Silicon Containing Doai Patents (Class 514/63)
  • Patent number: 10683311
    Abstract: The present disclosure relates to fungicidal active compounds, more specifically to trisubstitutedsilylphenoxyhetero-cycles and analogues thereof, processes and, intermediates for their preparation and use thereof as fungicidal active compound, particularly in the form of fungicide compositions. The present disclosure also relates to methods for the control of phytopathogenic fungi of plants using these compounds or compositions comprising thereof.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: June 16, 2020
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Jérémy Dufour, Philippe Desbordes, Christophe Dubost, Mathieu Gourgues, Ruth Meissner, Andrew Pettinger, Philippe Rinolfi, Valérie Toquin, Ulrike Wachendorff-Neumann
  • Patent number: 10669237
    Abstract: Provided herein is a process for the preparation of 4-((6-bromopyridin-3-yl)oxy)benzonitrile.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: June 2, 2020
    Assignee: Dow AgroSciences LLC
    Inventors: Nicholas R. Babij, Qiang Yang, Kaitlyn Gray, Yan Hao
  • Patent number: 10647923
    Abstract: A system and method produce hydrocarbons from biomass by fluid catalytic cracking. In one embodiment, the system is a fluid catalytic cracking system. The system includes a riser. The riser contains a catalyst. The system also includes a biological feed comprising biomass-derived liquid for the riser. In addition, the system includes a hydrocarbon feed comprising hydrocarbons for the riser. The biological feed and the hydrocarbons react in the riser in the presence of the catalyst to convert at least a portion of the biological feed and the hydrocarbons to hydrocarbon products. The hydrocarbon products comprise a concentration of oxygen from about 0.005 wt. % to about 6 wt. %.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 12, 2020
    Assignee: Phillips 66 Company
    Inventors: Kristi A. Fjare, TiePan Shi, Constantino Badra, Terry S. Cantu, Milena Vasic, Ruben van Duren, Marty Pronk, Leen Gerritsen
  • Patent number: 10600973
    Abstract: A method of synthesizing a fused heteroaromatic compound includes obtaining a first intermediate from a first compound represented by Chemical Formula 1 and a second compound represented by Chemical Formula 2, obtaining a second intermediate including a ring having a chalcogen element from the first intermediate, and obtaining a fused heteroaromatic compound by a cyclization reaction of the second intermediate.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: March 24, 2020
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Eigo Miyazaki, Jeong Il Park, Hyun Bum Kang, Eun Kyung Lee
  • Patent number: 10571465
    Abstract: Techniques for metal enhanced fluorescence include determining a calibration curve that relates concentration of a particular analyte to at least one of intensity or lifetime of fluorescent emissions at a plasmonic substrate in response to incident light, for a plurality of known concentrations of the particular analyte mixed with a reagent. The reagent comprises a detection molecule. A concentration of the particular analyte in a vicinity of a cell in a sample is determined directly from the calibration curve and measurements, in response to the incident light, of at least one of intensity or lifetime of fluorescent emissions at the plasmonic substrate in contact with the cell and reagent.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: February 25, 2020
    Assignee: The University of Maryland, Baltimore
    Inventors: Henryk Szmacinski, Joseph R. Lakowicz
  • Patent number: 10562922
    Abstract: The present invention discloses novel silicon incorporated cyclic compounds of formula I, Wherein Ar1 and Ar2 are individually selected from any aryl group which can be optionally substituted; X is selected from any inorganic anion such as halide, carbonate, sulfate, nitrate or any organic anion selected from acetate, tartarate, citrate, carbonate or organosulfonates such as tosylate, mesylate, triflate; R1 and R2 are individually selected from C1-C8 alkyl, cycloalkyl, aryl, heteroaryl, aralkyl, alkoxyalkyl, aminoalkyl, thioalkyl, haloalkyl or hydroxyalkyl. R1 and R2 together may form a ring which optionally may be substituted or may contain heteroatoms; a pharmaceutical composition comprising a therapeutically effective amount of compounds of general formula I, including geometrical isomers and/or salts thereof along with a drug and optionally along with a carrier or diluent or pharmaceutically acceptable excipient for treating malaria and toxoplasmosis.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: February 18, 2020
    Assignee: Council of Scientific and Industrial Research
    Inventors: Dumbala Srinivasa Reddy, Dhanasekaran Shanmugam, Remya Ramesh, Anurag Shukla, Meenakshi Anil Belekar
  • Patent number: 10556889
    Abstract: Provided herein is a compound of Formula I, or a salt thereof, wherein R1 is a moiety having the following structure: wherein Z is selected from the group consisting of O and N; X is selected from the group consisting of a bond, NH, and C(O)NH; and A is selected from the group consisting of substituted aryl and substituted heteroaryl. Compounds of Formula I are useful as opioid receptor agonists. Because the compounds exhibit relatively low levels of ?-arrestin recruitment, they do not produce the negative side effects commonly associated with morphine-derived compounds.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: February 11, 2020
    Assignee: Blue Sky Pharmaceuticals, LLC
    Inventors: David Gindelberger, John J. Talley
  • Patent number: 10550135
    Abstract: The present invention discloses a silicon incorporated quinoline of formula (I) wherein, X, Y, A, R1 and R2 are as described. The present invention further discloses a process for the preparation of silicon incorporated quinolines of formula I; a pharmaceutical composition comprising silicon incorporated quinolines of formula (I) or pharmaceutically acceptable salt thereof. The present invention also discloses a method for treating diseases caused by Plasmodium falciparum or other coccidian parasites using the silicon incorporated quinolines of formula I or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: February 4, 2020
    Assignee: Council of Scientific & Industrial Research
    Inventors: Dumbala Srinivasa Reddy, Dhanasekaran Shanmugam, Remya Ramesh, Anurag Shukla, Meenakshi Anil Belekar
  • Patent number: 10526303
    Abstract: In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted flavone derivatives disclosed herein are prodrugs of 7,8-dihydoxyflavone and analogs.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: January 7, 2020
    Assignee: Emory University
    Inventor: Keqiang Ye
  • Patent number: 10479792
    Abstract: A compound of Formula (I), or a salt thereof, compositions comprising the compound, processes for its preparation and its use in therapy, for example in the treatment of parasitic diseases such as Chagas disease, Human African Trypanosomiasis (HAT), Animal African trypanosomiasis (AAT) and leishmaniasis, particularly visceral leishmaniasis (VL).
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: November 19, 2019
    Assignees: GiaxoSmithKline Intellectual Property Development Limited, University of Dundee
    Inventors: Stephen Brand, Peter George Dodd, Eun Jung Ko, Maria Marco Martin, Timothy James Miles, Lars Henrik Sandberg, Michael George Thomas, Stephen Thompson
  • Patent number: 10425485
    Abstract: In one embodiment, a device in a network joins an Information Centric Networking (ICN)-based directed acyclic graph (DAG) based on the device being able to act as an ICN cache in the network. The device receives ICN content data for forwarding between a content provider node in the network and a destination node in the network. The device forwards the ICN content data towards the destination node in the network. The device coordinates, with one or more other members of the ICN-based DAG, caching of the ICN content data by the device or by one of other members of the ICN-based DAG.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: September 24, 2019
    Assignee: Cisco Technology, Inc.
    Inventor: Ganesh Prasad Narayan Palankar
  • Patent number: 10363315
    Abstract: The present invention relates to a composition for use in the treatment of a detached retina, comprising an oil and an additive capable of increasing the extensional viscosity of the oil. The present invention also relates to a method and kit of parts for producing the composition.
    Type: Grant
    Filed: May 18, 2006
    Date of Patent: July 30, 2019
    Assignee: University of Liverpool
    Inventors: Michael Joseph Garvey, Rachel Lucinda Williams, Michael Day
  • Patent number: 10357036
    Abstract: The invention relates inter alia to compounds of the general formula (I). Also described are methods for preparing the compounds of the formula (I). The compounds according to the invention are especially suitable for controlling insects, arachnids and nematodes in agriculture, and ectoparasites in veterinary medicine and also as herbicides.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: July 23, 2019
    Assignee: Bayer CropScience Aktiengesellschaft
    Inventors: Tobias Harschneck, Michael Maue, Werner Hallenbach, Alexander Arlt, Robert Velten, Reiner Fischer, Hans-Georg Schwarz, Ulrich Görgens, Kerstin Ilg, Klaus Raming, Sebastian Horstmann, Daniela Portz, Johannes Köbberling, Andreas Turberg, Hansjörg Dietrich
  • Patent number: 10251393
    Abstract: A synthetic polymer film includes a surface which has a plurality of raised portions. A two-dimensional size of the plurality of raised portions is in a range of more than 20 nm and less than 500 nm when viewed in a normal direction of the synthetic polymer film. The surface has a microbicidal effect. Further, a concentration of a nitrogen element included in the surface is not less than 0.7 at %.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: April 9, 2019
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Miho Yamada, Kiyoshi Minoura, Takahiro Nakahara, Ken Atsumo
  • Patent number: 10239849
    Abstract: In its many embodiments, the present invention provides substituted cyanopyridine containing compounds of the Formula (I): and acceptable salts thereof, wherein R1, R2, R3, R4, R5, X, Y, Q, and the moiety are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver X-? receptor (LXR?) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: March 26, 2019
    Inventors: Michael T. Rudd, Edward J. Brnardic, Yuntae Kim, Robert S. Meissner, Vanessa L. Rada, Shawn J. Stachel, Celina V. Zerbinatti
  • Patent number: 10213377
    Abstract: A method of stimulating adipogenesis in a person's skin is disclosed. The method can include topically applying to skin in need thereof, a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein adipogenesis in the person's skin is stimulated.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: February 26, 2019
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 10206390
    Abstract: A herbicidal suspension concentrate composition is provided, the composition comprising at least one pyridine sulfonamide active ingredient and a polyether-polysiloxane.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 19, 2019
    Assignee: ROTAM AGROCHEM INTERNATIONAL COMPANY LIMITED
    Inventor: James Timothy Bristow
  • Patent number: 10123537
    Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. Under such circumstances, the development of novel agricultural and horticultural insecticides is desired. The present invention provides an amide compound represented by the general formula (I): (wherein A1, A2 and A3 each represent a nitrogen atom or a CH group, R1 represents an alkyl group, R2 and R4 each represent a haloalkyl group, R3 represents an alkyl group, and m represents 0, 1 or 2) or a salt thereof; an agricultural and horticultural insecticide and microbicide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide and microbicide.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: November 13, 2018
    Assignee: NIHON NOHYAKU CO., LTD.
    Inventors: Ikki Yonemura, Soichiro Matsuo, Akiyuki Suwa, Masao Yamashita, Atsushi Okada
  • Patent number: 10071967
    Abstract: The present invention relates to fungicidal N-cycloalkyl-N-{[2-(1-substitutedcycloalkyl)phenyl]methylene} carboxamide derivatives and their thiocarbonyl derivatives, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: September 11, 2018
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Pierre Cristau, Philippe Desbordes, Julie Geist, Lionel Nicolas, Philippe Rinolfi, Jan-Peter Schmidt, Tomoki Tsuchiya, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Patent number: 9981913
    Abstract: Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 29, 2018
    Assignee: Ralexar Therapeutics, Inc.
    Inventor: Raju Mohan
  • Patent number: 9981962
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-?B-inducing kinase (NIK—also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: May 29, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: George Hynd, Patrizia Tisselli, Janusz Jozef Kulagowski, Calum Macleod, Samuel Edward Mann, John Gary Montana, Stephen Colin Price, Fabien Jean Ghislain Roussel
  • Patent number: 9968538
    Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: May 15, 2018
    Assignee: Avon Products, Inc.
    Inventors: Uma Santhanam, Jolanta Idkowiak-Baldys, Daniel Thorn Leeson, Anthony David Gonzalez, Glen Thomas Anderson
  • Patent number: 9956151
    Abstract: Provided are methods of treating skin with at least two alternating treatment modalities to improve the health and/or diminish signs of aging. Some methods according to the present invention may comprise topically applying at least two separate compositions, in a sequential, rotating, or alternating fashion to overcome adaptation, tolerance, or sensitization phenomena.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: May 1, 2018
    Assignee: AVON PRODUCTS, INC.
    Inventors: Uma Santhanam, Jolanta Idkowiak-Baldys, Daniel Thorn Leeson, Anthony David Gonzalez, Glen Thomas Anderson
  • Patent number: 9902744
    Abstract: Compositions of matter that have antimicrobial properties and adhesion properties and are highly dispersible in aqueous solutions. The presence of a large number of silanols on the molecules of this invention creates a solubility or dispersability of these molecules in aqueous solutions that is not obtainable from prior art antimicrobial monomers.
    Type: Grant
    Filed: March 28, 2016
    Date of Patent: February 27, 2018
    Inventors: John D. Blizzard, Robert L. McKellar
  • Patent number: 9833404
    Abstract: Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, Commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: December 5, 2017
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 9765052
    Abstract: Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6a and R6b are as defined in the description; or a stereoisomer, salt, tautomer or N-oxide, or a polymorphic crystalline form, a co-crystal or a solvate of a compound or a stereoisomer, salt, tautomer or N-oxide thereof, and to mixtures, methods and uses thereof.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: September 19, 2017
    Assignee: BASF SE
    Inventors: Florian Kaiser, Karsten Koerber, Prashant Deshmukh, Matthias Pohlman, Jean-Yves Wach, Juergen Langewald, Egon Haden, Deborah L. Culbertson, W. David Rogers, Koshi Gunjima, Michael David, Franz Josef Braun
  • Patent number: 9693562
    Abstract: A liquid insecticide composition is provided containing a neonicotinoid-based compound, a silicone-based surfactant, and a water-soluble organic solvent. Furthermore, a method is provided for enhancing an insecticidal effect which includes using a silicone-based surfactant in combination with a neonicotinoid-based compound as an insecticidal active ingredient.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: July 4, 2017
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Kaoru Nishimura, Rieko Nakamura, Rie Sakamoto
  • Patent number: 9682948
    Abstract: In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diseases or conditions related to BDNF and TrkB activity, such as psychiatric disorders, depression, post-traumatic stress disorder, and autism spectrum disorders, stroke, Rett syndrome, Parkinson's disease, and Alzheimer's disease by administering effective amounts of pharmaceutical compositions comprising compounds disclosed herein to a subject in need thereof. In certain embodiments, it is contemplated that the 7,8-substituted flavone derivatives disclosed herein are prodrugs of 7,8-dihydoxyflavone and analogs.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: June 20, 2017
    Assignee: Emory University
    Inventor: Keqiang Ye
  • Patent number: 9656965
    Abstract: A new one-step process for the preparation of pyrazole carboxamide derivatives of the general formula (I) by reaction of 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbaldehyde with an amine or its salt.
    Type: Grant
    Filed: September 4, 2014
    Date of Patent: May 23, 2017
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Peter Bruchner, Sergii Pazenok
  • Patent number: 9642793
    Abstract: Disclosed is a method for reducing the appearance of a wrinkle on skin comprising topically applying to said wrinkle a composition that includes an effective amount of ornithine, retinol, Commiphora mukul resin or an extract thereof, and hyaluronic acid, wherein topical application of the composition reduces the appearance of said wrinkle within 120 seconds after application of the composition, and wherein topical application of said composition stimulates adipogenesis in said skin.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: May 9, 2017
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
  • Patent number: 9617286
    Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivatives with formula: their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: April 11, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Benting, Pierre Cristau, Philippe Desbordes, Helene Lachaise, Philippe Rinolfi
  • Patent number: 9585382
    Abstract: The present invention relates to an agrochemical composition comprising a pesticide and a solvent of the formula (B) as described hereinbelow. The invention furthermore relates to a process for the preparation of the composition by bringing the pesticide and the solvent into contact; a use of the solvent of the formula (B) as a solvent for pesticides; methods for controlling phytopathogenic fungi and/or undesired vegetation and/or undesired insect or mite attack and/or for regulating the growth of plants, wherein the composition is allowed to act on the respective pests, their environment or on the plants to be protected from the respective pest, on the soil and/or on undesired plants and/or on the crop plants and/or on their environment; and on seed comprising the composition.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: March 7, 2017
    Assignee: BASF SE
    Inventors: Paul Klingelhoefer, Gerhard Schnabel, Ralf Pelzer, Wolfgang Spiegler
  • Patent number: 9586192
    Abstract: Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing functional group. The medium or the scaffold including the selenium-containing functional group has affinity and specificity to metal ions or compounds having one or more metals, and efficiently separates, recovers, and scavenges of the metals from a target such as a sample, solution, suspension, or mixture.
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: March 7, 2017
    Assignee: BROWN UNIVERSITY
    Inventors: Yongsong Huang, James Dillon
  • Patent number: 9572788
    Abstract: The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.
    Type: Grant
    Filed: May 13, 2014
    Date of Patent: February 21, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: Randall King, Xing Zeng, Katharine L. Sackton
  • Patent number: 9556205
    Abstract: The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: January 31, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Jurgen Benting, Peter Dahmen, Philippe Desbordes, Stephanie Gary, Marie-Claire Grosjean-Cournoyer, Hiroyuki Hadano, Ruth Meissner, Rachel Rama, Philippe Rinolfi, Ulrike Wachendorff-Neumann
  • Patent number: 9555046
    Abstract: The invention provides and describes solid state 17?-ethynyl-androst-5-ene-3?,7?,17?-triol including amorphous and crystalline forms and specific polymorphic forms thereof. Anhydrates and solvates of 17?-ethynyl-androst-5-ene-3?,7?,17?-triol include Form I anhydrate and Form IV and Form V solvates. The invention further relates to solid and suspension formulations containing 17?-ethynyl-androst-5-ene-3?,7?,17?-triol in a described solid state form and use of the formulations to treat hyperglycemic conditions, such as type 2 diabetes and metabolic syndrome, and autoimmune conditions, such as rheumatoid arthritis, ulcerative colitis and type 1 diabetes, among other inflammation related conditions in subjects or human patients. The invention also relates to methods to make liquid formulations from solid state forms of 17?-ethynyl-androst-5-ene-3?,7?,17?-triol and uses of such formulations in treating the described conditions.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 31, 2017
    Assignee: NEURMEDIX, INC.
    Inventors: Steven K White, Igor Ivanisevic, Kyle Stephens, Mark Andres, Brenton Skylar Wolfe
  • Patent number: 9522935
    Abstract: Lanosterol derivatives useful as anti-cancer agent, which can inhibit the growth of lung cancer cells, liver cancer cells, mammary cancer cells, brain cancer cells and pancreatic cancer cells, possibly by acting on the RHO pathway.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: December 20, 2016
    Inventors: Xin Liu, Weidong Xie
  • Patent number: 9481613
    Abstract: Insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizers are disclosed. The compositions include bifenthrin, a polymeric dispersant, a suspension agent, a freeze-thaw stabilizer, and optionally a preservative.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: November 1, 2016
    Assignee: FMC Corporation
    Inventor: Timothy M. Martin
  • Patent number: 9447126
    Abstract: Methods and systems for making camptothecin analogs and intermediates are provided. Aspects include safer and lower cost methodologies for making camptothecin analogs and intermediates from synthetic materials. In another aspect, the methods and systems can achieve a yield of the camptothecin analogs greater than about 0.4%.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: September 20, 2016
    Assignee: ARNO THERAPEUTICS, INC.
    Inventors: Bin-Feng Li, Ke Yuan
  • Patent number: 9439426
    Abstract: The present invention relates to active compound combinations, in particular within a composition, which comprises (A)) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and (B) a biological control agent. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: September 13, 2016
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Pierre Cristau, Peter Dahmen
  • Patent number: 9428505
    Abstract: The present invention provides compounds represented by formula (1) below and pharmacologically acceptable salts thereof: wherein R1, R2, R3, and R4 are as defined in the claims.
    Type: Grant
    Filed: December 10, 2013
    Date of Patent: August 30, 2016
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yoshikazu Nishimura, Toru Esaki, Tatsuya Tamura
  • Patent number: 9422303
    Abstract: Provided are compositions, methods of making the compositions, and methods of using the compositions. The compositions can be provided as pharmaceutical preparations for use in disease treatment, such as cancer therapy. The compositions include novel pharmaceutical preparations which contain effective concentrations of a chemical compound. One compound used is 10H-1,3-Dioxolo[4,5-g]pyrano[3?,4?:6,7]indolizino[1,2-b]quinoline-8,11(7H,12H)-dione, 7-ethyl-7-hydroxy-, (S)-. The invention also provides methodologies for preparing pharmaceutical preparations for use in intravenous and oral pharmaceutical preparations that contain drug compounds that are difficult to dissolve in water.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: August 23, 2016
    Assignee: Health Research, Inc.
    Inventors: Fengzhi Li, Xiang Ling, Shousong Cao
  • Patent number: 9352049
    Abstract: The present invention relates to ligand-therapeutic agent conjugate compounds, silicon linkers for the conjugate compounds, compositions, methods for making them, and methods for the treatment of cancer using the conjugate compounds. The silicon-based linkers described herein can be used to deliver desired therapeutic agents to particular cells or tissue types targeted by the ligand.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: May 31, 2016
    Assignee: Albany Molecular Research, Inc.
    Inventors: Peter R. Guzzo, David D. Manning
  • Patent number: 9271930
    Abstract: Intermediate compositions and in particular gels and suspensions for a foam composition comprising adapalene are described. Also described, is the dermatological use of such compositions.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: March 1, 2016
    Assignee: GALDERMA RESEARCH AND DEVELOPMENT
    Inventor: Emmanuelle At
  • Patent number: 9265254
    Abstract: A granular pesticidal composition which comprises a pyrazolinone compound given by the formula (1): wherein R1 represents a chlorine atom etc.; R2 represents a chlorine atom etc.; R3 represents a 1-methylethyl group etc.; and R4 represents a C1-C4 alkoxy group etc. and a salt of ligninsulfonic acid, and the amount of the salt of ligninsulfonic acid in the granular pesticidal composition is 10-60% by weight has good disintegrability in water when it is diluted with water.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: February 23, 2016
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Toshiro Otsubo, Rei Matsunaga, Eriko Takeko
  • Patent number: 9216950
    Abstract: The present invention provides new compounds of formula I, II or III, which have Src homology-2 containing protein tyrosine phosphatase-1 (SHP-1) agonist activity. Also provided are treatment methods using the compounds of formula I, II or III.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: December 22, 2015
    Assignees: NATIONAL TAIWAN UNIVERSITY, NATIONAL YANG-MING UNIVERSITY, DCB-USA LLC
    Inventors: Chung-Wai Shiau, Kuen-Feng Chen
  • Patent number: 9205069
    Abstract: The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex (APC). The invention further provides methods of inhibiting the ubiquitination activity of the APC by administering compositions of the invention.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: December 8, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Randall King, Xing Zeng, Shantanu Gaur
  • Patent number: 9198415
    Abstract: The present invention is directed to methods of increasing the environmental stress tolerance of a plant, to methods of improving the quality and/or yield of a plant crop, to methods of application of agrochemicals having a physiological effect on a plant in the plant irrigation water, and to crops produced using said methods.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: December 1, 2015
    Assignee: Syngenta Participations AG
    Inventors: Ulrich Johannes Haas, Christophe Weider, Ronald Zeun, Albert Bassi, Daniel Perkins
  • Patent number: 9187450
    Abstract: The present invention provides a substituted pyridine compound or a pharmacologically acceptable salt thereof which has excellent CETP inhibition activity and is useful as a medicament. The present invention provides a compound represented by a general formula (I), wherein R1 is H, optionally substituted alkyl, OH, optionally substituted alkoxy, alkylsulfonyl, optionally substituted amino, carboxy, optionally substituted carbonyl, CN, halogeno, optionally substituted phenyl, optionally substituted aromatic heterocyclyl, optionally substituted saturated heterocyclyl, optionally substituted saturated heterocyclyloxy or optionally substituted saturated heterocyclylcarbonyl, etc., and the like.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: November 17, 2015
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Tsuyoshi Nakamura, Hidenori Namiki, Naoki Terasaka, Akiko Shima, Masahiko Hagihara, Noriaki Iwase, Katsunori Takata, Osamu Kikuchi, Kazunari Tsuboike, Hiroyuki Setoguchi, Kenji Yoneda, Hidetoshi Sunamoto, Koji Ito
  • Patent number: 9145367
    Abstract: The present invention relates to compound Formula (I) wherein: Formula (II) means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR1 group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, a NO2 group, a NR1R2 group, a (C1-C4)alkoxy group, a phenoxy group and a (C1-C3)alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C1-C3)alkyl group, a hydroxyl group, a COOR1 group, a NO2 group, a NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a (C1-C4)alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating AIDS. Some of said compounds are new and also form part of the invention.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: September 29, 2015
    Assignees: ABIVAX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT CURIE, UNIVERSITE DE MONTPELLIER 2
    Inventors: Jamal Tazi, Florence Mahuteau, Romain Najman, Didier Scherrer, Noelie Campos, Aude Garcel