Gold Or Silver Patents (Class 514/495)
  • Patent number: 10160773
    Abstract: A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl2]Cl.2H2O (1) or [Au(npen)2]Cl3 (2); the complexes, and methods for making them.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 25, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein A. Isab, Muhammad Altaf
  • Patent number: 10144835
    Abstract: A coating composition comprising an oxidized ?-olefin having 16 to 40 carbon atoms and one or more carboxylic acid or ester groups; a hydrocarbon-soluble ester-containing polymer having at least one branch of 10 to 36 carbon atoms and having a number average molecular weight of 5000 to 300,000; a carboxylic acid of at least 10 carbon atoms; a salt of an alkylarylsulfonic acid; an oil in an amount sufficient to dissolve said metal salt; and optionally, a volatile diluent, provides good rust protection.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: December 4, 2018
    Assignee: The Lubrizol Corporation
    Inventors: Jennifer E. Clark, Ben Faber, Gregory E. Moran, Britt A. Minch, David Boothe, Hannah Greenfield, Pedro J. Velis, David J. Moreton
  • Patent number: 10111892
    Abstract: The anti-cancer agent of the present invention contains at least one kind of phosphine transition metal complex selected from a group of compounds represented by the following Formulae (1a) to (1d). According to this anti-cancer agent, an anti-cancer agent is provided which has a higher anti-cancer activity and lower toxicity compared to anti-cancer agents in the related art. In Formulae (1a), (1b), (1c), and (1d), R1 and R2 represent a linear or branched alkyl group, and R1 has a higher priority than R2 as ranked according to RS notation. R3 and R4 represent a hydrogen atom or a linear or branched alkyl group. M represents an atom of a transition metal selected from a group consisting of gold, copper, and silver. X? represents an anion.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: October 30, 2018
    Assignee: Nippon Chemical Industrial Co., Ltd.
    Inventors: Nobuhiko Oohara, Kazuhiro Nakatsui
  • Patent number: 10092579
    Abstract: Monomeric and dimeric gold(I) complexes as anticancer agents. The gold(I) complexes are coordinated to mixed ligands: one phosphine-based ligand that may be monodentate or bidentate and at least one dithiocarbamate-based ligand that is monodentate. Pharmaceutical compositions incorporating the gold(I) complexes, methods of synthesis, methods of treating cancer and methods of inhibiting cancer cell proliferation and inducing cancer cell apoptosis are also provided.
    Type: Grant
    Filed: May 4, 2017
    Date of Patent: October 9, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Muhammad Altaf, Muhammad Monim-Ul-Mehboob, Anvarhusein Abdulkadir Isab, Saleh Altuwaijri
  • Patent number: 9994592
    Abstract: A method for treating a proliferative disease, disorder, or condition comprising administering a gold(III) complex such as [Au(npen)Cl2]Cl.2H2O (1) or [Au(npen)2]Cl3 (2); the complexes, and methods for making them.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: June 12, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein A. Isab, Muhammad Altaf
  • Patent number: 9880170
    Abstract: A method for treating cancer and gold(III) complexes with diaminocyclohexane ligand as anticancer agents. Also described are a pharmaceutical composition incorporating the gold(III) complexes and a method of synthesizing the gold(III) complexes.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: January 30, 2018
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Anvarhusein A. Isab, Muhammad Altaf
  • Patent number: 9034393
    Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: May 19, 2015
    Assignee: SCIESSENT LLC
    Inventor: Joseph J. Crudden
  • Patent number: 9023370
    Abstract: The present invention relates to conjugates of formula (I) having colloidal stability in a medium, wherein NP is a gold, silver or platinum nanoparticle; L is a linker selected from the group consisting of formula (II), formula (III), and a stereoisomer of any of the formulas (II) and (III), which is attached to the nanoparticle NP through sulfur atoms; wherein the meanings of X, n, p, Y and s are further specified in the description; and A is a platinum (II) biradical selected from the group consisting of formula (IV), formula (V) and formula (VI) including any of the stereoisomers of all of them, wherein the biradical is optionally in the form of a salt and is attached to the linker L through the single bonded oxygen atoms of the carboxyl groups. It also relates to a process for the preparation of the conjugates of formula (I) and to pharmaceutical compositions containing them. The conjugates of the invention are used for the treatment of cancer.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: May 5, 2015
    Assignees: Fundacio Privada Institut Catala de Nanotecnologia, Institucio Catalana de Recerca I Estudis Avancats, Universidade de Santiago de Compostela, Universitat de Valencia, Fundacio Institut de Recerca de l'Hospital de la Santa Creu J Sant Pau
    Inventors: Victor Franco Puntes, Fernando Domíguez Puente, Francisco Manuel Romero Martínez, Óscar Gallego Rubio
  • Patent number: 8968793
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: March 3, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Noa Hadar, Amihay Freeman
  • Patent number: 8968794
    Abstract: Antiseptic compositions and kits containing a source of silver ions and menthol, which act in synergy such that a concentration of silver ions in the composition is substantially reduced, are disclosed. Further disclosed are uses of the antiseptic compositions as disinfectants and in the treatment of wounds.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: March 3, 2015
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Noa Hadar, Amihay Freeman
  • Patent number: 8952057
    Abstract: Compositions containing polymetal complexes are useful in treating anorectal disorders.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: February 10, 2015
    Assignee: JR Chem, LLC
    Inventor: José E. Ramirez
  • Publication number: 20150038578
    Abstract: The present disclosure describes a method and series of compositions for surface functionalization of nanoparticles that eliminates the possibility of ligand loss in alien environments. In particular, the present disclosure provides method and compositions for production of highly-stable surface-functionalized nanorods of noble metals for in-vivo applications as well as use in composite materials.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 5, 2015
    Inventor: Babak Nikoobakht
  • Publication number: 20140377175
    Abstract: Provided herein are compositions and methods of preparing nanoparticle aggregates.
    Type: Application
    Filed: June 24, 2014
    Publication date: December 25, 2014
    Inventors: Jacob Berlin, Desiree van Haute
  • Patent number: 8895611
    Abstract: The cytotoxic compounds are gold(III) complexes of the type [(diaminocyclohexane)AuCl2]Cl, derived from sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O. Specifically, the cytotoxic compounds are gold complexes of isomers of 1,2-diaminocyclohexane, namely cis-(±)-1,2-(diaminocyclohexane)AuCl3, trans-(±)-1,2-(diaminocyclohexane)AuCl3 and S,S-(+)-1,2-(diaminocyclohexane)AuCl3. In order to treat cancer cells in a patient, such as human prostate cancer cells or human gastric cancer cells, an effective amount of the isomer of 1,2-(diaminocyclohexane)AuCl3 is administered to the cancer cells in the patient. The isomer of 1,2-(diaminocyclohexane)AuCl3 is preferably administered with a concentration ranging between about 10 ?M and 20 ?M.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: November 25, 2014
    Assignees: King Fahd University of Petroleum and Minerals, King Abdulaziz City for Science and Technology
    Inventors: Anvarhusein Abdulkadir Isab, Mohammed Ismail Mohammed Wazeer, Said Salman Al-Jaroudi, Saleh Abdulaziz Altuwaijri
  • Publication number: 20140329899
    Abstract: A method for producing silver-ion antibacterial liquid using a type A or type X silver zeolite includes a process to weigh silver zeolite for obtain its blending quantity in a range of 0.1 to 20.0 percent by weight and to weigh citric acid for obtaining its blending quantity such that its blending ratio to the silver zeolite becomes 1.2 or greater, followed by blending of the two into purified water; a process to mix under agitation the silver zeolite and citric acid blended in the purified water to prepare a mixture liquid containing at least a citric acid-silver complex and silica hydrate; and a process to remove the silica hydrate produced in the mixture liquid. The production method can produce at low cost a silver-ion antibacterial liquid offering immediate bactericidal effect.
    Type: Application
    Filed: August 31, 2012
    Publication date: November 6, 2014
    Applicant: TAIKI CORP., LTD.
    Inventors: Kenji Nakamura, Koji Nakamura
  • Patent number: 8877256
    Abstract: The invention is an antimicrobial photo-stable coating composition that deters photo-induced discoloration, does not stain tissue and can be applied to the surface of a variety of medical materials. The composition comprises in an aspect silver-PCA complex and dye.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: November 4, 2014
    Assignee: Covalon Technologies Ltd.
    Inventors: Vyacheslav Dudnik, Yakeemovich Natali, Valerio DiTizio, Frank DiCosmo
  • Publication number: 20140288171
    Abstract: Methods of forming antimicrobial polymeric materials comprising metallic nanoparticles are disclosed. Such methods generally comprise: combining a metal-containing material with a resin in situ; and curing the resin in the presence of a metal-containing material. Antimicrobial polymeric materials formed by said methods are also disclosed.
    Type: Application
    Filed: June 7, 2014
    Publication date: September 25, 2014
    Inventors: Kyumin Whang, H. Ralph Rawls, Barry K. Norling
  • Publication number: 20140271760
    Abstract: Described are antimicrobial liquid products comprising one or more antimicrobial organometallic additives dispersed throughout an organic host liquid.
    Type: Application
    Filed: May 14, 2014
    Publication date: September 18, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
  • Publication number: 20140205644
    Abstract: The present invention concerns antimicrobial expandable polystyrene (EPS) beads, comprising as main antimicrobial agent metal ions selected from silver and copper and combinations thereof, which antimicrobial agent(s) may be either mixed into the polymer matrix or coated onto the beads. The invention also concerns a method for producing the coated form of these antimicrobial beads.
    Type: Application
    Filed: August 29, 2012
    Publication date: July 24, 2014
    Applicant: StyroChem Finland Oy
    Inventors: Jyri Nieminen, Ville Nurminen, Markus Mäki
  • Patent number: 8785493
    Abstract: Activation of HIV-1 replication causes oxidative stress, which in turn potentiates HIV-1 replication. The common basis for the compounds of the present invention is: A) the capacity of reactivating HIV-1 from latency, and B) the ability to counteract the cellular machinery which activates in order to limit the effects of oxidative stress. In this way, oxidative stress can be potentiated and a “chain reaction” is sparked. This “chain reaction” induces a more efficient reactivation of HIV-1 from latency and, in some cases, induces selective killing of the infected cells. Actions A) and B) can either be carried out by one drug exerting both effects, or obtained by the combined use of distinct drugs. There are two main cellular machineries counteracting oxidative stress, i.e. the thioredoxin (Trx) thioredoxin reductase (TrxR) system and glutathione. Herein, we present drug strategies capable of exerting action B) by blocking either of the two machineries.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: July 22, 2014
    Assignee: Istituto Superiore di Sanita
    Inventors: Andrea Savarino, Antonello Mai, Anna Teresa Palamara, Enrico Garaci
  • Patent number: 8785202
    Abstract: The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: July 22, 2014
    Assignee: CytImmune Sciences, Inc.
    Inventors: Lawrence Tamarkin, Giulio F. Paciotti
  • Publication number: 20140199358
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
  • Publication number: 20140199359
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Applicant: DMR INTERNATIONAL, INC.
    Inventors: MARC CHASON, DANIEL ROMAN GAMOTA, RICK LATELLA
  • Publication number: 20140199356
    Abstract: Described are antimicrobial polymer products made from mixtures of antimicrobial organometallic additives dispersed throughout a polymer host matrix.
    Type: Application
    Filed: March 15, 2013
    Publication date: July 17, 2014
    Inventors: MARC CHASON, Daniel Roman Gamota, Rick Latella
  • Patent number: 8758777
    Abstract: The present invention provides pharmaceutical compositions comprising water-soluble sulfonate-protected nanoparticles, more particularly, pharmaceutical compositions comprising water-soluble sulfonate-protected silver or gold nanoparticles. The pharmaceutical compositions of the invention are useful in prevention or treatment of infections or conditions or disorders caused by microorganisms capable of binding to heparan sulfate, e.g., herpes simplex viruses.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: June 24, 2014
    Assignee: Bar-Ilan University
    Inventors: Ronit Sarid, Aharon Gedanken, Dana Baram-Pinto
  • Publication number: 20140170070
    Abstract: In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
    Type: Application
    Filed: February 24, 2014
    Publication date: June 19, 2014
    Inventors: Wei Qian, Makoto Murakami, Yuki Ichikawa, Yong Che
  • Patent number: 8735538
    Abstract: The invention provides compositions comprising and methods employing methanobactin, as well as methanobactin synthetase sequences.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: May 27, 2014
    Assignees: Iowa State University Research Foundation, Inc., The Regents of the University of Michigan
    Inventors: Alan Angelo DiSpirito, Dong-Won Choi, Jeremy David Semrau, David Keeney
  • Patent number: 8709827
    Abstract: The invention provides polypeptide microparticles and methods for the preparation thereof using a nucleating agent.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: April 29, 2014
    Assignee: SurModics, Inc.
    Inventors: Joram Slager, John V. Wall
  • Publication number: 20140066418
    Abstract: The present invention provides a construction material preservative for wood and the like that retains preservative effects over a long period of time and continuously demonstrates those effects even at low concentrations even when using in combination with an insecticide. The construction material preservative contains a water-soluble silver-amino acid complex composed of 1 molar part of silver and 1 to 3 molar parts of amino acid.
    Type: Application
    Filed: May 9, 2012
    Publication date: March 6, 2014
    Inventors: Shinya Watanabe, Satoru Makita, Motoaki Yabe, Shigebumi Arai
  • Patent number: 8658193
    Abstract: Technologies are described herein for styptic compounds comprising a hemostatic or styptic agent suspended within a hydrophobic carrier medium. Example carrier mediums may include waxes, lipids, oils, or combinations thereof. The compound may be a semisolid at room temperature and soft enough to be easily dispensed and formed into or onto bleeding tissue of an animal or human. The hydrophobic qualities of the carrier medium can protect the styptic agent from absorbing moisture. The carrier medium can mechanically support positioning treatments adjacent to the bleeding tissue. The carrier medium can further serve to mechanically seal the tissue to aid in hemostasis while also protecting the tissue from debris and contamination. The carrier medium can aid in maintaining moisture within the tissue. Slurry-based manufacturing processes can support a substantially homogeneous dispersal of styptic agent throughout the carrier medium.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: February 25, 2014
    Inventor: Robert J. Greenwald
  • Patent number: 8647647
    Abstract: A topical formulation for application to exposed body tissue, the formulation comprising a silver(II) oxide and zinc oxide, intimately dispersed within a carrier medium.
    Type: Grant
    Filed: July 21, 2010
    Date of Patent: February 11, 2014
    Assignee: Aidance Skincare and Topical Solutions, LLC
    Inventor: Perry Antelman
  • Patent number: 8637088
    Abstract: An antimicrobial composition contains a soluble silver salt and an alkanolamine or aminoalcohol. The composition may additionally contain an amino acid or amino acid salt and surfactant. The composition has additional stability and activity compared to prior art silver complexes.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: January 28, 2014
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, Erika Szekeres, Steven Bromberg
  • Patent number: 8609141
    Abstract: The present invention pertains to silver ion bearing carriers useful in treating monorrhagia of a mammalian uterus, comprising a physiologically inert, flexible earner, e.g., a coil, bearing a tissue cauterizing amount of a silver ion. Silver ions are delivered to the endometrium and cause necrosis of the endometrial tissue. The silver ions remaining within the uterine cavity can then be neutralized with a sodium chloride solution delivered to the uterus e.g., by catheter, and the carrier recovered from the uterus.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: December 17, 2013
    Assignee: Ablation Products LLC
    Inventor: Robert S. Neuwirth
  • Patent number: 8580309
    Abstract: The present invention presents a mixture comprising charge-stabilized metallic nanoparticles and a photosensitizer, a method for making such mixture, and a method of using such mixture for killing or preventing the growth of microbes.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: November 12, 2013
    Assignee: UCL Business PLC
    Inventors: Michael Wilson, Ivan P. Parkin, Sean Nair
  • Patent number: 8580769
    Abstract: Disclosed herein are methods for treating obesity, metabolic syndrome, diabetes, or a combination of these conditions. The methods include selecting a subject with obesity, metabolic syndrome, or diabetes and administering to the subject a therapeutically effective amount of a composition comprising a compound that specifically inhibits hepatic protein kinase C (PKC)-?, thereby treating the obesity, metabolic syndrome, or diabetes in the subject. In some embodiments the compound that specifically inhibits hepatic PKC-? includes a thio-gold compound (such as aurothiomalate, aurothioglucose, and auranofin) or a derivative thereof, or a pharmaceutically acceptable salt thereof. In other embodiments, the compound that specifically inhibits hepatic PKC-? includes 1H-imidazole-4-carboxamide, 5-amino-1-[2,3-dihydroxy-4-[(phosphonooxy)methyl]cyclopentyl]-[1R-(1?,2?,3?,4?)] (ICAPP) or a derivative thereof, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 12, 2013
    Assignees: The United States of America as represented by the Department of Veterans Affairs, The Roskamp Institute
    Inventor: Robert V. Farese
  • Patent number: 8568757
    Abstract: Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: October 29, 2013
    Assignee: Pure Bioscience
    Inventors: Michael L. Krall, Dolana Jonte, Richard Gumienny, Jr.
  • Patent number: 8563021
    Abstract: Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: October 22, 2013
    Assignee: Pure Bioscience
    Inventors: Michael L. Krall, Dolana Jonte, Richard Gumienny
  • Patent number: 8535729
    Abstract: An antimicrobial composition contains a soluble silver salt and an alkanolamine or aminoalcohol. The composition may additionally contain an amino acid or amino acid salt and surfactant. The composition has additional stability and activity compared to prior art silver complexes.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: September 17, 2013
    Assignee: The Clorox Company
    Inventors: David R. Scheuing, Erika Szekeres, Steven Bromberg
  • Patent number: 8529963
    Abstract: The present invention is directed to a method for preparing colloidal dispersions of precious metal nanoparticles selected from the group consisting of Pt, Au, Pd, Ag, Rh, Ru and mixtures or alloys thereof, and to a method for isolating such precious metal nanoparticles from these colloidal dispersions. The colloidal dispersions are prepared by reducing suitable precious metal precursor compounds in aqueous alkaline solutions at reaction temperatures between 40 and 70° C. and a pH?12.0 in the presence of polysaccharides with average molecular weights (Mw) in the range of 300,000 to 1,000,000. The precious metal nanoparticles are isolated after decomposing the polysaccharide by heating the colloidal dispersions to temperatures >80° C. The nanoparticles can be used for the manufacture of core/shell-type catalyst materials and for electronic, decorative and medical applications.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: September 10, 2013
    Assignee: Umicore AG & Co. KG
    Inventors: Dan V. Goia, Benjamin Morrow, Egon Matijevic, Krishna Balantrapu, Brendan P. Farrell
  • Patent number: 8513303
    Abstract: The present invention provides a method of killing and/or inactivating microbes, the method comprising the step of placing the microbes in contact with a catalyst by means of a fluid medium, wherein the catalyst comprises a solid support, which solid support comprises one or more fibers, and a first metal cation fixed to the support. The fibers are keratinous fibers like wool fibers, or polyacrylonitrile (PAN) fibers. The first metal cation is selected from transition metal copper, silver and gold included. A second non-transition metal cation can be present. The catalyst is prepared by first treating the fibers with hydrazine and/or hydroxylamine salt in presence of a base, the modified fibers are then treated with an aqueous solution of containing the metal cations.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: August 20, 2013
    Assignee: De Montfort University
    Inventors: Katherine Huddersman, Susannah Elizabeth Walsh
  • Publication number: 20130209386
    Abstract: An antibacterial or anti-acne formulation containing (a) tropone or a substituted tropone and (b) a metal or metal salt selected from copper, copper salts, bismuth, bismuth salts, silver, silver salts, and mixtures thereof, for use in the treatment of either acne or body odour. The substituted tropone may be for example tropolone or hinokitiol.
    Type: Application
    Filed: July 25, 2011
    Publication date: August 15, 2013
    Applicant: EVOCUTIS PLC
    Inventors: Jonathan Cove, Daniel Fitzgerald, Nicholas Read
  • Publication number: 20130150439
    Abstract: A method of treating soils to eradicate or reduce the proliferation of nematodes said method comprising the application of select metal ion-acid compositions to the soil.
    Type: Application
    Filed: December 10, 2012
    Publication date: June 13, 2013
    Applicant: SCIESSENT LLC
    Inventor: SCIESSENT LLC
  • Publication number: 20130096090
    Abstract: The present invention relates to the fields of chemistry and pharmaceuticals. Embodiments of the present invention provide transition metal complexes of amino acids. Transition metal complexes of embodiments of the invention according to Categories I, II, III, and/or IV may be used as antimicrobial, anti-malarial, and anti-cancer agents, as well as catalysts in chemical reactions. Such compounds of the invention are particularly useful for combating multi-drug resistance against a broad range of microbials (such as MRSA and mycobacteria), including gram positive and gram negative bacteria, as well as can be used as anti-cancer agents against bladder cancer, breast cancer, colon cancer, rectal cancer, endometrial cancer, kidney cancer, leukemia, lung cancer, melanoma, non-Hodgkin's lymphoma, pancreatic cancer, prostate cancer, and thyroid cancer, to name a few.
    Type: Application
    Filed: October 17, 2012
    Publication date: April 18, 2013
    Applicant: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventor: Virginia Tech Intellectual Properties, Inc.
  • Publication number: 20130096098
    Abstract: Silver(I) cyanoximates of AgL composition (L=NC—C(NO)—R, where R is electron withdrawing groups: —CN, —C(O)NR2, —C(O)R? (alkyl), —C(O)OEt, 2-heteroaryl fragments such as 2-pyridyl, 2-benzimidazolyl, 2-benzoxazolyl, 2-benzthiazolyl) are synthesized and characterized using spectroscopic methods and X-ray analysis. The synthesized compounds also demonstrate remarkable insensitivity toward visible light and UV-radiation. The combined characteristics of these compounds, such as light insensitivity, poor water solubility, high thermal stability, lack of toxicity of organic ligands, and antimicrobial activity make these silver(I) cyanoximates compounds suitable for use in biomaterial and medical devices.
    Type: Application
    Filed: September 12, 2012
    Publication date: April 18, 2013
    Applicant: MISSOURI STATE UNIVERSITY
    Inventors: Nikolay Gerasimchuk, Andrzej Garmian
  • Publication number: 20130071461
    Abstract: Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.
    Type: Application
    Filed: November 14, 2012
    Publication date: March 21, 2013
    Applicant: Pure Bioscience
    Inventor: Pure Bioscience
  • Publication number: 20130071459
    Abstract: Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.
    Type: Application
    Filed: November 14, 2012
    Publication date: March 21, 2013
    Applicant: Pure Bioscience
    Inventor: Pure Bioscience
  • Patent number: 8399003
    Abstract: Use of dried compositions of silver dihydrogen citrate along with citric acid in antimicrobial amounts directly as disinfectants is described.
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: March 19, 2013
    Assignee: Pure Bioscience
    Inventors: Michael L. Krall, Dolana Jonte, Richard Gumienny, Jr.
  • Patent number: 8399027
    Abstract: A silver composition comprising silver sulfate and a method of coating the composition on a substrate is disclosed.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: March 19, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Scott A. Burton, David R. Holm
  • Publication number: 20130052131
    Abstract: Embodiments of the present disclosure, in one aspect, relate to a nanoparticle, methods of imaging a tumor, method of imaging a disease, method of treating a condition, disease, or related biological event, or the like.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 28, 2013
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Zhen Cheng, Kai Cheng
  • Patent number: 8383674
    Abstract: Silver nanoclusters were synthesized by reducing silver nitrate with ethylene glycol at a certain temperature in the presence of zeolite. A one-pot procedure rendered uniform size distributions of quasi-spherical silver clusters synthesized on the surfaces of cubic-like zeolite.
    Type: Grant
    Filed: July 1, 2010
    Date of Patent: February 26, 2013
    Assignee: University of Puerto Rico
    Inventor: Yury Posada