Abstract: Insl5 has been found to be orexigenic, i.e. it increases appetite. Insl5, or a derivative or fragment thereof that retains the ability to bind to the GPR100 receptor, or an Insl5 antibody, are useful in therapy, in particular to treat anorexia nervosa, bulimia, cachexia or wasting disease.
Type:
Application
Filed:
September 5, 2008
Publication date:
October 28, 2010
Applicant:
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventors:
Johannes Grosse, Helen Heffron, Kate Day
Abstract: Clusterin possesses an excellent anorexigenic effect and, accordingly, is useful for treating or preventing obesity or an obesity-related disorder. Co-administration of sub-clinical dose of clustrin potentiates the anorexigenic effect of leptin.
Type:
Application
Filed:
May 7, 2007
Publication date:
October 7, 2010
Inventors:
Min-Seon Kim, Namkoong Churl, Pil-Geurn Jang, Byung-Soo Yoon