Abstract: arboxyalkcylethers are useful for treating eating disorders such as obesity.

Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

Abstract: This invention provides compositions for repelling insects, particularly biting insects, such as mosquitoes, ticks, and biting flies comprising ratite oil, active fractions of ratite oil obtained by flash chromatography or compositions comprising mixtures of fatty acids found in ratite oil. Also provided are compositions for repelling insects comprising ratite oil, active fractions of ratite oil or compositions comprising mixtures of fatty acids found in ratite oil further comprising at least one additional insect repellent. Methods of repelling insects, particularly biting insects, are provided comprising topically applying ratite oil, active fractions of ratite oil, or compositions comprising mixtures of fatty acids found in ratite oil; or ratite oil, active fractions thereof, or compositions comprising fatty acids found in ratite oil and further comprising at least one additional insect repellent.

Abstract: This invention relates to disinfectant concentrates having improved biocidal activity containing an aldehyde, such as glutaraldehyde, a glycol and a lithium based buffer.

Abstract: A molluscicidal material having a predetermined size, composed of an interior core having predetermined properties, at least one adhesive, a mollusk attractant and a molluscicide coating, and the process of treating plants and mollusks with the same.

Abstract: A microbial inhibiting composition and method are disclosed. The composition comprises an amount, effective for the intended purpose, of glutaraldehyde and 2,2-dibromo-3-nitrilopropionamide. The method comprises administering between about 0.1 and 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: A molluscicide containing a non-toxic animal repellant and metaldehyde, in which the molluscicidal efficacy of the molluscicide greater than that of the molluscicide if it did not contain repellant. The repellant may be an anthranilate compound or d-pulegone which present at a concentration of up to 1%.

Abstract: Oleamide is an endogenous fatty acid primary amide that possesses sleep-inducing properties in animals and has been shown to effect seratonergic systems and block gap junction communication in a structurally specific manner. Certain agents can serve both as an oleamide agonist and as an inhibitor of fatty acid amide hydrolase. Fatty acid amide hydrolase is responsible for the rapid inactivation of oleamide in vivo. The structural features of oleamide required for inhibition of gap junction-mediated chemical and electrical transmission in rat glial cells are defined. Effective inhibitors fall into two classes of fatty acid primary amides of which oleamide and arachidonamide are the prototypical members. Of these two, oleamide constitutes the most effective and its structural requirements for inhibition of the gap junction are well defined.

Abstract: Pest infestations of plant materials are controlled by the application of vaporized organic aldehydes of 3 or more carbon atoms, with at least the initial part of the exposure being performed under a subatmospheric pressure.

Abstract: A method for reducing formation of deposits on a surface in contact with an aqueous system includes applying to the surface a composition comprising a polyoxypropylene-polyoxyethylene block copolymer and a biocide. The composition optionally may also include a dispersant.

Abstract: This invention provides a disinfectant composition which is suited to the disinfection of confined spaces such as the interior of an ambulance or the like. It is prepared extemporaneously by blending a highly concentrated alcohol with glutaraldehyde and a buffer solution such as an aqueous solution of diethanolamine. This composition containing 65 to 80% of alcohol and 2 to 4% of glutaraldehyde exhibits a strong and lasting disinfectant effect. The invention further provides a method for space disinfection which comprises atomizing and spraying this disinfectant composition by means of a high-pressure gas such as pressurized carbon dioxide gas.

Abstract: A high level disinfectant and sterilant solution that is useful to disinfect and sterilize heat-sensitive medical, dental and veterinary devices. The disinfectant solution is a two-part system for mixing just prior to use. The first part comprises glutaraldehyde and a phenolic chemical at a concentration of from about 0.5% w/w to 2.2% w/w, and a second separately contained part that is an activated buffer form of ethylene diamine tetraacetic acid (EDTA). The third part of the system is local potable tap water.

Abstract: The present invention comprises a concentrated solid or semi-solid disinfectant or sterilant composition for use in an aqueous disinfecting or sterilizing solution, comprising an oxidant and a protected glutaraldehyde such as a glutaraldehyde bisulfite addition compound (GBS): ##STR1## or a glutaraldehyde dioxime compound (GDO): ##STR2## The present invention further provides a method for disinfecting or sterilizing a surface or apparatus comprising the steps of mixing a concentrated solid or semi-solid glutaraldehyde sterilant composition comprising an oxidizing compound and a protected sterilant with water to form a solution and bringing the solution into contact with the surface or apparatus.

Abstract: The instant invention is concerned with acetylphenols which are useful as antiobesity and antidiabetic compounds. Compositions and methods for the use of the compounds in the treatment of diabetes and obesity and for lowering or modulating triglyceride levels and cholesterol levels or raising high density lipoprotein levels or for increasing gut motility or for treating atherosclerosis are also disclosed.

Abstract: Methods are provided to prepare a variety of tissues in a pathology-stable form keyed to the use of an aqueous solution of C.sub.2-6 dialdehyde and/or dialdehyde addition products, including the group consisting of glyoxal and/or glutaraldehyde in an amount sufficient to prevent autolysis and other degradative changes in various tissues. The said solution is capable of treating a tissue so as to maintain the tissue in a condition suitable for pathology and/or other experimental observation. The stabilizing solution is also useful to prepare parts or whole animals and plants in an anatomically preserved state for a prolonged period of time, and compositions useful in that method.

Abstract: Stable solid forms of preservative and embalming compositions are described which can be prepared by adding a sufficient amount of a chemical or chemicals containing at least one polar group capable of forming hydrogen and Van der Waal bonds with the reactive moieties of the aldehydes and antimicrobial agents in the preservative and embalming compositions. The amount of polar chemical(s) necessary to stabilize the reactive aldehydes and antimicrobial compounds/agents is based on a molar ratio of (i) polar groups in the stabilizing chemicals to (ii) reactive groups in the active preservative ingredient of at least 0.8.

Abstract: A phase-stable, biocide concentrate and/or solution composition is provided for disinfecting surfaces such as in animal husbandry applications, food processing, medical purposes, and the like. In the concentrate form, the composition comprises a quaternary ammonium biocide, an aliphatic dialdehyde and a foam surfactant. Typically, the solution composition may employ glutaraldehyde, a foam producing surfactant, a chelating agent, an odor obscuring compound, and an acid to lower the pH and stabilize the glutaraldehyde. The concentrate has a stability at ambient temperature of up to about two years. When applied to surfaces employed in animal husbandry, the adhesive properties of the composition enable it to remain in contact with these surfaces a sufficiently long time and thereby provide effective cleaning and disinfecting capability.

Abstract: An aqueous formula is disclosed that combines a relatively low concentration of glutaraldehyde with very low concentrations of alcohol in a stabilizing alkaline buffer system. This formula is sporicidal within 10 hrs. at 20.degree. C., and bactericidal, fungicidal, tuberculocidal, and virucidal within 20 min. at 20.degree. C.

Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.

Abstract: Various hydroxy benzaldehyde derivatives including Vanillin, a natural product derived from the vanilla bean that is commonly used as a flavoring agent, is administered by injection (i.v., i.m., s.c., and the like) or intravenous infusion in an effective dose amount to a patient in need of calming or sedation.

Abstract: The present invention relates to a method for producing chlorine dioxide (ClO.sub.2) disinfecting solution which preferably minimizes the amount of residual chlorite ion (ClO.sub.2 --) so that the disinfecting solution can be used in a number of industries, preferably including the food, food processing, drinking water, pharmaceutical production, medical and dental industries. Chlorine dioxide generating solutions which are substantially corrosion free as well as gel formulations are also disclosed.

Abstract: The method of disinfecting and solidifying an aqueous liquid medical waste containing microorganisms is provided in which dry glutaraldehyde is used as the disinfectant. In preparing the product for use in the method dry glutaraldehyde is mixed with a superabsorbant to partially transfer an aqueous solution from the dry glutaraldehyde to the superabsorbant.

Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.

Abstract: The use of active gibberellins for the preparation of a pharmaceutical composition for the treatment of prostatitis. The method results in a decrease in prostate mass.

Abstract: A personal lubricant composition containing an antiviral, alkylphenoxypolyethoxyethanol spermicide, a water soluble polymer gel matrix and a solubilizer which permits the spermicide to be compatible with the gel matrix. Preferably, a polyethoxylated compound such as polyethoxylated castor oil may be used.

Abstract: Compounds such as 1-(4'-nitrophenyl)-2-propen-1-ol are disclosed which are non-steroidal mechanism-based inactivators of rat liver 3.alpha.-hydroxysteroid dehydrogenase. The corresponding ketones are time dependent inactivators of cyclooxygenase (PGH.sub.2 -synthase).

Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.

Abstract: Biowaste treatment agents for treating biowastes in a manner which: (a) keeps noxious and toxic substances from being released from the biowaste, and (b) neutralizes such substances released during the course of stabilizing the biowaste. The treatment agents include a surfactant in an amount of from 1.0 to 99 percent of the treatment agent, a metal component in an amount from 0.5 to 85 percent of the treatment agent, the metal component including a source of zinc, or copper, or a combination of copper with aluminum or iron, and an aldehyde in an amount from 0.1 to 80 percent of the treatment agent.

Abstract: Polymer-based composition effective for disinfecting and for sterilizing plus cleaning and/or lubricating devices. The composition contains, in solution, a hydrophilic polymer serving as a water-based lubricant, a disinfectant, and a surfactant. The addition of a hydrophilic polymer forms an anti-corrosive formula for sterilizing, disinfecting, cleaning, and lubricating devices including medical and dental devices where the efficacy of cleaning and sterilizing is enhanced by the addition of a hydrophilic polymer.

Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.

Abstract: A composition embraces an oil, for instance, a mineral oil, animal oil, or plant or vegetable oil, in combination with an acetal that can release aldehyde functionality on aqueous contact. It may be used in a method for kill or control of bacterium or virus for a suitable part of a human being or animal subject. For example, a 5% mineral oil and 2,2'-trimethylenebis(1,3-dioxolane) mixture can be used as a microbiocidal lubricant for drill bits in dentistry, or a suitably formulated composition may be used topically.

Abstract: A fortified glutaraldehyde compound with and without dual synergistic phenols is provided for disinfection and sanitization. One formula consists of: glutaraldehyde; dual quaternary ammonium chloride (n-alkyl dimethylethylbenzyl ammonium chloride and n-alkyl dimethylbenzyl ammonium chloride); para tertiary amyl phenol; ortho phenyl phenol; citric or acetic acid; sodium citrate; isopropyl or ethyl alcohol; triethanol amine-HCl; and water in the following proportions: 25.00 to 42.00 grams; 25.00 grams; 1.00 gram; 1.00 gram; 0.50 grams; 0.25 grams; 14.00 grams; 1.00 gram; and 32.25 to 15.25 grams. The formula for environmentally protected uses consists of: glutaraldehyde; dual quaternary ammonium chloride (n-alkyl dimethylethylbenzyl ammonium chloride and n-alkyl dimethylbenzyl ammonium chloride); citric or acetic acid; sodium citrate; isopropyl or ethyl alcohol; triethanol amine-HCl; and water in the following proportions: 25.00 to 42.00 grams; 25.00 grams; 0.50 grams; 0.25 grams; 14.00 grams; 1.

Abstract: A highly fortified glutaraldehyde formulation is provided consisting of guaternary ammonium chloride; glutaraldehyde; para tertiary amylphenol; citric acid, isopropyl alcohol, and water to form a concentrated formulation which may be diluted as requested.

Abstract: Efficacious phenol-free mycobactericidal liquid compositions having low odor and irritation potential are disclosed. These compositions consist of a solvent containing a glycol, a 2 to 6 carbon atom aldehyde, specific anionic surfactants, and buffer salts to stabilize the pH in the 6 to 7.4 range. The ratio of glycol to aldehyde is comprised between 0.1 and 6.0. The lower this ratio, the greater the mycobactericidal activity. The new odorless compositions can kill Mycobacterium tuberculosis (EPA quantitative procedure) in 10 minutes or less at 20.degree. C.

Abstract: A method for controlling microorganisms in industrial process waters which comprises treating these waters with a biocidal amount of a composition comprising glutaraldehyde and 2-(thiocyanomethylthio)benzothiazole.

Abstract: Glutaraldehyde is effective in controlling Zebra mussels found in industrial process waters.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of 2-(2-bromo-2-nitroethenyl) furan and glutaraldehyde. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: A stable, solid or semi-solid, antimicrobial composition is provided comprising a dialdehyde antimicrobial agent such as glutaraldehyde, and a carbohydrate such as a sugar or a polyol such as a sugar alcohol. The composition can be employed to preserve, sanitize, disinfect, or sterilize a contaminated surface or area. The composition can also be combined with an absorbing agent to produce a moisture absorbent antimicrobial composition which can be used to absorb and disinfect biological spills such as body fluid spills.

Abstract: A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises:(i) a special protein tyrosine kinase inhibitor; and(ii) a cosmetically acceptable vehicle for the inhibitor.

Abstract: A biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium compound, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having form one to eight carbon atoms.This sterilant is stable for weeks, is especially useful between pH 4 to 9, and may additionally comprise a chelating agent.

Abstract: A sprayable aqueous disinfecting composition for disinfecting hard surfaces comprising 20 to 30% by weight of a mixture of ethyl alcohol and isopropyl alcohol in a weight ratio of 1:2 to 2:1, 0.05 to 0.5% by weight of a mixture of a primary or secondary C.sub.10-18 -alkane sulfonate and/or a C.sub.10-18 -alkyl sulfate with a C.sub.10-14 -alkyl ether sulfate, a pH adjusting agent for adjusting the pH in the range of 2 to 6 or 8 to 12, and the remainder to 100% by weight water.

Abstract: This invention describes the use of a hydroxyoctadecadienic acid, its acid oxidized to keto form or the ester derivatives of the acids, where the ester derivatives are low esters with 1 to 4 carbon atoms for the preparation of a pharmaceutical for treatment of breast carcinomas or benign prostatic hyperplasia. In particular, those compounds are suitable in which the double bonds and the hydroxy group or the oxo group are present on the carbon atoms at positions 9 to 13.

Abstract: A bacterial composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and 2-(decylthio) ethanamine (DTEA). The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and dodecylguanidine hydrochloride. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and bis(trichloromethyl) sulfone. The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: A bactericidal composition and method for inhibiting and controlling the growth of the capsulated, facultative bacterium, Klebsiella pneumoniae, are disclosed. The composition comprises an amount, effective for the intended purpose of glutaraldehyde and 2-(decylthio) ethanamine (DTEA). The method comprises administering between about 0.1 to about 200 parts of this combined treatment (based on one million parts of the desired aqueous system) to the particular water containing system for which treatment is desired.

Abstract: Very potent, stable, ordorless, and phenol-free virciudal solutions are active at high dilution when used for surface decontamination of animate and inanimate objects. The virucidal compositions described are efficacious in a matter of minutes against both the lipophilic and the more resistant hydrophilic viruses. The three active ingredients in these virucidal compositions are the glutaraldehyde monomer in equilibrium with its hydrates and polymers, hydrogen-bonded glycol molecules to eliminate aldehydes odor, and an anionic surfactant of the alkyl sulfate, alkyl sulfonate, alcohol sulfate or alkyl aryl sulfonate type. A preferred anionic surfactant would be the Sodium Dodecyl Sulfate (SDS), which exhibits strong cidal synergism against the Herpes Simplex Virus type 1 when mixed at a concentration as low as 0.0005% in diluted glutaraldehyde aqueous solutions (0.0025%). Improved virucidal killing at higher dilutions of the same formula were observed with the more resistant Coxsackie B viruses.

Abstract: A process for sanitizing, disinfecting, and killing spores involves providing a tangible object made from polymeric material impregnated with an aqueous glutaraldehyde solution which is packaged in an air-tight enclosure, removing the impregnated tangible object from the enclosure, and applying the impregnated tangible object to the surface to be sterilized and/or sanitized and disinfected so as to expose spores, bacteria, virus, and other microorganisms present on the surface to the action of the glutaraldehyde solution. A sanitary attachment for a receiver or mouthpiece of a telephone made from plastic material incorporating a glutaraldehyde solution. A fabric made from cellulosic or plastic material having sporicidal and/or sanitizing and disinfectant activity as a result of being impregnated with a glutaraldehyde solution.

Abstract: A novel, biocidal, aqueous composition for killing bacteria, spores, fungi, and viruses on nonabsorbent surfaces comprises at least one quaternary ammonium salt, at least one aliphatic dialdehyde having from two to six carbon atoms, and at least one aliphatic hydroxyl compound having from one to eight atoms.Optionally, a chelating agent and an inorganic nitrite salt may be employed. This sterilant kills bacteria, spores, fungi, and viruses over a pH range from about pH 4 to about pH 9.

Abstract: A mixture of bactericides of nitroimidazoles, particularly 1,2-dimethyl-5-nitro-1H-imidazole, or salts thereof and aldehydes, particularly glutaraldehyde and formaldehyde, has been found to exhibit synergistic results in inhibiting the growth of sulfate-reducing bacteria.