Platelet-derived Growth Factor (pdgf) Or Derivative Patents (Class 514/8.2)
  • Publication number: 20140105856
    Abstract: System and methods for isolation of collagen and other fibrous tissue from adipose tissue are described herein. The method of the present invention isolates the collagen from adipose tissue by sonication. The tissue to be sonicated is placed in a container or a flow cell transparent to ultrasound waves. After sonication the sonicated material is filtered out through the bottom of the flow cell and the sonicated collagen is trapped in the filter, which may be taken for further processing. The isolated collagen can then be combined with a suitable carrier for re-injection to correct various tissue defects such as wrinkles, to form a carrier for the stem cells, a filler, and matrix for new collagen production by injecting into the desired area of the host.
    Type: Application
    Filed: June 22, 2012
    Publication date: April 17, 2014
    Inventor: Stephen Schendel
  • Publication number: 20140105960
    Abstract: Provided herein are hydrogels and hydrogel-forming compositions that are useful for, among others, tissue regeneration in vivo. Methods for generating such hydrogels, for example, from such hydrogel-forming compositions are also provided herein. Therapeutic methods employing hydrogels and hydrogel-forming composition, for example, for restoration of tissue perfusion in the context of acute ischemia, are also provided. The disclosure also describes kits comprising components useful for generating hydrogels as described herein.
    Type: Application
    Filed: October 9, 2013
    Publication date: April 17, 2014
    Applicants: Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: JANETA ZOLDAN, Robert S. Langer, Daniel S. Kohane, Daniel Griffith Anderson, Akihiko Kusanagi, Hila Epstein-Barash, Beata Chertok
  • Patent number: 8697107
    Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: April 15, 2014
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Daniel A. Shimko
  • Publication number: 20140099270
    Abstract: The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (HSA) with cytokine peptides (EGF, FGF, KGF, HGH, HGF, PDGF, GCSF, interferon, IL-11 or IGF) by genetic engineering technology. The fusion protein can be used independently or in a combination or combination with yeast fermentation products, or with varied emulsifiers, thickeners, moisturizer, preservatives, yeasts and ferments.
    Type: Application
    Filed: October 28, 2013
    Publication date: April 10, 2014
    Applicants: FORTUNEROCK, INC. USA, TIANJIN SINOBIOTECH LTD.
    Inventors: Yan Fu, Zailin Yu
  • Publication number: 20140094410
    Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.
    Type: Application
    Filed: November 19, 2012
    Publication date: April 3, 2014
    Inventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel
  • Patent number: 8685464
    Abstract: The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 70 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; and iii) a ?-tricalcium phosphate powder having a median particle size of less than about 20 microns. Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: April 1, 2014
    Assignee: Agnovos Healthcare, LLC
    Inventors: Jon P. Moseley, Michael E. Carroll, Jonathan D. McCanless
  • Publication number: 20140086974
    Abstract: Biodegradable drug delivery systems, such as extruded implants, for the sustained delivery of a protein to an ocular region of the eye or intraarticular region in the body are described. The drug delivery systems may be used to treat a variety of ocular and medical conditions, including macular degeneration. Methods for using and making the drug delivery systems are also described. The drug delivery systems can be in the form of extruded filaments configured for placement in an ocular region such as the vitreous body or anterior chamber of the eye.
    Type: Application
    Filed: September 26, 2013
    Publication date: March 27, 2014
    Inventors: Cindy W. Wu, Michael R. Robinson, James A. Burke, Patrick M. Hughes
  • Publication number: 20140088502
    Abstract: An injector system for delivery of a pharmacological agent to biological tissue having a plurality of needles arranged in an array, a plurality of reservoirs configured to receive a pharmacological composition therein, the reservoirs being in fluid communication with a respective one of the plurality of needles, a pneumatic pressure source, a pneumatic drive system that is configured to induce a first discharge of the pharmacological composition out of the reservoirs and needles in a plurality of delivery modes, agent delivery volume control means for controlling volume of the pharmacological composition discharged from the needles, and a control system having actuation control means for controlling said pneumatic drive system. The control system is programmed to control the delivery modes.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 27, 2014
    Inventors: Robert G. Matheny, Bret Herscher, Michael Perry
  • Publication number: 20140072531
    Abstract: A method for preparing polymer microparticles with a reduced initial burst, and the polymer microparticles prepared thereby, the method including: contacting polymer microparticles with an alcohol aqueous solution, the polymer microparticles prepared thereby, and use for drug delivery of the polymer microparticles.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 13, 2014
    Applicant: SK CHEMICALS CO., LTD.
    Inventors: Hong Kee KIM, Kyu Ho Lee, Joon-Gyo OH, Bong-Yong Lee
  • Publication number: 20140065119
    Abstract: Compositions and methods for treating wounds are provided. The compositions include cyclic analogues of histatin (5).
    Type: Application
    Filed: November 10, 2011
    Publication date: March 6, 2014
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Gilles Andre Lajoie, Greg John Adams Vilk, Ian Welch
  • Publication number: 20140056989
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Application
    Filed: November 5, 2013
    Publication date: February 27, 2014
    Applicant: Omrix Biopharmaceuticals Ltd.
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
  • Patent number: 8658196
    Abstract: Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of the invention comprises a first layer of remodelable extracellular matrix (ECM) material bonded to a second layer of remodelable ECM material, wherein the first material layer is enriched with a growth factor relative to the second material layer. Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).
    Type: Grant
    Filed: August 12, 2010
    Date of Patent: February 25, 2014
    Assignee: Cook Biotech Incorporated
    Inventor: Abram D. Janis
  • Publication number: 20140050771
    Abstract: Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a tissue defect. Further provided is a tissue scaffold comprising platelet-derived growth factor (PDGF). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.
    Type: Application
    Filed: October 3, 2011
    Publication date: February 20, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Jeremy J. Mao, Wenli Zhao
  • Patent number: 8647663
    Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.
    Type: Grant
    Filed: November 14, 2012
    Date of Patent: February 11, 2014
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Randall G. Rupp, Howard C. Wessel
  • Patent number: 8647662
    Abstract: The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: February 11, 2014
    Assignee: Stemnion, Inc.
    Inventors: David L. Steed, Linda O. Palladino
  • Publication number: 20140037708
    Abstract: The present invention provides a biocompatible composition that comprises a bioactive material and a method for using the same. In particular, the composition of the invention is useful for spatio and/or temporal release of the bioactive material. Specifically, the composition of the invention comprises at least one polymeric mixture layer comprising a plurality of biodegradable polymers. The polymeric mixture layer comprises a first biodegradable polymer and a second biodegradable polymer. The relative amount of the first biodegradable polymer or the second biodegradable polymer increases within the polymeric mixture layer in one direction, and the relative amount of the other biodegradable polymer decreases in the polymeric mixture layer in the same direction. The rate of degradation of the first biodegradable polymer is different from the rate of degradation of the second biodegradable polymer. In this manner, the composition allows spatio and/or temporal release of the bioactive material.
    Type: Application
    Filed: July 30, 2013
    Publication date: February 6, 2014
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventors: Wei Tan, Walter Bonani
  • Publication number: 20140010832
    Abstract: Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a PlGF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, and vaccines.
    Type: Application
    Filed: July 2, 2013
    Publication date: January 9, 2014
    Applicant: EPFL-TTO
    Inventors: Jeffrey A. Hubbell, Mikael Martino, Priscilla S. Maithili Briquez
  • Publication number: 20140005110
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Application
    Filed: June 21, 2013
    Publication date: January 2, 2014
    Applicant: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20130337076
    Abstract: The present invention concerns particles containing at least one covalently cross-linked polysaccharide and at least one growth factor, a method of preparation, and uses thereof.
    Type: Application
    Filed: March 5, 2012
    Publication date: December 19, 2013
    Applicants: UNIVERSITE DE REIMS CHAMPAGNE-ARDENNE, UNIVERSITE DE ROUEN
    Inventors: Ebba Brakenhielm, Sébastien Banquet, Florence Edwards-Levy, Christian Thuillez
  • Patent number: 8603541
    Abstract: The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. Advantageously, the extract comprises a balanced proportion of the factors and is non-clottable.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: December 10, 2013
    Assignee: Omrix Biopharmaceuticals Ltd.
    Inventors: Lior Weissman, Nina Raver-Shapira, Israel Nur, Oleg Belyaev
  • Publication number: 20130323199
    Abstract: A collagen material is characterized in being constituted of collagen gel fragments. Furthermore, the collagen gel fragments may have an orientation. A method for producing a collagen material is characterized in comprising a step for preparing collagen gel fragments, a step for arranging the collagen gel fragments in a desired shape, and a step for drying the collagen gel fragments arranged in the desired shape. Moreover, in one embodiment of the method for producing a collagen material a step may include imparting an orientation to the collagen gel fragments.
    Type: Application
    Filed: February 20, 2012
    Publication date: December 5, 2013
    Applicant: Atree, Inc.
    Inventors: Taro Saku, Yoshihiro Isobe, Takaoki Isobe
  • Publication number: 20130309304
    Abstract: The present invention relates to pharmaceutical formulations suitable for targeting particular tissue and/or organ(s) with a formulated active ingredient, for example when administered upstream of the target organ or tissue, and to use of the same in treatment, methods of treatment administering the same and methods of preparing the formulations. The pharmaceutical formulations of the invention are for parenteral administration to a target tissue and comprise particles containing an active ingredient, and a biodegradable excipient, wherein 90% or more of the particles have a diameter of between 10 and 20 microns and the formulation is substantially free of particles with a diameter greater than 50 microns and less than 5 microns, such that where the formulation is administered upstream of the target tissue the ability of the active to pass through the target tissue and pass into systemic circulation is restricted.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 21, 2013
    Inventor: Bernardo Nadal-Ginard
  • Patent number: 8586070
    Abstract: The present invention relates to compositions devices and methods for treating bone and/or cartilage defects, and a method for manufacturing such a composition or device. In a certain embodiment, the invention provides a device and/or composition for treating bone and/or cartilage defects, having at least one collagen, for example of animal origin, and further containing at least one substance having an osteo-inductive or chondro-inductive activity, at least one differentiation and/or growth factor having osteo-stimulative and/or chondro-stimulative effect, and at least one filling material, in which the composition is in the form of a lyophil.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: November 19, 2013
    Assignee: SBF Synthetic Bone Factory GmbH
    Inventor: Arne Briest
  • Publication number: 20130288965
    Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 31, 2013
    Inventors: JOHANNES GERHARDUS MARIA BOLSCHER, ARIE VAN NIEUW AMERONGEN, ENGELMUNDUS CORNELIS IGNATIUS VEERMAN, MENNO JOHANNES OUDHOFF, WILLEM VAN'T HOF, KAMRAN NAZMI, PETRONELLA ADRIANA MARIA VAN DEN KEIJBUS
  • Publication number: 20130287817
    Abstract: A flowable biomedical implant for application to a bone defect to promote bone growth is provided. The flowable biomedical implant comprises a carrier matrix including a biodegradable polysaccharide and ceramic material. An impermeable membrane can be integrally formed at the surface of the carrier matrix by applying a crosslinking agent to the biodegradable polysaccharide mixed with ceramic materials.
    Type: Application
    Filed: April 27, 2012
    Publication date: October 31, 2013
    Applicant: Warsaw Orthopedic, Inc.
    Inventors: Susan J. Drapeau, Daniel A. Shimko
  • Publication number: 20130288963
    Abstract: A fusion protein comprising domain (a) which is a functional fragment of hTRAIL protein sequence, which fragment begins with an amino acid at a position not lower than hTRAIL95, or a homolog of said functional fragment having at least 70% sequence identity; and domain (b) which is a sequence of an anti-angiogenic effector peptide, wherein the sequence of domain (b) is attached at the C-terminus or N-terminus of domain (a). The fusion protein can be used for the treatment of cancer diseases.
    Type: Application
    Filed: January 5, 2012
    Publication date: October 31, 2013
    Applicant: ADAMED SP. Z O.O.
    Inventors: Jerzy Szczepan Pieczykolan, Sebastian Dominik Pawlak, Bartlomiej Maciej Zerek, Piotr Kamil Rózga
  • Publication number: 20130288964
    Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 31, 2013
    Inventors: Johannes Gerhardus Maria Bolscher, Arie van Nieuw Amerongen, Engelmundus Cornelis Ignatius Veerman, Menno Johannes Oudhoff, Willem van't Hof, Kamran Nazmi, Petronella Adriana Maria van den Keijbus
  • Publication number: 20130281369
    Abstract: A method for promoting hair growth in a human in need of promoting hair growth. The method includes preparing a composition comprising a therapeutically effective amount of at least three of: a Bone Morphogenetic Protein, Transforming Growth Factor Beta, Platelet Derived Growth Factor, Insulin-like Growth Factor, Basic Fibroblastic Growth Factor and Vascular Endothelial Growth Factor; and administering the composition to the human.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 24, 2013
    Inventor: Mark Laney
  • Publication number: 20130272999
    Abstract: A composition for treating a wound, wherein the composition can comprise therapeutically effective amount of an epidermal growth factor and a physiologically acceptable agent, wherein the physiologically acceptable agent comprises at least one of a stabilizer, a preservative, a thickening agent, carrier/diluent, and optionally pH regulating agent and humectant.
    Type: Application
    Filed: June 6, 2013
    Publication date: October 17, 2013
    Inventors: Krishna Murthy Ella, Srinivas Kannappa Vellimedu
  • Publication number: 20130251764
    Abstract: Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 26, 2013
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Syed Hossainy, Michael Ngo, Mikael Trollsas, John Stankus, Gene Michal
  • Publication number: 20130245528
    Abstract: Provided herein is a topical wound dressing that comprises a collagen and a flexible paste. Also provided is a wound dressing with a first layer of a sterilized mixture of collagen and a second adhesive layer effective to adhere to surrounding skin and to keep the first layer in contact with the wound. In addition there is provided a wound dressing foil that comprises collagen and a plastic compound that can provide a foil shape. Furthermore, methods of dressing wounds utilizing the wound dressings and wound dressing foil are provided herein.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 19, 2013
    Inventor: Carl Randall Harrell
  • Publication number: 20130243822
    Abstract: This invention provides compositions and methods for topically treating skin wounds. The composition comprises C7, C7M, a variant thereof, or a combination thereof in a pharmaceutically acceptable carrier. The method comprises the steps of topically applying compositions of this invention to the skin wound.
    Type: Application
    Filed: September 11, 2012
    Publication date: September 19, 2013
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mei Chen, David Woodley
  • Publication number: 20130243866
    Abstract: A method was developed to prepare silk fibroin microspheres using lipid vesicles as templates to efficiently load therapeutic agents in active form for controlled release. The lipids are subsequently removed through the use of a dehydration agent, such as methanol or sodium chloride, resulting in ?-sheet structure dominant silk microsphere structures having about 2 ?m in diameter. The therapeutic agent can be entrapped in the silk microspheres and used in pharmaceutical formulations for controlled-release treatments.
    Type: Application
    Filed: May 7, 2013
    Publication date: September 19, 2013
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. KAPLAN, Xiaoqin WANG
  • Patent number: 8530418
    Abstract: The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 10, 2013
    Assignee: Stemnion, Inc.
    Inventors: Vivienne S Marshall, Catherine J Trumpower, Charlotte Emig
  • Patent number: 8518879
    Abstract: The present invention relates to skin care compositions, including cosmeceuticals, for topical application, and more particularly, a skin cream, comprising cell culture medium conditioned by cells grown in two-dimensional culture. Also included are methods of using such compositions and kits comprising the skin cream therein.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: August 27, 2013
    Inventor: Ahmed H. Al-Qahtani
  • Publication number: 20130195991
    Abstract: The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.
    Type: Application
    Filed: March 25, 2011
    Publication date: August 1, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Minoru Ueda, Yoichi Yamada, Katsumi Ebisawa, Akihito Yamamoto, Kiyoshi Sakai, Kohki Matsubara, Hisashi Hattori, Masahiko Sugiyama, Takanori Inoue
  • Publication number: 20130195926
    Abstract: The instant invention provides methods for treating a solid tumor in a subject comprising modulating nitric oxide production in the tumor to normalize tumor vasculature and administering an anti-tumor therapy to the subject. The invention further provides methods of treating a solid tumor in a subject comprising selectively increasing cyclic guanosine monophosphate (cGMP) or cGMP dependent protein kinase G production in the tumor vasculature to an amount effective to normalize tumor vasculature and administering an anti-tumor therapy to the subject.
    Type: Application
    Filed: December 4, 2012
    Publication date: August 1, 2013
    Applicant: The General Hospital Corporation
    Inventor: The General Hospital Corporation
  • Patent number: 8492335
    Abstract: Provided herein are compositions and methods for the treatment of tendinopathies, such as tenosynovitis, tendinosis or tendinitis, including Achilles tendinopathy, patellar tendinopathy, lateral epicondylitis or “tennis elbow,” medial epicondylitis or “golfer's elbow,” plantar fasciitis, and rotator cuff tendinopathy, and in particular to methods for the treatment of tendinopathies by administering compositions comprising platelet-derived growth factor (PDGF).
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: July 23, 2013
    Assignee: BioMimetic Therapeutics, LLC
    Inventors: Hans K. Kestler, Vivek Shah, Dean James Rager-Aguiar
  • Publication number: 20130183365
    Abstract: The invention is directed to a novel wound healing device. In particular, the invention is directed to a novel wound healing device comprising a suture or knitted mesh that has adsorbed onto it novel cellular factor-containing compositions (referred to herein as CFC), including Amnion-derived Cellular Cytokine Solution (referred to herein as ACCS) or Physiologic Cytokine Solutions (herein referred to as PCS), as well as methods of making and uses thereof.
    Type: Application
    Filed: November 14, 2012
    Publication date: July 18, 2013
    Applicant: STEMNION, INC.
    Inventor: Stemnion, Inc.
  • Patent number: 8486387
    Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: July 16, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu
  • Patent number: 8486386
    Abstract: Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: July 16, 2013
    Assignee: Abbott Cardiovascular Systems Inc.
    Inventors: Eugene Michal, Olof Mikael Trollsas, Shubhayu Basu
  • Patent number: 8481064
    Abstract: The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: July 9, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: William F. McKay
  • Publication number: 20130171094
    Abstract: This invention provides a method of promoting bone healing by locally administering a vanadium-based insulin mimetic agent to a patient in need thereof. The invention also provides a new use of insulin-mimetic vanadium compounds for manufacture of medicaments for accelerating bone-healing processes. In addition, the invention also encompasses a bone injury treatment kit suitable for localized administration of insulin-mimetic vanadium compounds or compositions thereof to a patient in need of such treatment.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 4, 2013
    Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
    Inventors: Sheldon Suton Lin, David Naisby Paglia, James Patrick O'Connor, Eric Breitbart, Joseph Benevenia
  • Publication number: 20130172236
    Abstract: This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same.
    Type: Application
    Filed: October 5, 2012
    Publication date: July 4, 2013
    Applicant: The Regents of the University of Colorado, a body corporate
    Inventor: Mark T. Roedersheimer
  • Publication number: 20130150285
    Abstract: Therapeutic and cosmetic uses and applications of calreticulin are provided. In particular, the invention relates to therapeutic and cosmetic uses and applications of calreticulin to a patient in need of such treatment including in tissue repair, wound healing, ulcers, reducing scar formation, and reducing or eliminating wrinkles.
    Type: Application
    Filed: June 17, 2011
    Publication date: June 13, 2013
    Applicants: CALREGEN INC., NEW YORK UNIVERSITY
    Inventors: Leslie I. Gold, Marek Michalak
  • Publication number: 20130149318
    Abstract: A PEG based hydrogel and a procedure for its topical application to the surface of the pia mater of the spinal cord that can be used for intrathecal delivery of diverse drug and biomolecular therapies for the treatment of traumatic central nervous system injuries and disorders including spinal cord injury (SCI), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are provided. This “painting of the pia” with biofunctionalized hydrogel material may be used as a prelude strategy in the therapeutic management of these CNS disorders. The strategy may be designed to create a microenvironment within the damaged regions of the spinal cord that is more conducive to the successful application of subsequent regeneration based treatments such as cell replacement therapies or endogenous regeneration and plasticity stimulation via application of growth factors or gene therapy.
    Type: Application
    Filed: December 13, 2012
    Publication date: June 13, 2013
    Applicant: INVIVO THERAPEUTICS CORPORATION
    Inventor: InVivo Therapeutics Corporation
  • Publication number: 20130149314
    Abstract: Provided are novel methods and compositions for the diagnosis, prognosis and treatment of leiomyomas, in particular uterine leiomyoma (UL). In addition, methods of identifying anti-tumor agents are described. Furthermore, novel methods and compositions are provided for the treatment of diseases characterized by an aberrant growth of mesenchymal stem cells and their descendants and for the treatment of obesity are disclosed.
    Type: Application
    Filed: February 9, 2011
    Publication date: June 13, 2013
    Inventors: Jörn Bullerdiek, Dominique N. Markowski
  • Publication number: 20130143807
    Abstract: Disclosed herein are heretofore undescribed preparations of highly concentrated, solubilized proteins, such as but not limited to, Bone Morphogenetic Proteins. Such protein preparations can be formulated in an aqueous carrier at protein concentrations in excess of 10 mg/ml when using the methods of manufacture taught herein. Such methods yield stable protein preparations in either solubilized or lyophilized form. The protein preparations of the present invention are particularly beneficial when administered either locally or systemically, in part, because low administration volumes can be accomplished. This is especially important for local treatment of certain anatomic locations such as, for example, the synovial fluid of a joint when treating osteoarthritis with BMP-7 or the intradiscal space when treating degenerative disc disease with BMP-7.
    Type: Application
    Filed: June 7, 2012
    Publication date: June 6, 2013
    Inventor: Niles Ron
  • Publication number: 20130143808
    Abstract: The present invention relates, in general, to fibrin sealants, which contain platelet derived growth factor (PDGF) for controlled release in situ for therapeutic applications, including musculoskeletal disorders, soft tissue disorders and vascular diseases.
    Type: Application
    Filed: January 25, 2013
    Publication date: June 6, 2013
    Applicants: BAXTER HEALTHCARE SA, BAXTER INTERNATIONAL INC.
    Inventors: BAXTER INTERNATIONAL INC., BAXTER HEALTHCRE SA
  • Patent number: 8452483
    Abstract: A cell-based vehicle driving control system includes a local server for obtaining road environment information on roads within a cell and target vehicle information on a target vehicle within the cell and generating local waypoints based on the road environment information and the target vehicle information; a global server for monitoring the target vehicle information, the road environment information and local server information on the local server received from the local server; and a vehicle control terminal, mounted in the target vehicle, for receiving the local waypoints from the local server and controlling the target vehicle based on the local waypoints. The road environment information is obtained by using at least one sensor installed on the roads.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: May 28, 2013
    Assignee: Electronics and Telecommunications Research Institute
    Inventors: Do Hyun Kim, Sung Won Sohn, Jong-Hyun Park, Byung Tae Jang, Jeong Dan Choi, Kyung Bok Sung, Kyoung Hwan An, Ju Wan Kim, Seong Ik Cho, Jungsook Kim