Abstract: An ophthalmic solution, which comprises diquafosol tetrasodium salt and is free from benzalkonium chloride, treats onset and/or exacerbation of dry eye symptom caused by wearing soft contact lenses.

Abstract: Disclosed herein are methods of treating viral infections by administration of ethyl mercury or thiol derivative thereof in an amount effective to treat the viral infection.

Abstract: The present invention relates to vesicular formulations for use in the topical administration of a biologically active agent, methods of administering a biologically active agent, a combined preparation comprising a vesicular formulation and a kit comprising a vesicular formulation.

Abstract: The present invention relates to the use of one or more compounds selected from the following classes of biologically active agents: an a-adrenergic antagonist, an anthelmintic agent, an antifungal agent, an antimalarial agent, an antineoplastic agent, an antipsychotic agent, an antioxidant, a vasodilator and/or a vitamin, or a pharmaceutically acceptable derivative thereof, for use in the treatment of a microbial infection and in particular for killing multiplying, non-multiplying and/or clinically latent microorganisms associated with such an infection.

Abstract: Compositions, kits and regimens for treatment of damaged skin, especially décolletage, include application of a retinoid, hydroquinone or hydroquinone derivatives, and a composition containing a multi-metal complex.

Abstract: This document discloses molecules having the following formula (“Formula One”): and processes associated therewith.

Abstract: This invention relates to a process for the co-encapsulation of biocidally active ingredients in a clay mineral, the process comprising the step of bringing the clay mineral into contact with a biocidally active nitrogen compound that contains at least one hydrocarbon group with 6 to 20 carbon atoms, and at the same time or subsequently with at least one biocidally active compound selected from the group consisting of 2-n-octyl-4-isothiazoline-3-one, 3-iodopropenylbutyl-carbamate and tetrahis(hydroxymethyl)phosphonium sulfate. And the use of such encapsulated product in water based paints, coatings and varnishes.

Abstract: In one aspect, the invention relates to a method for identifying a drug candidate with activity as a neuroprotective agent. The method includes determining whether a compound reduces ATF4 activity; and identifying the compound that reduces ATF4 activity as a drug candidate.

Abstract: Disclosed herein are methods of treating viral infections by administration of ethyl mercury or thiol derivative thereof in an amount effective to treat the viral infection.

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

Abstract: The invention is directed to enzyme immobilization compositions comprising: one or more enzymes, a humectant, an acrylic-based monomer, a water-soluble organic photo-initiator and a water-soluble acrylic-based cross-linker in a substantially homogeneous aqueous mixture. The invention is also directed to methods for forming sensors comprising such compositions and to apparati for forming arrays of immobilized layers on an array of sensors by dispensing such compositions onto a substrate.

Abstract: The invention involves PKC? signaling. The invention provides, for example, transgenic animals, inhibitors of PKC? signaling, methods for inhibiting PKC? signaling, methods for identifying inhibitors of PKC? signaling, and methods for diagnosing cancer.

Abstract: A dual adhesive layer dosage form for delivery of active agent to and across, the mucosa is disclosed. Particularly, bioadhesive tablets for administration at the vaginal mucosa are disclosed as having a central active layer sandwiched between two bioadhesive layers.

Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.

Abstract: Bioactive agrichemical concentrates and compositions having improved bioactivity comprising combinations of acid solutions and conventional bioactive agrichemical actives or formulations.

Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.

Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.

Abstract: A mollusc repellent, which includes a substantially insoluble metal oxalate and a suitable carrier therefor, which exhibits prolonged efficacy. The mollusc repellent is environmentally friendly, being both non-phytotoxic and harmless to non-target animals, and is therefore suitable for use in sustainable agriculture, where the use of toxic chemicals is unacceptable. The mollusc repellent can be used in the form of a solid or as a coating composition.

Abstract: The present invention relates to the use of NAD(P)H oxidase inhibitors to increase cellular uptake of glucose and in the treatment and/or prevention of diseases caused by insulin resistance or diseases related thereto, such as type II diabetes. Specifically, the invention relates to a method for identifying an agent useful for the treatment or prophylaxis of a medical condition associated with elevated levels of blood glucose, the method comprising (i) contacting a candidate agent with a mammalian NAD(P)H oxidase or NAD(P)H oxidase complex; and (ii) determining whether said candidate agent inhibits the biological activities of the NAD(P)H oxidase or NAD(P)H oxidase complex.

Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.

Abstract: A method of arresting the flow of blood and other protein containing body fluids flowing from an open wound and for promoting wound healing. In the method, a substantially anhydrous compound of a salt ferrate is provided for a unique use which, when hydrated after mixing with a victim's own blood or other aqueous media, produces Fe+++ thereby promoting clotting when applied in a paste form to the wound for a time sufficient to arrest substantial further blood and other body fluid flow from the wound. The compound is formed of a ferrate (VI) salt taken from the group consisting of H, Li, Na, K, Rb, Cs and Fr. However, to decrease or eliminate stinging sensation, the compound may be formed having a ferrate (VI) salt taken from the group consisting of Be, Mg, Ca, Sr, Ba, Ra, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, Ge, Zr, Nb, Mo, Tc, Ru, Rh, Pd, Ag, Cd, In, Sn, Hf, Ta, W, Re, Os, Ir, Pt, Au, Hg, TI, Pb, Bi, Al, As, NH4 and N(C4H9)4.

Abstract: A biocidal composition composed of a ternary complex of a negatively-charged biocide, a transition metal ion and chelator has synergistic biocidal effects as compared with a composition of each of the components alone. The chelator is preferably a neutral or positively-charged chelator. The ternary complex may be used for killing or inhibiting the growth of living cells.

Abstract: Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are also disclosed.

Abstract: Disclosed is a method for preventing neuronal cell death subsequent to an injury to neuronal tissue, particularly central nervous tissue exposed to an ischemic or hypoxic event, to trauma or to a chronic neurodegenerative disorder. The method includes exposing the cells to a glutaminase inhibitor that is relatively impermeant to healthy, intact cell membranes, and which is preferably a specific inhibitor of the form of glutaminase that is widely present in brain tissue.

Abstract: An agent for contact lenses, which comprises an aqueous medium and synthetic smectites particulates consisting essentially of primary particles having a particle size of at most 200 nm, dispersed in the aqueous medium.

Abstract: Methods and compositions are provided for alleviation of disease states involving plaque formation, such as are manifested in Alzheimer's Disease and other amyloid disorders, and arteriosclerotic disease. Methods for the treatment of herpes virus infections including chronic fatigue syndrome by administration of thimerosal are further provided by the invention.

Abstract: An exogenous stimulus is applied to tissues or cells which are at risk in a subsequent surgical procedure or other intervention which induces a response by the cells that minimizes reaction to the subsequent procedure. Stimuli can be chemical, physiological or physical. Examples include those stimuli known to induce expression of stress response proteins or heat shock proteins, especially heat shock protein 70 (hsp 70) and hsp 90, for example, exposure to heat or dilute hydrogen peroxide, or direct administration of exogenous heat shock proteins, or those stimuli which act to inhibit or reduce heat shock protein expression, for example, treatment with flavonoids.

Abstract: This invention relates to preservative compositions which comprise a biocidal metal compound and an fungicidal compound containing a triazole group. Methods of treating wood with the composition are also described.

Abstract: An exogenous stimulus is applied to tissues or cells which are at risk in a subsequent surgical procedure or other intervention which induces a response by the cells that minimizes reaction to the subsequent procedure. Stimuli can be chemical, physiological or physical. Examples include those stimuli known to induce expression of stress response proteins or heat shock proteins, especially heat shock protein 70 (hsp 70) and hsp 90, for example, exposure to heat or dilute hydrogen peroxide, or direct administration of exogenous heat shock proteins, or those stimuli which act to inhibit or reduce heat shock protein expression, for example, treatment with flavonoids.

Abstract: A pharmaceutical formulation having immunomodulating and regenerating effect on abnormal function of cell tissue division-regulating system comprises, as an active ingredient, mercury dichloride or potassium arsenite or sodium arsenate in the amount of 0.01-1.5% by weight and of a diluent up to 100% by weight. The proposed pharmaceutical formulation preferably contains natural white grape wine with sugar content of 3-4% by weight or whey with sugar content of 3-4% by weight as the diluent.

Abstract: Disclosed herein is a bi-metallic cross-linking reagent according to the following formula: ##STR1## where M.sub.1 is a metal ion species capable of forming a complex of coordination number four or coordination number six; wherein L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are each independently a halide, ammonia, dimethyl sulfoxide, carboxylate, thiolate, imidazole, a nucleobase, or an empty coordination site, provided that no more than two of L.sub.1, L.sub.2, L.sub.3, and L.sub.4 are empty coordination sites; wherein M.sub.2 is a metal ion species capable of forming a complex of coordination number two with a first ligand that is a hydrocarbon moiety and a second ligand that is kinetically lablie; and wherein n is an integer from two to nine. Also disclosed are cross-linked species, methods of preparing the crosslinking reagents of the invention, and methods for their use in tissue-specific targeting of anti-tumor agents.

Abstract: Methods are provided for inhibition of leaf rust infections of plants, especially wheat, using inhibitors which disrupt sulfhydryl bonds of the enzymes used by the leaf rust germ tube to ingest and metabolize components of epicuticular waxes.

Abstract: A method of treating gastrointgestinal ulcer disease is provided which involves administration of a proteinase inhibitor or analogue to patients suffering from same. Of particular interest is the use of inhibitors of serine, cysteine, carboxyl, and metallo proteinases.

Abstract: The invention relates to a method for making a composition which comprises selecting at least one fatty acid or fatty ester compound having an allylic unsaturation of the type --CH.dbd.CH--CH.sub.2 --CH.dbd.CH-- or --CH.dbd.CH--CH.dbd.CH--CH.sub.2 --, adding to said compound a salt of an element having a rhombohedral crystal structure, such as Bi, Hg, As, B, Sb or Sm, to form a mixture, heating said mixture above about 260.degree. C. for a sufficient period of time to incorporate at least about 0.1% by weight of the element into the compound, cooling the mixture, and recovering the incorporated compound as the remaining fluid of the mixture. The invention also relates to the reaction products thus produced along with methods of administering these compositions to a subject to treat abnormal conditions caused mainly by a catabolic imbalance.

Abstract: The invention relates to the stabilization of mercury-containing preservatives in liquid or gel-form ophthalmic medicaments. This stabilization against chemical decomposition after the preservative has become deposited on the inner walls of the plastics containers is achieved by adding to the formulation 2-amino-2-hydroxymethyl-1,3-propanediol or a homologue thereof having up to 10 carbon atoms.

Abstract: A method of treating inflammation or arthritis with metal complexes that can traverse skin and animal cell membranes intact and effectively deliver and release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes have an aqueous proton induced dissociation property represented by a sigmoidally-shaped curve on a cartesian coordinate plot of the negative log of the metal ion concentration versus the negative log of hydrogen ion concentration. This dissociation property enables the metal complexes to release metal ions in a controlled manner upon demand at the targeted inflammatory or arthritic areas containing endogenous reacting moieties which demand the metal ions. The metal complexes can be effectively administered either topically or subcutaneously.

Abstract: Water dispersible compositions containing hydrocarbon wax are described which are useful in preparing aqueous water repellent systems. Aqueous water repellent systems containing a hydrocarbon wax also are described. The water repellent system comprises an aqueous system comprising water, a saturated hydrocarbon wax, at least one oil-soluble metal salt of an organic carboxylic acid, at least one surfactant and at least one hydrocarbon solvent. A process for impregnating permeable substrates such as wood, cloth, concrete, rope, etc. with the water repellent system is also described. Penetration of the various components into the substrate is obtained by brushing, dipping, soaking, spraying or immersion at atmospheric pressure, at elevated pressures or under vacuum. The oil-soluble metal salt often is a fungicide. Moreover, additional components can be contained in the aqueous system such as insecticides, colorants, flame retardants, moldicides, wood stabilizing agents, etc.

Abstract: Buffered aqueous solution of thimerosal wherein the buffer is citric acid and sodium citrate having a pH between 3.5 and 7.

Abstract: New mercurobutol derivatives characterized in that they comprise at least one functional group, bonded to the mercurobutol phenol ring, which functional group being capable of intervening in a polymerization or polyaddition reaction, and said derivatives having the bioactive properties of mercurobutol, even after such reaction.These new derivatives can intervene in a grafting operation either as termination agent or a polymerization agent.These new derivatives, when grafted on a support, give it protection against bacteria, mushrooms and other micro-organisms.

Abstract: A method for treating wood with an aqueous composition having fungicidal and insecticidal properties. The aqueous composition comprises(a) at least one oil-soluble metal salt of an organic carboxylic acid having fungicidal properties wherein the metal is zinc, chromium, iron, antimony, lead, mercury or a mixture thereof,(b) at least one halopyridyl phosphate of the formula ##STR1## wherein R represents a halopyridyl group, Z represents oxygen or sulfur, and each R' is independently a lower alkoxy, amino or lower alkylamino group,(c) at least one surfactant, and(d) from about 60 to 99% of water.Such compositions penetrate into both dry and green wood rather readily, and the result is wood which is resistant to fungi and insects.

Abstract: An aqueous composition having fungicidal and insecticidal properties is described which is useful particularly for treating wood. The aqueous composition comprises(a) at least one oil-soluble metal salt of an organic carboxylic acid having fungicidal properties wherein the metal is zinc, chromium, iron, antimony, lead, mercury or a mixture thereof,(b) at least one halopyridyl phosphate of the formula ##STR1## wherein R represents a halopyridyl group, Z represents oxygen or sulfur, and each R' is independently a lower alkoxy, amino or lower alkylamino group,(c) at least one surfactant, and(d) from about 60 to 99% of water.Such compositions penetrate into both dry and green wood rather readily, and the result is wood which is resistant to fungi and insects.

Abstract: Metal oxycarboxylates are made by reacting a metal, a carboxylic acid, and hydrogen peroxide in aqueous reaction mixture. The metal oxycarboxylate is precipitated and removed from the reaction mixture in high yield and with high purity. The compound is effective in supplying the metal to plants, animals and humans.