Abstract: The present invention is directed to use of a series of compounds and compositions comprising the same for activating telomerase and treating diseases, disorders and/or conditions related thereto.

Abstract: The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.

Abstract: Classes of compounds that exhibit effective inhibition of autotaxin enzymes are provided. Such classes include thioureas, diphenyldiazerenes, xanthenes, and isoindoles and exhibit reactivity with autotaxin to ultimately reduce the size of the reactive sites thereon to prevent conversion of lysophosphatidyl choline to lysophophatidic acid. Furthermore, such compounds can be incorporated within delivery forms for human ingestion. As such, these compounds accord an excellent manner of potentially reducing generation of certain cancers attributable to the presence of naturally occurring autotaxin within the human body. Methods of inactivating autotaxin to certain degrees therewith such compounds are encompassed within invention as well.

Abstract: Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor.

Abstract: Compositions of matter and methods of treating cancer patients may prevent or limit cardiotoxicity during or after chemotherapy, and/or may prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by the human enzyme carbonyl reductase. Thus, the compositions and methods may be used to reduce the dosages of anthracycline anti-cancer drugs necessary to produce a desired cancer-cell-killing performance. Preferred embodiments comprise treating cancer patients with a pharmaceutical composition comprising biphenyl compounds having two halogenated (or pseudo-halogenated) and/or hydroxylated, aryl groups that are linked by a bridging atom. The preferred composition of biphenyl compound(s) may be administered in a pharmaceutical composition also comprising at least one anthracycline compound, or may be administered separately than the at least one anthracycline compound. Especially-preferred biphenyl compounds include triclosan, hexachlorophene, and dichlorophene.

Abstract: The present invention describes 1-aminoadamantane derivatives and 3-aminoadamantane-1-carboxylic derivatives in which the 5- or 7-position of the basic adamantane structure can be optionally substituted, methods for the production of the compounds based on the present invention, and methods for the coupling of the monomeric 3-aminoadamantane-1-carboxylic derivatives thus obtained to oligomers. The compounds based on the present invention are suitable for the utilisation as antiviral active ingredients, artificial ion channels, as well as for the therapy, diagnostics and prophylaxis of diseases in which a dysfunction of the GABA system occurs.

Abstract: This invention describes the new benzocycloheptenes of general formula I 1

Abstract: An insecticidal system for killing social insects comprises an insecticide together with a synthetic equivalent, such as 3-octanol, to at least one component of the alarm pheromone of the insect. The system is particularly effective against members of the Acromyrmex, Atta and Solenopsis species.

Abstract: A method for the acceleration of tissue growth using continuous fluorocarbon liquid-based positive pressure is disclosed, whereby significant increase in tissue growth is achieved.

Abstract: A method of assisting a mammal having a lung disorder to breathe ambient gas normally, i.e., without the assistance of a ventilator. The method includes providing an animal having a lung disorder, such as surfactant deficiency, stiff lung or hyperinflated lung syndrome, and instilling a perfluorochemical liquid into the trachea for administration in the alveolar sacs of a lung of the animal. The perfluorochemical is permeable to the ambient gas and resides substantially permanently within the alveolar sacs without inducing hyperinflated lung syndrome. The liquid is instilled in an amount sufficient to enable the animal to breathe the ambient gas normally with O.sub.2 /CO.sub.2 blood gas exchange. In another aspect of the invention, the method further includes the step of alleviating the lung disorder without inducing hyperinflated lung syndrome.

Abstract: Compositions for topical application in gel form comprising a fluorocarbon or perfluorocarbon compound or mixtures thereof at a concentration of at least about 75% v/v, a minor quantity of a surface active agent and an aqueous phase.The compositions provide a storage-stable high concentration fluorocarbon gel that is prepared without the use of thickeners or additional stabilizing agents. The gels are useful in formulations for pharmaceutical, cosmetic purposes and for other products as well.

Abstract: Disclosed are conditioning compositions for the hair and skin containing compounds of the formula (R.sup.1)(R.sup.2)N(CHCH.sub.2 OC(O)R).sub.2 X.sup.- wherein R.sup.1 is alkyl containing 1 to 6 carbon atoms, or hydroxyalkyl containing 1 to 6 carbon atoms; R.sup.2 is alkyl containing 1 to 6 carbon atoms, or benzyl; X.sup.- is an anion; and R is alkyl and alkylene of 12 to 22 carbon atoms having 0 to 3 carbon-carbon double bonds, provided that at least 2 different chain lengths R are present and 0, 1 and 2 such double bonds are present.

Abstract: A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.

Abstract: Stable and flowable aqueous dispersions of at least one water-insoluble material are formulated by dispersing such water-insoluble material, e.g., solid particulates of a plant protection compound, into a homogeneous, stable and flowable aqueous composition that includes (1) at least one water-soluble derivative of a plant protection active agent bearing at least one ionizable functional group and at least one hydrophilic functional group, (2) at least one nonionic surface-active agent and/or at least one aliphatic, cycloaliphatic or arylaliphatic alcohol having from 4 to 15 carbon atoms, and (3) water, this composition exhibiting optical birefringence and a yield point of at least 0.1 pascal.

Abstract: A process for identifying the location to which an agricultural chemical composition has been applied whereby a water soluble, alkyleneoxy substituted fugitive colorant is added to said agricultural chemical composition prior to its application. The colorant is nontoxic to aquatic life and may be used within the watershed of a body of water having aquatic life. Preferred colorants include alkyleneoxy substituted triphenylmethane and azo dyes.

Abstract: The present invention relates to new plant-protection suspo-emulsions. More specifically, the invention relates to a suspo-emulsion of a solid active substance, having a melting point greater than or equal to 45.degree. C. and which is substantially insoluble in water. The suspo-emulsion comprises at least one oil; a first surface-active system comprising at least sucroglycerides; the solid active substance; and either (A) a nonionic or anionic surface-active agent, or (B) a second surface-active system containing sucroglycerides and at least one compound selected from the group consisting of an alkoxylated triglyceride, an alkoxylated fatty acid, a sorbitan ester, and an alkoxylated sorbitan ester, and optionally a phospholipid.

Abstract: Disclosed are (1) pest control chemicals against the pine wood nematodes containing an extract from a pine tree with an organic solvent, (2) a repellent against the pine wood nematodes containing .alpha.-humulene or a mixture of .alpha.-humulene and .beta.-bisabolene, (3) a repellent against the pine wood nematodes containing a mixture of .alpha.-pinene and calarene, (4) a nematicide against the pine wood nematodes containing methyl ferulate, (+)-pinoresinol or a mixture thereof, and (5) highly effective pest control chemicals against pine wood nematodes containing hydroxystilbenes or salts thereof which are prepared by synthesizing methoxystilbenes from benzyl phosphonates and methoxybenzaldehydes by a Wittig-Horner reaction, performing demethylation to obtain the hydroxystilbenes, and preparing the salts thereof by conventional methods if necessary.

Abstract: Novel pesticidal compositions, which are characterized by biodegradability and do not bioaccumulate to an unacceptable level in fats and tissues of animals, fowl and fish, containing active compounds and optionally a carrier suitable for administering said compounds to a pest by contact, ingestion or inhalation, are disclosed. Such compositions comprise in addition to the carrier compounds of the formula ##STR1## where R is H, Cl or other Hal, hydroxyl, lower alkoxyl, lower alkyl, cyano, CONR.sub.2 or NR.sub.2 where R.sub.

Abstract: The invention provides a storage stable lyophilized collagen product comprising acid soluble purified native collagen in combination with platelet derived growth factors and a pharmaceutical composition for enhancing wound healing comprising an aqueous solution of water soluble acid-soluble purified native collagen and platelet derived growth factors.

Abstract: Aggregation of fluorocarbon emulsion particles, which occurs when the emulsion mixes with blood, is reduced by the addition of relatively large amounts of phosphate.

Abstract: Alkyl or alkylamido dimethyl 2,3-dihydroxypropyl ammonium salts may be used in hair and skin conditioning compositions and methods to provide improved manageability, static control, and ease of wet and dry combing when applied to hair, particularly human scalp hair, and smooth and lubricated surfaces with pleasant after-feel when applied in topical conditioner compositions to the human skin. The hair conditioning formulations may include styling, cleaning and rinsing compositions such as gels, mousses, sprays, lotions, glazes and shampoos, while the skin conditioning compositions may include moisturizing creams and lotions, bath oils, liquid cleaners, body mousses or bath gels, as well as alcoholic or hydroalcoholic astringents, toners, pre-electric shave conditioners, after-bath splashes and fragrance products. A preferred quaternary according to the invention is oleamidoproyl dimethyl 2,3-dihydroxypropyl ammonium chloride, which forms exceptionally stable, clear, dilutable gels.

Abstract: The invention relates to a process for the preparation of microcapsules having a capsule wall of polyurea and encapsulating a water-immiscible pesticide. The process comprises first dispersing a solution of a polyisocyanate in the sparingly water-soluble pesticide, in the presence of an anionic dispersant and at least one nonionic protective colloid and/or a nonionic surfactant, and subsequently reacting the dispersion with a polyamine, to give a stable aqueous suspension of microcapsules which can be used either direct or after dilution with water as pesticidal composition.

Abstract: Compositions having enhanced gas and drug transporting capability, are prepared by providing a perfluoro compound dispersed in an aqueous medium with a surfactant to form an aqueous initial dispersion, concentrating the perfluoro compound phase of the dispersion as by centrifugation or filtration, wherein a portion of the surfactant remains complexed with the particles of the perfluoro compound phase and the balance of the surfactant is in the aqueous phase, separating the phases, and redispersing the particles of the concentrated perfluoro compound phase to form a final dispersion in which greater than 65% by weight, and preferably at least 75%, of the surfactant present is complexed with the perfluoro compound particles.

Abstract: Infestation of cockroaches in buildings and houses are treated and effectively eliminated by determining the location of the eggs or the young, immature insects and treating them with a suitable insecticide before the insects emerge and begin to migrate to other areas. The treatment can also be applied to mature roaches in these areas before they lay their eggs. Frequently the places where the young roaches develop or hatch is in the foundations and walls of buildings and under concrete slabs where sewer or water lines occur and other damp or humid areas. A particularly effective insecticide has been found to be a dilute solution of O, O-diethyl-O- (2-isopropyl-6- methyl-4 pyrimidinyl phosphorothioate which is used to saturate the area being treated.

Abstract: A stable concentrated aqueous emulsion of perfluorochemical, a phospholipid and a triglyceride of fatty acids has been demonstrated which has enhanced stability, diminished particle size and heightened tolerance by biological systems. The emulsion has utility as an oxygen transport medium, such as artificial blood. The emulsion can optionally include additional emulsifiers of SURFYNOL.RTM.SE surfactant and PLURONIC.RTM. P-105 surfactant. The emulsion is produced using an improved emulsification technique. The invention includes methods of oxygen transport in vascular systems wherein the oxygen carrying capacity of the vascular systems is improved with the emulsions of the present invention. Methods are also described for organ preservation extra-vivo by perfusing, suffusing, flushing and filling organs outside the body with the oxygen carrying emulsions of the present invention.

Abstract: Increased stability is conferred on oil-in-water emulsions of perfluorocarbons by addition of a minor (0.1-5% w/v) amount of a fluorinated compound of higher boiling point than the perfluorocarbon being emulsified. The added fluorinated compound is preferably a perfluorinated saturated polycyclic hydrocarbon. The most preferred additive is perfluoroperhydrofluoranthene.

Abstract: Gas transport agents such as artificial blood containing a perfluorocyclocarbon and an amine oxide are disclosed. These compositions have been found to provide transparent emulsions or solutions for use in oxygen transport, particularly in animals. Large concentrations of perfluorocarbons may be employed even up to 50% or more by volume in preparing emulsions, microemulsions or solutions. The emulsions or solutions have been found to be very stable at room temperature storage conditions thereby providing significant advantages.

Abstract: The present invention is based on the discovery that the administration of at least one immunoconjugate and at least one chemotherapeutic agent provides an unexpectedly superior treatment for cancer. The present invention is directed to compositions comprising at least one immunoconjugate and at least one chemotherapeutic agent and to methods of treating cancer using at least one immunoconjugate and at least one chemotherapeutic agent. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one chemotherapeutic agent and at least one immunoconjugate.