Alkyne Patents (Class 514/745)
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Patent number: 9040066Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.Type: GrantFiled: April 7, 2014Date of Patent: May 26, 2015Assignee: Ad Lunam Labs, Inc.Inventors: William H. Beeson, Alvin T. Rockhill
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Patent number: 9034926Abstract: Psoriasis is treated by application of a composition containing a nitrone spin trap such as ?-phenyl t-butyl nitrone (PBN) and derivatives thereof. Preferred compositions and method of treatments further comprise at least one adjunctive ingredient including fatty acid esters of ascorbic acid such as ascorbyl palmitate and ascorbyl stearate, and polyenylphosphatidylcholine.Type: GrantFiled: December 30, 2010Date of Patent: May 19, 2015Inventor: Nicholas V. Perricone
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Patent number: 8703829Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: GrantFiled: May 23, 2012Date of Patent: April 22, 2014Assignee: University of Louisville Research Foundation, Inc.Inventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Patent number: 8691247Abstract: The subject invention relates to a skin cream that can be used to moisturize and rejuvenate skin that has been damaged by exposure to sunlight or which has simply been affected over the years by intrinsic aging. It inhibits the formation of wrinkles and in some cases reduces the depth of existing wrinkles or eliminates them entirely. This invention is based upon the discovery that alkyl lactates, such as ethyl lactate, can be used to improve the penetration of active ingredients in skin care formulations deep into lower layers of the skin tissue. The present invention more specifically discloses a topical formulation comprising ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, an alkyl lactate, and a pharmaceutically acceptable carrier.Type: GrantFiled: December 17, 2007Date of Patent: April 8, 2014Assignee: Ad Lunam Labs Inc.Inventors: William H. Beeson, Alvin T. Rockhill
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Publication number: 20120329866Abstract: The invention provides compounds of Formula (I): R1?R2??(I) wherein R1 and R2 have any of the values or specific values defined herein, as well as compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.Type: ApplicationFiled: May 23, 2012Publication date: December 27, 2012Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATIONInventors: Gerald B. Hammond, Bo Xu, Paula J. Bates
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Patent number: 7740876Abstract: An antimicrobial composition of 3-iodo-2-propynylbutyl carbamate (IPBC) and 1,3-butylene glycol (BG) as solvent, in a defined weight ratio, preferably 9-11% IPBC and 89-91% BG, and personal care formulations including the composition in an amount of about 0.1-0.2% therein, at a pH of 4-9, is described.Type: GrantFiled: May 23, 2006Date of Patent: June 22, 2010Assignee: ISP Investments Inc.Inventors: John J. Merianos, Paul Garelick, Susan M. Lindstrom
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Patent number: 7026359Abstract: The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [—RF(CH2)nCR1—CR2—]x, wherein RF is a linear or branched perfluorinated alkyl chain C2F5 to C12F23, R1 and R2 are independently selected from the group consisting of H, CH3, C2H5 and C3H7, n is selected from the numbers 0, 1 and 2, and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.Type: GrantFiled: April 27, 2000Date of Patent: April 11, 2006Assignee: Bausch & Lomb IncorporatedInventors: Udo Gross, Dirk-Henning Menz, Erhard Kemnitz, Hans Hoerauf, Karin Kobuch
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Patent number: 7015367Abstract: Propargyl bromide is effectively stabilized against shock or thermal decomposition by use therewith of an environmentally acceptable inert liquid solvent that forms an azeotrope with propargyl bromide.Type: GrantFiled: January 12, 2004Date of Patent: March 21, 2006Assignee: Albemarle CorporationInventors: Robert C. Herndon, Jr., Robert H. Allen, Noel H. Brantley, Ronny W. Lin, Ralph W. Magin, Mahmood Sabahi
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Publication number: 20040176474Abstract: The stabilization of 3BP throughout its life-cycle is achieved via the use of azeotropic mixtures for dilution and prevention of shock or temperature sensitivity.Type: ApplicationFiled: March 9, 2004Publication date: September 9, 2004Applicant: Bromine Compounds Ltd.Inventor: Ron Frim
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Patent number: 6777375Abstract: Propargyl bromide is effectively stabilized against shock or thermal decomposition by use therewith of an environmentally acceptable inert liquid solvent that forms an azeotrope with propargyl bromide.Type: GrantFiled: April 8, 2002Date of Patent: August 17, 2004Assignee: Albemarle CorporationInventors: Ralph W. Magin, Robert C. Herndon, Jr., Mahmood Sabahi, Robert H. Allen, Noel H. Brantley, Hassan Y. Elnagar, Ronny W. Lin
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Patent number: 6008209Abstract: This invention provides a method of treating or preventing neoplastic diseases. The method comprises adminstering to a host in need of such treatment or prevention an effective amount of a Vitamin D.sub.3 analog of the Formula I wherein:X is H.sub.2 or CH.sub.2 ;Y is hydrogen, hydroxy or fluorine;Z is hydroxy;R.sub.1 and R.sub.2 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.1 and R.sub.2 together with C.sub.25 form a (C.sub.3 -C.sub.6) cycloalkyl or cyclofluoroalkyl;R.sub.3 and R.sub.4 are a (C.sub.1 -C.sub.4) alkyl or fluoroalkyl, or R.sub.3 and R.sub.4 together with C.sub.25' form a (C.sub.3 -C.sub.6)cycloalkyl or cyclofluoroalkyl;A is a single bond or a double bond;B.sub.1 is a single bond, an E-double bond, a Z-double bond or a triple bond; andB.sub.2 is a single bond, an E-double bond, a Z-double bond or a triple bond; or a prodrug thereof.Type: GrantFiled: April 16, 1998Date of Patent: December 28, 1999Assignees: Hoffmann-La Roche Inc., Syntex (U.S.A.)Inventors: Percy Sarwood Manchand, Milan Radoje Uskokovic
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Patent number: 5859068Abstract: A method for the acceleration of tissue growth using continuous fluorocarbon liquid-based positive pressure is disclosed, whereby significant increase in tissue growth is achieved.Type: GrantFiled: February 24, 1995Date of Patent: January 12, 1999Assignee: Children's Medical Center CorporationInventor: Jay M. Wilson
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Patent number: 5614562Abstract: Organoselenones of the formulaR.sub.1 --Se(O.sub.2)--(CH.sub.2).sub.n --Xwherein R.sub.1 is selected from the group consisting of aryl, vinyl, acetylenyl, and aralkyl, n is an integer equal to 2 to 6 and X is a leaving group selected from the group consisting of halides, sulfonates and selenones; were surprisingly found to be useful as alkylating agents which possessed a high degree of selectivity for nitrogen nucleophiles without the usual increased preference for sulfur nucleophiles. This property allows the effective use of these compounds as anti-cancer alkylating agents suitable for use in drug-resistant cell lines which display either thiol mediated drug resistance or MER(+)-mediated drug resistance. Two methods of synthesizing these compounds are also provided.Type: GrantFiled: December 16, 1992Date of Patent: March 25, 1997Assignee: The University of Sourthern CaliforniaInventors: Colin P. Spears, Sang-Ihn Kang
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Patent number: 5480914Abstract: Nonaqueous thixotropic drug delivery vehicles for use in aqueous physiological systems are disclosed comprising a substantially homogeneous dispersion of at least one suspending aid in a nonaqueous perfluorocarbon or fluorinated silicone liquid carrier. Pharmaceutical compounds may be incorporated to provide thixotropic pharmaceutical compositions having improved delivery profiles and high drug localization. The thixotropic compositions act as free-flowing, drop-instillable liquids upon the application of stress yet behave as a visco-elastic material when at rest. Due to these thixotropic properties the pharmaceutical compositions have improved bioavailability, are capable of low dose volume delivery, and do not degrade the incorporated therapeutic or diagnostic compounds making them well suited for multidose packaging and administration.Type: GrantFiled: May 6, 1994Date of Patent: January 2, 1996Assignee: Allergan, Inc.Inventor: David L. Meadows
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Patent number: 4839390Abstract: A method of combating arthropods and nematodes which comprises applying thereto, to a habitat thereof or to an area from which they are to be excluded an arthropodicidally or nematocidally effective amount of at least one long-chain halogenoolefine of the formula (I) ##STR1## in which R represents a straight-chain or branched alkyl radical with 8 to 25 carbon atoms in the straight chain, the alkyl radical optionally being interrupted once or several times by a --C.tbd.C-- and/or ##STR2## in which Z and Z.sup.1 are identical or different and represent hydrogen or methyl andR.sup.1 represents hydrogen, alkyl or halogen.Those compounds are new wherein R has at least 12 carbon atoms in the straight chain.Type: GrantFiled: May 8, 1987Date of Patent: June 13, 1989Assignee: Bayer AktiengesellschaftInventors: Klaus Naumann, Benedikt Becker, Wolfgang Behrenz, Bernhard Homeyer, Wilhelm Stendel
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Patent number: 4791139Abstract: A compound of formula: ##STR1## wherein W represents one or more substituents selected from halo, alkyl, alkoxy, alkoxyalkyl, haloalkyl and haloalkoxy or W represents a bidentate group linking adjacent carbon atoms selected from alkylene and alkylenedioxy; Y is a group of formula ##STR2## wherein X is a group of formula --(CF.sub.2).sub.n R.sup.3, where R.sup.3 is selected from hydrogen, chloro and fluoro, and n is one or two, R.sup.1 is selected from hydrogen, chloro, fluoro and hydroxy and R.sup.2 is selected from methyl, cyano, ethynyl and hydrogen; Q is selected from carbon bearing a hydrogen atom and nitrogen; and Z represents one or more substituents selected from fluoro, benzyl, phenoxy, chlorophenoxy, fluorophenoxy and bromophenoxy, or any isomer thereof. Processes for preparing these compounds and intermediates for use therein, insecticidal compositions containing these compounds and the use thereof are also disclosed.Type: GrantFiled: February 25, 1987Date of Patent: December 13, 1988Assignee: Imperial Chemical Industries PLCInventors: Michael J. Bushell, Robin A. E. Carr