Phosphorus Or Halogen Containing Organic Oxygen Compound Patents (Class 514/73)
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Long-acting injectable formulations comprising an isoxazoline active agent, methods and uses thereof
Patent number: 11484528Abstract: This invention relates to long-acting injectable formulations for combating parasites in animals, comprising at least one isoxazoline active agent, a poloxamer, and a co-solvent. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the long-acting injectable formulations of the invention to the animal in need thereof.Type: GrantFiled: September 30, 2019Date of Patent: November 1, 2022Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.Inventors: Susan Mancini Cady, Peter Cheifetz, Izabela Galeska, Loic Le Hir de Fallois -
Patent number: 8729052Abstract: Disclosed is a composition for prevention and treatment of alopecia or for hair growth, comprising a phytosphingosine-1-phosphate derivative or a pharmaceutically acceptable salt thereof as an active ingredient. Also, a medicine comprising the composition and a quasi-drug comprising the composition are provided.Type: GrantFiled: July 30, 2009Date of Patent: May 20, 2014Assignee: Phytos Co., Ltd.Inventors: Myeong Jun Choi, Joo Hyun Cho
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Patent number: 8486860Abstract: Methods for protecting fruit, vegetables and ornamentals against post harvest microbial decay by applying systemic acquired resistance inducers in combination with sorbic acid, and/or one or more of its alkali metal salts, and/or phosphorous acid, and/or one or more of its alkali metal salts.Type: GrantFiled: March 3, 2009Date of Patent: July 16, 2013Assignee: Plant Protectants, LLCInventor: Nigel M Grech
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Patent number: 8198247Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.Type: GrantFiled: December 21, 2004Date of Patent: June 12, 2012Assignee: Telik, Inc.Inventors: William A. Boulanger, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Harold Meckler, Steven R. Schow, Pavel E. Zhichkin
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Patent number: 7943588Abstract: The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is attenuated thereby preventing or treating neuropathic pain in a subject in need of such treatment.Type: GrantFiled: March 27, 2007Date of Patent: May 17, 2011Assignee: Trustees of Dartmouth CollegeInventors: Joyce A. DeLeo, Flobert Y. Tanga
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Patent number: 6991776Abstract: New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation.Type: GrantFiled: December 30, 2002Date of Patent: January 31, 2006Assignee: Xantech Pharmaceuticals, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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Patent number: 6620816Abstract: This invention provides a method of treating a tumor in a warm-blooded animal, including humans, by administering, in combination, an anti-tumor effective amount of tegafur, uracil, folinic acid or pharmaceutically acceptable salt thereof and cyclophosphamide.Type: GrantFiled: April 19, 2002Date of Patent: September 16, 2003Assignee: Bristol-Myers Squibb CompanyInventors: Eric P. Winer, Craig A. Bunnell, Jody Ressler-Tatro, Terry S. Dugan
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Patent number: 6399612Abstract: Heteroaryl butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromelysin-1 and for the treatment of multiple sclerosis, atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, or other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.Type: GrantFiled: October 23, 2000Date of Patent: June 4, 2002Assignee: Warner-Lambert CompanyInventors: Claude Forsey Purchase, Jr., Bruce David Roth, Gerald Paul Schielke, Lary Craswell Walker, Andrew David White
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Patent number: 6331286Abstract: Methods of treating and imaging diseased tissue having the steps of administering a radiosensitizer agent proximate to or into the diseased tissue; and treating the diseased tissue with x-rays or other ionizing radiation so as to activate the radiosensitizer agent in the diseased tissue. Preferably, the radiosensitizer agent is a halogenated xanthene.Type: GrantFiled: December 21, 1998Date of Patent: December 18, 2001Assignee: Photogen, Inc.Inventors: H. Craig Dees, Timothy Scott, John T. Smolik, Eric A. Wachter
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Patent number: 5874476Abstract: Disclosed is a method of inhibiting the growth of microorganisms in, at, or on a locus subject to microbial attack, comprising introducing to said locus an antimicrobially effective amount of at least one dihaloformaldoxime carbamate.Type: GrantFiled: July 14, 1997Date of Patent: February 23, 1999Assignee: Rohm and Haas CompanyInventors: Adam Chi-Tung Hsu, Barry Clifford Lange, Jemin Charles Hsu
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Patent number: 5609878Abstract: Insecticide composition, especially a pediculicide, comprising as active agent, rotenone or reduced rotenone. The composition is characterized in that said agent is bound to small polymer spherules. The retonone and/or reduced is preferably at least 90% pure. The composition may be in the form of a suspension, an emulsion, a powder, a paste, a cream or a foam and the like. The novel composition is useful in the treatment of parasites in both humans and animals.Type: GrantFiled: January 5, 1996Date of Patent: March 11, 1997Inventors: Jean Gueyne, Marie-Christine Seguin
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Patent number: 5591727Abstract: The invention relates to an insecticidal composition which comprises at least one pyrethroid, at least one UV absorbing agent and at least one antioxidant from the group consisting of tocopherol derivatives and citric acid esters. This insecticidal composition can in particular be used as an emulsion or on a powdery carrier for the control of flying and crawling insects such as flies and cockroaches.Type: GrantFiled: February 7, 1995Date of Patent: January 7, 1997Assignees: Perycut-Chemie AG, Franz BencsitsInventor: Franz Bencsits
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Patent number: 5407920Abstract: A method of treating wood and timber is disclosed. Wood or timber is treated with a pesticidal microemulsion or other water-miscible formulation that has an average particle size of at most 200 nm. The treatment is particularly effective in protecting wood and timber against the common furniture beetle (Anobium punctatum), the house longhorn (Hylotrupes bajulus), the death watch beetle (Xestobium rufovillorum), dry rot (Serpula (merulius) lacrymans) and wet rot (Coniophora puteena).Type: GrantFiled: August 26, 1993Date of Patent: April 18, 1995Assignee: NC Development, Inc.Inventor: Howard B. Dawson
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Patent number: 5334585Abstract: Stable pyrethroid microemulsion compositions having from 0.1% to 95% by weight/weight of at least one pyrethroid in liquid form; from 2% to 90% by weight/weight of a three-component surfactant system having at least one anionic surfactant, at least one nonionic surfactant and at least one co-surfactant chosen from aliphatic alcohols, cycloaliphatic alcohols, arylaliphatic alcohols, ether-alcohols and aliphatic carboxylic acids; and water.The ratio by weight of anionic surfactant/nonionic surfactant is from 10/90 to 90/10, and the ratio by weight of co-surfactant/anionic and nonionic surfactants is from 0.1 to 1.5.The microemulsion compositions are applied directly or after dilution with water to plants (crops) or wood for controlling insects.Type: GrantFiled: February 21, 1992Date of Patent: August 2, 1994Assignee: Rhone-Poulenc ChimieInventors: Paul-Joel Derian, Gilles Guerin
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Patent number: 5242907Abstract: Tropical and temperate crops, particularly rice, maize, cotton, soya and fruit, can be protected, particularly against insect pests of the orders Leoidoptera, Diptera, Coleoptera, Hemiptera, Orthoptera, Dictyoptera, Hymenoptera and Isoctera and acarine pests, by treatment with a pesticidal water-miscible formulation whose average particle size is at most 200 nm. Public health pests, including the house fly (Musca domestica), cockroach (Blatta sp. or Periplaneta sp.) and mosquito (Aedes aegyoti) as well as pests which infest or affect timber, particularly in buildings, can also be controlled with such formulations. The formulations include water, oil, a surfactant, and a cosurfactant, wherein either the oil is a pesticide or the formulation comprises a pesticide dissolved in the oil. The pesticide may be a pyrethroid such as cypermethrin or deltamethrin. The formulations can be molecular solutions, micellar solutions or microemulsions (water-in-oil or oil-in-water) and are generally clear.Type: GrantFiled: April 29, 1991Date of Patent: September 7, 1993Assignee: NC Development, Inc.Inventor: Howard B. Dawson
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Patent number: 5178872Abstract: An insecticidal and/or acaricidal and/or nematicidal composition having a rapid efficacy and residual activity which comprises a mixture of a poorly water-soluble organophosphorus insecticide and/or acaricide and/or nematicide and/or a poorly water-soluble carbamate insecticide and/or acaricide which have been microencapsulated in water-insoluble polymer coatings with a dispersing agent used in forming a microcapsule part, with a poorly water-soluble pyrethroid insecticide and/or acaricide emulsified or suspended in water with the above-mentioned dispersing agent used in forming a flowable part.Type: GrantFiled: November 8, 1990Date of Patent: January 12, 1993Assignee: Sumitomo Chemical Co., Ltd.Inventors: Toshiro Ohtsubo, Shigenori Tsuda, Kozo Tsuji
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Phosphoric acid ester, process for preparing the same, and detergent composition containing the same
Patent number: 5071585Abstract: Phosphoric acid esters represented by the following formulae (I) and (IX) as well as processes for preparing them are disclosed. ##STR1## wherein R.sub.1 represents a linear or branched, alkyl or alkenyl group having a C.sub.1-36 carbon atom content, with or without the hydrogen atom(s) being substituted with fluorine atom(s), or a phenyl group with substituted linear or branched alkyl group(s) having a C.sub.1-15 carbon atom content, R.sub.2 represents an alkylene group having a C.sub.2-3 carbon atom content, R.sub.3 and R.sub.4 independently denote a hydrogen atom or an alkyl group having a C.sub.1-3 carbon atom content, R.sub.5 and R.sub.6 independently denote a hydrogen atom, or an alkyl, alkenyl, or phenyl group with or without the hydrogen atom(s) being substituted with group(s) containing hetero atom(s), excepting for a mercapto group, R.sub.7 and R.sub.Type: GrantFiled: October 29, 1990Date of Patent: December 10, 1991Assignee: Kao CorporationInventors: Akira Matsunaga, Junya Wakatsuki, Nobutaka Horinishi, Takashi Imamura, Tomihiro Kurosaki -
Patent number: 4824663Abstract: The present invention relates to new macroemulsions which contain0.001 to 60 percent by weight of at least one active compound from the class comprising the phosphates and/or carbamates,0 to 50 percent by weight of aromatic diluents,0.001 to 20 percent by weight of polyvinyl alcohol having a mean molecular weight of between 5,000 and 150,000 and a content of acetate groups of between 2 and 30 mol %, and/or0.001 to 20 percent by weight of a nonlphenol/propylene oxide/ethylene oxide adduct of the formula ##STR1## in which X represents integers from 10 to 50 andY represents integers from 15 to 65,and/or0.001 to 20 percent by weight of ethylene oxide/propylene oxide/ethylene oxide block copolymers having a mean molecular weight of between 2,000 and 8,000 and HLB values of between 8 and 30,and water and, if appropriate, additives, andin which the oil phase is dispersed in the aqueous phase in the form of droplets having a mean particle diameter of 0.1 to 3.0 .mu.m.Type: GrantFiled: March 7, 1986Date of Patent: April 25, 1989Assignee: Bayer AktiengesellschaftInventors: Wolfgang Wirth, Heinz J. Niessen, John W. S. Goossens, Hans Schulze
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Patent number: 4814167Abstract: A macroemulsion which is stable to separation and crystallization over a wide range of temperature is disclosed. These macroemulsions contain:0.0001 to 30% by weight of at least one solid pyrethroid,0.0005 to 50% by weight of an aromatic diluent,0.0001 to 15% by weight of polyvinyl alcohol having a mean molecular weight of between 5,000 and 60,000 and a content of acetate groups of between 2 and 30 mol %, if appropriate as a mixture with polyvinyl alcohol having a mean molecular weight of between 70,000 and 150,000 and a content of acetate groups of between 2 and 30 mol %,and water and acid and, if appropriate, further additives in which the oil phase is dispersed in the aqueous phase in the form of droplets having a mean particle diameter of 0.1 to 3.0 .mu.m.Type: GrantFiled: March 7, 1986Date of Patent: March 21, 1989Assignee: Bayer AktiengesellschaftInventors: Wolfgang Wirth, Heinz J. Niessen, Bernd Klinksiek