With Carboxylic Acid Metal Salt Patents (Class 514/69)
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Patent number: 8784790Abstract: Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.Type: GrantFiled: June 11, 2009Date of Patent: July 22, 2014Assignee: Medtronic Xomed, Inc.Inventors: Matthew F. Myntti, Dana A. Oliver, James B. Hissong, Jennifer G. Medina
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Patent number: 7605146Abstract: There is disclosed a process for producing an amide compound, which process is characterized in that a compound having an amino group are reacted with a polyaminopolycarboxylic acid anhydride in the presence of the polyaminopolycarboxylic acid.Type: GrantFiled: October 9, 2001Date of Patent: October 20, 2009Assignee: Nihon Medi-Physics Company, LimitedInventors: Naoyuki Takano, Daisaku Nakamura
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Patent number: 6986905Abstract: The present invention relates to a pharmaceutical composition and the method for the preparation thereof, The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium chloride, sodium bicarbonate, potassium chloride, magnesium sulfate, calcium chloride, calcium gluconate, and the like, and 3˜18% (w/v) of one or more substances selected from hydroxyethylstarch, dextran, carboxymethylstarch, polyvinyl-pyrrolidone, gelatin derivatives, and the like as well as the remainder of conventional injections, as long as sodium chloride is not less than 1.5% (w/v). The pharmaceutical composition of the present invention is used to treat and save the wounded and patients, as well as to treat shock, its advantages include safe and convenient use, rapid and good curative effect, long time maintenance, extensive uses and the like.Type: GrantFiled: November 15, 2000Date of Patent: January 17, 2006Inventor: Chaoying Zhao
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Patent number: 6844328Abstract: The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.Type: GrantFiled: March 16, 2001Date of Patent: January 18, 2005Assignee: Eurand Pharmaceuticals Ltd.Inventors: Giuliana Miglierini, Luca Stucchi, Alessandro Rastrelli
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Patent number: 5773001Abstract: This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.Type: GrantFiled: June 3, 1994Date of Patent: June 30, 1998Assignee: American Cyanamid CompanyInventors: Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei-Ru Tsou, Martin J. Weiss
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Patent number: 5591727Abstract: The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal composition can in particular be used as an emulsion or on a powdery carrier for the control of flying and crawling insects such as flies and cockroaches.Type: GrantFiled: February 7, 1995Date of Patent: January 7, 1997Assignees: Perycut-Chemie AG, Franz BencsitsInventor: Franz Bencsits
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Patent number: 5462928Abstract: The invention features an inhibitor of DP-IV, having the structure: ##STR1## wherein m is an integer between 0 and 10, inclusive; A and A' are L-amino acid residues such that the A in each repeating bracketed unit can be a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A' and C, and between A' and N are peptide bonds; and each X.sup.1 and X.sup.2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group at physiological pH.Type: GrantFiled: July 15, 1993Date of Patent: October 31, 1995Assignees: New England Medical Center Hospitals, Inc., Tufts UniversityInventors: William W. Bachovchin, Andrew G. Plaut, Flentke George R.
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Patent number: 5362482Abstract: A water-in-oil type emulsified solid composition containing (a) an oil component such as a silicone oil, (b) a solid wax and/or an oil-gelling agent, (c) water, and (d) (i) a polyoxyalkylene modified organopolysiloxane or (ii) a lipophilic surfactant and a hydrophobically treated powder, wherein the water content is 5% by weight or more, based upon the total amount of the composition.Type: GrantFiled: February 10, 1993Date of Patent: November 8, 1994Assignee: Shiseido Company Ltd.Inventors: Toshio Yoneyama, Yasuo Matsuoka, Harumi Suzuki, Shigenori Kumagai, Susumu Takada
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Patent number: 5346698Abstract: Described and claimed are methods and compositions for the control of pests. According to the subject invention, a fatty acid or mixture of fatty acids can be combined with one or more avermectins or related compounds to achieve synergistic control of pests.Type: GrantFiled: March 8, 1993Date of Patent: September 13, 1994Assignee: Mycogen CorporationInventor: Kenneth D. Abercrombie
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Patent number: 5192546Abstract: Described and claimed are methods and compositions for the control of pests. According to the subject invention, a fatty acid or mixture of fatty acids can be combined with one or more avermectins or related compounds to achieve synergistic control of pests.Type: GrantFiled: January 15, 1991Date of Patent: March 9, 1993Assignee: Mycogen CorporationInventor: Kenneth D. Abercrombie
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Patent number: 5047424Abstract: An environmetally safe, broad spectrum insecticidal composition is disclosed. The composition combines a mixture of monocarboxylic acids (such as oleic and linoleic) and their alkali metal salts, and a pyrethroid compound. In a concentrated form of the composition, the monocarboxylic acid mixture comprises about 50 percent by weight monocarboxylic acids and their salts, at least 70 percent of which comprise oleic acid and at least 6 percent comprise linoleic acid. The pyrethroid compound is present in the concentrate at about 0.2 to 2.0 percent by weight.Type: GrantFiled: October 3, 1988Date of Patent: September 10, 1991Assignee: Safer, Inc.Inventors: George S. Puritch, Gregory S. Salloum
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Patent number: 4983591Abstract: A combination of pyrethrum and fatty acid salt materials has been formulated which produces a stable, commercially useful, and environmentally safe pesticide. The specific composition comprises an aqueous solution having a pH within the range of 7.5 to 8.8; an aqueous solution comprising at least about 0.5 percent by weight of monocarboxylic acids and their alkali metal salts, where the acid mixture is at least 70% oleic acid and 6% linoleic acid; a pyrethrum extract; a solvent for the pyrethrum, which is preferably a 2-6 carbon alcohol; a trace amount of an antioxidant. The composition is effective against insects of at least the orders Homoptera, Coleoptera, Dermaptera, Hemiptera, and Lepidoptera, and against crustacea of the order Isopoda.Type: GrantFiled: November 6, 1989Date of Patent: January 8, 1991Assignee: Safer, Ltd.Inventors: George S. Puritch, Gregory S. Salloum, Willem W. Nijholt
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Patent number: 4904645Abstract: A combination of pyrethrum and fatty acid salt materials has been formulated which produces a stable, commercially useful, and environmentally safe pesticide. The specific composition comprises an aqueous solutioon having a pH within the range of 7.5 to 8.8; an aqueous solution comprising about 50% by weight of monocarboxylic acids and their alkali metal salts, where the acid mixture is at least 70% oleic acid and 6% linoleic acid; a pyrethrum extract; a solvent for the pyrethrum, which is preferably a 2-6 carbon alcohol; a trace amount of an antioxidant. The composition is effective against insects of at least the orders Homoptera, Coleoptera, Dermaptera, Hemiptera, and Lepidoptera, and against crustacea of the order Isopoda.Type: GrantFiled: January 27, 1988Date of Patent: February 27, 1990Assignee: Safer, Ltd.Inventors: George S. Puritch, Gregory S. Salloum, Willem W. Nijholt