Silicon Containing Doai Patents (Class 514/63)
  • Patent number: 11447476
    Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein Q, Z, R2, R3 and m are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: September 20, 2022
    Assignee: FMC Corporation
    Inventors: Nicholas Ryan Deprez, Ravisekhara Pochimireddy Reddy, Paula Louise Sharpe, Thomas Martin Stevenson
  • Patent number: 11395485
    Abstract: Insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizers are disclosed. The compositions include bifenthrin, a polymeric dispersant, a suspension agent, a freeze-thaw stabilizer, and optionally a preservative.
    Type: Grant
    Filed: December 1, 2020
    Date of Patent: July 26, 2022
    Assignee: FMC Corporation
    Inventor: Timothy M. Martin
  • Patent number: 11311513
    Abstract: A method of treating a subject suffering from a condition characterized by over-expression of Ten-eleven translocation 1 (TET1) is provided, the method including administering to the subject an effective amount of a compound, or a pharmaceutically acceptable salt thereof, having the Formula I: wherein: R1, R2, R3, R4, and R5 are each independently selected from the group consisting of H, hydroxyl, alkyl, alkoxy, amine, halo, and trifluoromethyl, and wherein any two adjacent moieties of R1, R2, R3, R4, and R5 may come together to form a heterocyclic ring; R6 is H or hydroxyl; and R7 is selected from H, wherein R8 is C or O. Also provided are methods for selectively suppressing transcription of TET1 and/or reducing a level of 5-hydroxymethylcytosine in a subject by administering an effective amount of a Formula I compound and pharmaceutical compositions comprising Formula I compounds.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: April 26, 2022
    Assignee: University of Cincinnati
    Inventors: Jianjun Chen, Xi Jiang
  • Patent number: 11305033
    Abstract: A splinting system that includes a curable splint member including layers of fiberglass cloth coated with a water curable resin, and a pad at least partially enveloping the layers of fiberglass cloth, the pad having an exterior surface and an antimicrobial coating applied to the exterior surface; and a metal foil pouch containing the curable splint member, the metal foil pouch including an exterior surface. The antimicrobial coating includes a silane quaternary ammonium ion or salt thereof. The silane quaternary ammonium ion or salt thereof is one or more of: 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium ion, 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium ion, or 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride. The antimicrobial coating can be applied to the curable splint member by applying a solution, which includes 0.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: April 19, 2022
    Assignee: Parasol Medical, LLC
    Inventor: Patrick E. Eddy
  • Patent number: 11278025
    Abstract: The present application provides compounds and methods of treating bacterial infection, including bacterial infection caused by P. acnes.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: March 22, 2022
    Assignees: The General Hospital Corporation, Rhode Island Hospital, A Lifespan-Partner, Temple University-Of The Commonwealth System of Higher Education
    Inventors: Frederick M. Ausubel, Wooseong Kim, Eleftherios Mylonakis, William M. Wuest
  • Patent number: 11241436
    Abstract: The invention provides a compound of formula (I): wherein R1, R2, R3, and R4 are as defined herein, ginsenoside Rg2 of structure (II): or a combination thereof, for use in treating or preventing a condition responsive to the induction of autophagy in a brain of a mammal in need thereof.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: February 8, 2022
    Assignees: Northwestern University, The United States of Americans represented by the Secretary, Department of Health and Human Services, University of Kansas
    Inventors: Congcong He, Sui Huang, Chen Wang, Altea Rocchi, Juan Jose Marugan, Marc Ferrer, Samarjit Patnaik, Yuchi Chen, Kevin Frankowski, Frank J. Schoenen
  • Patent number: 11225478
    Abstract: The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: January 18, 2022
    Assignee: JANSSEN PHARMACEUTICA NV
    Inventors: Manuel Jesus Alcazar Vaca, Jose Ignacio Andres Gil, Christa C. Chrovian, Heather R. Coate, Meri De angelis, Curt A. Dvorak, Christine F. Gelin, Michael A. Letavic, Brad M. Savall, Akinola Soyode-Johnson, Brice M. Stenne, Devin M. Swanson
  • Patent number: 11214541
    Abstract: Compounds of formula (I): wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a —COOH, a —OH or a —OPO(OH)2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or a —OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a —COOH, —OH or —OPO(OH)2 group, then R5 represents a hydrogen atom; when R5 represents a —OH group, then R3 and R4 represent hydrogen atoms; and R6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl and heterocycloalkyl group; and the preparation and the therapeutic uses of the compounds of formula (I) as inhibitors and degraders of estrogen receptors, useful especially in the treatment of cancer.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: January 4, 2022
    Assignee: SANOFI
    Inventors: Monsif Bouaboula, Maurice Brollo, Victor Certal, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Gary Mccort, Laurent Schio, Michel Tabart, Corinne Terrier, Fabienne Thompson
  • Patent number: 11160880
    Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: November 2, 2021
    Assignee: MediBeacon Inc.
    Inventors: Richard B. Dorshow, Thomas E. Rogers
  • Patent number: 11118352
    Abstract: A microbial growth and dust retardant roofing shingle comprising a substrate and a pore filling composition applied on the surface of the substrate is disclosed. The pore filling composition comprises a silane or acrylic composition. A method of protecting a substrate from microbial growth and soiling using the pore filling composition of the present disclosure is also disclosed.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: September 14, 2021
    Assignee: CertainTeed LLC
    Inventors: Rathish Sa, Sriram Y, Vinay Natrajan
  • Patent number: 11059784
    Abstract: Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is CH or N; Y is CH or N; R1 is —OH or —OP(O)(OH)2; L is —CR3?N—O—CRaRa— or CRaR—O—N?CR3; L2 is a bond, —C(O)—, or S(O)2—; and R2, R3, Ra, m, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: July 13, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: Alaric J. Dyckman, Ling Li, T. G. Murali Dhar, Hai-Yun Xiao
  • Patent number: 11045429
    Abstract: Network materials which exhibit both shear thinning and self-healing properties are disclosed. The networks contain particles and gel-forming compounds. The networks are useful for a variety of biomedical uses, including drug delivery.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: June 29, 2021
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Eric A. Appel, Mark W. Tibbitt, Robert S. Langer
  • Patent number: 10966969
    Abstract: Disclosed is a pharmaceutical composition for preventing or treating a fatty liver disease containing, as an active ingredient, a pyrazole-based compound or a pharmaceutically acceptable salt thereof. 3-phenyl-4-alkyl-1-(pyridin-2-yl)-1H-pyrazol-5-ol or a pharmaceutically acceptable salt thereof is capable of effectively inhibiting fatty liver, hepatic inflammation and hepatic fibrosis, and is useful for preventing or treating NAFLD, in particular, NASH.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: April 6, 2021
    Assignee: APTABIO THERAPEUTICS INC.
    Inventors: Sung Hwan Moon, Soo Jin Lee, Sung Chan Lee, Yun Soo Bae
  • Patent number: 10940139
    Abstract: Provided herein are methods and compositions for treating cancers, inflammatory diseases, rasopathies, and fibrotic disease involving aberrant Ras superfamily signaling through the binding of compounds to the GTP binding domain of Ras superfamily proteins including, in certain cases, K-Ras and mutants thereof, and a novel method for assaying such compositions.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: March 9, 2021
    Assignee: Shy Therapeutics LLC
    Inventors: Yaron R. Hadari, Luca Carta, Michael Schmertzler, Theresa M. Williams, Charles H. Reynolds, Rebecca Hutcheson
  • Patent number: 10918637
    Abstract: Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: February 16, 2021
    Assignee: Aptinyx Inc.
    Inventor: M. Amin Khan
  • Patent number: 10852052
    Abstract: A refrigerating device includes a cabinet, a condenser and a dehumidifying device. The cabinet defines a compartment therein and includes a rear panel, and an inner wall of the compartment defines an air permeable hole. The condenser is disposed to the rear panel. The dehumidifying device includes a casing and a dehumidifying assembly disposed in the casing, the casing is disposed to the rear panel and located outside the cabinet, the casing defines a first air through hole and a second air through hole in communication with the casing respectively, the first air through hole is communicated with the air permeable hole through an air communication assembly, and the second air through hole is communicated with an external environment.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: December 1, 2020
    Inventors: Benlei Liang, Pingfang Li, Chao Liu
  • Patent number: 10722484
    Abstract: This present disclosure is directed to a method of treating a subject with cancer with a combination of a protein kinase C (PKC) activator and a second therapeutic agent.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: July 28, 2020
    Assignee: K-Gen, Inc.
    Inventors: Ruihong Chen, Chun Jiang
  • Patent number: 10717735
    Abstract: Forms of 4-(6-(3,5-dimethylisoxazol-4-yl)-1-[(1S)-1-(2-pyridyl)ethyl]pyrrolo[3,2-b]pyridin-3-yl)benzoic acid (Compound I) were prepared and characterized in the solid state: Also provided are processes of manufacture and methods of using the forms of Compound I.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: July 21, 2020
    Assignee: Plexxikon Inc.
    Inventors: Prabha N. Ibrahim, Hamid Rezaei, Marika Nespi, Ben Powell, Rashmin Patel
  • Patent number: 10683311
    Abstract: The present disclosure relates to fungicidal active compounds, more specifically to trisubstitutedsilylphenoxyhetero-cycles and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 16, 2020
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Jérémy Dufour, Philippe Desbordes, Christophe Dubost, Mathieu Gourgues, Ruth Meissner, Andrew Pettinger, Philippe Rinolfi, Valérie Toquin, Ulrike Wachendorff-Neumann
  • Patent number: 10669237
    Abstract: Provided herein is a process for the preparation of 4-((6-bromopyridin-3-yl)oxy)benzonitrile.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 2, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Nicholas R. Babij, Qiang Yang, Kaitlyn Gray, Yan Hao
  • Patent number: 10647923
    Abstract: A system and method produce hydrocarbons from biomass by fluid catalytic cracking. In one embodiment, the system is a fluid catalytic cracking system. The system includes a riser. The riser contains a catalyst. The system also includes a biological feed comprising biomass-derived liquid for the riser. In addition, the system includes a hydrocarbon feed comprising hydrocarbons for the riser. The biological feed and the hydrocarbons react in the riser in the presence of the catalyst to convert at least a portion of the biological feed and the hydrocarbons to hydrocarbon products. The hydrocarbon products comprise a concentration of oxygen from about 0.005 wt. % to about 6 wt. %.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 12, 2020
    Assignee: Phillips 66 Company
    Inventors: Kristi A. Fjare, TiePan Shi, Constantino Badra, Terry S. Cantu, Milena Vasic, Ruben van Duren, Marty Pronk, Leen Gerritsen
  • Patent number: 10600973
    Abstract: A method of synthesizing a fused heteroaromatic compound includes obtaining a first intermediate from a first compound represented by Chemical Formula 1 and a second compound represented by Chemical Formula 2, obtaining a second intermediate including a ring having a chalcogen element from the first intermediate, and obtaining a fused heteroaromatic compound by a cyclization reaction of the second intermediate.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 24, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Eigo Miyazaki, Jeong Il Park, Hyun Bum Kang, Eun Kyung Lee
  • Patent number: 10571465
    Abstract: Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: February 25, 2020
    Assignee: The University of Maryland, Baltimore
    Inventors: Henryk Szmacinski, Joseph R. Lakowicz
  • Patent number: 10562922
    Abstract: The present invention discloses novel silicon incorporated cyclic compounds of formula I, Wherein Ar1 and Ar2 are individually selected from any aryl group which can be optionally substituted; X is selected from any inorganic anion such as halide, carbonate, sulfate, nitrate or any organic anion selected from acetate, tartarate, citrate, carbonate or organosulfonates such as tosylate, mesylate, triflate; R1 and R2 are individually selected from C1-C8 alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, alkoxyalkyl, aminoalkyl, thioalkyl, haloalkyl or hydroxyalkyl. R1 and R2 together may form a ring which optionally may be substituted or may contain heteroatoms; a pharmaceutical composition comprising a therapeutically effective amount of compounds of general formula I, including geometrical isomers and/or salts thereof along with a drug and optionally along with a carrier or diluent or pharmaceutically acceptable excipient for treating malaria and toxoplasmosis.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 18, 2020
    Assignee: Council of Scientific and Industrial Research
    Inventors: Dumbala Srinivasa Reddy, Dhanasekaran Shanmugam, Remya Ramesh, Anurag Shukla, Meenakshi Anil Belekar
  • Patent number: 10556889
    Abstract: Provided herein is a compound of Formula I, or a salt thereof, wherein R1 is a moiety having the following structure: wherein Z is selected from the group consisting of O and N; X is selected from the group consisting of a bond, NH, and C(O)NH; and A is selected from the group consisting of substituted aryl and substituted heteroaryl. Compounds of Formula I are useful as opioid receptor agonists. Because the compounds exhibit relatively low levels of ?-arrestin recruitment, they do not produce the negative side effects commonly associated with morphine-derived compounds.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: February 11, 2020
    Assignee: Blue Sky Pharmaceuticals, LLC
    Inventors: David Gindelberger, John J. Talley
  • Patent number: 10550135
    Abstract: The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R1 and R2 are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by Plasmodium falciparum or other coccidian parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: February 4, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventors: Dumbala Srinivasa Reddy, Dhanasekaran Shanmugam, Remya Ramesh, Anurag Shukla, Meenakshi Anil Belekar
  • Patent number: 10526303
    Abstract: In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted flavone derivatives disclosed herein are prodrugs of 7,8-dihydoxyflavone and analogs.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: January 7, 2020
    Assignee: Emory University
    Inventor: Keqiang Ye
  • Patent number: 10479792
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: November 19, 2019
    Assignees: GiaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Stephen Brand, Peter George Dodd, Eun Jung Ko, Maria Marco Martin, Timothy James Miles, Lars Henrik Sandberg, Michael George Thomas, Stephen Thompson
  • Patent number: 10425485
    Abstract: In one embodiment, a device in a network joins an Information Centric Networking (ICN)-based directed acyclic graph (DAG) based on the device being able to act as an ICN cache in the network. The device receives ICN content data for forwarding between a content provider node in the network and a destination node in the network. The device forwards the ICN content data towards the destination node in the network. The device coordinates, with one or more other members of the ICN-based DAG, caching of the ICN content data by the device or by one of other members of the ICN-based DAG.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 24, 2019
    Assignee: Cisco Technology, Inc.
    Inventor: Ganesh Prasad Narayan Palankar
  • Patent number: 10363315
    Abstract: The present invention relates to a composition for use in the treatment of a detached retina, comprising an oil and an additive capable of increasing the extensional viscosity of the oil. The present invention also relates to a method and kit of parts for producing the composition.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 30, 2019
    Assignee: University of Liverpool
    Inventors: Michael Joseph Garvey, Rachel Lucinda Williams, Michael Day
  • Patent number: 10357036
    Abstract: The invention relates inter alia to compounds of the general formula (I). Also described are methods for preparing the compounds of the formula (I). The compounds according to the invention are especially suitable for controlling insects, arachnids and nematodes in agriculture, and ectoparasites in veterinary medicine and also as herbicides.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: July 23, 2019
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Tobias Harschneck, Michael Maue, Werner Hallenbach, Alexander Arlt, Robert Velten, Reiner Fischer, Hans-Georg Schwarz, Ulrich Görgens, Kerstin Ilg, Klaus Raming, Sebastian Horstmann, Daniela Portz, Johannes Köbberling, Andreas Turberg, Hansjörg Dietrich
  • Patent number: 10251393
    Abstract: A synthetic polymer film includes a surface which has a plurality of raised portions. A two-dimensional size of the plurality of raised portions is in a range of more than 20 nm and less than 500 nm when viewed in a normal direction of the synthetic polymer film. The surface has a microbicidal effect. Further, a concentration of a nitrogen element included in the surface is not less than 0.7 at %.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: April 9, 2019
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Miho Yamada, Kiyoshi Minoura, Takahiro Nakahara, Ken Atsumo
  • Patent number: 10239849
    Abstract: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: March 26, 2019
    Inventors: Michael T. Rudd, Edward J. Brnardic, Yuntae Kim, Robert S. Meissner, Vanessa L. Rada, Shawn J. Stachel, Celina V. Zerbinatti
  • Patent number: 10213377
    Abstract: A method of stimulating adipogenesis in a person's skin is disclosed. The method can include topically applying to skin in need thereof, a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein adipogenesis in the person's skin is stimulated.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: February 26, 2019
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 10206390
    Abstract: A herbicidal suspension concentrate composition is provided, the composition comprising at least one pyridine sulfonamide active ingredient and a polyether-polysiloxane.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 19, 2019
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventor: James Timothy Bristow
  • Patent number: 10123537
    Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. Under such circumstances, the development of novel agricultural and horticultural insecticides is desired. The present invention provides an amide compound represented by the general formula (I): (wherein A1, A2 and A3 each represent a nitrogen atom or a CH group, R1 represents an alkyl group, R2 and R4 each represent a haloalkyl group, R3 represents an alkyl group, and m represents 0, 1 or 2) or a salt thereof; an agricultural and horticultural insecticide and microbicide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide and microbicide.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: November 13, 2018
    Assignee: NIHON NOHYAKU CO., LTD.
    Inventors: Ikki Yonemura, Soichiro Matsuo, Akiyuki Suwa, Masao Yamashita, Atsushi Okada
  • Patent number: 10071967
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene} carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 11, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Pierre Cristau, Philippe Desbordes, Julie Geist, Lionel Nicolas, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchiya, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Patent number: 9981913
    Abstract: Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 29, 2018
    Assignee: Ralexar Therapeutics, Inc.
    Inventor: Raju Mohan
  • Patent number: 9981962
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 29, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: George Hynd, Patrizia Tisselli, Janusz Jozef Kulagowski, Calum Macleod, Samuel Edward Mann, John Gary Montana, Stephen Colin Price, Fabien Jean Ghislain Roussel
  • Patent number: 9968538
    Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: May 15, 2018
    Assignee: Avon Products, Inc.
    Inventors: Uma Santhanam, Jolanta Idkowiak-Baldys, Daniel Thorn Leeson, Anthony David Gonzalez, Glen Thomas Anderson
  • Patent number: 9956151
    Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: May 1, 2018
    Assignee: AVON PRODUCTS, INC.
    Inventors: Uma Santhanam, Jolanta Idkowiak-Baldys, Daniel Thorn Leeson, Anthony David Gonzalez, Glen Thomas Anderson
  • Patent number: 9902744
    Abstract: Compositions of matter that have antimicrobial properties and adhesion properties and are highly dispersible in aqueous solutions. The presence of a large number of silanols on the molecules of this invention creates a solubility or dispersability of these molecules in aqueous solutions that is not obtainable from prior art antimicrobial monomers.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: February 27, 2018
    Inventors: John D. Blizzard, Robert L. McKellar
  • Patent number: 9833404
    Abstract: Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, Commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: December 5, 2017
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 9765052
    Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6a and R6b are as defined in the description; or a stereoisomer, salt, tautomer or N-oxide, or a polymorphic crystalline form, a co-crystal or a solvate of a compound or a stereoisomer, salt, tautomer or N-oxide thereof, and to mixtures, methods and uses thereof.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: September 19, 2017
    Assignee: BASF SE
    Inventors: Florian Kaiser, Karsten Koerber, Prashant Deshmukh, Matthias Pohlman, Jean-Yves Wach, Juergen Langewald, Egon Haden, Deborah L. Culbertson, W. David Rogers, Koshi Gunjima, Michael David, Franz Josef Braun
  • Patent number: 9693562
    Abstract: A liquid insecticide composition is provided containing a neonicotinoid-based compound, a silicone-based surfactant, and a water-soluble organic solvent. Furthermore, a method is provided for enhancing an insecticidal effect which includes using a silicone-based surfactant in combination with a neonicotinoid-based compound as an insecticidal active ingredient.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: July 4, 2017
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Kaoru Nishimura, Rieko Nakamura, Rie Sakamoto
  • Patent number: 9682948
    Abstract: In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted flavone derivatives disclosed herein are prodrugs of 7,8-dihydoxyflavone and analogs.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: June 20, 2017
    Assignee: Emory University
    Inventor: Keqiang Ye
  • Patent number: 9656965
    Abstract: A new one-step process for the preparation of pyrazole carboxamide derivatives of the general formula (I) by reaction of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde with an amine or its salt.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 23, 2017
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Peter Bruchner, Sergii Pazenok
  • Patent number: 9642793
    Abstract: Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, Commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: May 9, 2017
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 9617286
    Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivatives with formula: their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: April 11, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Benting, Pierre Cristau, Philippe Desbordes, Helene Lachaise, Philippe Rinolfi
  • Patent number: 9586192
    Abstract: Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing functional group. The medium or the scaffold including the selenium-containing functional group has affinity and specificity to metal ions or compounds having one or more metals, and efficiently separates, recovers, and scavenges of the metals from a target such as a sample, solution, suspension, or mixture.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: March 7, 2017
    Assignee: BROWN UNIVERSITY
    Inventors: Yongsong Huang, James Dillon