S-x-c Containing (e.g., Sulfates, Etc.) (x Is Chalcogen) Patents (Class 514/517)
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Publication number: 20140017506Abstract: The present application relates to wood preservation, for example, surfactants and phospholipids for improving wood preservation. Included are surfactants and phospholipids containing a 2-amino-N,N-dimethylacetamide. Provided are wood preservative compositions containing these surfactants or phospholipids, methods of applying such wood preservative compositions to wood, and wood products resultant from some such methods. Also provided are wood products containing the wood preservative compositions provided herein.Type: ApplicationFiled: July 16, 2012Publication date: January 16, 2014Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLCInventor: Atsushi Mizusawa
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Publication number: 20140018330Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative of formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of, inter alia, rosacea.Type: ApplicationFiled: July 9, 2013Publication date: January 16, 2014Inventors: Pedro Cuevas Sànchez, Guillermo Gimenez Gallego, Inigo Saenz de Tejada Gorman, Javier Angulo Frutos, Serafin Valverde Lopez, Antonio Romero Garrido, Rosa Maria Lozano Puerto
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Publication number: 20140017301Abstract: The present invention provides drug-free adaptable aggregate compositions, typically having a form of bilayer vesicles suspended in a polar, optionally thickened, fluid comprising different pharmaceutically acceptable excipients for use in or on a mammal for any medical indication, specifically for non-invasive treatment of local inflammation and the associated pain, in particular for use on the skin and underlying tissues, including muscles and/or superficial joints. Accompanying guidelines for selecting components to thereby optimizing the formulations are also provided.Type: ApplicationFiled: March 21, 2012Publication date: January 16, 2014Inventor: Gregor Cevc
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Publication number: 20130338160Abstract: The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.Type: ApplicationFiled: June 18, 2013Publication date: December 19, 2013Inventors: Charles SHIH, Qian Shi, Hui-kang Wang
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Patent number: 8609864Abstract: The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds.Type: GrantFiled: January 7, 2010Date of Patent: December 17, 2013Assignee: Purdue Pharmaceutical Products, L.P.Inventors: Yu Chen, Yi Chen
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Patent number: 8609641Abstract: The invention relates to a medicament containing (S)-2-N-propylamino-5-hydroxytetralin, the salts or prodrugs thereof. As a D3 agonist, (S)-2-N-propylamino-5-hydroxytetralin is suitable particularly for the treatment of dopa-sensitive movement disorders.Type: GrantFiled: December 13, 2004Date of Patent: December 17, 2013Assignee: UCB Pharma GmbHInventors: Dieter Scheller, Klaus Hansen
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Publication number: 20130310453Abstract: A new vegetable, referred to herein as green garlic, grown from garlic bulbils is disclosed. In particular examples, the green garlic is rich in one or more thiosulfinates. Methods of producing green garlic are also disclosed. In some examples, such methods permit year-round commercial production of green garlic.Type: ApplicationFiled: December 19, 2012Publication date: November 21, 2013Applicant: VoloAgri Group, Inc.Inventor: VoloAgri Group, Inc.
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Publication number: 20130296323Abstract: This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.Type: ApplicationFiled: February 27, 2013Publication date: November 7, 2013Applicant: COYOTE PHARMACEUTICALS, INC.Inventors: Hiroaki Serizawa, Ankush B. Argade, Akash Datwani, Natalie Spencer, Yonghua Pan, Florian Ermini
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Publication number: 20130295198Abstract: Methods for selecting chemotherapeutic agents for treating a cancer are provided that include the steps of providing a cancer cell sample having a population of bulk cancer cells and a population of cancer stem-like cells, culturing a first portion of the cancer cell sample in a hydrodynamic focusing bioreactor under microgravity conditions and for a period of time to selectively enhance the population of cancer stem-like cells and selectively kill the population of bulk cancer cells, contacting the cancer stem-like cells with one or more chemotherapeutic agents, and then selecting the one or more chemotherapeutic agents for treating the cancer if there is an increase in an amount of cytotoxicity. Methods for treating a cancer are also provided in which the identified chemotherapeutic agents are administered to a subject. Further provided are methods for identifying a test compound useful for treating a cancer.Type: ApplicationFiled: March 19, 2013Publication date: November 7, 2013Applicant: Marshall University Research CorporationInventor: Marshall University Research Corporation
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Publication number: 20130281387Abstract: Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.Type: ApplicationFiled: October 18, 2011Publication date: October 24, 2013Applicant: ELCELYX THERAPEUTICS, INC.Inventors: Alain D. Baron, Martin R. Brown, Christopher R.G. Jones, Nigel R.A. Beeley
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Publication number: 20130261133Abstract: The compounds of the invention exhibit antiprotozoal, antimicrobial, and anticancer properties that are useful for the treatment or prevention of infections or cancer in a patient (e.g., a human). For example, the compounds and methods described herein can be used for the treatment or prevention of protozoal infections such as leishmaniasis, malaria, and trypanosoma infections, bacterial infections such as S. aureus and C. albicans, and cancers such as breast, colon, lung, or prostate cancer. The invention further provides methods of synthesizing such compounds as well as kits useful for administering the compounds.Type: ApplicationFiled: March 14, 2013Publication date: October 3, 2013Applicant: The University of MontanaInventors: John Howard Hoody, David Brian Bolstad
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Publication number: 20130253053Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific microRNAs and the methods of using active agents identified by the screening protocol in the treatment of skin.Type: ApplicationFiled: May 30, 2013Publication date: September 26, 2013Applicant: Avon Products, Inc.Inventors: Permanan Raaj Khusial, Uma Santhanam, John W. Lyga
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Patent number: 8455518Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific microRNAs and the methods of using active agents identified by the screening protocol in the treatment of skin.Type: GrantFiled: December 28, 2010Date of Patent: June 4, 2013Assignee: Avon Products, Inc.Inventors: Permanan Raaj Khusial, Uma Santhanam, John W. Lyga
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Patent number: 8436045Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, actinic keratosis.Type: GrantFiled: November 15, 2010Date of Patent: May 7, 2013Assignee: AmDerma Pharmaceuticals, LLCInventor: Pedro Cuevas Sánchez
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Publication number: 20130090380Abstract: A non-aerosol, foaming high alcohol content hand sanitizer is provided which has excellent antimicrobial activity and tolerance for organic load and excellent residual activity, as well as enhanced moisturization and skin-feel properties over currently marketed alcohol-based sanitizers. The inventive composition achieves an unexpectedly large amount of quality, stable foam even in the presence of significant quantities of skin conditioning agents through the use of novel silicone surfactants and achieves enhanced and prolonged antimicrobial efficacy through the combination of high alcohol content and activity enhancing components.Type: ApplicationFiled: October 4, 2012Publication date: April 11, 2013Applicant: AMERICAN STERILIZER COMPANYInventor: AMERICAN STERILIZER COMPANY
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Publication number: 20130079402Abstract: The invention relates to the use of at least one dialkyl thiosulfonate or thiosulfinate in order to reduce the number of apicomplexa, such as coccidioides and, in particular, Eimeria, in monogastric animals, such as poultry or pigs, or ruminants, such as cattle, sheep or goats.Type: ApplicationFiled: April 1, 2011Publication date: March 28, 2013Applicant: Pancosma S.A.Inventors: David Bravo, Hyun Lillehoj
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Publication number: 20130059909Abstract: The invention is directed to emulsifiable oil suspension concentrate formulations containing cinnamaldehyde (cinnamic aldehyde) and allicin that are effective in protecting plants from pests, especially nematodes, and methods of their use.Type: ApplicationFiled: November 2, 2012Publication date: March 7, 2013Applicant: Valent BioSciences CorporationInventor: Valent BioSciences Corporation
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Publication number: 20130059908Abstract: The use of sulfonamides of formula (I) wherein R and R1 are as defined in the description, for the preparation of medicaments for the prevention of diabetes, in particular of type-1 diabetes is herein disclosed.Type: ApplicationFiled: October 6, 2010Publication date: March 7, 2013Applicant: DOMPE' S.P.A.Inventors: Lorenzo Piemonti, Luisa Daffonchio, Marcello Allegretti
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Publication number: 20130053392Abstract: A carbonic anhydrase IX (CA IX) inhibitor which comprises a compound of general formula: R—NH—CX—NH—(CH2)n—Ar-Q-SO2—NH2 or a pharmaceutically-acceptable salt, derivative or prodrug thereof; wherein n=0, 1 or 2; Q is O or NH; X is O or S; and R comprises an organic substituent group.Type: ApplicationFiled: February 14, 2011Publication date: February 28, 2013Inventors: Peter Ebbesen, Claudlu T. Supuran, Andrea Scozzafava, Erik Olai Pettersen, Kaye Williams, Ludwig Dubois, Philippe Lambin
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Publication number: 20130039977Abstract: Pharmaceutically acceptable liposome-encapsulated busulphan formulations for parenteral administration are provided, as well as such formulations furthermore comprising glutathione and/or at least one glutathione precursor and a process for manufacture of the preparations. The formulations are stable, have improved biodistribution and significantly reduced side effects over those produced by oral administration or parenteral administration of free drug. The formulations are useful as part of stem cell and/or bone marrow transplant conditioning regimens. A method of treatment of a mammal by use of such formulations.Type: ApplicationFiled: October 18, 2012Publication date: February 14, 2013Applicant: BUSULIPO ABInventor: BUSULIPO AB
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Publication number: 20120329712Abstract: This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents.Type: ApplicationFiled: June 5, 2012Publication date: December 27, 2012Applicant: University of Southern CaliforniaInventor: Valter Longo
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Publication number: 20120328519Abstract: The present invention relates to the novel compound classes of dendritic polyglycerol sulfates and sultanates as well as to their production and use for the treatment of diseases, particularly inflammatory diseases, and to their use as selectin inhibitors and selectin indicators. The dendritic polyglycerol sulfates and sulfonates are also suitable for imaging diagnostics, particularly with respect to inflammatory diseases.Type: ApplicationFiled: August 3, 2007Publication date: December 27, 2012Inventors: Rainer Haag, Jens Dernedde, Rudolf Tauber, Gesche Bernhard, Sven Enders, Heidemarie Weinhart, Arne Von Bonin, Ulrich Zügel, Holger Türk
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Patent number: 8334408Abstract: Compounds of formula wherein the variables are defined in the specification, are used in compositions which stimulate T cell responses.Type: GrantFiled: May 4, 2012Date of Patent: December 18, 2012Assignee: Ludwig Institute for Cancer ResearchInventors: Vincenzo Cerundolo, Richard Schmidt, Gopal Reddy, Rengarajan Balamurugan, Gerd Ritter, Gurdyal Besra, Mariolina Salio, Jonathan Silk
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Publication number: 20120316169Abstract: (R,S) 2-aryl-propionamide derivatives, or their single enantiomers (R) and (S) are disclosed useful in the treatment or prevention of symptoms and disorders such as pain and inflammation associated with the bradykinin B1 pathway.Type: ApplicationFiled: October 28, 2010Publication date: December 13, 2012Applicant: DOMPÉ S.P.A.Inventors: Andrea Beccari, Andrea Aramini, Gianluca Bianchini, Alessio Moriconi
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Patent number: 8329734Abstract: The invention is directed to formulations and methods of treating a migraine and/or cluster headache with a serotonin agonist, pharmaceutically acceptable salt thereof, or derivative thereof.Type: GrantFiled: July 27, 2009Date of Patent: December 11, 2012Assignee: AFGIN Pharma LLCInventor: Ronald Aung-Din
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Patent number: 8314051Abstract: Disclosed is a method for directly preparing in situ 1-methylcyclopropene which inhibits the action of ethylene of accelerating the ripening process of plants, which comprises reacting a predetermined 1-methylcyclopropene precursor represented by the following Formula 2 or 3 with a base or fluoride anion material, and applying the 1-methylcyclopropene to plants: wherein Me, Et, R1, R2 and X are defined in the specification.Type: GrantFiled: September 3, 2009Date of Patent: November 20, 2012Assignee: Erum Biotechnologies Inc.Inventor: Sang-Ku Yoo
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Publication number: 20120282172Abstract: The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target organ, like, for example, tumor cells and/or vascular cells of tumor blood vessels. Moreover, this invention provides a method where, upon internalization of the previous-mentioned system by the target cells, triggered release at a high rate of the associated agent takes place, permitting efficient intracellular delivery and, thus, increased concentration of the transported cargo at the target site. Overall, this invention provides a method for the diagnosis, prevention and treatment of human diseases and disorders.Type: ApplicationFiled: May 9, 2012Publication date: November 8, 2012Applicants: Centro de Neurociencias e Biologia Celular, Universidade de CoimbraInventors: João Nuno Sereno de Almeida Moreira, Vera Lúcia Dantas Nunes Caldeira de Moura, Sérgio Paulo de Magalhães Simões, Maria da Conceição Monteiro Pedroso de Lima
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Publication number: 20120277169Abstract: Estrogenic compositions comprising nyasol and analogs thereof are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.Type: ApplicationFiled: November 1, 2011Publication date: November 1, 2012Applicant: BioNovo, Inc.Inventor: Isaac Cohen
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Publication number: 20120277249Abstract: There may be provided compositions of lipophilic pharmaceutical agents with improved solubility and stability. For example, there may be provided a non-aqueous composition that comprises a lipophilic pharmaceutical agent, and an amphiphilic polymeric solvent such as PEG400 but essentially free of organic solvents and non-solubilized particles. The composition may be further diluted with a desired aqueous diluent such as an infusion fluid for parenteral administration to a subject such as a human. The compositions may be useful for the treatment for diseases or conditions that are sensitive to lipophilic agents, such as infectious diseases, malignant or autoimmune diseases.Type: ApplicationFiled: April 20, 2012Publication date: November 1, 2012Inventors: Borje S. Andersson, Benigno C. Valdez, Jeffrey Tarrand
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Publication number: 20120270939Abstract: Methods, formulations, and compositions for the treatment of amyloidosis are described.Type: ApplicationFiled: May 15, 2012Publication date: October 25, 2012Inventors: Denis Garceau, Wendy Hauck, Richard Briand
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Patent number: 8293788Abstract: 4-(trifluoromethanesulfonyloxyphenyl)propionic acid derivatives and pharmaceutical composition containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.Type: GrantFiled: September 15, 2011Date of Patent: October 23, 2012Inventors: Marcello Allegretti, Marla Candida Cesta, Riccardo Bertini, Marco Mosca, Francesco Colotta
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Publication number: 20120251492Abstract: Provided are a triterpene derivative represented by a general formula (I), a pharmaceutically acceptable salt thereof, and an agent for preventing or treating chronic hepatitis C comprising the triterpene derivative or the salt as an active ingredient: [in the formula (I), R1 represents a carboxyl group, a hydroxymethyl group, —CH2OSO3H, or and R2 represents —OR3 or —O— (CH2) m-OR4, where R3 represents a benzyl group which may be substituted with a hydroxymethyl group, a dimethylaminomethyl group, a phenylaminomethyl group, a morpholinomethyl group, a carboxyl group, or a formyl group, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or a hydroxy C1-6 alkyl group, R4 represents a phenyl group which may be substituted with a carboxyl group, and m represents an integer of 1 to 3, with the proviso that a case where R1 is —CH2OH, and R3 is a C1-6 alkyl group, a C2-6 alkenyl group, or a benzyl group is excluded].Type: ApplicationFiled: December 15, 2010Publication date: October 4, 2012Applicant: MEIJI SEIKA PHARMA CO., LTD.Inventors: Makoto Ishikawa, Shigeki Suzuki, Makoto Aoki, Nobuto Minowa, Kokichi Suzuki
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Publication number: 20120237446Abstract: The present invention relates to novel compounds (3-aminopropen-1-ones) useful for binding and imaging beta amyloid deposits and their use in detecting or treating Alzheimer's disease and amyloidosis.Type: ApplicationFiled: March 26, 2012Publication date: September 20, 2012Applicant: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Ulrike Röhn, Hermann Künzer, Tobias Heinrich, Markus Berger, Damian Brockschnieder, Sabine Krause, Thomas Dyrks, Andrea Thiele, Ursula Mönning, Ulf Bömer
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Patent number: 8258182Abstract: The present invention involves substituted 1,3-diphenylpropane derivatives, pharmaceutical compositions comprising them and the therapeutic uses thereof, in particular in the fields of human and animal health.Type: GrantFiled: June 21, 2007Date of Patent: September 4, 2012Assignee: GenfitInventors: Jean-François Delhomel, Rémy Hanf, Karine Caumont-Bertrand
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Publication number: 20120219636Abstract: A formulation and method for removing viruses from fresh produce, including at least one surfactant, and a solvent. Preferably, the formulation also includes at least one sanitizer.Type: ApplicationFiled: February 28, 2012Publication date: August 30, 2012Applicant: THE OHIO STATE UNIVERSITYInventors: Jianrong Li, Ashley Predmore
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Publication number: 20120220454Abstract: Coating compositions and methods of use, allowing for improved water and/or nutrient usage by seeds, plants, shrubs, and vegetation, among others, are disclosed.Type: ApplicationFiled: February 28, 2012Publication date: August 30, 2012Applicant: RHODIA OPERATIONSInventors: Zhiyun Chen, Jean-Christophe Castaing, PengFei JI, Galder Cristobal
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Publication number: 20120207856Abstract: Methods for treating a patient at risk for or diagnosed with colorectal cancer are disclosed herein. The method of the present invention determines the overall expression of MSH3 in cells suspected of being colorectal cancer cells from the patient and predicting the efficacy of therapy with a genotoxic anti-neoplastic agent for treating the patient, wherein a decrease in the overall expression of MSH3 in the patient cells when compared to the expression of MSH3 in normal colorectal cells indicates a predisposition to responsiveness to genotoxic anti-neoplastic agent therapy, wherein the therapy comprises administering an effective amount of the genotoxic anti-neoplastic agent therapy to patients.Type: ApplicationFiled: February 10, 2012Publication date: August 16, 2012Applicant: Baylor Research InstituteInventors: Ajay Goel, C. Richard Boland, Minoru Koi, Masanobu Takahashi
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Publication number: 20120208850Abstract: The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.Type: ApplicationFiled: August 6, 2010Publication date: August 16, 2012Applicant: BELLUS HEALTH INC.Inventors: Xianqi Kong, Nigel Levens, Abderrahim Bouzide, Stephane Ciblat, Richard Frenette, Johanne Renaud
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Publication number: 20120207730Abstract: Disclosed herein are methods and compositions for treating viral hemorrhagic fever in a subject by use of at least one inhibitor or suppressor of oxidase, inducible nitric oxide synthase (iNOS) and apoptosis pathway.Type: ApplicationFiled: April 30, 2012Publication date: August 16, 2012Applicant: NATIONAL TAIWAN UNIVERSITYInventors: Betty A. Wu-Hsieh, Yu-Ting Yen
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Publication number: 20120171133Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate dynein expression in the skin. Also provided are methods for screening for substances which modulate dynein expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.Type: ApplicationFiled: November 29, 2011Publication date: July 5, 2012Applicant: AVON PRODUCTS, INC.Inventors: Qian ZHENG, John W. LYGA, Russell J. WYBORSKI
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Publication number: 20120165373Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that suppress or down-regulate microRNA expression in dermal fibroblast, resulting in enhanced production of collagen, elastin and/or fibrillin in the skin. Also provided are methods for screening for activity against specific microRNAs and the methods of using active agents identified by the screening protocol in the treatment of skin.Type: ApplicationFiled: December 28, 2010Publication date: June 28, 2012Applicant: Avon Products, Inc.Inventors: Permanan Raaj Khusial, Uma Santhanam, John W. Lyga
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Publication number: 20120149678Abstract: The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.Type: ApplicationFiled: December 9, 2011Publication date: June 14, 2012Inventors: Bryan T. Oronsky, Susan Knox, Jan Scicinski, Shoucheng Ning
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Publication number: 20120148653Abstract: A pest-combating composition including sodium lauryl sulfate and one or more of C6-12 fatty acids, preferably lauric and/or capric and/or caprylic acid, soy methyl ester, and 2-undecanone, and methods of combating pests utilizing same, are disclosed. The compositions can include a carrier oil such as silicon oil, soy methyl ester, or a vegetable oil, and can be in the form of an emulsion. The composition may be constituted as a spray composition, an aerosol, a lotion, a paste, or another compositional form. Pests that may be usefully combated with such composition include flying insects, including flies, mosquitoes, and wasps, ants, including arthropods such as fire ants, ticks, fleas, cockroaches, silver fish, thrips, gnats, aphids, Japanese beetles, and agricultural and horticultural arthropods and insects including beetles (potato and bean), flea beetles, fleahoppers, squash bugs, slugs, leaf hoppers, harlequin bugs, milk weed bugs, spiders, mites, lice, rodents, and deer.Type: ApplicationFiled: February 22, 2012Publication date: June 14, 2012Applicant: EcoBlend, LLCInventor: Allen Jones
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Patent number: 8193242Abstract: (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.Type: GrantFiled: January 20, 2011Date of Patent: June 5, 2012Assignee: XenoPort, Inc.Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen
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Publication number: 20120136051Abstract: The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.Type: ApplicationFiled: May 20, 2011Publication date: May 31, 2012Applicant: ECOLAB USA INC.Inventors: Junzhong Li, Steven J. Lange, Richard K. Staub, David D. McSherry
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Patent number: 8188313Abstract: Compounds of formula wherein the variable are defined in the specification, are used in compositions which stimulate T cell responses.Type: GrantFiled: September 13, 2011Date of Patent: May 29, 2012Assignees: The University of Birmingham, Chancellor Masters and Scholars of the University of Oxford, Ludwig Institute for Cancer ResearchInventors: Vincenzo Cerundolo, Richard Schmidt, Gopal Reddy, Rengarajan Balamurugan, Gerd Ritter, Gurdyal Besra, Mariolina Salio, Jonathan Silk
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Publication number: 20120129928Abstract: The combination of the surfactant SDS with levulinic acid produces a synergistic effect in relation to the antimicrobial effectiveness of the individual compounds. Accordingly, this surprising synergy allows the formulation of compositions wherein the active agents are present at concentrations effective to reduce bacterial counts in liquids, including, but not limited to, water and other beverages, especially those having a pH value less than about 7.0 by a factor between 103 and 107 without altering the organoleptic properties of the treated food substance. The active agents are FDA-approved as food additives, and the treated beverages can be any aqueous-based beverage consumable by humans or animals.Type: ApplicationFiled: January 17, 2012Publication date: May 24, 2012Applicant: University of Georgia Research Foundation, Inc.Inventors: Michael P. Doyle, Tong Zhao
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Patent number: 8168617Abstract: Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.Type: GrantFiled: September 5, 2008Date of Patent: May 1, 2012Assignee: XenoPort, Inc.Inventors: Bernd Jandeleit, Yunxiao Li, Mark A. Gallop, Noa Zerangue, Peter A. Virsik, Wolf-Nicolas Fischer
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Publication number: 20120100098Abstract: A composition and method of eliminating pests combines water and a solid form of sodium lauryl sulfate to form a pesticide composition effective to cause mortality in pests. The composition is applied to the indoor structure in an area which the pests inhabit. The sodium lauryl sulfate can be in needle form, pellet form or powder form and constitutes between about 1% and about 10% by weight of the pesticide composition. The composition may be applied to an area inhabited by cockroaches, including, but not limited to, in crevices, cracks, corners, wall and floor junctures or other enclosed or partially enclosed areas of a structure.Type: ApplicationFiled: December 29, 2011Publication date: April 26, 2012Applicant: Ecolab USA Inc.Inventors: Kelly Herrera, Stephen John Barcay
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Publication number: 20120087947Abstract: The present invention relates to the use of a 2,5-dihydroxybenzene derivative represented by Formula (I) or a pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the therapeutic and/or prophylactic treatment of, inter alia, dermatitis.Type: ApplicationFiled: August 15, 2011Publication date: April 12, 2012Applicant: AmDerma Pharmaceuticals, LLCInventors: Pedro Cuevas Sánchez, Guillermo Gimenez Gallego, Inigo Saenz de Tejada Gorgan, Javier Angulo Frutos, Serafin Valverde Lopez, Antonio Romero Garrido, Rosa Maria Lozano Puerto