C-c(=x)-x-c Containing (x Is Chalcogen And At Least One X Is Other Than Oxygen) Patents (Class 514/513)
-
Patent number: 4766119Abstract: p is an integer from one to three;NR is selected from the group consisting of pyrrolidino, piperidino, morpholino and dialkylamino containing a total of two to eight carbon atoms either straight chain or branched; or pharmaceutically acceptable salts thereof.Type: GrantFiled: February 20, 1985Date of Patent: August 23, 1988Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4755531Abstract: Thiol esters of 4,5-allenyl prostaglandins, methods of making them, and pharmaceutical compositions containing them. These compounds are useful as gastric acid secretion inhibitors.Type: GrantFiled: August 11, 1986Date of Patent: July 5, 1988Assignee: Syntex (U.S.A.) Inc.Inventors: Joseph M. Muchowski, Angel Guzman
-
Patent number: 4752615Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or cyclic imide fungicides.Type: GrantFiled: November 13, 1986Date of Patent: June 21, 1988Assignee: Sumitomo Chemical Company, LimitedInventors: Junya Takahashi, Toshiro Kato, Hiroshi Noguchi, Yukio Oguri, Shigeo Yamamoto, Katsuzo Kamoshita
-
Patent number: 4734281Abstract: An efficient cost- and labor-saving method is proposed for controlling the population of two kinds or more of different species of insectan pests in a field by means of distributing dispensers of sex pheromone compounds for the respective species of the insects when one of the sex pheromone compounds is an unsaturated C.sub.10 to C.sub.12 alcohol and the other is an unsaturated C.sub.14 to C.sub.20 acetate or aldehyde. When these two classes of the compounds are mixed in such a proportion that the overall solubility paramater .delta. of the mixture is 9.1 to 9.7 and the mixture is contained in a dispenser body made of polyethylene or a copolymer mainly composed of ethylene moiety, the two compounds can be concurrently emitted from the dispenser in the form of vapor each at a controlled rate over a desired length of time.Type: GrantFiled: February 2, 1987Date of Patent: March 29, 1988Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Akira Yamamoto, Kinya Ogawa, Shigehiro Nagura
-
Patent number: 4727180Abstract: Polyhalohydroxyisopropyl phenylalkanoic and phenylalkenoic acids, amides, and esters, such as methyl 2-methoxy-4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]benzenepro panoate, are useful as antihypertensive agents.Type: GrantFiled: January 4, 1985Date of Patent: February 23, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventors: Paul E. Aldrich, Gilbert H. Berezin
-
Patent number: 4725593Abstract: A new method of treating a patient suffering smooth muscle spasm comprises administering to the patient an effective amount of anti-spasmodic compound having the general formula: ##STR1## where R is selected from the group consisting of: ##STR2## wherein W is CH.sub.2, NH, O or S, ##STR3## wherein Y is an alicyclic ring ring having 3-12 carbon atoms, and ##STR4## the total number of carbon atoms in R is equal to or less than 20. Furthermore, m is an integer from 1 to 4, n is an integer from 1 to 4, p is an integer from 1 to 4 and q is an integer from 1 to 4. X may be nonexistent or may be 0, S, NH or CH.sub.2 or salts thereof. However, when X is nonexistent the terminal group in both the n-chain and the p-chain is a methyl group provided that a is zero or 1 and when a is 1, X is selected from the group consisting of 0, S, and CH.sub.Type: GrantFiled: April 15, 1986Date of Patent: February 16, 1988Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4721722Abstract: A new class of anti-spasmodic compounds having two branch chains and containing quaternary nitrogen is provided. The compounds have the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are defined hereinbelow and m is an integer from 0 to 3.Type: GrantFiled: July 12, 1985Date of Patent: January 26, 1988Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4721705Abstract: Compositions for treating sun eczema or dyshydrosis of skin comprising (a) 0.1 to 5% by weight of panthenol, (b) 0.1 to 3% by weight of at least one member of the group consisting of methionine, N-acyl-cysteine and S-acyl-cysteine, said acyl being derived from an alkanoic acid of 1 to 7 carbon atoms, or cystine in an amount of at most 0.009% by weight, (c) 0.25 to 4% by weight of carraghenate, (d) 0.1 to 5% by weight of sodium chloride, (e) 0.1 to 2% by weight of a preservative and (f) sufficient water for 100% by weight, all weights based on the weight of the total composition and a method for treating sun eczema or dyshydrosis.Type: GrantFiled: September 20, 1984Date of Patent: January 26, 1988Assignee: Chemish Adviesbureau Drs. J.C.P. Schreuder B.V.Inventor: Johannes C. P. Schreuder
-
3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives and an analgesic agent comprising the same
Patent number: 4719231Abstract: New 3-[N-(mercaptoacyl)]amino-4-arylbutanoic acid derivatives are now provided, which exhibit analgesic activity and are effective to enhance the analgesia induced by a known analgesic compound, ]D-ala.sup.2,met.sup.5 ]-enkephalin (DAME).Type: GrantFiled: May 20, 1985Date of Patent: January 12, 1988Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Mitsugu Hachisu, Masao Hirayama, Shinjiro Murata, Shunzo Fukatsu -
Patent number: 4707480Abstract: A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises administering to the patient a di-N-substituted aminoethyl ester of diphenylthioacetic acid having the formula: ##STR1## in which R represents a disubstituted amino radical of the group consisting of the diethylamino group, the morpholino group or the piperidino group.Type: GrantFiled: October 3, 1985Date of Patent: November 17, 1987Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4678780Abstract: A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where R, X, m, n and p are defined hereinbelow.Type: GrantFiled: October 27, 1986Date of Patent: July 7, 1987Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4647562Abstract: A new class of anti-spasmodic compounds having three branch chains is provided. These compounds have the general formula: ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are saturated straight chain or branched alkyl groups contained from 1 to 8 carbon atoms, and are separated or linked to one another to form an aliphatic ring system. k is an integer from 0 to 5, and the total number of carbon atoms in R.sub.1 plus R.sub.2 plus R.sub.3 plus k are equal to or less than 12. Furthermore, l is an integer from 1 to 3, m is an integer from 1 to 3, n is an integer from 1 to 3, and X may be nonexistent or may be O, S, NH or CH.sub.2 or salts thereof. However, when X is nonexistent the terminal group in both the m chain and the n chain is a methyl group.Type: GrantFiled: February 20, 1985Date of Patent: March 3, 1987Assignee: United Pharmaceuticals, Inc.Inventor: William M. Davis
-
Patent number: 4633014Abstract: Substituted 3-hydrazinopropionates comprising compounds of the general fola: ##STR1## wherein R.sup.1, R.sup.2 =H, an alkyl, a substituted alkyl, hydroxycarbonyl, alkoxycarbonyl, an aryl, an aralkyl, an unsaturated alkyl, a substituted aryl or a substituted aralkyl: ##STR2## wherein R.sup.7, R.sup.8 =H, an alkyl, an unsaturated alkyl, an aralkyl, an aryl, a substituted alkyl,R.sup.9 =OH, an alkoxy, an aralkoxy, an alkyl, an unsaturated alkyl, an aryl, a substituted aryl, an aralkyl;R.sup.4 is --C.tbd.N, --COR.sup.10, wherein R.sup.10 =OR.sup.11, NR.sup.12 R.sup.13, where R.sup.11 is H, an alkyl, an aralkyl and an alkali metal, R.sup.11 and R.sup.12 are each H, an alkyl, an aralkyl, an aryl;R.sup.5, R.sup.6 = an alkyl, an aryl, an aralkyl.Type: GrantFiled: July 6, 1984Date of Patent: December 30, 1986Assignee: Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi SsrInventors: Gunar A. Bremanis, Ivars Y. Kalvinsh, Irene B. Antsena, Edmund Y. Lukevits, Maris M. Veveris, Valeryans Y. Kauss, Peter T. Trapentsier, Edvards E. Liepinsh
-
Patent number: 4619944Abstract: Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,m is an integer from 0 to 2 inclusive,n is an integer from 0 to 4 inclusive,M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl.Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkyl-alkyl, heterocyclic, --CO--SR, --CS--SR, ##STR2## CH.sub.2 CO.sub.2 R, --CHM--CO.sub.2 R, --CH.sub.2 --CO--SR, --CN, ##STR3## --CO--NH--CH.sub.2 CO.sub.2 R, ##STR4## or --CO--CO.sub.Type: GrantFiled: February 19, 1985Date of Patent: October 28, 1986Assignee: USV Pharmaceutical CorporationInventors: Raymond D. Youssefyeh, Howard Jones
-
Patent number: 4611002Abstract: New carboxymethyl esters of mercaptopropanoic acids, and salts thereof, have the formula ##STR1## wherein R is hydrogen or lower alkanoyl;R.sub.1 is hydrogen, lower alkyl, phenylalkyl and phenyl;R.sub.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, 4-hydroxyphenyl-lower alkyl or indolyl-lower alkyl.These compounds are useful as enkephalinase inhibitors and hypotensive agents.Type: GrantFiled: June 8, 1984Date of Patent: September 9, 1986Assignee: E. R. Squibb and Sons, Inc.Inventor: Miguel A. Ondetti
-
Patent number: 4607026Abstract: This invention relates to stereoisomeric forms and mixtures thereof of compounds of the formula ##STR1## having insecticidal, nematocidal, and acaricidal properties.Type: GrantFiled: September 29, 1982Date of Patent: August 19, 1986Assignee: Roussel UclafInventors: Jean Tessier, Andre Teche
-
Patent number: 4600576Abstract: Described is the genus of thiogeranyl esters defined according to the structure: ##STR1## wherein R represents hydrogen, C.sub.1 -C.sub.5 alkyl or C.sub.2 -C.sub.6 alkenyl and uses thereof in augmenting or enhancing the aroma or taste of consumable materials including foodstuffs, chewing gums, toothpastes, medicinal products, perfume compositions, colognes and perfumed articles.Type: GrantFiled: June 21, 1985Date of Patent: July 15, 1986Assignee: International Flavors & Fragrances Inc.Inventors: Alan O. Pittet, Ranya Muralidhara, Manfred H. Vock, Kevin P. Miller, Domenick Luccarelli, Jr.
-
Patent number: 4596706Abstract: A method for treating or aiding in the treatment of a tobacco habit or addiction in a human by controlling the craving for tobacco or controlling tobacco withdrawal symptoms which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving or said withdrawal symptoms so as to reduce the desire for tobacco.Type: GrantFiled: April 12, 1985Date of Patent: June 24, 1986Assignee: Elena AvramInventor: Emanuel Revici
-
Patent number: 4595696Abstract: Polyene compounds represented by the general formula ##STR1## where R.dbd.H or lower alkyl group of from 1 to 5 carbon atoms ##STR2## n is 0-1 x is O or S; andR.sub.1 =an alkyl group of from 1 to 5 carbon atoms; and the pharmaceutically acceptable salts thereof.and the pharmaceutically acceptable salts thereof.The foregoing compounds have been found to be effective in regulating the formation of lipoxygenese and as such possess therapeutic value in the treatment of inflammatory conditions and allergic responses.Type: GrantFiled: September 13, 1985Date of Patent: June 17, 1986Assignee: USV Pharmaceutical Corp.Inventors: Bernard Loev, Wan-Kit Chan
-
Patent number: 4585793Abstract: Certain novel heterocyclic compounds, aromatic thioesters, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity and in the treatment of diseases such as emphysema which involve tissue proteolysis.Type: GrantFiled: May 9, 1983Date of Patent: April 29, 1986Assignee: Georgia Tech Research InstituteInventor: James C. Powers
-
Patent number: 4569928Abstract: Novel esters in all possible isomeric forms and mixtures thereof of the formula ##STR1## wherein R is selected from the group consisting of (a) optionally unsaturated alkyl of 1 to 18 carbon atoms and optionally unsaturated cycloalkyl or cycloalkylalkyl of 3 to 8 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --OH, --SH, --OR', --SR', --NO.sub.2, ##STR2## --SO.sub.2 AlK.sub.2, --SO.sub.3 AlK.sub.3, aryl optionally substituted with at least one member of the group consisting of --OH, alkoxy of 1 to 8 carbon atoms, alkyl of 1 to 8 carbon atoms, halogen, --CF.sub.3, --OCF.sub.3, --SCF.sub.3 and ##STR3## R' is alkyl of 1 to 8 carbon atoms, R" and R'" are individually selected from the group consisting of hydrogen and alkyl of 1 to 8 carbon atoms, AlK.sub.1, AlK.sub.2 and AlK.sub.Type: GrantFiled: October 28, 1983Date of Patent: February 11, 1986Assignee: Roussel UclafInventors: Jean Tessier, Andre Teche, Jean-Pierre Demoute
-
Patent number: 4567163Abstract: The thioester of N-acetylcysteine with salicylic acid and the pharmacologically acceptable and non-toxic organic and inorganic salts thereof, exhibit anti-pyretic, anti-inflammatory and analgesic activity as well as mucolytic activity. The compounds are prepared by the reaction of N-acetylcysteine with either the acid chloride of acetylsalicylic acid or with the mixed anhydride formed from acetylsalicylic acid and ethyl chloroformate, the reaction taking place in an aqueous medium and at low temperature.Type: GrantFiled: November 16, 1982Date of Patent: January 28, 1986Assignee: Pietro Ismardi & C. S.p.A.Inventor: Osvaldo Ponchiroli
-
Patent number: 4567198Abstract: Novel analgesic and enkephalinase inhibiting compositions comprising an analgesically and enkephalinase inhibitory effective amount of at least one compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and acetyl, n is 1 or 2 and when n is 1, R.sub.2 is selected from the group consisting of phenyl, p-chlorophenyl, m-trifluoromethylphenyl and thiazolyl and when n is 2, R.sub.2 is selected from the group consisting of phenyl and p-chlorophenyl and their salts with non-toxic, pharmaceutically acceptable acids and bases and an inert pharmaceutical carrier and novel method of relieving pain and inhibiting enkephalinase activity in warm-blooded animals and novel amides.Type: GrantFiled: February 6, 1984Date of Patent: January 28, 1986Assignee: Roussel UclafInventors: Francoise Delevallee, Roger Deraedt, Odile Le Martret
-
Patent number: 4565689Abstract: A method for treating or aiding in the treatment of the manifestations of alcoholism or alcohol intoxication by aiding in the control of the craving for alcohol or by aiding in the control of alcohol withdrawal symptoms, or by aiding in the control of alcohol intoxication in a human which comprises internally administering to said human an effective amount of a compound having an active ingredient containing at least one bivalent negative sulfur to control said craving, symptoms, or intoxication so as to counteract the effects of alcohol.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Wirth Maschinen-und Bohrgerate-Fabrik GmbHInventor: Emanuel Revici
-
Patent number: 4565690Abstract: A method for treating drug addiction from compounds which cause a catabolic effect on the human body, which comprises administering to said body, a sufficient amount of an anabolic agent containing bivalent negative selenium or sulfur.Type: GrantFiled: April 12, 1985Date of Patent: January 21, 1986Assignee: Elena AvramInventor: Emanuel Revici
-
Patent number: 4563443Abstract: Acetylsalicylic acid thioesters having antipyretic activity and useful for the symptomatic treatment of influenza of formula: ##STR1## wherein n is zero or 1, R.sub.1 is hydrogen, methyl or carboxy and R.sub.2 is hydrogen or an acetamido group; a process for their preparation by reacting a functional derivative of acetylsalicylic acid with the suitable thiol; and pharmaceutical compositions containing them as active ingredient.Type: GrantFiled: August 9, 1983Date of Patent: January 7, 1986Assignee: Edmond Pharma S.r.l.Inventors: Marino Gobetti, Guido Vandoni
-
Patent number: 4552765Abstract: Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.Type: GrantFiled: April 25, 1983Date of Patent: November 12, 1985Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Itaru Mita, Jun-ichi Iwao, Tadashi Iso, Masayuki Oya
-
Patent number: 4537905Abstract: Substituted oximinoacetanilides of the general formula ##STR1## in which R.sup.1 denotes an alkyl or alkoxy group or a halogen atom,R.sup.2 denotes a hydrogen or halogen atom or an alkyl or trifluoromethyl group,R.sup.3 denotes a hydrogen or halogen atom or an alkyl group,R.sup.4 denotes a hydrogen atom or a methyl group,R.sup.5 denotes an alkoxy, amino or --NH--CO--NH--R.sup.7 group,whereinR.sup.7 represents a hydrogen atom or an optionally cyano-, alkoxy- or alkoxycarbonyl-substituted alkyl group, or represents a cycloalkyl group, andR.sup.6 denotes various aliphatic or heterocyclic radicals, are new and find use as pest-combating agents, in particular as fungicides.Type: GrantFiled: January 27, 1983Date of Patent: August 27, 1985Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Werner Daum
-
Patent number: 4518613Abstract: Thioalkanoyl-carnitines of general formula (I) ##STR1## wherein R is a straight alkylene radical having from 2 to 6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms, or is a branched alkylene radical having from 3-6 carbon atoms,R.sub.1 is a straight or branched lower alkyl radical having from 1 to 4 carbon atoms, andX.sup.- is a halogen anionare prepared by reacting a thio-acid (II) of general formula R.sub.1 COSH(a) if in (I) the thioalkanoyl radical R.sub.1 COS-- is in terminal position, with a compound of general formula (III) ##STR2## wherein n is an integer comprised between 0 and 4 or(b) if in (I) the thioalkanoyl radical R.sub.1 COS-- is not in terminal position, with a compound of general formula (IV) ##STR3## wherein m and m.sup.1 are integers comprised between 0 and 3, andR.sub.2 is a lower alkyl radical having from 1 to 4 carbon atoms.The pharmaceutical compositions containing the thioalkanoyl-carnitines (I) possess mucolytic and antitussive activity.Type: GrantFiled: October 22, 1982Date of Patent: May 21, 1985Inventors: Claudio Cavazza, Maria O. Tinti
-
Patent number: 4515807Abstract: Fungicides of the formula: ##STR1## in which: R.sup.1 and R.sup.3, which are identical or different, represent an alkyl radical having from 1 to 4 carbon atoms and are preferably the methyl radical,R.sup.4 represents the hydrogen atom or a methyl radical,R.sup.5 represents the hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms,R.sup.6 represents an optionally monohalogenated or dihalogenated alkyl radical having from 1 to 6 carbon atoms, a cycloalkyl radical having from 3 to 6 carbon atoms or a radical --CH.sub.2 --X--R.sup.7,X represents the oxygen or sulphur atom, andR.sup.7 represents an alkyl radical having from 1 to 4 carbon atoms.Type: GrantFiled: September 29, 1982Date of Patent: May 7, 1985Assignee: Rhone-Poulenc AgrochimieInventors: Jean-Claude Debourge, Guy Lacroix
-
Patent number: 4513009Abstract: This invention relates to aminoacid derivatives, and compositions containing the same and having enkephalinase-inhibiting, antalgic, antidiarrhea and hypotensive activities, of the formula ##STR1## whose variables are as set forth herein, for example ##STR2##Type: GrantFiled: April 14, 1981Date of Patent: April 23, 1985Assignee: Societe Civile BioprojetInventors: Bernard Roques, Jean-Charles Schwartz, Jeanne-Marie Lecomte
-
Patent number: 4507316Abstract: Provided are antihypertensive compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl, and may be the same or different,m is an integer from 0 to 2 inclusive,n is an integer from 0 to 4 inclusive,M is alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, polycycloalkyl, polycycloalkyl-alkyl, aryl, aralkyl, heteroaryl, heteroaryl-alkyl, hetero-cycloalkyl, hetero-cycloalkyl-alkyl, fused aryl-cycloalkyl, fused aryl-cycloalkyl-alkyl, fused heteroaryl-cycloalkyl, fused heteroaryl-cycloalkyl-alkyl, alkoxyalkyl, alkylthioalkyl, alkylamino-alkyl, or dialkylaminoalkyl.Y is hydroxy, alkoxy, amino, or substituted amino, aminoalkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclic, ##STR2## wherein R is hydrogen, alkyl, or aryl, and where Y is hydroxy, their pharmaceutically acceptable, nontoxic alkali metal, alkaline earth metal, and amine salts.Type: GrantFiled: June 1, 1981Date of Patent: March 26, 1985Assignee: USV Pharmaceutical CorporationInventors: Raymond D. Youssefyeh, Howard Jones