Benzene Ring In Acid Moiety Patents (Class 514/555)
  • Antidepressant derivatives of trans-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4556676
    Abstract: Novel trans-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of norepinephrine and serotonin (5-hydroxy-tryptamine), thereby alleviating abnormalities at central receptor sites. The preferred embodiment is the enantiomer trans-(1R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalen amine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: September 5, 1980
    Date of Patent: December 3, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Salts of 1-(aminodihalophenyl)-2-aminoethanols and antilipogenic compositions prepared therefrom
    Patent number: 4552897
    Abstract: Novel acid addition salts of 1-(aminodihalophenyl)-2-aminoethanols and method of preparation thereof. The invention describes certain non-dusting, antilipogenic compositions used as animal feed supplements and/or concentrates and a method for increasing weight gain and improving the lean meat to fat ratio of warm-blooded animals.
    Type: Grant
    Filed: February 1, 1983
    Date of Patent: November 12, 1985
    Assignee: American Cyanamid Company
    Inventors: Goro Asato, Lawrence J. Ross
  • Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine
    Patent number: 4536518
    Abstract: Novel cis-isomeric derivatives of 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine are useful as antidepressant agents. These novel compounds act to block the synaptosomal uptake of serotonin (5-hydroxy-tryptamine), thereby alleviating serotonin abnormalities at central receptor sites. The preferred embodiment is the enantiomer cis-(1S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenam ine and its pharmaceutically acceptable acid addition salts.
    Type: Grant
    Filed: November 1, 1979
    Date of Patent: August 20, 1985
    Assignee: Pfizer Inc.
    Inventors: Willard M. Welch, Jr., Charles A. Harbert, B. Kenneth Koe, Allen R. Kraska
  • Method for treatment or prophylaxis of gastro-intestinal disease
    Patent number: 4529602
    Abstract: A method for the therapeutic treatment and/or prophylaxis of gastro-intestinal diseases using a sulfodehydroabietic acid of the formula: ##STR1## or a pharmaceutically acceptable salt thereof is disclosed.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: July 16, 1985
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hiroshi Wada, Masatoshi Kawamori, Hajime Tamaki, Yuichi Onoda
  • Method for treating heart disease
    Patent number: 4513007
    Abstract: Calcium Dobesilate of the formula: ##STR1## Can be used against coronary heart disease, myocardial infarction or disturbances of the lymphatic circulation of the heart.
    Type: Grant
    Filed: May 3, 1983
    Date of Patent: April 23, 1985
    Assignee: Laboratoires OM SA
    Inventors: Alfred de Courten, Adrian Schulthess, Jose Esteve-Soler
  • Antiinflammatory and analgesic gel
    Patent number: 4500511
    Abstract: An antiinflammatory and analgesic gel composition for external use which comprises 0.03 to 1.5 percent by weight of clidanac or a pharmacologically acceptable salt thereof as a pharmacologically active ingredient and 0.5 to 5.0 percent by weight of gelling agent, 0.3 to 4.0 percent by weight of a neutralizer, 30 to 60 percent by weight of a solubilizer and 35 to 65 percent by weight of water, has an excellent antiinflammatory and analgesic effect.
    Type: Grant
    Filed: September 13, 1983
    Date of Patent: February 19, 1985
    Assignee: Grelan Pharmaceutical Co., Ltd.
    Inventors: Kazuo Kigasawa, Hideaki Ohtani, Toshiyuki Kanezuka