Abstract: A method of combating pests which comprises applying to such pests or to a pest habitat a pesticidally effective amouht of a substituted 2-cyclohexen-1-yl-amine derivative of the formula ##STR1## and addition products thereof with acids and metal salts. Most of the compounds are new.

Abstract: The present invention describes a composition for enhanced pesticidal activity comprising a pesticide or a mixture of pesticides and a potentiating amount of a stilbene compound. This invention further describes a method for enhancing pesticide toxicity against an insect, an acarina, a mollusk or a nematode which employs the sequential or concurrent application of a pesticide and a stilbene compound.

Abstract: Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections.In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.

Abstract: Fluorosubstituted benzene derivatives of Formula I ##STR1## wherein Y, R.sup.2, R.sup.3 and R.sup.4 are defined herein, are NMR diagnostic agents.

Abstract: The synthesis of novel ethanesulfonamide compounds is described. The novel ethanesulfonamide compounds have antisecretory activity and are used in the treatment of peptic ulcer disease. The intermediates used to prepare the ethanesulfonamides are useful in the treatment of osteoporosis and other bone wasting diseases.

Abstract: The present invention relates to vinylogous hydroxamic acids, processes for their manufacture, pharmaceutical preparations containing them, and their use in the treatment of various disorders.

Abstract: A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of ibuprofen and hydrochlorothiazide, and, optionally, an antihistamine.

Abstract: A compound of the formula ##STR1## wherein X has the formula ##STR2## wherein ring a is phenyl, naphthyl or heterocyclic; wherein R.sup.1 is hydrogen, alkyl, alkanoyl or aroyl; wherein R.sup.2, R.sup.3 and R.sup.4, which may be the same or different, each is an electron withdrawing substituent selected from halogeno, nitro, cyano, trifluoromethyl, alkylthio, alkylsulphinyl, and alkylsulphonyl or each is hydrogen, alkyl, alkoxy or dialkylamino provided that when ring A is phenyl or naphthyl at least one of R.sup.2, R.sup.3 and R.sup.4 is an electron-withdrawing substituent; wherein R.sup.5 and R.sup.6, which may be the same or different, each is hydrogen, halogeno or alkyl; wherein R.sup.7 is alkyl or halogenoalkyl; and wherein R.sup.8 is carbamoyl, alkyl, cycloalkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalkenyl, halogenoalkynyl, alkanoyl, alkylcarbamoyl, dialkylcarbamoyl or aroyl; or wherein R.sup.

Abstract: The invention relates to benzylketone phospholipase A.sub.2 inhibitors, pharmaceutical compositions containing them, and methods of treating phospholipase A.sub.2 -mediated conditions in mammals by administration of a therapeutically effective amount of such a benzylketone phospholipase A.sub.2 inhibitor. These compounds are also intermediates in the synthesis of other PLA.sub.2 inhibitors.

Abstract: Postsurgical adhesion formation is inhibited by the topical administration to the site of surgical trauma of a non-steroidal anti-inflammatory drug, preferably ibuprofen, suprofen, or tolmetin.

Abstract: Novel bis-S-alkylbenzene derivatives capable of inhibiting lipoxygenase, inparticular, 5-lipoxygenase are disclosed. It is expected that the compounds, which are hardly metabolized in vivo, are highly useful in the treatment and/or prevention of various diseases, including allergic diseases such as asthma, inflammation, myocardial infarction, nephritis, scabies and gout.

Abstract: Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norleucine, and L-methionine methyl ester azolides succinimides or pyridones and sulfonate salts, and related compounds such as L-leucine and L-phenylalanine methyl ester derivatives. The compounds were found to be excellent inhibitors in that they embody both inhibitory and anti-oxidant or anti-inflammatory activity.

Abstract: Disclosed are phenol derivatives of the formula ##STR1## wherein R.sup.1 is a substituted phenyl group, R.sup.2 and R.sup.3 are C.sub.1 -C.sub.6 alkyl group and of the formula ##STR2## wherein R.sup.8, R.sup.9 and R.sup.10 are C.sub.1 -C.sub.6 alkyl and the like and A is H, C.sub.1 -C.sub.6 alkylsulfonyl and the like substituents. These compounds and some related compounds have anti-inflammatory activity and lipoxygenase inhibitory activity.

Abstract: The present invention relates to 1-substituted derivatives of 4-methoxy-2,3,6-trimethylbenzene which are useful in cosmetic or pharmaceutical preparations for use in the treamtnet of dermatological complaints connected with a keratinisation disorder, dermatological complaints having an inflammatory and/or immuno-alleric component or ophthalmological complaints.

Abstract: Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.

Abstract: A pharmaceutical composition for relieving symptoms of dysmenorrhea and/or premenstrual syndrome comprising a combination of aspirin or ibuprofen and a diuretic from the group pamabrom and hydrochlorothiazide; optionally it may also contain an antihistamine.

Abstract: Pharmaceutical compositions of the prodrug type, a process for the preparation thereof, a process for the preparation of the as prodrug functioning compounds and compounds obtained herein.The pharmaceutical compositions of the invention contain organic acid anhydrides with formula 1 through 5, as well as the pharmacological acceptable salts thereof as prodrug functioning compounds, together with a suitable pharmaceutically acceptable gaseous, liquid or solid carrier.The prodrug systems of the invention possess as favorable property that they amend the residence time of the pharmaceutical composition in the body by influencing the transport system.Furthermore they increase the biological availability because of the more lipophilic properties of the anhydride compared with the acid, so that this improved administration performance may contribute to lower dosages.

Abstract: Ibuprofen, pharmaceutically acceptable salt thereof or lower alkyl C.sub.1-6 ester thereof, in solution in periodontal gum device comprising elongated handle member terminating proximally in a flexible tip portion provided with an aperture for discharge of the solution which is effective to reduce gingival inflammation and swelling.

Abstract: Pharmaceutical compositions and methods of using same comprising a non-steroidal anti-inflammatory drug in combination with at least one other active component selected from an anti-histamine, decongestant, cough suppressant (antitussive) or expectorant are provided for the relief of cough, cold and cold-like symptoms.

Abstract: The invention relates to novel crystalline salts of aryloxypropanolamines with diphenylacetic acid, a process for their preparation and the use of these salts for the preparation of chemically pure aryloxy-propanolamines or pharmaceutically acceptable salts thereof.

Abstract: A compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl or acyl, R.sub.2 is hydroxy, alkoxy or amino, is useful as an antidiabetic agent.

Abstract: Our invention pertains to various new compositions, methods for using such compositions and products treated with such compositions. Our new compositions include, among other things, certain antimicrobial agents solubilized with certain disubstituted aryl compounds.

Abstract: Sprayable pharmaceutical preparations with an arylalkanoic acid or its salts as the active agent, suitable for topical application, containing as solvent a mixture of one or more volatile solvents and one or more non-volatile solvents in the weight ratio range of 1:1 to 20:1. They are especially suitable for the treatment of traumatic and rheumatic diseases.

Abstract: This invention relates to organic acid-substituted guanidine compounds. Also disclosed are methods for preparing the compounds, compositions containing them, and methods for their use as anthelmintics.

Abstract: Biphenylylpropionic acid derivatives of the formula: ##STR1## wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: ##STR2## wherein R.sup.1 is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms and m is 0 or an integer of 1. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long-acting, and high safety margin.

Abstract: Benzoic acid derivatives of the formula: ##STR1## wherein n is an integer of 0 to 2; R.sub.1 to R.sub.3 which may be the same or different each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or nitro group; R.sub.4 is a hydroxyl group or the group --NHZ (Z is hydrogen atom or a lower alkyl group), or an alkali metal salts thereof are useful as an infection control agent.These derivatives excepting compounds of the formula above wherein n is 0 or 1; any one of R.sub.1 to R.sub.3 is 5-chloro, 5-methoxy or 5-nitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxyl group; and compounds of the formula wherein n is 0 or 1; two of R.sub.1 to R.sub.3 are 3,5-dichloro or 3,5-dinitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxy group) are novel, and they were first prepared in this invention.

Abstract: A method of treating diabetes mellitus using arylglyoxals which are known compounds.

Abstract: Novel oxiodinium and thiaiodinium compounds having a superior inhibitory effect against micro-organisms coupled with outstanding stability and low toxicity are described.

Abstract: Our invention pertains to various new compositions, methods for using such compositions and products treated with such compositions. Our new compositions include, among other things, certain antimicrobial agents solubilized with certain disubstituted aryl compounds.

Abstract: Pharmaceutical compositions containing hydrocodone or a pharmaceutically acceptable acid addition salt thereof and ibuprofen or a pharmaceutically acceptable salt thereof are useful in treating pain in mammals.

Abstract: Substituted phenylalkenoic acids and esters of the formula: ##STR1## having useful pharmaceutical activity are disclosed.

Abstract: Substituted phenylalkenoic acids and esters of the formula: ##STR1## having useful pharmaceutical activity are disclosed.

Abstract: A method of treating diabetes mellitus using arylglyoxals which are known compounds.

Abstract: Calcium Dobesilate of the formula: ##STR1## Can be used against coronary heart disease, myocardial infarction or disturbances of the lymphatic circulation of the heart.

Abstract: Compositions for increasing oxygen supply in tissue of warm-blooded animals comprising at least one vasoactive compound selected from the group consisting of (a) calcium 2,5-dihydroxy-phenylsulfonate, (b) a 3,7-dihydro-3,7-dialkyl-1H-purine-2,6-dione of the formula ##STR1## wherein AlK and AlK' are individually alkyl of 1 to 4 carbon atoms, n is an integer from 2 to 4 and R is selected from the group consisting of ##STR2## and --CH.sub.2 --CH.sub.3, (c) a pyrazolo-[3,4-d]pyrimidine of the formula ##STR3## wherein R.sup.1 and R.sup.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and alkylcarbonylalkyl of 4 to 8 carbon atoms with the proviso that R.sup.1 and R.sup.2 are not both hydrogen and A is selected from the group consisting of ##STR4## wherein R.sup.3 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sup.