Zc(=o)oy, Wherein Z Is An Acyclic Radical Bonded To The C=o By A Carbon And Y Is An Organic Radical Bonded To The Oxygen By A Carbon Patents (Class 514/546)
Compound contains two or more c(=o)o groups (Class 514/547)
Z radical contains carbon to carbon unsaturation (Class 514/549)
Z radical contains sulfur or halogen (Class 514/550)
Z radical contains nitrogen (Class 514/551)
Z contains an unbroken chain of at least seven carbon atoms bonded directly to the c(=o) group (Class 514/552)
  • Environmentally safe insecticides
    Publication number: 20040253287
    Abstract: An environmentally safe insecticide and its method of use are disclosed. The inventive insecticide comprises an effective concentration of an alkyl ester of lactic acid. Ethyl lactate is a preferred alkyl ester of lactic acid. Reduction in insect infestation is achieved by applying the insecticide of the invention to an infested substrate. Typical substrates include plants, crops, trees, animals, and humans, and surfaces that come into contact with plants, crops, trees, animals, and humans.
    Type: Application
    Filed: August 2, 2003
    Publication date: December 16, 2004
    Inventor: Robert Michael Denton
  • Enzyme inhibition
    Patent number: 6831099
    Abstract: Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.
    Type: Grant
    Filed: May 11, 2000
    Date of Patent: December 14, 2004
    Assignee: Yale University
    Inventors: Craig M. Crews, Mikael Elofsson, Ute Splittgerber, Ny Sin, Kyung Bo Kim
  • Method for preventing hepatic encephalopathic episodes
    Publication number: 20040229948
    Abstract: A method for preventing an initial hepatic encephalopathic episode in persons at risk for hepatic encephalopathic episodes by administering to the person a therapeutically effective amount of at least one phenyl butyrate compounds or a salt, derivative or metabolite of phenyl butyrate in a pharmaceutically acceptable vehicle.
    Type: Application
    Filed: December 1, 2003
    Publication date: November 18, 2004
    Inventors: Marshall L. Summar, Sharron Ema Gargosky
  • Compounds having fungicidal activity and processes to make and use same
    Patent number: 6815556
    Abstract: A compound according to formula one that is useful as a fungicide is provided. Additionally, processes to make and use same are provided.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: November 9, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Carla Jean Rasmussen Klittich, Jeannie Rachel Cetusic, Marilene Tenguan Iamauti, Irene Mae Morrison, Michael Thomas Sullenberger, William Chi-Leung Lo, Ann Marie Buysse, Brent Jeffrey Rieder, John Todd Mathieson, Monica Britt Olson, Michael John Ricks
  • Use of pheromone compounds having MAP kinase modulating activity
    Patent number: 6806293
    Abstract: A method of screening pheromone compounds for mitogen-activated protein (MAP) kinase modulating activity and for employing such pheromone compounds in compositions suitable for the prevention or treatment of diseases, conditions, and symptoms thereof benefitting from modulation of MAP kinase activity.
    Type: Grant
    Filed: March 12, 2001
    Date of Patent: October 19, 2004
    Assignee: Darley Pharmaceuticals LTD
    Inventor: Nadav Zamir
  • Methods for treating certain diseases using naaladase inhibitors
    Patent number: 6806261
    Abstract: The present invention relates to methods for regulating the release of TGF-&bgr; from living cells in vitro or in vivo, comprising bringing the cells into contact with an effective amount of a NAALADase inhibitor. Such methods are believed to be useful for affecting neuroregeneration, cell proliferation, cell differentiation, extracellular matrix formation, myelination, inflammation, immune function, liver function, pancreatic function, angiogenesis, or wound healing; and/or for preventing or treating diabetes.
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: October 19, 2004
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Xi-Chun May Lu, Krystyna Wozniak
  • Mating disruption agent and method of mating disruption
    Publication number: 20040197365
    Abstract: Provided are a mating disruption agent toward the peach twig borer and a mating disruption method comprising the use of the mating disruption agent. The attraction inhibition of this mating disruption agent, which gets rid of harmful insects without the use of insecticide, is extremely effective and flawless right up to the post harvest of fruits such as peaches. More specifically, provided is a mating disruption agent comprising 5-decenyl acetate having an E/Z ratio of 65/35 to 100/0 and 5-decen-1-ol having an E/Z ratio of 65/35 to 100/0 wherein the 5-decen-1-ol is 10% by weight or less based on total weight of the 5-decenyl acetate and 5 -decen-1-ol. Also provided is a method of peach twig borer mating disruption comprising use of the mating disruption agent.
    Type: Application
    Filed: March 12, 2004
    Publication date: October 7, 2004
    Inventors: Takehiko Fukumoto, Tatsuya Hojo, Noboru Aiba, Kouichi Ogura, Fumiaki Mochizuki
  • Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation
    Patent number: 6800658
    Abstract: The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: October 5, 2004
    Assignees: Children's Medical Center Corporation, President & Fellows of Harvard College, Nuchem Pharmaceuticals, Inc.
    Inventors: Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Jr., Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
  • Method for improving the well-being of poultry by in-ovo injection of carnitine
    Publication number: 20040192774
    Abstract: Carnitine is injected in-ovo in incubating eggs of poultry in order to improve the well-being of poultry and/or prevent or alleviate ascites. A small amount of carnitine injected in ovo shows an efficacy similar to conventional feeding techniques requiring larger amounts of carnitine.
    Type: Application
    Filed: May 17, 2004
    Publication date: September 30, 2004
    Inventors: Robert G. Teeter, Stanley L. Van Hooser, Kevin Q. Owen
  • Inhibitors of phosphatidyl myo-inositol cycle
    Publication number: 20040192770
    Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-Dmyo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor 5 agents which effectively inhibit the growth of mammalian cells.
    Type: Application
    Filed: December 11, 2003
    Publication date: September 30, 2004
    Inventors: Alan P. Kozikowski, Lixin Qiao, Garth Powis
  • Method of treating an infection
    Publication number: 20040176447
    Abstract: There is disclosed a method of treating an infection in a person in need of such treatment, which comprises the administration to such person of an effective amount of at least one compound represented by formula (I)
    Type: Application
    Filed: March 4, 2004
    Publication date: September 9, 2004
    Inventor: Arthur Vanmoor
  • Castor polyester as gloss agents in anionic systems
    Patent number: 6787129
    Abstract: The invention relates to a blend, and a process for its use, which is made up of specific castor polyesters and anionic surfactants, which when used to clean the hair provide detergency and cleaning attributes, but surprisingly also provide the hair with gloss.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: September 7, 2004
    Assignee: Zenitech LLC
    Inventors: Kenneth Klein, Irwin Paleksky, Anthony J. O'Lenick, Jr.
  • Use of an alkanoyl l-carnitine for the preparation of a medication to treat anhedonia
    Publication number: 20040171685
    Abstract: The present invention relates to the use of an alkanoyl L-carnitine, or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of anhedonia.
    Type: Application
    Filed: November 26, 2003
    Publication date: September 2, 2004
    Inventors: Menotti Calvani, Luigi Mosconi
  • Cancer treatment method and compositions
    Publication number: 20040156799
    Abstract: The present invention provides pharmaceutical compositions including: a combination of a compound of the formula (I) wherein R1 is C1-C6 alkyl and R2 is independently —H or —OH, or a pharmaceutically acceptable salt thereof; and a phorbol compound. The present invention also provides for these and other compositions and their use for the treatment of established cancers or tumors.
    Type: Application
    Filed: December 5, 2003
    Publication date: August 12, 2004
    Inventors: Zigang Dong, Ann M. Bode, Wei-Ya Ma
  • Ethers of o-desmethyl venlafaxine
    Publication number: 20040147601
    Abstract: This invention provides O-&agr;-acyloxyalkyl ethers of the venlafaxine metabolite 4-[2-(Dimethylamino-1-(1-hydroxycyclohexyl)ethyl]phenol, represented by Formula (I): 1
    Type: Application
    Filed: October 24, 2003
    Publication date: July 29, 2004
    Applicant: Wyeth
    Inventors: John P. Yardley, Magid A. Abou-Gharbia, John W. Ullrich
  • IL-8 receptor antagonists
    Patent number: 6767922
    Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
    Type: Grant
    Filed: September 6, 2002
    Date of Patent: July 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Katherine Louisa Widdowson, Qi Jin
  • Agent for lowering prolactin
    Publication number: 20040138297
    Abstract: The present invention relates to a prolactin lowering drug containing at least one bicyclic diterpene of the labdane type.
    Type: Application
    Filed: October 2, 2003
    Publication date: July 15, 2004
    Inventors: Wolfgang Wuttke, Hubertus Jarry, Michael Popp, Volker Christoffel, Barbara Spengler
  • Oil composition
    Patent number: 6762203
    Abstract: The invention relates to oil composition comprising 0.1 to 59.8% by weight of a triglyceride, 40 to 99.7% by weight of a diglyceride, 0.1 to 10% by weight of a monoglyceride and at most 5% by weight of a free fatty acid, wherein contents of &ohgr;3 type unsaturated acyl groups having at least 20 carbon atoms and monoenoic acyl groups in acyl groups constituting the diglyceride are 15 to 89.5% by weight and 10 to 84.5% by weight, respectively; and oral medicinal compositions and foods comprising such an oil composition. The oil composition effectively develops physiological functions derived from &ohgr;3 type unsaturated fatty acids, such as inhibition of platelet aggregation, and is excellent in effect of facilitating combustion of body fat, oxidation stability, flavor and the like, and also excellent in flowability.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: July 13, 2004
    Assignee: Kao Corporation
    Inventors: Shin Koike, Naoki Hosoya, Takeshi Yasumasu
  • Cell adhesion inhibitors
    Publication number: 20040132809
    Abstract: A cell adhesion inhibitor of the general formula:
    Type: Application
    Filed: October 3, 2003
    Publication date: July 8, 2004
    Applicant: Biogen, Inc.
    Inventors: Daniel Scott, Wen-Cherng Lee, Russell C. Petter, Mark Cornebise
  • Method for treatment of tumors using nordihydroguaiaretic acid derivatives
    Publication number: 20040127562
    Abstract: Use of nordihydroguaiaretic derivatives to suppress CDC-2 and survivin, stimulate apoptosis, and treat tumors.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Applicant: JOHNS HOPKINS UNIVERSITY
    Inventors: Ru Chih C. Huang, Jonathan D. Heller, Chih-Chuan Chang
  • Conjugated linoleic acid powder
    Patent number: 6756405
    Abstract: A powder containing a high amount of conjugated linoleic acid or other oil is provided. The powder contains either triglycerides containing CLA, free fatty acids of CLA, or alkylesters of CLA, or another desired oil. The powder is free flowing and has good organoleptic properties. The powder may be used as a dietary supplement or combined with foodstuffs to form a food product suitable for consumption by animals or humans.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: June 29, 2004
    Assignee: Natural ASA
    Inventor: Duane Fimreite
  • Polyol ester insecticides
    Patent number: 6756046
    Abstract: The present invention relates to an environmentally acceptable synthesis method of polyol esters that produces no toxic by-products methods during the synthesis and the resultant esters are environmentally friendly insecticides. The present invention also provides for the use of these esters in a mixture as safe effective insecticides.
    Type: Grant
    Filed: April 24, 2002
    Date of Patent: June 29, 2004
    Assignee: Ava Chemical Ventures L.L.C.
    Inventors: William A. Farone, Tracy Palmer, Gary Joseph Puterka
  • Quaternary ammonium esters for disinfection and preservation
    Publication number: 20040115160
    Abstract: The use of one or more quaternary ammonium ester compositions to disinfect contact lenses and preserve ophthalmic lens compositions is described. Ophthalmic lens compositions containing one or more quaternary ammonium ester compositions and methods of making and using the same are also described.
    Type: Application
    Filed: April 11, 2003
    Publication date: June 17, 2004
    Inventors: Joseph C. Salamone, Richard Ozark, Zhenze Hu, Roya Nicole Borazjani
  • Method of using pyruvate and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions
    Publication number: 20040110833
    Abstract: This invention is directed to a method of using a therapeutic composition comprising a compound of an alpha-ketoalkanoic acid (pyruvate) and/or its derivatives for the treatment of cytokine-mediated inflammatory conditions. The compound is an alpha-ketoalkanoic acid, a physiologically acceptable salt of an alpha-ketoalkanoic acid, an ester of an alpha-ketoalkanoic acid, or an amide of an alpha-ketoalkanoic acid. A component for inducing and stabilizing the enol resonance form of the ester at physiological pH values is also disclosed. The cytokine-mediated inflammatory conditions are mediated by, for example, an “early” (Tumor Necrosis Factor (TNF), interleukin-1&bgr; (IL-1&bgr;)) or “late” (high mobility group B-1 (HMGB-1)) mediator of inflammation.
    Type: Application
    Filed: September 15, 2003
    Publication date: June 10, 2004
    Applicants: University of Pittsburgh of the Commonwealth System of Higher Education, North Shore-Long Island Jewish Research Institute
    Inventors: Mitchell P. Fink, Luis Ulloa, Kevin J. Tracey
  • Regulation of wound healing by nitric oxide
    Patent number: 6747062
    Abstract: The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also provided are methods and compositions for inhibiting unwanted wound healing by inhibiting the activity of nitric oxide in the tissue.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 8, 2004
    Assignee: New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery
    Inventor: George Anthony Calvert Murrell
  • Compositions and methods for inhibiting proliferation in human prostate cancer cells
    Publication number: 20040106673
    Abstract: The present invention includes compositions and methods for treatment of prostate cancer which involve the use of 12-O-tetradecanoylphorbol-13-acetate combined with a retinoid such as all-trans-retinoic acid or paclitaxol, wherein the drugs are administered together, and further wherein the combined use of these agents results in a synergistic effect on prostate tumor cell growth.
    Type: Application
    Filed: September 8, 2003
    Publication date: June 3, 2004
    Inventor: Allan H. Conney
  • Glycerol-lactate esters for use as an energy supplement during exercise and recovery
    Patent number: 6743821
    Abstract: A method and lactate compound for four unique purposes: (1) the provision of a fuel energy source to skeletal muscles, hearts and other tissues and organs of humans and other mammals during exercise and recovery; (2) cardiac energy supplementation following ischemia; (3) the maintenance of blood glucose and restoration of liver glycogen; and (4) the provision of fluid and electrolytes to humans and other mammals before, during and after exercise. The lactate compound is preferably a glycerol-lactate ester or a glycerol-acetate ester.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: June 1, 2004
    Inventor: George A. Brooks
  • Chemical attractants for yellowjacket wasps
    Patent number: 6740319
    Abstract: A combination of volatile components which act synergistically to effectively attract yellowjackets in the Vespula species group is provided. A preferred formulation includes (E)-2-hexenal and linalool in the first component (A) and acetic acid and isobutanol in the second component (B). The two components are combined such that the vapors of the components blend to effectively attract the targeted yellowjackets. A dispenser may be utilized to release the vapors and may also be included within a trap to provide a means for monitoring or controlling the insects.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: May 25, 2004
    Assignee: The United States of America as Represented by the Secretary of Agriculture
    Inventor: Jeffrey R. Aldrich
  • Double salts of fumaric acid with a carnitine and an amino acid and food supplements, dietary supplements and drugs containing same
    Patent number: 6730693
    Abstract: Double fumarates of L-carnitine or isovaleryl L-carnitine and an amino acid having formula (I) are disclosed which are useful as active ingredients of food supplements, dietary supplements or drugs. wherein: R is hydrogen or isovaleryl; and [A+] is a positively charged amino acid selected from the group consisting of creatine, ornithine, lysine, arginine and histidine.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: May 4, 2004
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventor: Antonietta Buononato
  • Epothilone synthesis building blocks III and IV: asymmetrically substituted acyloins and acyloin derivatives, methods for their production and methods for the production of epothilones B, D and epothilone derivatives
    Publication number: 20040082651
    Abstract: The present invention is directed to novel acyloins, their derivatives, methods for their production and their use for the production of novel epothilones and their derivatives. In addition, the invention is directed to the building blocks for epothilone synthesis, methods for their production and the use of synthetic building blocks for the production of epothilones and their derivatives.
    Type: Application
    Filed: April 15, 2003
    Publication date: April 29, 2004
    Inventors: Ludger A. Wessjohann, Gunther Scheid, Uwe Bornscheuer, Erik Henke, Wouter Kuit, Romano Orru
  • Fungicidal mixtures from benzophenones and n-biphenyl nicotinamides
    Publication number: 20040077692
    Abstract: Fungicidal mixtures, comprising
    Type: Application
    Filed: July 14, 2003
    Publication date: April 22, 2004
    Inventors: Karl Eicken, Ingo Rose, Eberhard Ammermann, Reinhard Stierl, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Egon Haden, Manfred Hampel
  • Synergistic methods and compositions for treating cancer
    Publication number: 20040072760
    Abstract: Methods of using IGF1R inhibitors in combination with cytotoxic agents are described for the synergistic treatment of cancer.
    Type: Application
    Filed: October 1, 2003
    Publication date: April 15, 2004
    Inventors: Joan M. Carboni, Warren W. Hurlburt, Marco M. Gottardis
  • Method for preventing acute renal failure
    Publication number: 20040068006
    Abstract: Disclosed is a method of treating acute renal failure in a subject. The method comprises the step of administering to the subject an effective amount of a composition comprising a 2-ketoalkanoic acid, a pharmaceutically acceptable salt of a 2-ketoalkanoic acid, an ester of a 2-ketoalkanoic acid, or an amide of a 2-ketoalkanoic acid. Preferably, the composition comprises an enolization agent and an alkyl aralkyl, alkoxyalkyl or carboxyalkyl ester of a 2-ketoalkanoic acid dissolved in a pharmaceutically acceptable vehicle.
    Type: Application
    Filed: October 3, 2003
    Publication date: April 8, 2004
    Applicant: Critical Therapeutics, Inc.
    Inventors: Mitchell P. Fink, Howland Shaw Warren
  • Caspase inhibitors and the use thereof
    Patent number: 6716818
    Abstract: The present invention is directed to novel dipeptide thereof, represented by the general Formula I: where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula I are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: April 6, 2004
    Assignee: Cytovia, Inc.
    Inventors: Sui Xiong Cai, Eckard Weber, Yan Wang, Gordon B Mills, Douglas R Green
  • Devices and methods for eliminating termite colonies
    Patent number: 6716421
    Abstract: This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of termites within about 24 to about 84 days after the termites begin to ingest the termiticide or the bait matrix comprising the termiticide, b) a cellulose containing material, and c) water. The termiticidal bait matrix can be used in a bait station installed in the ground. The kits are suitable to be used by consumers in their homes.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: April 6, 2004
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Philip Frederick Brode, III, Garry Steven Garrett, Leo Timothy Laughlin, Randall Stryker Matthews, Dale Edwin Barker, Daniel James Kinne, Gary Eugene McKibben, Christopher Miles Miller, Timothy Robert Probst
  • Cyclopentane(ENE)heptenoic or heptanoic acids and derivatives thereof useful as therapeutic agents
    Patent number: 6716876
    Abstract: The invention relates to 7-[5-hydroxy-2-(hydroxyhydrocarbyl or heteroatom-substituted hydroxy hydrocarbyl)-3-hydroxy-cyclopentyl(enyl)] heptanoic or heptenoic acids and derivatives of said acids, wherein one or more of said hydroxy groups are replaced by an ether group. The compounds of the present invention are potent ocular hypotensives, and are particularly suitable for the management of glaucoma.
    Type: Grant
    Filed: February 28, 2002
    Date of Patent: April 6, 2004
    Assignee: Allergan, Inc.
    Inventor: Robert M. Burk
  • Anti-angiogenic compositions and methods of use
    Publication number: 20040062810
    Abstract: The present invention provides compositions comprising an anti-angiogenic factor, and a polymeric carrier. Representative examples of anti-angiogenic factors include Anti-Invasive Factor, Retinoic acids and derivatives thereof, and paclitaxel. Also provided are methods for embolizing blood vessels, and eliminating biliary, urethral, esophageal, and tracheal/bronchial obstructions.
    Type: Application
    Filed: March 14, 2003
    Publication date: April 1, 2004
    Applicant: Angiotech Pharmaceuticals, Inc.
    Inventors: William L. Hunter, Lindsay S. Machan, A. Larry Arsenault
  • Non-hazardous pest control
    Patent number: 6713518
    Abstract: Pesticidal compositions for the control of pests containing one or more neurally effective substances. In addition, the present invention is directed to a method for controlling pests by applying a pesticidally-effective amount of the pesticidal compositions to a locus where pest control is desired.
    Type: Grant
    Filed: May 26, 2000
    Date of Patent: March 30, 2004
    Assignee: Ecosmart Technologies, Inc.
    Inventors: Steven M. Bessette, Arthur M. Knight
  • Derivatives of 3,3-diphenylpropylamines
    Patent number: 6713464
    Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: March 30, 2004
    Assignee: Schwarz Pharma AG
    Inventors: Claus Meese, Bengt Sparf
  • Composition for the prevention and treatment of kidney dysfunctions and diseases
    Publication number: 20040057994
    Abstract: A composition is disclosed which is suitable for the prevention and treatment of kidney dysfunctions and diseases and which can therefore take the form of a food supplement or of an actual medicinal drug comprising a combination of acetyl L-carnitine and propionyl L-carnitine or their pharmacologically acceptable salts.
    Type: Application
    Filed: September 23, 2003
    Publication date: March 25, 2004
    Applicant: Sigma-Tau HealthScience S.p.A.
    Inventor: Claudio Cavazza
  • Process for the preparation of beta-keto aliphatic acid ester
    Publication number: 20040053380
    Abstract: The present invention provides a process for the preparation of antimicrobial compound &bgr;-keto aliphatic acid ester, a novel, aliphatic, fatty acid derivative from Bacillus sp.
    Type: Application
    Filed: July 24, 2003
    Publication date: March 18, 2004
    Inventors: Annapurna Jetty, Dattatray M. Akkewar, Kondapuram Vijaya Raghavan
  • Fungicidal mixtures comprising benzophenone and imidazole derivatives
    Publication number: 20040053984
    Abstract: Fungicidal mixtures, comprising
    Type: Application
    Filed: July 14, 2003
    Publication date: March 18, 2004
    Inventors: Arne Ptoc k, Ingo Rose, Eberhard Ammermann, Reinhard Stierl, Gisela Lorenz, Siegfried Strathmann, Maria Scherer, Klaus Schelberger, Egon Haden
  • Attractants and repellants for colorado potato beetle
    Patent number: 6703014
    Abstract: A method has been discovered for attracting Colorado potato beetles to an area of object or area, which method involves treating the object or area with a Colorado potato beetle attracting composition (with or without an insecticide) containing a carrier material and a Colorado potato beetle attracting effective amount of (a) (Z)-3-hexenyl acetate, (±)-linalool, nonanal, and methyl salicylate, (b) (Z)-3-hexenyl acetate, (±)-linalool, and methyl salicylate, (c) (Z)-3-hexen-1-ol, (E)-2-hexen-1-ol, and (±)-linalool, (d) (Z)-3-hexenyl acetate and methyl salicylate, or (e) (Z)-3-hexenyl acetate and (±)-linalool.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: March 9, 2004
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Joseph C. Dickens, A. Randall Alford
  • Use of L-carnitine and derivatives for reducing ceramide levels and potentiating antiretroviral drugs
    Publication number: 20040039054
    Abstract: The present invention provides a novel use of L-carnitine, the derivatives thereof and their pharmacologically acceptable salts in combination with antiretroviral drugs for reducing ceramide levels and enhance the activity of the aforesaid antiretroviral drugs for the therapeutic treatment of HIV-infection and AIDS.
    Type: Application
    Filed: June 17, 2003
    Publication date: February 26, 2004
    Applicant: SIGMA-TAU INDUSTRIE
    Inventor: Sonia Moretti
  • Methods and compounds for treating depression and other disorders
    Publication number: 20040039014
    Abstract: The present invention features compounds active at both the serotonin reuptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor (“multi-active compounds”) can be used to treat different types of disorders such as depression, obsessive-compulsive disorders (OCD), sleep, disorders, sexual dysfunction, and eating disorders. Preferably, the multi-active compounds are used to treat depression.
    Type: Application
    Filed: November 21, 2001
    Publication date: February 26, 2004
    Applicant: NPS Pharmaceuticals, Inc.
    Inventors: Alan L. Mueller, Scott T. Moe, Manuel F. Balandrin
  • Slow release insect repellent compounds and process for delivering active
    Patent number: 6696490
    Abstract: Novel insect repellents having ester bonds such that when deposited on skin, natural skin cleaning agents provide slow release of the active.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: February 24, 2004
    Assignee: Unilever Home & Personal Care USA Division of Conopco, Inc.
    Inventors: Frank Meyer, Ferial Khorshahi-Arvanaghi, Bijan Harichian, Victor DeFlorio, Yu-Wen Feng
  • B-homoestra-1,3,5(10)-trienes as modulators of tubulin polymerization
    Patent number: 6696436
    Abstract: The invention provides B-ring expanded estra-1,3,5(10)-triene compounds of general formula (1) which modulate the polymerization of tubulin and/or the depolymerization of microtubules. The compounds have anti-angiogenic and anti-tumor activity. The invention also provides methods of preparing the compounds, and methods of using the compounds for the treatment of cancer or other mammalian diseases characterized by undesirable angiogenesis. The compounds of the invention are also expected to have utility as research tools.
    Type: Grant
    Filed: August 16, 2002
    Date of Patent: February 24, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ernest Hamel, Mark S. Cushman
  • Sulphonamide derivatives
    Patent number: 6693137
    Abstract: The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: February 17, 2004
    Assignee: Eli Lilly and Company
    Inventors: Macklin Brian Arnold, David Michael Bender, Buddy Eugene Cantrell, Winton Dennis Jones, Paul Leslie Ornstein, Richard Lee Simon, Edward C. R. Smith, Eric George Tromiczak, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
  • Novel antibiotic compounds
    Publication number: 20040029918
    Abstract: A method for treating a microbial infection or disease in a subject, said method comprising administering to said subject an effective amount of a compound according to the formula (1). Wherein; denotes a single or double bond or an epoxidised bond, and A1 to A13 are independently selected from moieties as depicted in the description. Also claimed are methods for disinfecting surfaces using the above compound, and claims to the above compound.
    Type: Application
    Filed: May 22, 2003
    Publication date: February 12, 2004
    Inventors: Rodney Warren Rickards, Chunjiu Zhao, Stephen Charles Trowell
  • Fluid therapy with L-lactate and/or pyruvate anions
    Patent number: RE38604
    Abstract: Electrolyte solutions are provided which are useful in electrolyte and fluid therapy, parenteral nutrition and dialysis. The Na:Cl ratio is normalized, plasma and cellular pH are normalized and cellular cofactor ratios are normalized in a manner which decreases toxicity over prior art solutions.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: September 28, 2004
    Assignee: BTG International Limited
    Inventor: Richard L. Veech