X-c(=x)-x Containing (e.g., Carbonic Acid Ester, Thiocarbonic Acid Ester, Etc.) (x Is Chalcogen) Patents (Class 514/512)
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Patent number: 4851435Abstract: The invention refers to antiviral and antitumor compositions which are useful for the control of viruses and tumors and which, in addition to a known antiviral or antitumor active xanthate, contain an adjuvant which increases its antiviral and antitumor action. The adjuvant is an ionic, preferably an anionic, compound with a lipophilic group and a hydrophilic group, preferably an alkali metal deoxycholate or a compound the lipophilic moiety of which is a straight or branched, saturated or unsaturated, aliphatic group with six to eighteen carbon atoms, and the hydrophilic group of which has one or two carboxyl, sulphate, sulphonate, or phosphate groups, or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: August 1, 1986Date of Patent: July 25, 1989Assignee: Merz +Co. GmbH & Co.Inventors: Gerhard Sauer, Eberhard Amtmann, Klaus W. Hummel
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Patent number: 4851426Abstract: Novel esters of the general formula ##STR1## in which ##STR2## is the acyl residue of a non-steroidal anti-inflammatory compound containing a carboxylic acid function. The novel esters are prepared by reacting an acide R--COOH when R is as above, with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions containing any of the said novel esters.Type: GrantFiled: February 12, 1986Date of Patent: July 25, 1989Assignee: Teva Pharmaceutical Industries, Ltd.Inventors: David Ladkani, Haim Yellin, Ben Z. Weiner, David Avnir
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Patent number: 4810498Abstract: A nail oil composition is disclosed consisting essentially of a cosmetic oil containing at least 5% by weight jojoba oil, said cosmetic oil having at least 1% by weight tolnaftate dissolved therein. This composition is effective for treating and preventing fungal infestations in fingernails, particularly sculptured nails.Type: GrantFiled: February 13, 1986Date of Patent: March 7, 1989Assignee: The Peau CorporationInventor: Paul J. DiMeglio
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Patent number: 4801610Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.Type: GrantFiled: June 5, 1987Date of Patent: January 31, 1989Assignee: G. D. Searle & Co.Inventors: Masateru Miyano, James R. Deason
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Patent number: 4777166Abstract: This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.Type: GrantFiled: March 31, 1986Date of Patent: October 11, 1988Assignees: The United States of America as represented by the Secretary of the Army, The Regents of The University of MichiganInventors: Sandra H. Smith, John C. Drach, Gordon L. Flynn
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Patent number: 4752615Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.Type: GrantFiled: November 13, 1986Date of Patent: June 21, 1988Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
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Patent number: 4751240Abstract: A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl, phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R.sup.1 is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 --or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --(PO)R.sup.2 13 , --S--, --SO--or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.Type: GrantFiled: April 24, 1985Date of Patent: June 14, 1988Assignee: Imperial Chemical Industries PLCInventors: Jean Bowler, Graham C. Crawley, Philip N. Edwards, Alasdair T. Glen, Michael S. Large, Brian S. Tait
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Patent number: 4748186Abstract: S-trifluorobutenyl thiocarbonic acid esters of the formula ##STR1## and salts thereof, wherein X is R.sup.1 N or S and Y is RS or R.sup.3 R.sup.2 N;wherein R is a metal or a radical selected from alkyl, cycloalkylalkyl, halocycloalkylalkyl, alkenyl, haloalkyl, haloalkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonylalkyl, halophenoxyalkyl, trialkylsilylalkyl, (vinyl)dialkylsilylalkyl, (allyl)dialkylsilylalkyl, 2-chlorothiophene-5-ylmethyl, phenylalkyl, halophenylalkyl, nitrophenylalkyl, haloalkylphenylalkyl, dialkyl-2,3-dihydrobenzofuran-7-yl, [2-methyl-(1,1'-biphenyl)-3-yl]methyl, 3-phenoxybenzyl, phenylthioalkyl, halophenylthioalkyl, dialkylphosphoryl, dialkylthiophosphoryl, dialkylisoxazolylalkyl and thienylisoxazolylalkyl;wherein R.sup.1 is alkyl, cycloalkyl, cyano, dialkyl-2,3-dihydrobenzofuran-7-yl, halophenyl, halophenylalkyl, haloalkoxyphenyl, pyridinyl, halopyridinyl, alkyl-1,3,4-thiadiazolyl, haloalkyl-1,3,4-thiadiazolyl, benzothiazolyl, dialkyloxazolyl or thiazolinyl;wherein R.sup.Type: GrantFiled: June 30, 1986Date of Patent: May 31, 1988Assignee: FMC CorporationInventors: Thomas G. Cullen, Anthony J. Martinez, Jacob J. Vukich
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Patent number: 4746678Abstract: The invention relates to new phenanthrene derivatives wherein R stand for C.sub.1-10 alkylamino; C.sub.1-10 alkylthio; C.sub.1-5 alkoxy; or phenyl or phenylamino, the two latter groups being optionally substituted on the phenyl ring by one or more identical or different C.sub.1-4 alkyl, C.sub.1-4 alkoxy, nitro, amino, cyano and/or halogen substituent(s) .The compounds of the present invention possess valuable fungicidal properties and may be used in agriculture, horticulture and therapy as active ingredient of fungicidal or antifungal compositions.The compounds of the general Formula I ##STR1## may be prepared by acylating 9,10-phenanthrene-dione-9-oxime or an alkali or alkali earth metal salt thereof.Type: GrantFiled: June 4, 1986Date of Patent: May 24, 1988Assignee: EGIS GyoryszergyarInventors: Pal Benko, Tibor Zsolnai, Marta Kininczky, Laszlo Pallos, Iren Zsolnai nee Csillag, Peter Tetenyi, Jeno Bernath
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Patent number: 4740524Abstract: Alpha-halopyruvate oximes of the formula: ##STR1## wherein R, R.sup.1, and X are as defined herein having bactericidal and, fungicidal activity are disclosed.Type: GrantFiled: May 16, 1986Date of Patent: April 26, 1988Assignee: Rohm and Haas CompanyInventor: Adam C. Hsu
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Patent number: 4698365Abstract: Compounds of the formula ##STR1## in which "halogen" represents chlorine or fluorine and n is zero, one, two or three, that have useful pesticidal activity.Type: GrantFiled: November 25, 1986Date of Patent: October 6, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Martin Anderson
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Patent number: 4683241Abstract: Phenolic esters of the general formula I ##STR1## are useful for the prevention, management or alleviation of elastase mediated diseases or conditions.Type: GrantFiled: May 21, 1984Date of Patent: July 28, 1987Assignee: G. D. Searle & Co.Inventors: Masateru Miyano, James R. Deason
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Patent number: 4680310Abstract: Tetrahydronaphthalene derivatives of the formula ##STR1## wherein Y, m, n, R and R.sup.1 to R.sup.9 are as set forth herein, are described.These compounds have a pronounced calcium-antagonistic and anti-arrhythmic activity and can accordingly be used as medicaments, especially for the control or prevention of angina pectoris, ischaemia, arrhythmias and high blood pressure. The compounds of formula I can be prepared by the amination of a compound of the formula ##STR2## with a corresponding N-methyl-phenylalkylamine and optional subsequent O-acylation. Compounds of formula II and IV are also described and are within the scope of the invention.Type: GrantFiled: October 10, 1985Date of Patent: July 14, 1987Assignee: Hoffmann-La Roche Inc.Inventors: Urs Hengartner, Henri Ramuz
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Patent number: 4661515Abstract: Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, and cycloalkyl, and may be the same or different; n is an integer from 0 to 4 inclusive; M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cyloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl, or M and R.sub.6 taken together with the nitrogen to which M is bonded and the carbon to which R.sub.Type: GrantFiled: January 17, 1986Date of Patent: April 28, 1987Assignee: USV Pharmaceutical CorporationInventors: Edward S. Neiss, John T. Suh, John J. Piwinski
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Patent number: 4623658Abstract: Pesticidal benzoylurea compounds of the formula: ##STR1## wherein R represents a moiety --C(O)OR.sup.1 or --NR.sup.2 R.sup.3, and the meanings of each of the other symbols is described in the specification.Type: GrantFiled: February 3, 1986Date of Patent: November 18, 1986Assignee: Shell Oil CompanyInventor: Martin Anderson
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Patent number: 4602037Abstract: Novel antiviral xanthate compounds, a process for their production, pharmaceutical compositions containing said xanthate compounds, and a method of combating viruses therewith, are disclosed.Type: GrantFiled: May 13, 1983Date of Patent: July 22, 1986Assignee: Merz+Co. GmbH & Co.Inventors: Arthur Scherm, Klaus Hummel
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Patent number: 4596706Abstract: A method for treating or aiding in the treatment of a tobacco habit or addiction in a human by controlling the craving for tobacco or controlling tobacco withdrawal symptoms which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving or said withdrawal symptoms so as to reduce the desire for tobacco.Type: GrantFiled: April 12, 1985Date of Patent: June 24, 1986Assignee: Elena AvramInventor: Emanuel Revici
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Patent number: 4596798Abstract: This invention relates to the use of various 2-acetylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom in the treatment of viral infections. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.Type: GrantFiled: March 30, 1982Date of Patent: June 24, 1986Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Charles Shipman, Jr., Daniel L. Klayman, Sandra H. Smith, John C. Drach
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Patent number: 4595695Abstract: 1'-Ethoxycarbonyloxyethyl ester of di-n-propylacetic acid, also known as valproic acid. The novel compound is prepared by reacting valproic acid with 1-haloethyl ethyl carbonate. There are also provided pharmaceutical compositions for oral administration containing the said ester.Type: GrantFiled: November 16, 1983Date of Patent: June 17, 1986Assignee: Teva Pharmaceutical Industries Ltd.Inventors: David Ladkani, Haim Yellin, Ben Z. Weiner
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Patent number: 4565689Abstract: A method for treating or aiding in the treatment of the manifestations of alcoholism or alcohol intoxication by aiding in the control of the craving for alcohol or by aiding in the control of alcohol withdrawal symptoms, or by aiding in the control of alcohol intoxication in a human which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving, symptoms, or intoxication so as to counteract the effects of alcohol.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Wirth Maschinen-und Bohrgerate-Fabrik GmbHInventor: Emanuel Revici
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Patent number: 4565690Abstract: A method for treating drug addiction from compounds which cause a catabolic effect on the human body, which comprises administering to said body, a sufficient amount of an anabolic agent containing bivalent negative selenium or sulfur.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Elena AvramInventor: Emanuel Revici
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Patent number: 4565648Abstract: A process for producing storage-stable solutions of pyrocarbonic acid dialkyl esters in organic liquids inert to these esters comprising adding certain carbonyl compounds, sulfonyl compounds and/or thiourea to these pyrocarbonic acid dialkyl ester solutions. Also the use of these carbonyl compounds, sulfonyl compounds and/or thiourea for producing stabilized polyisocyanate preparations suitable for the production of polyurethane foams.Type: GrantFiled: August 15, 1983Date of Patent: January 21, 1986Assignee: Bayer AktiengesellschaftInventors: Richard Kopp, Wolfgang Reichmann
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Patent number: 4542158Abstract: 1-(Alkoxy or aroxy)carbonyloxyalkyl esters of diflunisal and related compounds are stable in aqueous medium and non-irritant to mucous membranes of mouth, throat, and stomach. Accordingly, they are useful Prodrugs of the analgesic and anti-inflammatory drug, diflunisal.Type: GrantFiled: October 25, 1982Date of Patent: September 17, 1985Assignee: Merck & Co., Inc.Inventor: Conrad P. Dorn
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Patent number: 4497823Abstract: Method of treating veterinary or human patients for relief of dermal or sub-dermal pain and inflammation by topical application of a therapeutic agent comprising propylene carbonate.Type: GrantFiled: March 29, 1983Date of Patent: February 5, 1985Inventors: William T. Moore, John W. Albright