Sulfur Containing Organic Nitrogen Compound Patents (Class 514/71)
  • Patent number: 8293214
    Abstract: New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: October 23, 2012
    Assignee: Bracco Suisse S.A.
    Inventors: Rolf E. Swenson, Philippe Bussat, Bernard Lamy, Sibylle Pochon, Kondareddiar Ramalingam
  • Patent number: 8183341
    Abstract: This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds.
    Type: Grant
    Filed: December 19, 2007
    Date of Patent: May 22, 2012
    Assignee: Novartis AG
    Inventors: Matthew J. Lamarche, Jennifer A. Leeds, Phillipp Krastel, Hans-Ulrich Naegeli
  • Patent number: 7262318
    Abstract: The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: August 28, 2007
    Assignee: Pfizer, Inc.
    Inventors: Ernest S. Hamanaka, Marcus E. Kehrli, Jr.
  • Patent number: 7022331
    Abstract: Novel thermochromic and/or photochromic compositions are described. The thermochromic compositions include a thermoset resin, fatty substance, water, and dye, while photochromic compositions include a benzene derivative and a binder, such as silica gel. When mixed, the ingredients of the thermochromic and photochromic compositions form chromic cells with an outer shell comprised of either the thermoset resin (in the case of thermochromic compositions) or potassium nitrate (in the case of photochromic compositions). When the chromic compositions are exposed to either a heat or light stimulus, the chromic cells compress to causing the dye within the cells to no longer be visible, thereby creating a color-changing effect.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: April 4, 2006
    Inventor: Lyle Theisen
  • Patent number: 7015208
    Abstract: Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: March 21, 2006
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
  • Patent number: 6835720
    Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: December 28, 2004
    Assignee: Nissin Food Products Co., Ltd.
    Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
  • Patent number: 6541461
    Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: April 1, 2003
    Assignee: Nissin Food Products Co., Ltd.
    Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
  • Patent number: 6482447
    Abstract: Compositions comprising lycopene, Serenoa repens, Pygeum africanum, and Urtica dioica are provided. The compositions are preferably formulated with an alcohol extract of the dried, cut plant parts. Methods of using such compositions for treating various conditions and diseases, including benign prostatic hypertrophy and prostate cancer are also provided.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: November 19, 2002
    Inventor: Chase Revel
  • Patent number: 6337390
    Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.
    Type: Grant
    Filed: January 19, 1999
    Date of Patent: January 8, 2002
    Assignee: Nissan Food Products Co., Ltd.
    Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
  • Patent number: 6242432
    Abstract: Compounds or compositions containing compounds of the formula A-(X1—NO2)to or salts thereof, for the preparation of antithrombotic medications wherein “to” is the integer 1 or 2X1 is an alkylene connecting bridge and “A” is the residue of timolol or analapril.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: June 5, 2001
    Assignee: Nicox S.A.
    Inventor: Piero del Soldato
  • Patent number: 6238659
    Abstract: The present invention relates to a preparation comprising a substance influencing the cellular redox state for treating papilloma virus-positive malignant lesions.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: May 29, 2001
    Assignee: Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen Rechts
    Inventors: Frank Rösl, Harald Zur Hausen
  • Patent number: 5660855
    Abstract: A lipid construct comprising an aminomannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain 6-(cholest-5-en-3.beta.-yloxyl)hexyl-6-amino-6-deoxy-1-thio-.alpha.-D-mann opyranoside in liposome formulations wherein the formulations are delivered generally to arteries using percutaneous transluminal coronary angioplasty procedures. These formulations have applications in the reduction of restenosis.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: August 26, 1997
    Assignee: California Institute of Technology
    Inventor: Roxanne Male-Brune
  • Patent number: 5591727
    Abstract: The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal composition can in particular be used as an emulsion or on a powdery carrier for the control of flying and crawling insects such as flies and cockroaches.
    Type: Grant
    Filed: February 7, 1995
    Date of Patent: January 7, 1997
    Assignees: Perycut-Chemie AG, Franz Bencsits
    Inventor: Franz Bencsits
  • Patent number: 5545672
    Abstract: Pharmaceutical compositions and methods for treatment of insulin-resistance and diabetes mellitus using thiol protease inhibitors such as E-64.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: August 13, 1996
    Assignee: The University of Texas System
    Inventor: Victoria P. Knutson
  • Patent number: 5334585
    Abstract: Stable pyrethroid microemulsion compositions having from 0.1% to 95% by weight/weight of at least one pyrethroid in liquid form; from 2% to 90% by weight/weight of a three-component surfactant system having at least one anionic surfactant, at least one nonionic surfactant and at least one co-surfactant chosen from aliphatic alcohols, cycloaliphatic alcohols, arylaliphatic alcohols, ether-alcohols and aliphatic carboxylic acids; and water.The ratio by weight of anionic surfactant/nonionic surfactant is from 10/90 to 90/10, and the ratio by weight of co-surfactant/anionic and nonionic surfactants is from 0.1 to 1.5.The microemulsion compositions are applied directly or after dilution with water to plants (crops) or wood for controlling insects.
    Type: Grant
    Filed: February 21, 1992
    Date of Patent: August 2, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventors: Paul-Joel Derian, Gilles Guerin
  • Patent number: 5198012
    Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: March 30, 1993
    Assignee: Kao Corporation
    Inventor: Tetsuji Iwasaki
  • Patent number: 5043008
    Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: August 27, 1991
    Assignee: Kao Corporation
    Inventor: Tetsuji Iwasaki