatment of alcoholism, wherein the composition comprises a therapeutically effective dosage of disulfiram and a drug that affects the neurological system in a manner similar to alcohol, preferably a habit-forming or addictive drug. The method comprises administering a composition to alcoholics that combines therapeutically effective dosages of disulfiram and a habit-forming or addictive drug into a single composition. Preferably, the habit-forming or addictive medication is an anti-anxiety drug and is a member of the benzodiazepine family. Most preferably, the habit-forming, anti-anxiety drug is diazepam.

Abstract: A synergistic antimicrobial composition comprising 4,5-dichloro-2-n-octyl-3-isothiazolone or 2-methyl-3-isothiazolone and ferric dimethyldithiocarbamate, in a ratio to each other which exhibits synergism is disclosed.

Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.

Abstract: Foam compositions containing a herbicide or pesticide which are readily absorbed systemically by plant life are made by incorporating a gas such as air into a composition made up of an alcohol, a modified coconut acid or a blend of nonionic and anionic surfactants, water and a systemic herbicide or pesticide. These foam compositions are applied directly to plant life such as trees and are absorbed within three minutes, often within one minute.

Abstract: There is described a fungicidal composition which comprises a synergistic amount of(a) propyl 3-(dimethylamino)propylcarbamate or an acid addition salt thereof, and(b) a compound selected from the group consisting of zinc propylenebis(dithiocarbamate) polymer (propineb), zinc ethylenebis(dithiocarbamate) polymer (zineb), manganese ethylenebis(dithiocarbamate) polymer (maneb), zinc ammoniate ethylenebis(dithiocarbamate)-poly(ethylenethiuramdisulphide) (metiram), tetrachloroisophthalonitrile (chlorothalonil) and copper(I)oxide, as well as carriers and/or other additives,the ratio of component A to component B being preferably from about 1:0.1-3.

Abstract: Synergistic fungicidal compositions comprising (i) a substituted 1-hydroxyethyl-triazole of the formula ##STR1## in which R.sup.1, R.sup.2, X, Y and A have various meanings, or addition products thereof with acids or metal salts, and (ii) at least one of(A) wettable sulphur,(B) a polyhalogenoalkylthio derivative,(C) a guanidine derivative,(D) an aromatic acid lactone,(E) a dithiocarbamate,(F) a benzimidazole derivative,(G) an imidazole or triazole derivative,(H) a phosphoric acid ester,(I) a tetrahydroquinoline derivative,(J) an S,N-heterocyclic compound,(K) a urea derivative,(L) a sulphonamide derivative,(M) a polyhydroxyether derivative,(N) a triazine derivative,(O) a copper-hydroxy quinoline complex,(P) an N-formul derivative,(Q) a morpholine derivative,(R) a quinoxaline derivative, and(S) a dicarboxamide derivative.

Abstract: The invention provides a fungicidal composition comprising at least one systemic, contact and/or soil fungicide and at least one acrylic acid morpholide derivative of the general formula ##STR1## in which R.sub.1 represents a hydrogen, chlorine or bromine atom, a trifluoromethyl, trifluoromethoxy, C.sub.3 -C.sub.7 alkyl, C.sub.3 -C.sub.5 alkoxy, C.sub.3 -C.sub.6 alkenyl, HClFC--CF.sub.2 O--, HClC.dbd.CClO--, cyclohexyl, cyclopentenyl, cyclohexenyl, phenyl, 4-chlorophenyl, 4-ethylphenyl, 4-chlorobenzyl or 4-chlorophenylthio group or a phenoxy group optionally substituted by one or more substituents selected from fluorine and chlorine atoms and methyl and ethoxycarbonyl groups and R.sub.2 represents a hydrogen atom, or R.sub.1 represents a hydrogen atom and R.sub.2 represents a 3-phenoxy group.

Abstract: The instant invention concerns a wood preservative composition comprising a synergistically effective amount of (a) a cuprammonium compound and (b) tebuconazole to preserve wood.