Alkyne Patents (Class 514/752)
  • Publication number: 20110166177
    Abstract: Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.
    Type: Application
    Filed: September 13, 2010
    Publication date: July 7, 2011
    Applicant: University of Kentucky Research Foundation
    Inventors: Joseph R. HOLTMAN, Peter A. Crooks, Linda P. Dwoskin, J. Michael McIntosh, Elzbieta Pogonowska Wala
  • Publication number: 20100179186
    Abstract: This application provides a method for the use of select quaternary ammonium antagonists to alpha-7 nAChR for the treatment of cancer and HIV and AIDS.
    Type: Application
    Filed: October 13, 2009
    Publication date: July 15, 2010
    Applicant: University of Kentucky Research Foundation
    Inventors: Roger L. PAPKE, Peter A. CROOKS, Linda P. DWOSKIN, Gretchen Lopez HERNANDEZ, Zhenfa ZHANG, Jeffrey S. THINSCHMIDT, Guangrong ZHENG
  • Patent number: 6500447
    Abstract: The present invention provides pH-sensitive micro-capsules, compositions containing them, methods for their preparation and methods for their use.
    Type: Grant
    Filed: August 13, 1999
    Date of Patent: December 31, 2002
    Assignee: BASF Aktiengesellschaft
    Inventors: Robin William Dexter, Brian Eric Benoff
  • Publication number: 20010001657
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Application
    Filed: April 4, 1997
    Publication date: May 24, 2001
    Inventors: MICHEL SCHNEIDER, FENG YAN, PASCAL GRENIER, NADINE GARCEL, JEROME PUGINIER, MARIE-BERNADETTE BARRAU
  • Patent number: 5859068
    Abstract: A method for the acceleration of tissue growth using continuous fluorocarbon liquid-based positive pressure is disclosed, whereby significant increase in tissue growth is achieved.
    Type: Grant
    Filed: February 24, 1995
    Date of Patent: January 12, 1999
    Assignee: Children's Medical Center Corporation
    Inventor: Jay M. Wilson
  • Patent number: 5578292
    Abstract: One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: November 26, 1996
    Assignee: Bracco International B.V.
    Inventors: Michel Schneider, Feng Yan, Pascal Grenier, deceased, Jerome Puginier, Marie-Bernadette Barrau
  • Patent number: 5573751
    Abstract: Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of a microbubble comprised of the gas.
    Type: Grant
    Filed: December 21, 1994
    Date of Patent: November 12, 1996
    Assignee: Sonus Pharmaceuticals, Inc.
    Inventor: Steven C. Quay
  • Patent number: 5558854
    Abstract: Ultrasound contrast media comprising gaseous perfluoropentane and gaseous perfluorohexane are disclosed.
    Type: Grant
    Filed: January 30, 1995
    Date of Patent: September 24, 1996
    Assignee: Sonus Pharmaceuticals
    Inventor: Steven C. Quay
  • Patent number: 5393524
    Abstract: Disclosed herein are agents for enhancing the contrast in an ultrasound image. These agents are extremely small bubbles, or "microbubbles," comprised of specially selected gases. The microbubbles described herein exhibit long life spans in solution and may be produced at a size small enough to traverse the lungs, thus enabling improved ultrasound imaging of the cardiovascular system and other vital organs. Also disclosed herein is a method for selecting gases from which contrast agents may be produced. The method is based on calculations using inherent physical properties of gases and describes a means to associate the properties of a gas with the time for dissolution of a microbubble comprised of the gas.
    Type: Grant
    Filed: June 4, 1993
    Date of Patent: February 28, 1995
    Assignee: Sonus Pharmaceuticals Inc.
    Inventor: Steven C. Quay
  • Patent number: 5126371
    Abstract: Novel diarylacetylenes of the formula I ##STR1## where A, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the meanings stated in the description, are useful for the treatment of disorders.
    Type: Grant
    Filed: August 20, 1990
    Date of Patent: June 30, 1992
    Assignee: BASF Akteingesellschaft
    Inventors: Hans-Heiner Wuest, Fritz-Frieder Frickel, Axel Nuerrenbach