Sulfur Containing Organic Nitrogen Compound Patents (Class 514/71)
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Patent number: 8293214Abstract: New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.Type: GrantFiled: December 19, 2007Date of Patent: October 23, 2012Assignee: Bracco Suisse S.A.Inventors: Rolf E. Swenson, Philippe Bussat, Bernard Lamy, Sibylle Pochon, Kondareddiar Ramalingam
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Patent number: 8183341Abstract: This invention relates to a novel antibiotic compounds, pharmaceutically acceptable salts and derivatives thereof, and to methods for obtaining such compounds.Type: GrantFiled: December 19, 2007Date of Patent: May 22, 2012Assignee: Novartis AGInventors: Matthew J. Lamarche, Jennifer A. Leeds, Phillipp Krastel, Hans-Ulrich Naegeli
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Patent number: 7262318Abstract: The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome proliferator activator receptor (PPAR) agonists. PPAR alpha activators, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans. The compounds are also useful for the treatment of negative energy balance (NEB) and associated diseases in ruminants.Type: GrantFiled: December 16, 2004Date of Patent: August 28, 2007Assignee: Pfizer, Inc.Inventors: Ernest S. Hamanaka, Marcus E. Kehrli, Jr.
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Patent number: 7022331Abstract: Novel thermochromic and/or photochromic compositions are described. The thermochromic compositions include a thermoset resin, fatty substance, water, and dye, while photochromic compositions include a benzene derivative and a binder, such as silica gel. When mixed, the ingredients of the thermochromic and photochromic compositions form chromic cells with an outer shell comprised of either the thermoset resin (in the case of thermochromic compositions) or potassium nitrate (in the case of photochromic compositions). When the chromic compositions are exposed to either a heat or light stimulus, the chromic cells compress to causing the dye within the cells to no longer be visible, thereby creating a color-changing effect.Type: GrantFiled: April 26, 2001Date of Patent: April 4, 2006Inventor: Lyle Theisen
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Patent number: 7015208Abstract: Embodiments of the invention relate to C2-substituted indan-1-ols and to their physiologically acceptable salts and physiologically functional derivatives. Compounds of embodiments of the invention may include compounds of formula I in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for use as anorectics.Type: GrantFiled: November 4, 2004Date of Patent: March 21, 2006Assignee: Aventis Pharma Deutschland GmbHInventors: Gerhard Jaehne, Volker Krone, Martin Bickel, Matthias Gossel
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Patent number: 6835720Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: September 23, 2002Date of Patent: December 28, 2004Assignee: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 6541461Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: October 31, 2001Date of Patent: April 1, 2003Assignee: Nissin Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 6482447Abstract: Compositions comprising lycopene, Serenoa repens, Pygeum africanum, and Urtica dioica are provided. The compositions are preferably formulated with an alcohol extract of the dried, cut plant parts. Methods of using such compositions for treating various conditions and diseases, including benign prostatic hypertrophy and prostate cancer are also provided.Type: GrantFiled: June 18, 2001Date of Patent: November 19, 2002Inventor: Chase Revel
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Patent number: 6337390Abstract: In order to provide the anti-retrovirus active compound with low anti-coagulant action and low cytotoxicity, compounds comprising glycoside or the salt thereof wherein lipid is linked to position 2 of sialic acid having all hydroxyl groups at positions 4, 7, 8 and 9 completely sulfated, or KDN (2-keto-3-deoxy-D-glycero-2-nononic acid) having all hydroxyl groups at positions 4, 5, 7, 8 and 9 completely sulfated are provided.Type: GrantFiled: January 19, 1999Date of Patent: January 8, 2002Assignee: Nissan Food Products Co., Ltd.Inventors: Shuji Fujita, Masaaki Numata, Kazuo Suzuki, Shigeki Nunomura, Mamoru Sugimoto, Masaki Terada
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Patent number: 6242432Abstract: Compounds or compositions containing compounds of the formula A-(X1—NO2)to or salts thereof, for the preparation of antithrombotic medications wherein “to” is the integer 1 or 2X1 is an alkylene connecting bridge and “A” is the residue of timolol or analapril.Type: GrantFiled: May 11, 1999Date of Patent: June 5, 2001Assignee: Nicox S.A.Inventor: Piero del Soldato
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Patent number: 6238659Abstract: The present invention relates to a preparation comprising a substance influencing the cellular redox state for treating papilloma virus-positive malignant lesions.Type: GrantFiled: September 4, 1997Date of Patent: May 29, 2001Assignee: Deutsches Krebsforschungszentrum Stiftung Des Öffentlichen RechtsInventors: Frank Rösl, Harald Zur Hausen
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Patent number: 5660855Abstract: A lipid construct comprising an aminomannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain 6-(cholest-5-en-3.beta.-yloxyl)hexyl-6-amino-6-deoxy-1-thio-.alpha.-D-mann opyranoside in liposome formulations wherein the formulations are delivered generally to arteries using percutaneous transluminal coronary angioplasty procedures. These formulations have applications in the reduction of restenosis.Type: GrantFiled: February 10, 1995Date of Patent: August 26, 1997Assignee: California Institute of TechnologyInventor: Roxanne Male-Brune
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Patent number: 5591727Abstract: The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal composition can in particular be used as an emulsion or on a powdery carrier for the control of flying and crawling insects such as flies and cockroaches.Type: GrantFiled: February 7, 1995Date of Patent: January 7, 1997Assignees: Perycut-Chemie AG, Franz BencsitsInventor: Franz Bencsits
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Patent number: 5545672Abstract: Pharmaceutical compositions and methods for treatment of insulin-resistance and diabetes mellitus using thiol protease inhibitors such as E-64.Type: GrantFiled: July 8, 1994Date of Patent: August 13, 1996Assignee: The University of Texas SystemInventor: Victoria P. Knutson
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Patent number: 5334585Abstract: Stable pyrethroid microemulsion compositions having from 0.1% to 95% by weight/weight of at least one pyrethroid in liquid form; from 2% to 90% by weight/weight of a three-component surfactant system having at least one anionic surfactant, at least one nonionic surfactant and at least one co-surfactant chosen from aliphatic alcohols, cycloaliphatic alcohols, arylaliphatic alcohols, ether-alcohols and aliphatic carboxylic acids; and water.The ratio by weight of anionic surfactant/nonionic surfactant is from 10/90 to 90/10, and the ratio by weight of co-surfactant/anionic and nonionic surfactants is from 0.1 to 1.5.The microemulsion compositions are applied directly or after dilution with water to plants (crops) or wood for controlling insects.Type: GrantFiled: February 21, 1992Date of Patent: August 2, 1994Assignee: Rhone-Poulenc ChimieInventors: Paul-Joel Derian, Gilles Guerin
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Patent number: 5198012Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.Type: GrantFiled: May 21, 1991Date of Patent: March 30, 1993Assignee: Kao CorporationInventor: Tetsuji Iwasaki
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Patent number: 5043008Abstract: A biocide composition comprises an effective amount of a biocide and an effective amount of a biocide activator selected from the group consisting of an alkyl phosphate, an alkenyl phosphate, a hydroxyalkyl phosphate, a polyoxyalkylene alkyl ether phosphate, a salt thereof, a polyoxyalkylene alkenyl ether phosphate, a salt thereof, a polyoxyalkylene hydroxyalkyl ether phosphate and a salt thereof.Type: GrantFiled: October 25, 1989Date of Patent: August 27, 1991Assignee: Kao CorporationInventor: Tetsuji Iwasaki