With Carboxylic Acid Metal Salt Patents (Class 514/69)
  • Patent number: 8784790
    Abstract: Chronic wounds may be treated by debriding necrotic and other devitalized tissue from the wound, and applying to the wound an extracellular polymeric substance solvating system comprising a metal ion sequestering agent, surfactant and buffering agent. The solvating system disrupts biofilms which may be present in the wound and aids or enables the resumption of normal healing.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: July 22, 2014
    Assignee: Medtronic Xomed, Inc.
    Inventors: Matthew F. Myntti, Dana A. Oliver, James B. Hissong, Jennifer G. Medina
  • Patent number: 7605146
    Abstract: There is disclosed a process for producing an amide compound, which process is characterized in that a compound having an amino group are reacted with a polyaminopolycarboxylic acid anhydride in the presence of the polyaminopolycarboxylic acid.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: October 20, 2009
    Assignee: Nihon Medi-Physics Company, Limited
    Inventors: Naoyuki Takano, Daisaku Nakamura
  • Patent number: 6986905
    Abstract: The present invention relates to a pharmaceutical composition and the method for the preparation thereof, The composition comprises 1.5˜6.9% (w/v) of one or more substances selected from sodium chloride, sodium bicarbonate, potassium chloride, magnesium sulfate, calcium chloride, calcium gluconate, and the like, and 3˜18% (w/v) of one or more substances selected from hydroxyethylstarch, dextran, carboxymethylstarch, polyvinyl-pyrrolidone, gelatin derivatives, and the like as well as the remainder of conventional injections, as long as sodium chloride is not less than 1.5% (w/v). The pharmaceutical composition of the present invention is used to treat and save the wounded and patients, as well as to treat shock, its advantages include safe and convenient use, rapid and good curative effect, long time maintenance, extensive uses and the like.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: January 17, 2006
    Inventor: Chaoying Zhao
  • Patent number: 6844328
    Abstract: The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: January 18, 2005
    Assignee: Eurand Pharmaceuticals Ltd.
    Inventors: Giuliana Miglierini, Luca Stucchi, Alessandro Rastrelli
  • Patent number: 5773001
    Abstract: This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.
    Type: Grant
    Filed: June 3, 1994
    Date of Patent: June 30, 1998
    Assignee: American Cyanamid Company
    Inventors: Philip Ross Hamann, Lois Hinman, Irwin Hollander, Ryan Holcomb, William Hallett, Hwei-Ru Tsou, Martin J. Weiss
  • Patent number: 5591727
    Abstract: The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal composition can in particular be used as an emulsion or on a powdery carrier for the control of flying and crawling insects such as flies and cockroaches.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: January 7, 1997
    Assignees: Perycut-Chemie AG, Franz Bencsits
    Inventor: Franz Bencsits
  • Patent number: 5462928
    Abstract: The invention features an inhibitor of DP-IV, having the structure: ##STR1## wherein m is an integer between 0 and 10, inclusive; A and A' are L-amino acid residues such that the A in each repeating bracketed unit can be a different amino acid residue; the C bonded to B is in the L-configuration; the bonds between A and N, A' and C, and between A' and N are peptide bonds; and each X.sup.1 and X.sup.2 is, independently, a hydroxyl group or a group capable of being hydrolyzed to a hydroxyl group at physiological pH.
    Type: Grant
    Filed: July 15, 1993
    Date of Patent: October 31, 1995
    Assignees: New England Medical Center Hospitals, Inc., Tufts University
    Inventors: William W. Bachovchin, Andrew G. Plaut, Flentke George R.
  • Patent number: 5362482
    Abstract: A water-in-oil type emulsified solid composition containing (a) an oil component such as a silicone oil, (b) a solid wax and/or an oil-gelling agent, (c) water, and (d) (i) a polyoxyalkylene modified organopolysiloxane or (ii) a lipophilic surfactant and a hydrophobically treated powder, wherein the water content is 5% by weight or more, based upon the total amount of the composition.
    Type: Grant
    Filed: February 10, 1993
    Date of Patent: November 8, 1994
    Assignee: Shiseido Company Ltd.
    Inventors: Toshio Yoneyama, Yasuo Matsuoka, Harumi Suzuki, Shigenori Kumagai, Susumu Takada
  • Patent number: 5346698
    Abstract: Described and claimed are methods and compositions for the control of pests. According to the subject invention, a fatty acid or mixture of fatty acids can be combined with one or more avermectins or related compounds to achieve synergistic control of pests.
    Type: Grant
    Filed: March 8, 1993
    Date of Patent: September 13, 1994
    Assignee: Mycogen Corporation
    Inventor: Kenneth D. Abercrombie
  • Patent number: 5192546
    Abstract: Described and claimed are methods and compositions for the control of pests. According to the subject invention, a fatty acid or mixture of fatty acids can be combined with one or more avermectins or related compounds to achieve synergistic control of pests.
    Type: Grant
    Filed: January 15, 1991
    Date of Patent: March 9, 1993
    Assignee: Mycogen Corporation
    Inventor: Kenneth D. Abercrombie
  • Patent number: 5047424
    Abstract: An environmetally safe, broad spectrum insecticidal composition is disclosed. The composition combines a mixture of monocarboxylic acids (such as oleic and linoleic) and their alkali metal salts, and a pyrethroid compound. In a concentrated form of the composition, the monocarboxylic acid mixture comprises about 50 percent by weight monocarboxylic acids and their salts, at least 70 percent of which comprise oleic acid and at least 6 percent comprise linoleic acid. The pyrethroid compound is present in the concentrate at about 0.2 to 2.0 percent by weight.
    Type: Grant
    Filed: October 3, 1988
    Date of Patent: September 10, 1991
    Assignee: Safer, Inc.
    Inventors: George S. Puritch, Gregory S. Salloum
  • Patent number: 4983591
    Abstract: A combination of pyrethrum and fatty acid salt materials has been formulated which produces a stable, commercially useful, and environmentally safe pesticide. The specific composition comprises an aqueous solution having a pH within the range of 7.5 to 8.8; an aqueous solution comprising at least about 0.5 percent by weight of monocarboxylic acids and their alkali metal salts, where the acid mixture is at least 70% oleic acid and 6% linoleic acid; a pyrethrum extract; a solvent for the pyrethrum, which is preferably a 2-6 carbon alcohol; a trace amount of an antioxidant. The composition is effective against insects of at least the orders Homoptera, Coleoptera, Dermaptera, Hemiptera, and Lepidoptera, and against crustacea of the order Isopoda.
    Type: Grant
    Filed: November 6, 1989
    Date of Patent: January 8, 1991
    Assignee: Safer, Ltd.
    Inventors: George S. Puritch, Gregory S. Salloum, Willem W. Nijholt
  • Patent number: 4904645
    Abstract: A combination of pyrethrum and fatty acid salt materials has been formulated which produces a stable, commercially useful, and environmentally safe pesticide. The specific composition comprises an aqueous solutioon having a pH within the range of 7.5 to 8.8; an aqueous solution comprising about 50% by weight of monocarboxylic acids and their alkali metal salts, where the acid mixture is at least 70% oleic acid and 6% linoleic acid; a pyrethrum extract; a solvent for the pyrethrum, which is preferably a 2-6 carbon alcohol; a trace amount of an antioxidant. The composition is effective against insects of at least the orders Homoptera, Coleoptera, Dermaptera, Hemiptera, and Lepidoptera, and against crustacea of the order Isopoda.
    Type: Grant
    Filed: January 27, 1988
    Date of Patent: February 27, 1990
    Assignee: Safer, Ltd.
    Inventors: George S. Puritch, Gregory S. Salloum, Willem W. Nijholt