Abstract: The present invention relates to a novel thixotropic oily vehicle comprising between about 0.2% to about 5% (w/w) of a colloidal silica and between about 0.2% to about 5% (w/w) of a hydrophilic polymer in an edible oil. The interaction between the hydrophylic polymer and the colloidal silica in the above concentration ranges confers thixotropy and a low viscosity under shear on the solution. The invention also relates to capsules filled with the above thixotropic solution used as a fill mass.

Abstract: The present invention provides an orally rapidly-disintegrating tablet comprising at least two particles. Regarding medicaments with unpleasant taste, the present invention provides a tablet comprising such medicament having a suitable hardness so that the tablet can be handled without any difficulty in the period from the formulation of the tablet to the administration thereof (in particular, a tablet which can maintain the hardness thereof when it is stored under a humidified condition); a small size; no unpleasant taste; a pleasant feeling in a mouth after administration; and an excellent disintegration character in the oral cavity and an excellent dissolution character in the gastrointestinal tract.

Abstract: The present disclosure relates to rheology modified, low foaming aqueous antimicrobial compositions. The compositions are phase stable under acidic conditions, and do not need to be rinsed from the surface to which they are applied. The present disclosure further relates to methods of use thereof.

Abstract: The disclosure describes a coating for medical implants, in particular, vascular stents, said coating comprising silicon dioxide, towards medical implants with a coating containing silicon dioxide and towards a method for their production. The coating can contain additional admixtures and have functionalization coats. The substrate of the coating is produced from a durable material, preferably from a stainless steel.

Abstract: Method of making particle compositions exhibiting improved floodability and/or flowability properties. The compositions generally contain particles and non-surface modified nanoparticles.

Abstract: A lotion composition is provided. The lotion composition can comprise a) about 0.1% to about 90%, by weight, of a microcrystalline wax; b) about 0.1% to about 25%, by weight, of POE-4 monolaurate; c) about 0.1% to about 50%, by weight, of POE-8 monostearate; and d) a carrier.

Abstract: The present invention is directed to a method of analyzing and establishing a proper dosage size in ingestible films for providing a more precise dosage delivery of an active ingredient.

Abstract: The invention relates to a compressible tablet material comprising the following components: an oil containing an active substance; silicified microcrystalline cellulose or microcrystalline cellulose as excipient.

Abstract: A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15® Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.

Abstract: A cosmetic composition comprising: (a) an aqueous and/or oil phase comprising: (i) water, and (ii) at least one cosmetically active ingredient; (b) a coupling agent; and (c) an oil phase comprising: (i) an isoparaffin solvent, and (ii) a silicone-containing solvent having the formula:

Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.

Abstract: A light emitting composition including first color emitters and second color emitters. The first color emitters are configured to emit, upon exposure to an energy source, visible light at a target color in response to absorption of energy across a first band of wavelengths. The second color emitters are configured to emit, upon exposure to the energy source, visible light at the target color in response to absorption of energy across a second band of wavelengths. The light intensity observable at the target color is enhanced relative to reflected white light without emission from the first and second color emitters. The light emitting composition can be a part of a paint, an ink, a fabric, a thread, a road sign, a highway marking, an automobile, a boat, a plane, a reflector, a building product, a concrete product, an epoxy product, a jewelry product, colored contact lens, a candle product, a rubber product, a plastic product, or other colored surface.

Abstract: The invention is directed to a seed coating composition, to a seed coating cocktail, to a method for preparing a coated seed, to a coated seed, and to the use of specific inorganic particles. The seed coating composition for a seed comprises water and at least 35 wt. % by weight of the coating composition of inorganic particles, wherein the mean particle size (D50) of said inorganic particles as measured by laser obscuration time technology is 250 ?m or less.

Abstract: The invention lies in the field of environmental technology and relates to a compound, in particular for the use, in particular as metabolically inert gas absorber for ruminants on the basis of zeolite, salt and a binding agent. It furthermore relates to a licking element with such a composition, a process for the production of such a licking element as well as its application. The use of zeolite relieves the organism of toxic substances, such as heavy metals and toxins. Clinoptilolite is a dietetically working ballast material, which stabilises the intestinal activities without depriving the body of nutrients such as vitamins and trace elements. Thus it is possible to achieve a reduction of the gas expulsion from the digestive tract. The licking element can be set up in the open, so that even free-ranging animals that belong to a farm can be reached in an easy manner.

Abstract: A lotion for opacifying a wet wipe. A wet wipe may comprise a lotion, the lotion comprising an opacifying agent. The lotion or the substrate may further comprise a retention aid. The substrate may comprise an opacifying agent the same as or different than the opacifying agent of the lotion. A method for opacifying a wet wipe by loading onto a wipe substrate a lotion comprising an opacifying agent. A method for aesthetically modifying a wet wipe by selectively loading onto a wipe substrate a lotion comprising an opacifying agent.

Abstract: Dermatological methods of cosmetic, therapeutic, prophylactic, and/or diagnostic treatment by topically applying compositions comprising a multiplicity of particles, at least one of the particles comprising porous and/or polycrystalline silicon. Included are methods and compositions for sun protection applications. The use of porous silicon, polycrystalline silicon, and porous silicon oxide mirrors is disclosed.

Abstract: The present invention relates to carriers for the controlled release of active agents, comprising surface reacted natural or synthetic calcium carbonate, one or more active agents, wherein said one or more active agent is associated with said surface-reacted calcium carbonate, and wherein said surface-reacted natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source. It further relates to the preparation of loaded carriers, as well as their use in different applications.

Abstract: The invention includes a microbe-mitigating architectural barrier that includes a barrier forming material, and at least one biocide. The barrier forming material may be a bitumen product, an elastomeric polymer and combinations thereof. The microbe-mitigating architectural barrier may be formed by applying an emulsion composition directly to an architectural surface, or it may be preformed and adhered or otherwise secured to the architectural surface in the form of a sheet or film. The invention also includes architectural assemblies and/or building envelopes that include the microbe-mitigating barrier. Related methods are encompassed within the scope of the invention.

Abstract: Compositions and methods of using the compositions are provided for forming an embolus within a region of an anatomical lumen for a transitory period in order to achieve a therapeutic effect.

Abstract: The present invention relates to effect pigments based on thin glass flakes and to a method for the production of such pigments. The resulting pigment can be used in any application for which pearlescent pigments have been heretofore used such as, for example, in plastics, paints, inks, cosmetic formulations, coatings including solvent or waterborne automotive paint systems, powder coatings, inks and agriculture foils.

Abstract: It is an object to provide an orally disintegrating tablet produced by dry granulation and compression, having a hardness of 40 N or more, a disintegration time of 30 seconds or shorter, a friability of 0.1% or less, and an excellent feeling upon ingestion, that is capable of disintegrating with a small amount of water, having a rapid disintegration time, and being maintained stably in a tablet form, which could not been achieved by conventional procedures. Disclosed is an orally disintegrating tablet produced by dry granulation which contains a medicinal ingredient with silica, and sugar alcohol or/and sugar.

Abstract: The present invention provides compositions and methods for detecting carboxymethyl-lysine (CML) and circulating receptor for advanced glycation end (RAGE) products, and methods for correlating CML and RAGE levels with age-related disease, hi particular, serum CML and/or circulating receptor for advanced glycation end (RAGE) products can be used as a clinical biomarker in diagnostics to identify people who are at a higher risk of developing adverse ageing-related outcomes.

Abstract: Modified clay minerals obtained by treating a clay mineral with a particular acylarginine derivative are useful for stabilizing emulsion compositions, inter alia, W/O emulsion composition, while hardly causing skin irritation, and providing moisture retention properties.

Abstract: The present invention relates to a controlled release medical composition comprising: a powder composition of a binder; a water based liquid; and a medical active pharmaceutical ingredient. In a first embodiment the powder composition comprises at least calcium carbonate of a first phase and calcium carbonate of a second different phase, the first and second phase are selected from the group: amorphous calcium carbonate; vaterite; aragonite; and calcite; and in a second embodiment the powder composition comprises calcium carbonate, or calcium sulphate, or calcium phosphate, or combinations thereof.

Abstract: A controlled release system and manufacturing method is provided. The method comprises providing a first aqueous solution containing a hydrophilic drug and an alkaline agent, providing an organic solution containing a hydrophobic molecule, providing a second aqueous solution containing a hydrophilic surfactant, mixing the first hydrophilic solution with the organic solution to form a first emulsion, and mixing the first emulsion with a second aqueous solution to form a second emulsion containing delayed-release microsphere.

Abstract: An angle-dependent interference pigment based on transparent or translucent inorganic flake serving as a substrate is provided. The substrate is coated by coatings (A)+(B)+(C) and optionally coating (D), so as to form a “high-low-high” refractive index layered structure. The coatings (A) and (C) consist of metal oxides, silicate, aluminates and/or a mixture thereof. The coating (B) consist of silicon oxide, hydrous silicon oxide, aluminum oxide, hydrous aluminum oxide, magnesium oxide, hydrous magnesium oxide and/or a mixture thereof. The angle-dependent interference pigments have high color saturation in the transitional region and a significantly gradual color change in the color changing region. The present pigments can be used as colored coatings, including printing ink, or can be used in the preparation of plastics, glass, ceramics and the like. The pigment of the present invention is particularly used in the cosmetic industry which has a very high requirement on gradual color change.

Abstract: A water dispersible granular composition comprising: at least one solid agrochemically active substance; at least one sorptive filler; at least one first agrochemically acceptable excipient; at least one liquid or low melting agrochemically active substance; and, at least one second agrochemically acceptable excipient. The invention further relates to a process of preparing the water dispersible granular composition.

Abstract: The disclosure relates to imaging agents and drug delivery systems.

Abstract: The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.

Abstract: Compositions, systems and methods utilizing engineered surgical irrigants providing delivery of components with therapeutic or other secondary benefits. Engineered irrigants provide targeted delivery of desired agents, including agents for propulsion of nano-devices, agents including molecular probes, gene expression agents, magnetically orientable agents, agents for discrete tissue temperature detection and tissue regeneration agents.

Abstract: The present invention relates to an oral dispersible tablet comprising at least one filler selected from sugars and sugar alcohols, and microcrystalline cellulose.

Abstract: A pourable ringing gel surfactant composition comprising a mixture of at least one anionic surfactant having a C8-C18 carbon chain and at least one zwitterionic or amphoteric surfactant having a C8-C18 carbon chain, wherein the ringing gel is capable of suspending solid or liquid particles without sedimentation.

Abstract: The present invention relates to pigments, comprising a plate-like substrate of perlite which does not contain 3D twin structure particles contained in milled expanded perlite in an amount of greater than 5% by weight, and (a) a dielectric material, especially a metal oxide, having a high index of refraction; and/or (a) a metal layer, especially a thin semi-transparent metal layer; a process for their production and their use in paints, ink-jet printing, for dyeing textiles, for pigmenting coatings (paints), printing inks, plastics, cosmetics, glazes for ceramics and glass.

Abstract: The present invention provides a process for making mesoporous nanoparticles. The process comprises providing an acidic mixture comprising a fluorocarbon surfactant, a second surfactant and a silica precursor. The silica precursor is then reacted to form the mesoporous nanoparticles.

Abstract: The invention relates to novel spill resistant formulations comprising either a weak base or a weak acid as the pharmaceutical ingredient, a liquid base, a clay and a water soluble cellulose ether. The clay and cellulose ether allow for a broader pH range into which the pharmaceutically active agent may be dispersed or dissolved, and therefore allows for easier preparation and formulation of the pharmaceutical composition.

Abstract: Glass particles colored with at least one colorant, where the colored glass particles are glass platelets with an average diameter of 1 to 500 ?m and the colorants comprise or consist of at least one of metallic nanoparticles and metal oxides. The glass platelets are planar and the colorants are present in a concentration from 1% to 55% by weight, based on the total weight of the colored glass platelets. The disclosure further relates to a method for producing the colored glass particles and to the use thereof.

Abstract: A moisture- or protein-adsorbability imparting agent, comprising a porous silica having a hexagonal pore structure, an average pore size of from 0.8 to 20 nm, an average particle size of 50 nm to 100 ?m, a specific surface area of from 400 to 2000 m2/g, and a pore volume of from 0.1 to 3.0 cm3/g; a material having an adsorbability of moisture or a protein, comprising the moisture- or protein-adsorbability imparting agent; and use of the moisture- or protein-adsorbability imparting agent for imparting absorbability of moisture or a protein to a material selected from the group consisting of food wrapping materials; filtration aid agents; sanitary articles; compositions containing a synthetic resin; moisture-controlled material; covering materials for wounds; insulation substrates; coating materials for semiconductor devices; cosmetics; inkjet recording media; and compositions containing synthetic fibers.

Abstract: A tablet composition, which in an easy, flexible and reproducible manner can be loaded with a relatively high amount of a pharmaceutically acceptable oily substance, may be produced in large-scale batches and stored until use; and tablets loaded with a pharmaceutically acceptable oily substance as well as a method for the preparation thereof. The tablet composition comprises a release enhancing agent and provides high and/or consistent release of the pharmaceutically acceptable oily substance, in particular release of a pharmaceutically acceptable, but substantially water-insoluble, oily substance.

Abstract: The invention relates to novel composite materials based on a collagen matrix mineralised with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralised with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analogue, a collagen derivative or a mixture of said collagens.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: The present invention relates to pigment compositions with improved and adjustable sparkling effect comprising A) a platelet-like perlite; and B) an effect pigment; and a process for their production and their use in paints, ink-jet printing, for dyeing textiles, for pigmenting coatings (paints), printing inks, plastics, cosmetics, glazes for ceramics and glass. The pigment compositions show an improved sparkle effect; in particular an attractive high sparkle intensity.

Abstract: A facile method to synthesize stable calcium carbonate microstructures is demonstrated which allows in situ encapsulation of sensitive molecules like drugs. The methodology involves a macromolecular assembly of anionic polypeptide with cationic peptide oligomer to concurrently template and hold to stabilize the mineralized structure. The heterogeneously distributed mixture of anionic and cationic residues in the macromolecular assembly, similar to that is found in natural systems assists in recognizing and coassembling Ca2+ and CO32? ionic clusters, especially for formation of a disordered precursor phase such as amorphous calcium carbonate (ACC) and further crystallization to form a metastable vaterite phase. The assembly also facilitates encapsulation of a guest molecule such as tetracycline at ambient conditions without affecting the mineralization process.

Abstract: Featured are a biocompatible, injectable, self-setting, cohesive, bone-bonding and remodeling calcium phosphate composite material and its use in methods of repairing defective bone, e.g., in vertebroplasty augmentation and kyphoplasty.

Abstract: A cosmetic composition comprising a first emulsion and a second emulsion and optionally one or more additional emulsions, each of said two or more emulsions being discretely contained within the composition and comprising an inner phase and an outer phase, each of said two or more emulsions being independently a water-in-oil emulsion, an oil-in-water emulsion, an oil-in-oil emulsion, a polyol-in-oil emulsion, a water-in-silicone emulsion, a silicone-in-water emulsion, or a polyol-in-silicone emulsion in physical contact with at least one other emulsion, at least one of said two or more emulsions being visually distinct from the others, and each of said two or more emulsions as well as said composition being independently both physically and visually stable within the composition for at least six months at ambient temperature.

Abstract: A porous silicon implant impregnated with a beneficial substance, such as a micromineral required for healthy physiology, is implanted subcutaneously and is entirely corroded away over the following months/year to release the micromineral in a controlled manner. In a second embodiment the implant may have a large number of holes which contain beneficial substance and which are closed by bio-errordable doors of different thickness so as to stagger the release of the beneficial substance over time as the doors are breached.

Abstract: The present invention relates to pigments which comprise a substrate and an iron(II) silicate-containing coating applied thereto, to a process for the preparation of these pigments, and to the use thereof.

Abstract: A pharmaceutical composition comprising: a) a 5-HT1 agonist; b) an NSAID; and c) a disintegrant characterised in that the disintegrant comprises between about 15 to about 50% w/w based on the weight of the composition, said composition optionally comprising one or more other pharmaceutically acceptable excipients.

Abstract: A method of producing a nanostructure composition from a solid powder is disclosed. The method comprises: (a) heating the solid powder, thereby providing a heated solid powder; (b) immersing the heated solid powder in a liquid in the presence of a gas medium, the liquid being colder than the heated powder, and (c) irradiating the cold liquid, the heated solid powder and the gas medium by electromagnetic radiation selected such that nanostructures are formed from particles of the solid powder and a stable gas phase is formed from the gas medium.

Abstract: The present invention relates to novel precipitated silicic acids for use as support materials, manufacture thereof and use thereof.

Abstract: The present invention relates to the use of titanium dioxide pigments and/or iron oxide pigments based on platy substrates for colouring food products and pharmaceutical products.