X-c(=x)-x Containing (e.g., Carbonic Acid Ester, Thiocarbonic Acid Ester, Etc.) (x Is Chalcogen) Patents (Class 514/512)
  • Patent number: 4851435
    Abstract: The invention refers to antiviral and antitumor compositions which are useful for the control of viruses and tumors and which, in addition to a known antiviral or antitumor active xanthate, contain an adjuvant which increases its antiviral and antitumor action. The adjuvant is an ionic, preferably an anionic, compound with a lipophilic group and a hydrophilic group, preferably an alkali metal deoxycholate or a compound the lipophilic moiety of which is a straight or branched, saturated or unsaturated, aliphatic group with six to eighteen carbon atoms, and the hydrophilic group of which has one or two carboxyl, sulphate, sulphonate, or phosphate groups, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: August 1, 1986
    Date of Patent: July 25, 1989
    Assignee: Merz +Co. GmbH & Co.
    Inventors: Gerhard Sauer, Eberhard Amtmann, Klaus W. Hummel
  • Patent number: 4851426
    Abstract: Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.
    Type: Grant
    Filed: February 12, 1986
    Date of Patent: July 25, 1989
    Assignee: Teva Pharmaceutical Industries, Ltd.
    Inventors: David Ladkani, Haim Yellin, Ben Z. Weiner, David Avnir
  • Patent number: 4810498
    Abstract: A nail oil composition is disclosed consisting essentially of a cosmetic oil containing at least 5% by weight jojoba oil, said cosmetic oil having at least 1% by weight tolnaftate dissolved therein. This composition is effective for treating and preventing fungal infestations in fingernails, particularly sculptured nails.
    Type: Grant
    Filed: February 13, 1986
    Date of Patent: March 7, 1989
    Assignee: The Peau Corporation
    Inventor: Paul J. DiMeglio
  • Patent number: 4801610
    Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.
    Type: Grant
    Filed: June 5, 1987
    Date of Patent: January 31, 1989
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, James R. Deason
  • Patent number: 4777166
    Abstract: This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.
    Type: Grant
    Filed: March 31, 1986
    Date of Patent: October 11, 1988
    Assignees: The United States of America as represented by the Secretary of the Army, The Regents of The University of Michigan
    Inventors: Sandra H. Smith, John C. Drach, Gordon L. Flynn
  • Patent number: 4752615
    Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.
    Type: Grant
    Filed: November 13, 1986
    Date of Patent: June 21, 1988
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
  • Patent number: 4751240
    Abstract: A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl, phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R.sup.1 is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 --or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --(PO)R.sup.2 13 , --S--, --SO--or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: June 14, 1988
    Assignee: Imperial Chemical Industries PLC
    Inventors: Jean Bowler, Graham C. Crawley, Philip N. Edwards, Alasdair T. Glen, Michael S. Large, Brian S. Tait
  • Patent number: 4748186
    Abstract: S-trifluorobutenyl thiocarbonic acid esters of the formula ##STR1## and salts thereof, wherein X is R.sup.1 N or S and Y is RS or R.sup.3 R.sup.2 N;wherein R is a metal or a radical selected from alkyl, cycloalkylalkyl, halocycloalkylalkyl, alkenyl, haloalkyl, haloalkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonylalkyl, halophenoxyalkyl, trialkylsilylalkyl, (vinyl)dialkylsilylalkyl, (allyl)dialkylsilylalkyl, 2-chlorothiophene-5-ylmethyl, phenylalkyl, halophenylalkyl, nitrophenylalkyl, haloalkylphenylalkyl, dialkyl-2,3-dihydrobenzofuran-7-yl, [2-methyl-(1,1'-biphenyl)-3-yl]methyl, 3-phenoxybenzyl, phenylthioalkyl, halophenylthioalkyl, dialkylphosphoryl, dialkylthiophosphoryl, dialkylisoxazolylalkyl and thienylisoxazolylalkyl;wherein R.sup.1 is alkyl, cycloalkyl, cyano, dialkyl-2,3-dihydrobenzofuran-7-yl, halophenyl, halophenylalkyl, haloalkoxyphenyl, pyridinyl, halopyridinyl, alkyl-1,3,4-thiadiazolyl, haloalkyl-1,3,4-thiadiazolyl, benzothiazolyl, dialkyloxazolyl or thiazolinyl;wherein R.sup.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: May 31, 1988
    Assignee: FMC Corporation
    Inventors: Thomas G. Cullen, Anthony J. Martinez, Jacob J. Vukich
  • Patent number: 4746678
    Abstract: The invention relates to new phenanthrene derivatives wherein R stand for C.sub.1-10 alkylamino; C.sub.1-10 alkylthio; C.sub.1-5 alkoxy; or phenyl or phenylamino, the two latter groups being optionally substituted on the phenyl ring by one or more identical or different C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, cyano and/or halogen substituent(s) .The compounds of the present invention possess valuable fungicidal properties and may be used in agriculture, horticulture and therapy as active ingredient of fungicidal or antifungal compositions.The compounds of the general Formula I ##STR1## may be prepared by acylating 9,10-phenanthrene-dione-9-oxime or an alkali or alkali earth metal salt thereof.
    Type: Grant
    Filed: June 4, 1986
    Date of Patent: May 24, 1988
    Assignee: EGIS Gyoryszergyar
    Inventors: Pal Benko, Tibor Zsolnai, Marta Kininczky, Laszlo Pallos, Iren Zsolnai nee Csillag, Peter Tetenyi, Jeno Bernath
  • Patent number: 4740524
    Abstract: Alpha-halopyruvate oximes of the formula: ##STR1## wherein R, R.sup.1, and X are as defined herein having bactericidal and, fungicidal activity are disclosed.
    Type: Grant
    Filed: May 16, 1986
    Date of Patent: April 26, 1988
    Assignee: Rohm and Haas Company
    Inventor: Adam C. Hsu
  • Patent number: 4698365
    Abstract: Compounds of the formula ##STR1## in which "halogen" represents chlorine or fluorine and n is zero, one, two or three, that have useful pesticidal activity.
    Type: Grant
    Filed: November 25, 1986
    Date of Patent: October 6, 1987
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Martin Anderson
  • Patent number: 4683241
    Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: July 28, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, James R. Deason
  • Patent number: 4680310
    Abstract: Tetrahydronaphthalene derivatives of the formula ##STR1## wherein Y, m, n, R and R.sup.1 to R.sup.9 are as set forth herein, are described.These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula ##STR2## with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.
    Type: Grant
    Filed: October 10, 1985
    Date of Patent: July 14, 1987
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Urs Hengartner, Henri Ramuz
  • Patent number: 4661515
    Abstract: Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, and cycloalkyl, and may be the same or different; n is an integer from 0 to 4 inclusive; M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cyloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl, or M and R.sub.6 taken together with the nitrogen to which M is bonded and the carbon to which R.sub.
    Type: Grant
    Filed: January 17, 1986
    Date of Patent: April 28, 1987
    Assignee: USV Pharmaceutical Corporation
    Inventors: Edward S. Neiss, John T. Suh, John J. Piwinski
  • Patent number: 4623658
    Abstract: Pesticidal benzoylurea compounds of the formula: ##STR1## wherein R represents a moiety --C(O)OR.sup.1 or --NR.sup.2 R.sup.3, and the meanings of each of the other symbols is described in the specification.
    Type: Grant
    Filed: February 3, 1986
    Date of Patent: November 18, 1986
    Assignee: Shell Oil Company
    Inventor: Martin Anderson
  • Patent number: 4602037
    Abstract: Novel antiviral xanthate compounds, a process for their production, pharmaceutical compositions containing said xanthate compounds, and a method of combating viruses therewith, are disclosed.
    Type: Grant
    Filed: May 13, 1983
    Date of Patent: July 22, 1986
    Assignee: Merz+Co. GmbH & Co.
    Inventors: Arthur Scherm, Klaus Hummel
  • Patent number: 4596706
    Abstract: A method for treating or aiding in the treatment of a tobacco habit or addiction in a human by controlling the craving for tobacco or controlling tobacco withdrawal symptoms which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving or said withdrawal symptoms so as to reduce the desire for tobacco.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: June 24, 1986
    Assignee: Elena Avram
    Inventor: Emanuel Revici
  • Patent number: 4596798
    Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.
    Type: Grant
    Filed: March 30, 1982
    Date of Patent: June 24, 1986
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Charles Shipman, Jr., Daniel L. Klayman, Sandra H. Smith, John C. Drach
  • Patent number: 4595695
    Abstract: 1'-Ethoxycarbonyloxyethyl ester of di-n-propylacetic acid, also known as valproic acid. The novel compound is prepared by reacting valproic acid with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions for oral administration containing the said ester.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: June 17, 1986
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: David Ladkani, Haim Yellin, Ben Z. Weiner
  • Patent number: 4565689
    Abstract: A method for treating or aiding in the treatment of the manifestations of alcoholism or alcohol intoxication by aiding in the control of the craving for alcohol or by aiding in the control of alcohol withdrawal symptoms, or by aiding in the control of alcohol intoxication in a human which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving, symptoms, or intoxication so as to counteract the effects of alcohol.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: January 21, 1986
    Assignee: Wirth Maschinen-und Bohrgerate-Fabrik GmbH
    Inventor: Emanuel Revici
  • Patent number: 4565690
    Abstract: A method for treating drug addiction from compounds which cause a catabolic effect on the human body, which comprises administering to said body, a sufficient amount of an anabolic agent containing bivalent negative selenium or sulfur.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: January 21, 1986
    Assignee: Elena Avram
    Inventor: Emanuel Revici
  • Patent number: 4565648
    Abstract: A process for producing storage-stable solutions of pyrocarbonic acid dialkyl esters in organic liquids inert to these esters comprising adding certain carbonyl compounds, sulfonyl compounds and/or thiourea to these pyrocarbonic acid dialkyl ester solutions. Also the use of these carbonyl compounds, sulfonyl compounds and/or thiourea for producing stabilized polyisocyanate preparations suitable for the production of polyurethane foams.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: January 21, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Richard Kopp, Wolfgang Reichmann
  • Patent number: 4542158
    Abstract: 1-(Alkoxy or aroxy)carbonyloxyalkyl esters of diflunisal and related compounds are stable in aqueous medium and non-irritant to mucous membranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory drug, diflunisal.
    Type: Grant
    Filed: October 25, 1982
    Date of Patent: September 17, 1985
    Assignee: Merck & Co., Inc.
    Inventor: Conrad P. Dorn
  • Patent number: 4497823
    Abstract: Method of treating veterinary or human patients for relief of dermal or sub-dermal pain and inflammation by topical application of a therapeutic agent comprising propylene carbonate.
    Type: Grant
    Filed: March 29, 1983
    Date of Patent: February 5, 1985
    Inventors: William T. Moore, John W. Albright