C=o Bonded Directly To Benzene Ring (e.g., Acetophenone, Etc.) Patents (Class 514/688)
  • Patent number: 9724313
    Abstract: The invention relates to the manufacturing and use of pharmaceutical compositions of medicines (ophthalmic preparations) comprising a mitochondria-addressed antioxidant and a set of auxiliary substances providing effective treatment for ophtalmological diseases in humans and animals.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: August 8, 2017
    Assignee: MITOTECH SA
    Inventor: Maxim V. Skulachev
  • Patent number: 9486435
    Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: November 8, 2016
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Andrew W. Hinman, Kieron E. Wesson
  • Patent number: 8980851
    Abstract: Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.
    Type: Grant
    Filed: November 5, 2010
    Date of Patent: March 17, 2015
    Assignee: Accelalox, Inc.
    Inventor: James Patrick O'Connor
  • Patent number: 8952071
    Abstract: Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), Kearns-Sayre Syndrome (KSS), are disclosed, as well as compounds useful in the methods of the invention, such as 2-(3-hydroxy-3-methyl-butyl)-6-(het)aryl-p-quinone or as 2-(3-hydroxy-3-methylbutyl)-3-(het)aryl-p-quinone derivatives. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
    Type: Grant
    Filed: January 6, 2009
    Date of Patent: February 10, 2015
    Assignee: Edison Pharmaceuticals, Inc.
    Inventors: Andrew W. Hinman, Kieron E. Wesson
  • Patent number: 8932584
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: January 13, 2015
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8932585
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: January 27, 2014
    Date of Patent: January 13, 2015
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Publication number: 20140336263
    Abstract: An animal deterrent device that generally includes a casing, a sensor, a power source and a deterrent means source. The animal deterrent device is used to provide protection to a target site, such as a carcass or part of a carcass left at or near the kill site from predatory animals and/or scavengers. Other uses for the device include preventing animals from disrupting trash or garbage receptacles or for preventing animals from gaining access to campsite rations, food, a temporary carcass or parts of a carcass storage area, or trash.
    Type: Application
    Filed: May 6, 2014
    Publication date: November 13, 2014
    Applicant: Grizzly Mountain Enterprises LLC
    Inventors: Dean Krebs, Shane Spencer
  • Patent number: 8865032
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: August 13, 2013
    Date of Patent: October 21, 2014
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8859626
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: October 14, 2014
    Assignee: Case Western Reserve University
    Inventor: Menachem Shoham
  • Patent number: 8841348
    Abstract: Compositions containing apocynin and paeonol. The compositions may be used for the treatment of inflammatory diseases.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: September 23, 2014
    Assignee: AKL Inflammatory Limited
    Inventor: Nicholas John Larkins
  • Publication number: 20140220164
    Abstract: Compositions useful for controlling pests are disclosed. In some embodiments, the composition includes a pesticidal natural oil and a polar aromatic solvent or an alkyl alcohol solvent. Methods of making and using the compositions are disclosed.
    Type: Application
    Filed: April 8, 2014
    Publication date: August 7, 2014
    Applicant: 0903608 B.C. Ltd.
    Inventors: Karan MANHAS, Annett ROZEK
  • Publication number: 20140105884
    Abstract: Disclosed herein are materials, means and methods for sustained release of therapeutic agents for topical treatments. In particular, disclosed are means and methods for topical treatment of diseases of internal body cavities by embedding therapeutic agents in a slowly degrading biocompatible mixture applied to affected tissue.
    Type: Application
    Filed: October 15, 2013
    Publication date: April 17, 2014
    Applicant: THERACOAT LTD.
    Inventors: Marina Konorty, Gil Hakim
  • Publication number: 20140088185
    Abstract: A buccally administered dosage for assisting with the relief of common digestive complaints where the dosage formed into a hard candy dosage drop, where the dosage is a sugar base infused with a botanical derivative that has concentrated active compositions in sufficient concentration to provide a soothing effect of digestive upset, and where the drop has favorable organoleptic properties.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Inventors: Dustin Garth James, Helen Kim-James
  • Publication number: 20140065082
    Abstract: A white, color-stable anti-aging emulsion formula containing CoQ10 and/or vanillin. The amount of vanillin can be adjusted to provide light or dark tanning of the skin. Lime oil and lime juice form a preferred emulsion foundation.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 6, 2014
    Inventor: Louise Holyfield
  • Patent number: 8658161
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: February 25, 2014
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8642660
    Abstract: A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: February 4, 2014
    Assignee: The University of Rochester
    Inventor: David Scott Goldfarb
  • Patent number: 8617541
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: December 31, 2013
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8563615
    Abstract: The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable salt, ester, prodrug or metabolite thereof.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 22, 2013
    Assignees: Massachusetts Institute of Technology, The Broad Institute, Inc., Massachusetts General Hospital
    Inventors: Li-Huei Tsai, Ji-Song Guan, Stephen J. Haggarty, Edward Holson, Florence Wagner, Johannes Graeff
  • Patent number: 8506859
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: August 13, 2013
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8445437
    Abstract: The present invention is directed to methods of treating or preventing the development of cardiovascular disease by administering compounds that stabilize mast cells. In addition, it includes pharmaceutical compositions which have both a mast cell stabilizer and instructions regarding the use of the stabilizer in treating or preventing cardiovascular disease. The methods and compositions will be of particular value for preventing aneurysms of the abdominal aorta in individuals with atherosclerosis, diabetes, hypertension or a family history of aneurysms.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: May 21, 2013
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventor: Guo-Ping Shi
  • Publication number: 20130065843
    Abstract: Described herein are phenolic compositions derived from apple skins. In particular, described herein are flavonoid-rich fractions derived from apple skin extract. The compositions are useful in the prevention and treatment of conditions associated with oxidative stress and/or inflammation, including certain neurodegenerative diseases. Methods of producing the compositions are also described.
    Type: Application
    Filed: May 10, 2011
    Publication date: March 14, 2013
    Applicant: DALHOUSIE UNIVERSITY
    Inventors: Handunkutti Pathirannehalage Vasantha Rupasinghe, George S. Robertson
  • Publication number: 20120232107
    Abstract: This invention relates, e.g., to methods for inhibiting or stimulating an activity of an adrenomedullin (AM) or gastrin releasing peptide (GRP) peptide hormone, comprising contacting the peptide with a small molecule, non-peptide, modulatory agent of the invention. Complexes of these modulatory agents with other components, such as the peptides or blocking antibodies specific for the peptides, are also described, as are pharmaceutical compositions comprising the modulatory agents, and methods for using the modulatory agents to diagnose or treat patients.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 13, 2012
    Inventors: Frank CUTTITTA, Alfredo MARTINEZ
  • Publication number: 20120142786
    Abstract: Oregano extract can act as a stimulant, yet it does not interfere with sleep patterns or induce nervousness the way many stimulants such as caffeine can. It also has the benefits of promoting improved vigilance, improving attention and ability to focus on a task, and improving general alertness.
    Type: Application
    Filed: February 19, 2010
    Publication date: June 7, 2012
    Inventors: Regina Goralczyk, Jonas Wittwer, Hasan Mohajeri
  • Patent number: 8147826
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: April 3, 2012
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8124072
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: February 28, 2012
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Publication number: 20120039796
    Abstract: A bio compatible free radical suspension, comprising of oxygen and electronically modified reaction intermediates, where a fluorocarbon is used as an inert medium for stabilization of reaction intermediates. A stabilized bio compatible electronically modified derivative suspension is produced by the subjecting a fluorocarbon to certain stressors, such as oxidizing agents, reactive intermediates, physiological gases, benzo-?-pyrone derivatives, ultrasonic-cavitation, electric fields, magnetic fields, UV radiation, active metal catalyst, surfactant reactants, buffers, electrolytes, glucose, glucose derivatives, for the purpose of inducing a cascading immune response.
    Type: Application
    Filed: August 13, 2011
    Publication date: February 16, 2012
    Inventor: Demetrios Markou
  • Patent number: 8105583
    Abstract: The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft gel capsules.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: January 31, 2012
    Assignee: Soft Gel Technologies, Inc.
    Inventor: Michael Fantuzzi
  • Patent number: 8067464
    Abstract: The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor compound, and, optionally, at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating gastrointestinal disorders; (h) treating inflammatory disorders; and (j) treating respiratory disorders; and (k) treating peripheral vascular diseases. The apocynin compound may preferably be apocynin.
    Type: Grant
    Filed: October 3, 2005
    Date of Patent: November 29, 2011
    Assignee: Nitromed, Inc.
    Inventor: David S. Garvey
  • Patent number: 8063108
    Abstract: The present invention provides compositions and methods for modulating bacterial quorum sensing using antagonist or agonist compounds. Further, the present invention provides methods of treating or preventing microbial damages and diseases, in particular for diseases where there is an advantage in inhibiting quorum sensing regulated phenotypes of pathogens.
    Type: Grant
    Filed: February 25, 2010
    Date of Patent: November 22, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jo E. Handelsman, Bradley R. Borlee
  • Patent number: 8048905
    Abstract: Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted tetrazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl or optionally substituted thienyl, and R3, R4, R5, R6 R7 and R8 are as defined herein. Also provided are methods of using the compounds for treating diseases associated with the P2X3 and/or a P2X2/3 receptor antagonist and methods of making the compounds.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: November 1, 2011
    Assignee: Roche Palo Alto LLC
    Inventors: Li Chen, Michael Patrick Dillon, Lichun Feng, Ronald Charles Hawley, Minmin Yang
  • Publication number: 20110124717
    Abstract: Methods for promoting osteogenesis to accelerate or enhance bone fracture healing, treat bone defects, and enhance bone formation are disclosed. The methods modulate an arachidonic acid metabolic or signaling pathway in general, and, in particular, utilize 5-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with one or more agents that inhibit bone resorption, regulate calcium resorption from bone, enhance bone accumulation, enhance bone formation, induce bone formation, impair growth of microorganisms, reduce inflammation, and/or reduce pain.
    Type: Application
    Filed: November 5, 2010
    Publication date: May 26, 2011
    Applicant: ACCELALOX, INC.
    Inventor: James Patrick O'Connor
  • Publication number: 20110117202
    Abstract: Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength ?1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
    Type: Application
    Filed: November 10, 2010
    Publication date: May 19, 2011
    Applicants: Immunolight, LLC, Duke University
    Inventors: Frederic A. Bourke, JR., Zakaryae Fathi, Ian Nicholas Stanton, Michael J. Therien, Paul Rath Stauffer, Paolo MacCarini, Katherine Sarah Hansen, Diane Renee Fels, Cory Robert Wyatt, Mark Wesley Dewhirst
  • Publication number: 20100311701
    Abstract: A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, ketone, thioketone, nitrate ester, phosphate ester, thiophosphate ester, ester, thioester, sulfate ester, carboxylic acid, phosphonic acid, phosphinic acid, sulfonic acid, amide, primary amine, secondary amine, ammonia, tertiary amine, imine, thiocyanate, cyanamide, oxime, nitrile diazo, organohalide, nitro, S-heterocyclic ring, thiophene, N-heterocyclic ring, pyrrole, O-heterocyclic ring, furan, epoxide, peroxide, hydroxamic acid, imidazole, pyridine and the co-crystal former has at least one functional group selected from amine, amide, pyridine, imidazole, indole, pyrrolidine, carbonyl, carboxyl, hydroxyl, phenol, sulfone, sulfonyl, mercapto and methyl thio, such that the API and co-crystal former are capable of co-crystallizing from a solution phase under crystallization conditions.
    Type: Application
    Filed: June 2, 2010
    Publication date: December 9, 2010
    Applicants: Transform Pharmaceuticals, Inc, University Of South Florida, The Regents of the University Of Michigan
    Inventors: Orn Almarsson, Magali Bourghol Hickey, Matthew Peterson, Michael J. Zaworotko, Brian Moulton, Nair Rodriguez-Hornedo
  • Patent number: 7834216
    Abstract: This invention discloses the method for preparing desmosdumotin C, the series of desmosdumotin C derivatives and their manufactures, and the total synthesis of desmosdumotin B. The invention also discloses uses of the derivatives and pharmaceutical compositions containing the same in preparation of medicines for treatment of tumor or AIDS.
    Type: Grant
    Filed: December 28, 2005
    Date of Patent: November 16, 2010
    Inventors: Jiuhong Wu, Kyoko Nakagawa-Goto, Xihong Wang, Ning Shi
  • Publication number: 20100279963
    Abstract: Derivatives of dicarbonyl compounds having antitumor and antibiotic activity which can be used as anticancer agents.
    Type: Application
    Filed: July 1, 2010
    Publication date: November 4, 2010
    Applicant: Abraxis BioScience, LLC
    Inventors: Chunlin Tao, Qinwei Wang, Vuong Trieu, Neil Desai, Patrick Soon-Shiong
  • Publication number: 20100273892
    Abstract: A formulation, comprising an ophthalmically effective amount of one or more tocotrienol quinones, particularly of alpha-tocotrienol quinone is disclosed. Use of a formulation comprising one or more tocotrienol quinones for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more tocotrienol quinones is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more tocotrienol quinones is also discussed.
    Type: Application
    Filed: April 27, 2010
    Publication date: October 28, 2010
    Inventors: Guy M. MILLER, William D. Shrader, Viktoria Kheifets
  • Publication number: 20100215725
    Abstract: The invention describes the use of an injectable form of Idebenone to protect against hepatic damage, improve recovery from liver trauma, poisoning, vapor intoxication, degenerative diseases, hepatocyte function loss and pathology associated with inflammation or infection. The use of injectable Idebenone restores liver function, suppresses elevated enzyme levels, decreases alcoholic and drug abuse associated syndromes, symptoms of acute hepatitis of various origins, the consequences of liver reperfusion and other signs of liver damage.
    Type: Application
    Filed: February 20, 2009
    Publication date: August 26, 2010
    Inventors: Joseph Schwarz, Michael Weisspapir
  • Publication number: 20100209354
    Abstract: The invention relates to nanoparticles made from organometallic hybrid materials made from iron carboxylates, used for example as contrast agents. The particles can also be used for the encapsulation and vectoring of molecules of interest such as active3 pharmaceutical agents, cosmetically interesting compounds and markers. Apart from the intrinsic properties thereof for imaging, said nanoparticles give good results in terms of capacity for loading with medicaments and in biocompatibility.
    Type: Application
    Filed: October 1, 2008
    Publication date: August 19, 2010
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, UNIVERSITE DE VERSAILLES - SAINT-QUENTIN- EN-YVELINES
    Inventors: Patricia Horcajada-Cortes, Gérard Ferey, Christian Serre, Ruxandra Gref, Patrick Couvreur
  • Publication number: 20100189818
    Abstract: Methods and compositions are provided for treating neuropsychiatric disorders such as schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia, and bipolar disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder (e.g., schizophrenia, depression, attention deficit disorder, mild cognitive impairment, dementia bipolar disorder, etc.) or as at risk for a neuropsychiatric disorder a benzoic acid, benzoic acid salt, and/or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, in combination with a neuropharmacological agent (e.g., an antipsychotic, an antidepressant, medications for attention deficit and hyperactivity disorder, cognitive impairment, or dementia, etc.) where the benzoic acid, benzoic acid salt, or benzoic acid derivative, and/or a sorbic acid, sorbic acid salt, and/or sorbic acid derivative, is in an amount sufficient to increase the efficacy of the neuropharmacological agent.
    Type: Application
    Filed: January 19, 2010
    Publication date: July 29, 2010
    Applicant: Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Inventor: GUOCHUAN EMIL TSAI
  • Publication number: 20100183692
    Abstract: Provided are essentially preservative-free personal care product compositions that comprise a combination of fragrance compounds that stabilises the personal care product against microorganisms. The combination comprises certain benzaldehyde or benzaldehyde derivative compounds combined with certain fragrant acids. The composition is free of classical preservatives including parabens or their derivatives. Further provided are methods of forming such compositions and products and the use of the combination of fragrance compounds in such compositions and products.
    Type: Application
    Filed: June 17, 2008
    Publication date: July 22, 2010
    Inventor: Andreas Natsch
  • Publication number: 20100144865
    Abstract: The present invention relates to a fish feed comprising dioxabicyclo[3.3.0]octane derivates, in particular selected sesame lignans, and a vegetable oil or oil mixture comprising at least one 18-carbon chain omega-3 fatty acid. The dioxabicyclo[3.3.0]octane derivate will induce a desaturation and elongation of the 18-carbon chain fatty acid in the fish muscle into longer carbon chain polyunsaturated fatty acids.
    Type: Application
    Filed: April 25, 2008
    Publication date: June 10, 2010
    Inventors: Jana Pickova, Afaf Kamal-Eldin, Sofia Trattner, Eva Brännäs
  • Publication number: 20100021989
    Abstract: The formulations have an antimicrobial, antiviral, and anti-pathogenic composition that combines, in various forms, a redox-active polyphenol, an oxidizing agent, and/or a redox-active, transition metal ion and/or electrochemical potential. The composition relates to methods for decreasing or eliminating the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for treating herpes simplex and HIV viruses and drug-resistant bacteria, and for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods, compositions, electrochemical devices, and storage containers for decreasing the infectivity of pathogenic organisms in pharmaceuticals, medical devices, personal care products, recreational products, and foodstuffs.
    Type: Application
    Filed: July 28, 2009
    Publication date: January 28, 2010
    Inventors: Steve Baugh, Thomas Hnat, Alok Nigam
  • Publication number: 20090311329
    Abstract: The present invention relates to the field of food technology and delivery of hydrophobic biologically active compounds, particularly nutrients, via food products and beverages. In particular the present invention provides isolated casein micelles useful for the encapsulation of hydrophobic nutrients, therapeutic and cosmetic compounds, compositions thereof and methods of preparing the micelles.
    Type: Application
    Filed: April 19, 2007
    Publication date: December 17, 2009
    Inventors: Yoav D. Livney, Douglas G. Dalgleish
  • Publication number: 20090306217
    Abstract: The present invention provides compositions for inhibiting the activity of an insect pest against a subject (or repelling an insect pest from an environment or preventing attraction to an environment) which compositions comprise geranylacetone as an active ingredient plus a carrier plus a further active ingredient selected from the list consisting of: 6-Methyl-hepten-2-one, octanal, plus optional other chemicals. Also provided are related materials and methods of use.
    Type: Application
    Filed: March 2, 2007
    Publication date: December 10, 2009
    Inventors: John Anthony Pickett, James George Logan, Michael Alexander Birkett, Anne Jennifer Mordue
  • Publication number: 20090275666
    Abstract: The invention relates to a condensation product obtainable by reaction of a1) at least one aromatic or heteroaromatic, where the aromatic or heteroaromatic is substituted by at least one hydroxyl group (—OH) and at least one carboxyl group (—COOH), and where the hydroxyl and/or carboxyl group can be present in salt form, a2) at least one carbonyl compound, a3) optionally at least one sulfonating agent a4) optionally at least one urea derivative, and a5) optionally at least one further aromatic or heteroaromatic, or a physiologically tolerable salt thereof, with the precondition that the component a1) is not salicylic acid or sulfosalicylic acid if the component a4) is melamine.
    Type: Application
    Filed: February 28, 2007
    Publication date: November 5, 2009
    Applicant: BASF SE
    Inventors: Stephan Hueffer, Sebastien Garnier, Oliver Reese, Guenter Scherr, Joachim Roser, Ulrich Mrowietz
  • Publication number: 20090233998
    Abstract: This invention discloses the method for preparing desmosdumotin C, the series of desmosdumotin C derivatives and their manufactures, and the total synthesis of desmosdumotin B. The invention also discloses uses of the derivatives and pharmaceutical compositions containing the same in preparation of medicines for treatment of tumor or AIDS.
    Type: Application
    Filed: December 28, 2005
    Publication date: September 17, 2009
    Inventors: Jiuhong Wu, Kyoko Nakagawa-Goto, Xihong Wang, Ning Shi
  • Patent number: 7579380
    Abstract: The present invention relates to pharmaceutical compositions, formulations and medicaments comprising a bupropion salt, in particular, modified-release tablets comprising an effective amount of bupropion hydrobromide, and the use of the bupropion salt to prepare a medicament to treat a condition.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: August 25, 2009
    Assignee: Biovail Laboratories International S.R.L.
    Inventors: Werner Oberegger, Fang Zhou, Paul Maes, Stefano Turchetta, Graham Jackson, Pietro Massardo, Mohammad Ashty Saleh
  • Publication number: 20090203652
    Abstract: The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.
    Type: Application
    Filed: December 3, 2008
    Publication date: August 13, 2009
    Applicant: Dompe pha.r.ma S.p.A.
    Inventors: Marcello ALLEGRETTI, Riccardo Bertini, Cinzia Bizzarri, Maria Candida Cesta, Francesco Colotta
  • Publication number: 20090196838
    Abstract: Disclosed herein is a pharmacophore model for arthropod repellent activity and methods of making and using thereof. The pharmacophore comprises two hydrophobic aliphatic functions, one aromatic function and one hydrogen bond acceptor function. The pharmacophore model was made using a test set of arthropod repellent compounds. Also disclosed are arthropod repellent compounds identified by screening databases with the pharmacophore model. Also disclosed are methods of repelling arthropods from a surface or area. Compositions and formulations comprising the compounds of the present invention as well as objects having the compounds of the present invention are disclosed.
    Type: Application
    Filed: December 24, 2008
    Publication date: August 6, 2009
    Inventors: Raj K Gupta, Apurba K. Bhattacharjee, Donna Ma Lee
  • Publication number: 20090163545
    Abstract: A method for altering the lifespan of a eukaryotic organism. The method comprises the steps of providing a lifespan altering compound, and administering an effective amount of the compound to a eukaryotic organism, such that the lifespan of the organism is altered. In one embodiment, the compound is identified using the DeaD assay.
    Type: Application
    Filed: December 22, 2008
    Publication date: June 25, 2009
    Applicant: UNIVERSITY OF ROCHESTER
    Inventor: David Scott Goldfarb