Dissacharide Patents (Class 514/53)
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Patent number: 7157431Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.Type: GrantFiled: March 10, 2004Date of Patent: January 2, 2007Assignee: Mannatech, Inc.Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
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Patent number: 7153877Abstract: A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bound chromium that prevents or reduces the symptoms. Compositions incorporating niacin-bound chromium and additional compounds also are disclosed that are particularly effective in synergistically preventing or reducing these symptoms.Type: GrantFiled: December 9, 2004Date of Patent: December 26, 2006Assignee: Interhealth Nutraceuticals IncorporatedInventors: Debasis Bagchi, Harry G. Preuss, Shil C. Kothari
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Patent number: 7141542Abstract: The invention is directed to a stable formulation of a biologically active protein useful for aerosol delivery to the respiratory tract of a patient in need of treatment comprising: (a) a carrier liquid comprising from about 10% to from about 100% V/V water and from about 0% to from about 90% V/V of an organic liquid; (b) a biologically effective amount of a protein suspended or dissolved in a carrier liquid; and (c) a stabilizing effective amount of a derivatized carbohydrate stabilizing agent suspended or dissolved in said carrier liquid. The stable formulations of the invention may optionally contain about 0.1% to about 5.0% W/V of a pharmaceutically acceptable excipient.Type: GrantFiled: November 30, 2001Date of Patent: November 28, 2006Assignee: Ventaira Pharmaceuticals, Inc.Inventors: Siu Man L. Cowan, Vincent McGinniss, Donna T. Palmer, Steven M. Risser, Richard S. Brody
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Patent number: 7132402Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structureType: GrantFiled: October 31, 2003Date of Patent: November 7, 2006Assignee: WyethInventors: Scott Christian Mayer, Robert E. McDevitt, Paul J. Dollings
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Patent number: 7119110Abstract: A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and administering to them an effective amount of a composition comprising niacin-bound chromium that prevents or reduces the symptoms. Compositions incorporating niacin-bound chromium and additional compounds also are disclosed that are particularly effective in synergistically preventing or reducing these symptoms.Type: GrantFiled: October 4, 2002Date of Patent: October 10, 2006Assignee: Interhealth Nutraceuticals IncorporatedInventors: Debasis Bagchi, Harry G. Preuss, Shil C. Kothari
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Patent number: 7109189Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: GrantFiled: February 11, 2005Date of Patent: September 19, 2006Assignees: University of Otago, Medical Research CouncilInventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 7101859Abstract: The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels.Type: GrantFiled: July 28, 2003Date of Patent: September 5, 2006Assignee: Yissum Research Development Company of The Hebrew University of JerusalemInventors: Saul Yedgar, Miron Krimsky, Grietje Beck, Benito Antonio Yard, Fokko Johannes van der Woude
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Patent number: 7087723Abstract: A Factor VIII composition formulated without albumin, comprising the following formulation excipients in addition to Factor VIII: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent for maintaining a pH of approximately between 6 and 8.Type: GrantFiled: July 1, 2003Date of Patent: August 8, 2006Assignees: Baxter International Inc., University of ConnecticutInventors: Marc Besman, Erik Bjornson, Feroz Jameel, Ramesh Kashi, Michael Pikal, Serguei Tchessalov, John Carpenter
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Patent number: 7084131Abstract: A method for preparing a polydispersed saccharide composition in which a fructan-containing material is dissolved in water prior to partial enzymatic treatment of the fructans.Type: GrantFiled: December 12, 2002Date of Patent: August 1, 2006Assignee: Raffinerie Tirlemontoise S.A.Inventors: Leen De Leenheer, Karl Booten
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Patent number: 7084129Abstract: The invention relates to a series of polyglycoside derivatives that contain water-soluble cationic groups introduced into the molecule by reaction with the hydroxyl groups present in the starting polyglycoside molecule, with an epoxy cationic material. The materials are multifunctional, providing not only wetting, and conditioning, but also antimicrobial properties, making them ideal for personal care applications.Type: GrantFiled: September 15, 2003Date of Patent: August 1, 2006Assignee: Colonial ChemicalInventors: Dean A. Smith, David Anderson, Anthony J. O'Lenick, Jr.
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Patent number: 7081509Abstract: The present invention relates to a process for preparing highly functional hyperbranched polyesters which comprises reacting a reaction solution comprising solvent and (a) one or more dicarboxylic acids or one or more derivatives thereof with one or more at least trifunctional alcohols (b) or one or more tricarboxylic acids or higher polycarboxylic acids or one or more derivatives thereof with one or more diols (c) or one or more tricarboxylic acids or higher polycarboxylic acids or one or more derivatives thereof with one or more at least trifunctional alcohols (d) or one or more di- or polyhydroxycarboxylic acids (e) or one or more hydroxydi- or hydroxypolycarboxylic acids or mixtures of at least two of the above reaction solutions in the presence of an enzyme at temperatures above 60° C. and pressures above 500 mbar.Type: GrantFiled: December 18, 2002Date of Patent: July 25, 2006Assignee: BASF AktiengesellschaftInventors: Eva Wagner, Bernd Bruchmann, Dietmar Haering, Peter Keller, Thomas Pouhe
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Patent number: 7081448Abstract: This invention provides smooth muscle cell proliferation inhibitors of formula I having the structure wherein R1, R2, R3, R4, R5, R6, R7, and R8 are each, independently, acyl of 2–7 carbon atoms, haloacyl of 2–7 carbon atoms, nitroacyl of 2–7 carbon atoms, cyanoacyl of 2–7 carbon atoms, trifluoromethylacyl of 3–8 carbon atoms, benzoyl, or —SO3H; R9 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, or alkoxy of 1–6 carbon atoms; R10 is hydrogen, —NO2, —NHR11, —NHR13, —N(R13)2, —NCH3R13, —NHCO2alkyl, wherein the alkyl moiety contains 1–6 carbon atoms, alkylsulfonamide of 1 to 4 carbon atoms, Z is O or S; R11 is an ?-amino acid in which the ? carboxyl group forms an amide with the nitrogen of R10, wherein if said amino acid is glutamic acid or aspartic acid, the non-? carboxylic acid is an alkyl ester in which the alkyl moiety contains from 1–6 carbon atoms; R12 is hydrogen, CN, NO2, halo, CF3, alkyl of 1–6 carbon atoms, alkoxy of 1–6 carbon atoms, acyl of 2–7 carbon atoms, or benzoyl;Type: GrantFiled: October 24, 2003Date of Patent: July 25, 2006Assignee: WyethInventor: Scott C Mayer
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Antimicrobial prevention and treatment of human immunedeficience virus and other infectious diseases
Patent number: 7071233Abstract: An improved medical treatment and medicine is provided to quickly and safely resolve HIV and other microbial infections. The inexpensive medicine can be self administered and maintained for the prescribed time. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent and a nutrient. In the preferred form, the medicine comprises: Echinacea and Commiphora myrrha phytochemicals, benzalkonium chloride, a sterile water solution, and folic acid.Type: GrantFiled: February 26, 2002Date of Patent: July 4, 2006Inventor: Meryl Squires -
Patent number: 7056900Abstract: The invention relates to the use of the disaccharide derivatives 3?-aminosucrose, sucrose-C6-acid and palatinose-C6?-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias.Type: GrantFiled: July 9, 2002Date of Patent: June 6, 2006Assignee: Sudzucker Aktiengesellschaft Mannheim OchsenfurtInventors: Fritz Heinz, Sabine Hertel, Markwart Kunz, Manfred Vogel
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Patent number: 7056889Abstract: The invention provides peptides and compounds that can bind to P2Y2 receptors that are useful for modulating the secretion of mucus within mucosal surfaces.Type: GrantFiled: December 16, 2002Date of Patent: June 6, 2006Assignee: Kimberly-Clark, Worldwide, Inc.Inventors: Julie M. Villanueva, Stephen Quirk
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Patent number: 7056678Abstract: The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.Type: GrantFiled: May 4, 2000Date of Patent: June 6, 2006Assignee: Procognia LTDInventor: Ofer Markman
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Patent number: 7056899Abstract: The invention relates to the use of the disaccharide derivatives 3?-aminosucrose, sucrose-C6-acid and palatinose-C6?-acid and/or of an amide or alkyl ester thereof for the prevention or treatment of hyperglycemias.Type: GrantFiled: July 9, 2002Date of Patent: June 6, 2006Assignee: Sudzucker Aktiengesellschaft Mannheim OchsenfurtInventors: Fritz Heinz, Sabine Hertel, Markwart Kunz, Manfred Vogel
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Patent number: 7056898Abstract: Provided are compounds and compositions thereof that are useful for treating inflammation, particularly pulmonary inflammations including asthma and asthma-related pathologies such as allergy. Also provided are methods for using such compounds and compositions of the invention to treat patients suffering from, or predisposed to develop inflammation.Type: GrantFiled: April 16, 2002Date of Patent: June 6, 2006Assignee: Baker Norton Pharmaceuticals, Inc.Inventors: Tahir Ahmed, Gregory Smith
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Patent number: 7048918Abstract: Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively control and eliminate insect populations. Methods for controlling insects using an insect bait of the invention are also disclosed.Type: GrantFiled: August 6, 2003Date of Patent: May 23, 2006Assignee: University of Florida Research Foundation, Inc.Inventors: Jack Richard Warner, Rudolf H. Scheffrahn
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Patent number: 7041651Abstract: Provided is a composition and a method for increasing cellular uptake of bioactive agents, particularly those compounds termed “small molecules” into the cells of mammalian tissue, such as the epithelial cells of the mucosa.Type: GrantFiled: March 9, 2004Date of Patent: May 9, 2006Assignee: Aesgen, Inc.Inventors: Robert G. Petit, II, Edward C. Shinal
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Patent number: 7034006Abstract: The invention provides novel methods for treating disease based upon the medicinal use of lipids and phospholipids covalently bound to physiologically acceptable monomers or polymers. Phosphatidylethanolamine moieties conjugated to physiologically acceptable monomers and polymers (PE conjugates) manifest an unexpectedly wide range of pharmacological effects, including stabilizing cell membranes; limiting oxidative damage to cell and blood components; limiting cell proliferation, cell extravasation and (tumor) cell migratory behavior; suppressing immune responses; and attenuating physiological reactions to stress, as expressed in elevated chemokine levels.Type: GrantFiled: January 10, 2001Date of Patent: April 25, 2006Assignee: Yissum Research Development Company of the Hebrew University of JerusalemInventors: Saul Yedgar, David Shuseyov, Gershon Golomb, Reuven Reich, Isaac Ginsburg, Abd-al-Roof Higazi, Moshe Ligumski, Miron Krimsky, David Ojcius, Benito Antonio Yard, Fokko Johannes van der Woude, Edit Schnitzer
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Patent number: 7022682Abstract: The present invention provides for a method for treatment and prevention of Type II Diabetes Mellitus and its complications comprising the step of administering to a patient a therapeutically-effective amount of Rhamnan Sulphate, its functional analogs, or its physiologically acceptable salts, in therapeutic proportions. Anticoagulation activity in the blood plasma of a patient is not appreciably increased.Type: GrantFiled: May 14, 2003Date of Patent: April 4, 2006Assignee: Endomatrix, Inc.Inventor: Bruce Alan Daniels
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Patent number: 7019131Abstract: The reactivity of a number of p-methylphenyl thioglycoside (STol) donors which are either fully protected or have one hydroxyl group exposed has been quantitatively determined by HPLC in conjunction with the development of a broadly applicable approach for a facile one-pot synthesis of oligosaccharides. The influence on reactivity of the structural effects of different monosaccharide cores and different protecting groups on each glycoside donor is characterized and quantified. In addition, a correlation between glycosyl donor reactivity and the chemical shift of the anomeric proton by 1 H NMR has been established. A database of thioglycosides as glycosyl donors has been created using this reactivity data. The utility is demonstrated by the easy and rapid one-pot assembly of various linear and branched oligosaccharide structures.Type: GrantFiled: March 25, 2003Date of Patent: March 28, 2006Assignee: The Scripps Research InstituteInventors: Chi-Huey Wong, Zhiyuan Zhang, Ian Ollmann, Timor Baasov, Xin-Shan Ye
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Patent number: 7015200Abstract: The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or can target specific organs.Type: GrantFiled: September 21, 2001Date of Patent: March 21, 2006Assignee: Orphan Medical, Inc.Inventors: Mortimer Mamelak, William C. Houghton, Dayton T. Reardan, Brian L. Miller
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Patent number: 7008930Abstract: The invention relates to a series of polyglycoside derivatives that contain water-soluble groups introduced into the molecule by reaction with the hydroxyl groups present in the starting polyglycoside molecule. The preferred products have more than one water-soluble group per molecule and are made with mild reagents to avoid discoloration and mal odor. The most preferred products have between 2 and 3 functional groups per molecule. The compounds are alkoxylated alkyl polyglucoside compounds.Type: GrantFiled: October 14, 2003Date of Patent: March 7, 2006Assignee: Colonial Chemical INCInventors: Anthony J. O'Lenick, Jr., Dean A. Smith, David Anderson
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Patent number: 7001892Abstract: Pharmaceutical compositions comprising crystals of a pharmaceutically-acceptable crystal lattice component, and an active pharmaceutical ingredient different from and included within the crystal lattice component in a growth-sector specific orientation. The crystals are prepared using components and methods which yield crystals having suitable purity and efficacy for use in administering the active pharmaceutical ingredients to a patient. The crystals are typically combined with adjuvants such as excipients, diluents or carriers, and are preferably formulated into tablets, capsules, suspensions, and other conventional forms containing predetermined amounts of the pharmaceuticals. Also provided are methods for preparing the crystals, and methods for storing and administering the active pharmaceutical ingredient either included within the crystals or upon reconstitution of the crystals to a solution.Type: GrantFiled: June 12, 2000Date of Patent: February 21, 2006Assignee: Purdue Research FoundationInventors: Jean A. Chmielewski, Bart E. Kahr, Jerry Lewis
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Patent number: 6998480Abstract: This invention relates to processes for purifying sucralose by the use of an initial non-crystallization purification procedure followed by three or more sequential crystallization steps and recycle of the mother liquor remaining from each crystallization step to the feed of another crystallization or purification step. This invention also relates to sucralose compositions as well as compositions comprising the sucralose compositions of the present invention. These compositions may be highly pure and have a superior taste profile.Type: GrantFiled: March 8, 2002Date of Patent: February 14, 2006Assignee: Tate & Lyle Public Limited CompanyInventors: Steven J. Catani, James E. Wiley, Nicholas M. Vernon, Carolyn M. Merkel, Edward Micinski
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Patent number: 6992183Abstract: The purification of the E.coli K5 polysaccharide by treatment with isopropyl alcohol and elimination of lipophilic substances is described. The purified product can be used to prepare, after N-deacetylation, new N,O-sulfated polysaccharides with high degree of sulfation.Type: GrantFiled: February 26, 2002Date of Patent: January 31, 2006Inventors: Pasqua Oreste, Giorgio Zoppetti
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Patent number: 6984636Abstract: The invention provides mitochondrially targeted antioxidant compounds comprising a lipophilic cation moiety covalently coupled to an antioxidant moiety which is either a superoxide dismutase (SOD) mimetic or a glutathione peroxidase mimetic. These compounds can be used to treat patients who would benefit from the reduction of oxidative stress.Type: GrantFiled: August 12, 2002Date of Patent: January 10, 2006Assignees: Medical Research Council, University of OtagoInventors: Michael P. Murphy, Robin A. J. Smith
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Patent number: 6979679Abstract: The invention provides compositions useful for the treatment and/or prevention of damage to diarthrodial (synovial) joints and, in particular, traumatic synovitis, inflammation of the synovial membrane, and damage to the articular cartilage of the joint. Specifically, provided are compositions specially formulated for intra-articular and/or parenteral use in the treatment and/or prevention of traumaticsynovitis and/or damage to articular cartilage. Compositions adapted specifically for post surgical joint lavage or treatment and/or prevention of inflammatory arthritis, osteoarthritis (OA) and/or degenerative joint disease (DJD) are also provided. Compositions adapted for intra-articular and/or systemic administration comprised of therapeutic amounts of: chondroitin sulfate; N-acetyl D-glucosamine; and hyaluronan (hyaluronic acid) are provided.Type: GrantFiled: October 16, 2003Date of Patent: December 27, 2005Inventor: Frank D. Marcum
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Patent number: 6974804Abstract: Acylated cellobiose compounds (CHME) which satisfy the formula; wherein X represents an acyl group (R—CO—) or H, Z represents an acyl group (R?—CO—) or H and not more than a minority of X+Z residues represent H, R represents a saturated or unsaturated, linear or branched chain hydrocarbon residue of 5 to 31 carbon atoms and R? represents a residue, different from R, which is: (i) a saturated or unsaturated, linear or branched chain hydrocarbon residue of 1 to 31 carbon atoms, or (ii) an aromatic hydrocarbon residue, or (iii) a cycloaliphatic hydrocarbon, each optionally substituted. CHME esters are particularly suited to thickening or structuring a water-immiscible liquid, for example, a phase in a cosmetic formulation, such as antiperspirant or deodorant formulations, eg water in oil emulsions and especially translucent ones.Type: GrantFiled: October 17, 2001Date of Patent: December 13, 2005Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Kevin Ronald Franklin, Andrew Hopkinson, Nicholas Webb, Michael Stephen White
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Patent number: 6964949Abstract: The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina which comprises sucrose and/to maltose, to the use of certain sucrose and/or maltose, in preparing the pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, in particular to a method of stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, treating the reduction of gram-positive bacilli and the lowness of acidity in vagina as well as the vaginitis and the disturbance of vaginal bacterioflora accompanying the reduction of gram-positive bacilli, especially bacterial vaginal disease.Type: GrantFiled: August 18, 2003Date of Patent: November 15, 2005Assignee: Shanghai Jiao Da Onlly Co., Ltd.Inventor: Zhongming Zeng
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Patent number: 6960571Abstract: A method of treating Restless Leg Syndrome, includes administering to a subject an iron complex having an iron release rate greater than IDI. The iron release rate is determined at a concentration of at least 2,000 ?g/dl.Type: GrantFiled: March 14, 2003Date of Patent: November 1, 2005Assignee: Luitpold Pharmaceuticals, Inc.Inventors: Mary Jane Helenek, Ralf A. Lange, Fred B. Oldham, Marc L. Tokars
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Patent number: 6953574Abstract: A method of producing a hydrolyzed fermented medium containing microorganisms includes providing at least one solid plant product reduced to small pieces and mixed with sugar and biocompatible liquid such as milk for fermentation at a temperature of between 35 and 58 degrees C. until the acidity of the medium reaches the range of 300 to 900 in Terner degrees. Alternatively, the medium is prepared by mixing in predetermined amounts of sprouted grains, biocompatible liquid inoculated with at least one of a variety of non-pathogenic microorganisms, vegetables, fruits, berries, high protein products, herbs, sugar, and a chemical element such as potassium. The mixture is then fermented at a selected temperature for a specified length of time to reach high acidity and high concentration of products of bacterial metabolism. A liquid phase is separated from a solid sediment phase and can be used to treat a wide variety of diseases.Type: GrantFiled: June 21, 2002Date of Patent: October 11, 2005Assignee: Technology Commercialization, Inc.Inventors: Constantin Vladimirovich Sobol, Yuzefa Tsezarevna Sobol
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Patent number: 6953592Abstract: The invention relates to water soluble or water dispersible powders, tablets, or precursors therefor based on a carbohydrate matrix with improved dissolution properties in water. These components are subjected to treatment with a gas so that gas is entrapped therein, and sufficient closed porosity is provided so that gas entrapped therein promotes dissolution or dispersion upon contact with water. The powders or tablets may be pharmaceuticals or foods that optionally contain an active ingredient therein.Type: GrantFiled: September 4, 2002Date of Patent: October 11, 2005Assignee: Nestec S.A.Inventors: John Darbyshire, Oliver Chmiel, Johan Bernard Ubbink, Annemarie Schoonman
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Patent number: 6949523Abstract: This invention relates to a group of novel sapogenins, their use in anti-cancer applications, and to a process for their production. More particularly, this invention pertains to a novel group of dammarane sapogenins, PAM-120, PBM-110 and PBM-100 (the dammarance sapogenine structure is specifically clean of any sugar moieties (glycons) at any position and hydroxyl at C-20) and PAN-20 and PAN-30 (the dammarance sapogenin structure has sugar moieties but is free of hydroxyl at C-20), obtained by chemical cleavage of dammarane saponins. The invention also includes a novel application of the said sapogenins for anti-cancer treatment by using them separately or together, and/or jointly with other drugs, as well as to the process of producing these novel sapogenins. Said novel dammarane sapogenins show surprising anti-cancer effect when applied, particularly against multi-drug resistant cancers.Type: GrantFiled: July 24, 2001Date of Patent: September 27, 2005Assignee: Panagin Pharmaceuticals, Inc.Inventors: Dong Huang, Dong Feng Qi
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Patent number: 6946490Abstract: An improved medical treatment and medicine is provided to quickly and safely resolve herpes and other microbial infections. The inexpensive user-friendly medicine can be applied and maintained on the infected region until the physical symptoms of the disease disappears and the patient is comfortable and has a normal appearance. The attractive medicine comprises an antimicrobial concentrate comprising microbe inhibitors, phytochemicals or isolates. Desirably, the effective medicine comprises a surfactant and an aqueous carrier or solvent. In the preferred form, the medicine comprises Echinacea phytochemicals and benzalkonium chloride in a sterile water solution.Type: GrantFiled: March 7, 2002Date of Patent: September 20, 2005Inventor: Meryl Squires
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Patent number: 6946551Abstract: Compositions and methods of preparing compositions containing hyaluronic acid derived from eggshell membrane are disclosed. The compositions can contain essentially pure hyaluronic acid or hyaluronic acid in combination with other naturally occurring constituents derived from eggshell membrane. In another aspect, the invention is directed to a method of treating a mammal that will benefit from the administration of hyaluronic acid, which includes administering to the mammal a composition containing hyaluronic acid derived from eggshell membrane.Type: GrantFiled: July 9, 2003Date of Patent: September 20, 2005Assignee: New Life Resources, LLCInventors: Frank Daniel Long, Randall Gene Adams, Dale Paul DeVore
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Patent number: 6946451Abstract: Provided are a method for promoting insulin secretion, a method for suppressing the elevation of a blood glucose level, a method for ameliorating diabetes mellitus, a method for promoting growth of an animal, and a method for increasing an insulin level in breast milk. These methods comprising administering at least one member selected from the group consisting of a di- or a higher saccharide containing galactose, a derivative thereof, a saccharide containing N-acetylneuraminic acid, and a derivative thereof, to a patient in need thereof or an animal.Type: GrantFiled: February 3, 2003Date of Patent: September 20, 2005Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Miho Takada, Toshikazu Kamiya, Tetsuo Endo, Satoshi Koizumi
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Patent number: 6943154Abstract: A water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a nucleophile, and an activating agent, under conditions sufficient to form the composition. Also, a water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a modifying compound, a nucleophile and an activating agent under conditions sufficient to form the composition.Type: GrantFiled: January 9, 2001Date of Patent: September 13, 2005Assignee: Genzyme CorporationInventors: Robert J. Miller, Xuejian Xu
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Patent number: 6942858Abstract: Purified, host-specific, non-toxic, wide host range and virulent bacteriophage preparations that are effective in killing bacterial organisms in vivo are disclosed. Also disclosed are compositions containing these bacteriophages, methods of making the bacteriophage preparations and methods of treating bacterial infections using the compositions. Methods of treating bacterial infections using the compositions containing the bacteriophages in combination with conventional antibiotics also are disclosed.Type: GrantFiled: May 31, 2000Date of Patent: September 13, 2005Assignee: Nymox CorporationInventors: Hossein A. Ghanbari, Paul Averback
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Patent number: 6939668Abstract: Methods and compositions for pre-treatment of lung transplants to reduce susceptibility to post-operative B. cepacia infection are provided. The methods and compositions employ saccharides, particularly dextrans and xylitol, which are applied to the lung transplant before transplantation.Type: GrantFiled: May 22, 2002Date of Patent: September 6, 2005Assignees: University Health NetworkInventors: Shaf Keshavje, Janet Forstner, Umadevi Sajjan
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Patent number: 6939858Abstract: The present invention provides a substance which strongly inhibits human ?-amylase and is effective for the prevention and treatment of hyperglycemia, for example, diabetes and the diseases caused thereby, and an ?-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia containing the said substance as active principle. Maltoligosaccharide derivatives represented by the following formula: (wherein n is an integer of 0 to 2; m is an integer of 0 to 2; and X represents a hydrogen atom or a hydrophobic group) or their hydrates or physiologically acceptable salts are provided, and they are contained as active principle to prepare an ?-amylase inhibitor and a prophylactic or therapeutic agent for hyperglycemia such as diabetes.Type: GrantFiled: June 1, 2001Date of Patent: September 6, 2005Assignee: Kikkoman CorporationInventors: Riichiro Uchida, Ayako Nasu
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Patent number: 6936588Abstract: The present invention relates to a method for the production and use of enteral nutrients, particularly an enteral solution, wherein this method is distinguished by a particularly gentle processing, particularly of the carbohydrate components contained in the solution.Type: GrantFiled: October 10, 2003Date of Patent: August 30, 2005Assignee: Südzucker Aktiengesellschaft Mannheim/OchsenfurtInventors: Jörg Kowalczyk, Gunhild Kozianowski, Markwart Kunz, Matthias Moser
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Patent number: 6929807Abstract: Compositions of plant carbohydrates for dietary supplements and nutritional support for promotion and maintenance of good health. Defined nutritionally effective amounts of one to eleven essential saccharides, glyconutrients, are used in various inventive compositions as dietary supplements. The dietary composition herein can include phytonutrients, vitamins, minerals, herbal extracts, and other non-toxic nutrients. The glyconutritional dietary supplement herein provides essential saccharides which are the building blocks of glycoproteins. These compositions, when administered orally or topically, have been found to improve the well being of mammals suffering from a variety of disorders.Type: GrantFiled: August 4, 1997Date of Patent: August 16, 2005Assignee: Mannatech, Inc.Inventors: Bill H. McAnalley, H. Reginald McDaniel, D. Eric Moore, Eileen P. Vennum, William C. Fioretti
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Patent number: 6919172Abstract: A protectant mixture for use in preserving biological materials comprising (1) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the mixture is from about 5% to about 60% by weight of the mixture where the mixture is an aqueous solution and is from about 10% to about 95% where the mixture is in solid form, and (2) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.625; a preservation medium comprising (1) a biological material, (2) at least one polyhydroxy compound, where the total amount of polyhydroxy compound in the medium is from about 5% to about 60% by weight of the medium, and (3) phosphate ions, where the total amount of phosphate ions in the mixture is such that the molar ratio of phosphate ions to hydroxy groups in the polyhydroxy compound is from about 0.025 to about 0.Type: GrantFiled: September 5, 2003Date of Patent: July 19, 2005Assignee: Wisconsin Alumni Research FoundationInventors: Juan DePablo, Danforth Miller, Paul Conrad, Horacio Corti
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Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same
Patent number: 6911436Abstract: The invention discloses the discovery that a pharmaceutical composition containing complex carbohydrates and natural or synthetic essential oils can work effectively as a topical pharmaceutical composition. Such pharmaceutical compositions reduce inflammation, assist in wound healing, protect against bruising, relieve itching, relieve pain and swelling and treat topical bacterial infections such as acne and decubitus ulcers. Such pharmaceutical compositions can be administered to mammals including humans. Also included in this invention are methods to deliver topically applied macromolecules into the tissue of mammals and methods of blocking the adhesion cascade.Type: GrantFiled: June 15, 2001Date of Patent: June 28, 2005Assignee: Dermal Reserach Laboratories, Inc.Inventors: Harold G. Brown, Karen K. Brown -
Patent number: 6908904Abstract: A method for treatment of a diabetic condition, wherein a therapeutically effective amount of at least one isoform of sulfatide is administered to a patient, wherein said at least one isoform of sulfatide upon administration to the patient affects the sulfatide metabolism in such a way that it results in an increased amount of sulfatide. Also the use of at least one isoform of sulfatide for the production of a pharmaceutical preparation for treatment of a diabetic condition is disclosed. Said isoform is preferably an isoform with 8-24 carbon atoms in the fatty acid chain, more preferably 12, 14, 16 or 18 carbon atoms, and most preferably 16 carbon atoms.Type: GrantFiled: July 23, 2002Date of Patent: June 21, 2005Inventors: Pam Fredman, Karsten Buschard
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Patent number: 6906042Abstract: The invention provides micelles, pharmaceutical formulations comprising micells, solutions comprising micells, methods for preparing micells, methods for delivering micells to patients, and methods for treating sepsis, endotoxemia, septic shock and systemic inflamatory response syndrome in patients by adiministering micelles. The micelles comprises compounds of Forumala (A): wherein the substituents are as defined herein.Type: GrantFiled: February 20, 2001Date of Patent: June 14, 2005Assignee: Eisai Co., Ltd.Inventors: James McShane, Tori Arens, Kazuhiro Kaneko, Tomohiro Watanabe, Kazuhide Ashizawa
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Patent number: 6899900Abstract: Disclosed are a multipurpose, high-functional, alkaline solution composition, preparation therefor and use thereof as a nonspecific immunostimulator. The composition comprises 1-25 parts by weight of borax (Na2B4O7.10H2O), 10?5-10?4 parts by weight of sodium thiosulfate (Na2S2O3.5H2O), 30-150 parts by weight of potassium carbonate, 30-200 parts by weight of refined sugar (C12H22O11), and 100-200 parts by weight of water, based on 100 parts by weight of sodium metasilicate (Na2SiO3.5H2O). In addition to bringing about an improvement in disease resistance, weight gain rate, crop yield, crop quality, harvest time, the composition shows nonspecific immunostimulating activities, including antibody production and immune enhancement, by activating immune cells, thereby maximizing vaccination effects on malignant viral diseases.Type: GrantFiled: April 25, 2003Date of Patent: May 31, 2005Assignee: BARODON-S.F. Corp.Inventors: Soo-Il Choi, Hyun-Suk Choi, Kyung-Soo Jeon, Byung-Woo Yoo, Yong-Ho Park