Collagen, Gelatin Or Derivatives Thereof Patents (Class 514/801)
  • Patent number: 9012406
    Abstract: Disclosed herein are compositions comprising gelatin, collagen, and a chromophore that produces a reactive oxygen species upon exposure to electromagnetic radiation. These compositions have also been found to be strong tissue adhesives that crosslinks the composition and tissue and are effective in closing and sealing wounds, fixation of grafts/implants and anastomoses.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: April 21, 2015
    Assignee: Conversion Energy Enterprises, Inc.
    Inventors: Barbara A. Soltz, Robert Soltz
  • Patent number: 8980278
    Abstract: The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: March 17, 2015
    Assignees: Universitaetsklinikum Freiburg, Albert-Ludwigs-Universitaet Freigburg
    Inventors: Thorsten Steinberg, Wilfried Weber, Raphael Guebeli, Pascal Tomakidi, Dougal Laird
  • Patent number: 8802626
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and detects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: August 12, 2014
    Assignee: Stryker Corporation
    Inventors: David C. Rueger, Marjorie M. Tucker, An-Cheng Chang
  • Patent number: 8703174
    Abstract: A pet supplement includes a joint preserving and joint rebuilding composition comprising chicken collagen type II, glucosamine hydrochloride and chondroitin sulfate, a vitamin composition comprising vitamins C, D and K, a mineral composition comprising calcium, magnesium, zinc, copper, manganese and boron, a herbal anti-oxidant cofactor blend comprising citrus bioflavonoids, red grapes anthocyanins, turmeric rhizome, boswellia resin and fennel seed. Each of these ingredients is intimately mixed into the pet supplement and orally delivered to the pet in the form of a segment, paste or powder having a size and weight or other dosage measuring feature adjusted in accordance with the pet's weight. A synergistic action between these ingredients preserves and rebuilds the pet's joints, and is nutritionally beneficial for the pet.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: April 22, 2014
    Assignee: I did It Inc
    Inventor: Marni Markell Hurwitz
  • Patent number: 8685092
    Abstract: A biomaterial for osteoplasty has a preserved native spatial organization of collagen matrix and mineral component of bone fabrics of natural origin, for example, containing 25% collagen and 75% mineral substances. The biomaterial is demineralized (compared to original concentration) to contain from 0 to 95% of the original mineral concentration, preferably from 5 to 80%, more preferably from 10 to 60%. The proteins are composed of 99% of collagen and 1% of other proteins. The biomaterial contains bone sulfated glycosaminoglycans (sGAG), whose concentration varies from 0.3 to 3 mg per 1 cm3 of the material. The sGAG is affinity-bound to the bone matrix. The biomaterial may also include bisphosphonates, whose concentration varies from 0.2 to 10 micrograms per 1 gram of material. The biomaterial may also include bone the morphogenetic proteins (BMP), whose concentration varies from 0.001 to 1 micrograms per 1 gram of material.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: April 1, 2014
    Inventor: Andrey Fedorovich Panasyuk
  • Patent number: 8613957
    Abstract: A scaffold material for wound care and/or other tissue healing applications and methods for making the same is described. The scaffold material is constituted of a decellularized extracellular matrix from fish skin. The scaffold material may also include lipids from the lipid layer of the fish skin. Methods for making and using the scaffold material are also described.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: December 24, 2013
    Assignee: Kerecis EHF
    Inventors: Gudmundur Fertram Sigurjonsson, Dora Hlin Gisladottir, Gudmundur Gudmundsson
  • Patent number: 8524226
    Abstract: The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation. The invention further includes methods for prolonging patency of hemodialysis access.
    Type: Grant
    Filed: February 7, 2011
    Date of Patent: September 3, 2013
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 8518422
    Abstract: A cosmetic or dermatological preparation that is obtainable by combining collagen and/or a derivative thereof, chitosan and/or a derivative thereof and glycosylaminoglycan and/or a derivative thereof with one or more selected substances. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.
    Type: Grant
    Filed: March 1, 2005
    Date of Patent: August 27, 2013
    Assignee: La Prairie Group AG
    Inventors: Monika Mönks, Sybille Ibanez, Carmen Evangelisti, Sven Gohla
  • Patent number: 8470354
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: June 25, 2013
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
  • Patent number: 8372805
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: February 12, 2013
    Assignee: Stryker Corporation
    Inventors: David C. Rueger, Marjorie M. Tucker, An-Cheng Chang
  • Patent number: 8354376
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: January 15, 2013
    Assignee: Stryker Corporation
    Inventors: David C. Rueger, Marjorie M. Tucker
  • Patent number: 8287915
    Abstract: Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: October 16, 2012
    Assignee: Orthovita, Inc.
    Inventors: Theodore D. Clineff, Gina M. Nagvajara, Antony Koblish, Erik M. Erbe, Charanpreet S. Bagga
  • Patent number: 8263557
    Abstract: A method and a composition for photochemical cross linking of collagen by photoactive agent in-vivo are presented. The method includes a non-toxic photoactive formulation of the composition with collagen, which is administered to treatment area locally; followed by irradiation with suitable wavelength. In one of the embodiment liposomal formulated mTHPC is added to the collagen and is irradiated with a 652 nm laser, resulting in producing efficient collagen scaffolds with strengthen and stabilized microstructure, thus improving the physiochemical properties of the collagen scaffold. It improves the thermostability, mechanical property and swelling ratio of newly formed scaffold. Photochemical cross-linked collagens shows antimicrobial effect, when irradiated with suitable wavelength it disinfects the treatment site and curbs microbial growth.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: September 11, 2012
    Assignee: Biolitec Pharma Marketing Ltd
    Inventors: Susanna Gräfe, Wolfgang Neuberger, Danilo Castro
  • Patent number: 8168599
    Abstract: The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated as an aqueous eye drop solution.
    Type: Grant
    Filed: March 16, 2010
    Date of Patent: May 1, 2012
    Inventors: George D. Petito, Anita M. Petito
  • Patent number: 8097274
    Abstract: Provided herein are skin substitutes suitable for use in a living subject for purpose of repairing damaged tissues, methods of producing the skin substitutes and their uses. A biocomposite membrane comprising poly(?-caprolactone) (PCL) and at least one material selected from collagen and gelatin is provided. In one embodiment, the biocomposite is a 2-component membrane of PCL and gelatin. In another embodiment, the biocomposite is a 3-component membrane of PCL, collagen and gelatin. The bio-composite membrane may be used directly in vivo as a wound dressing, or as a support for cell growth on each side of the membrane to produce an in vitro cultivated artificial skin for future in vivo and/or in vitro applications.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: January 17, 2012
    Assignee: National Defense Medical Center
    Inventors: Allan Gerald Arthur Coombes, Eric Frank Adams, Niann-Tzyy Dai, Tsung-Hsun Liu, Ming-Kung Yeh
  • Patent number: 8092823
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: January 10, 2012
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: William F. McKay, Scott D. Boden, Neil B. Beals
  • Patent number: 8048446
    Abstract: Non-woven fibrous scaffolds made by electrospinning from the synthetic biodegradable polymer such as, for example, poly(lactic-co-glycolic acid) (PLGA) and natural proteins, such as, for example, gelatin (denatured collagen) and elastin and a method of making thereof.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: November 1, 2011
    Assignee: Drexel University
    Inventors: Peter I. Lelkes, Mengyan Li, Mark Mondrinos, Frank Ko
  • Patent number: 7883699
    Abstract: The invention provides methods to for treating a an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzymes to the area or region of obstruction wherein the enzyme(s) have the capability to degrade extracellular matrix components within the obstruction thereby restoring the normal flow of transported fluid through the conduit. The invention also includes prophylactically dilating a section of conduit to minimize the risk of obstruction formation.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: February 8, 2011
    Assignee: Proteon Therapeutics, Inc.
    Inventor: F. Nicholas Franano
  • Patent number: 7741454
    Abstract: The crosslinking agents and condensing agents that have been employed in biological adhesives and in treating medical devices such as cardiac valves are non-natural compounds synthesized artificially. Thus, they are not metabolized in vivo and exhibit toxicity to living bodies. These compounds are thus used only in a restricted amount and for limited purposes in the clinical sites. The present invention provides a biological low-molecular-weight derivative obtained by modifying carboxyl groups of a biological low-molecular-weight compound with N-hydroxysuccinimide, N-hydroxysulfosuccinimide, or a derivative thereof and a crosslinked high-molecular-weight product obtained by crosslinking various high-molecular-weight compounds with this derivative.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: June 22, 2010
    Assignees: National Institute for Materials Science, Furuuchi Chemical Corporation
    Inventors: Tetsushi Taguchi, Hisatoshi Kobayashi, Junzo Tanaka, Hirofumi Saito
  • Patent number: 7722895
    Abstract: Described are osteogenic implants that include a first implant material covered at least in part by a second implant material carrying an osteogenic protein such as a bone morphogenic protein. The first implant material can comprise a mineral and provide an inner scaffolding portion for supporting bone ingrowth, and the second implant material can comprise a collagen or other sponge carrier covering the first implant material and having a liquid osteogenic protein formulation imbibed therein. Related implant materials and methods of preparation and use constitute additional aspects of the invention.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: May 25, 2010
    Inventors: William F. McKay, Scott D. Boden, Neil Beals
  • Patent number: 7723291
    Abstract: A pump to deliver bone-growth factors to a carrier matrix within a patient. Pump can be internal or external. With external pumps, additional amounts of the same growth factor may be added, or the bioactive agent may be changed during the course of treatment. An external pump permits the use of cells to promote bone growth. The pump can have several reservoirs and the pump can itself be received in the carrier matrix with an outlet tube or other structure to defuse the growth factors into the carrier matrix. The pump protocol can be used for slow-to-heal fractures, such as closed fractures, and can be used for slow-to-heal patients.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: May 25, 2010
    Inventors: Neil Beals, Jeffrey L. Scifert, Vanja M. King
  • Patent number: 7629384
    Abstract: The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient quantity to the skin. A hostile biophysical agent may be combined with the L-arginine to increase its absorption into the skin. The desired concentrations of the hostile biophysical agent is increased when concentration of L-arginine is less than 20% of the concentration of the substance applied to maximize its effect.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: December 8, 2009
    Assignee: Strategic Science & Technologies, LLC
    Inventor: Eric T. Fossel
  • Patent number: 7534451
    Abstract: Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: May 19, 2009
    Assignee: Orthovita, Inc.
    Inventors: Erik M. Erbe, Theodore D. Clineff, Charanpreet S. Bagga, Gina M. Nagvajara, Antony Koblish
  • Patent number: 7531004
    Abstract: A pliable bone restorative having an osteoconductive foam that at least partially surrounds a biocompatible mesh and the foam comprises a biocompatible, resorbable polymer and calcium phosphate.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: May 12, 2009
    Assignee: Orthovita, Inc.
    Inventors: Charanpreet S. Bagga, Antony Koblish, Erik M. Erbe, Theodore D. Clineff, Steven B. Brown, Gina M. Nagvajara
  • Patent number: 7468195
    Abstract: A skin treatment preparation including carriers, a medicinal vector encapsulating a plant extract (Cucumis melo protein extract) rich in reductase, catalase and superoxide dismutase is characterized in that the medicinal vector, of nanospheres, represents 1 to 20 wt. % of the weight of the preparation; and the encapsulated plant extract represents 5 to 15 wt. % of the weight of the nanospheres; and the encapsulated plant extract may have the following enzymatic concentrations: reductase between 100 and 1000 IU, catalase between 100 and 1000 IU, and superoxide dismutase between 500 and 5000 IU. The preparation is useful for limiting depigmentation and reducing inflammatory front in vilitigo pathology and possible repigmentation.
    Type: Grant
    Filed: May 4, 2007
    Date of Patent: December 23, 2008
    Assignee: Crawford Healthcare Limited
    Inventor: Christian Diehl
  • Patent number: 7410947
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: August 12, 2008
    Assignee: Stryker Corporation
    Inventors: David C. Rueger, Marjorie M. Tucker
  • Patent number: 7374774
    Abstract: The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: May 20, 2008
    Assignee: Virginia Commonwealth University Intellectual Property Foundation
    Inventors: Gary L. Bowlin, Gary E. Wnek, David G. Simpson
  • Patent number: 7358284
    Abstract: A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof.
    Type: Grant
    Filed: January 20, 2005
    Date of Patent: April 15, 2008
    Assignee: LifeCell Corporation
    Inventors: Edward S. Griffey, Stephen A. Livesey, Charles M. Schiff, Lawrence E. Boerboom
  • Patent number: 7241740
    Abstract: The present invention relates to compositions comprising excipients or solubilizing agents for proteins. The invention relates to the discovery that a peptide derived from the N-terminus extension of the T266 isoform of rhBMP-2 has properties that enhance the solubility of proteins. The invention also relates to methods of resolubilizing a protein that has precipitated, by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2. The invention also relates to methods of increasing the solubility of a protein by contacting the protein with a peptide comprised of the 17 amino acid extension of the T266 isoform of rhBMP-2.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: July 10, 2007
    Assignee: Wyeth
    Inventors: Pilarin E.L. Nichols, Bernardo Perez-Ramirez
  • Patent number: 7235527
    Abstract: A protein consisting of the amino acid sequence in SEQ ID No: 1 derived from human MP52 and a homodimer protein thereof useful for treating cartilage and/or bone diseases and a process for its preparation.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: June 26, 2007
    Assignee: Biopharm Gesellschaft zur Biotechnologieschen Entwicklung Von Pharmaka mbH
    Inventors: Fusao Makishima, Hiroyuki Takamatsu, Hideo Miki, Shinji Kawai, Michio Kimura, Tomoaki Matsumoto, Mieko Katsuura, Koichi Enomoto, Yusuke Satoh
  • Patent number: 7217691
    Abstract: Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: May 15, 2007
    Assignee: Genetics Institute, LLC
    Inventors: Elizabeth Wang, John M. Wozney, Vicki A. Rosen
  • Patent number: 7189263
    Abstract: Biocompatible bone graft material having a biocompatible, resorbable polymer and a biocompatible, resorbable inorganic material exhibiting macro, meso, and microporosities.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: March 13, 2007
    Assignee: Vita Special Purpose Corporation
    Inventors: Erik M. Erbe, Theodore D. Clineff, Charanpreet S. Bagga, Gina M. Nagvajara, Antony Koblish
  • Patent number: 7129209
    Abstract: The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bis(sulfosuccinimidyl)suberate, and dithiobis(succinimidyl)propionate. Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: October 31, 2006
    Assignee: Angiotech Pharmaceuticlas (US), Inc.
    Inventor: Woonza M. Rhee
  • Patent number: 7084082
    Abstract: The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fiber
    Type: Grant
    Filed: June 7, 1999
    Date of Patent: August 1, 2006
    Assignee: Tapic International Co., Ltd.
    Inventor: Yasuhiko Shimizu
  • Patent number: 7041641
    Abstract: Disclosed herein are improved osteogenic devices and methods of use thereof for repair of bone and cartilage defects. The devices and methods promote accelerated formation of repair tissue with enhanced stability using less osteogenic protein than devices in the art. Defects susceptible to repair with the instant invention include, but are not limited to: critical size defects, non-critical size defects, non-union fractures, fractures, osteochondral defects, subchondral defects, and defects resulting from degenerative diseases such as osteochondritis dessicans.
    Type: Grant
    Filed: March 20, 1997
    Date of Patent: May 9, 2006
    Assignee: Stryker Corporation
    Inventors: David C. Rueger, Marjorie M. Tucker
  • Patent number: 6962979
    Abstract: The present invention discloses novel crosslinked biomaterial compsotions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bix(sulfosuccinimidyl) suberate, and dithiobis(succinimidylpropionate). Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: November 8, 2005
    Assignee: Cohesion Technologies, Inc.
    Inventor: Woonza M. Rhee
  • Patent number: 6933326
    Abstract: A method of processing an acellular tissue matrix to give a particulate acellular tissue matrix includes: cutting sheets of dry acellular tissue matrix into strips; cryofracturing the dry acellular tissue matrix strips at cryogenic temperatures; separating the resulting particles by size at cryogenic temperatures; and freeze drying the fraction of particles desired size to remove any moisture that may have been absorbed to give a dry particulate acellular tissue matrix. Rehydration of the dry particulate acellular tissue matrix may take place just prior to use. The particulate acellular tissue may be applied to a recipient site, by way of injection, spraying, layering, packing, in-casing or combinations thereof.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: August 23, 2005
    Assignee: LifeCell Coporation
    Inventors: Edward S. Griffey, Stephen A. Livesey, Charles M. Schiff, Lawrence E. Boerboom
  • Patent number: 6821530
    Abstract: The invention relates to methods of treating mixtures containing polymeric materials, e.g., collagen, to form a polymer that intercalates into the polymeric material. The treatment provides greater tensile strength to the mixture, among other advantages. The polymer is formed of a monomeric unit having at least one catechol group that is oxidized to a quinone upon polymerization.
    Type: Grant
    Filed: May 19, 2003
    Date of Patent: November 23, 2004
    Assignee: Shriners Hospitals for Children
    Inventors: Thomas J. Koob, Daniel J. Hernandez
  • Patent number: 6797260
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: September 28, 2004
    Inventor: Terence Prevendar
  • Patent number: 6752834
    Abstract: The invention provides a multi-layer membrane comprising a matrix layer predominantly of collagen II and having an open sponge-like texture, and at least one barrier layer having a close, relatively impermeable texture. Such a membrane is particularly suitable for use in guided tissue regeneration, in particular for use in vivo in the reconstruction of bone or cartilage tissue.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: June 22, 2004
    Assignee: Ed Geistlich Soehne AG Fuer Chemische Industrie
    Inventors: Peter Geistlich, Zdenek Eckmayer, Lothar Schlösser
  • Patent number: 6710083
    Abstract: A method of treating palmar and plantar fibromatosis is disclosed. The method includes administering to a patient of a therapeutically effective amount of a composition comprising 13-cis-retinoic acid. Preferably, the treatment method includes administering to a patient of an initial dosage of a composition comprising 13-cis-retinoic acid for an initial treatment period, and thereafter administering a maintenance dosage of the composition.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: March 23, 2004
    Inventor: L. Dean Parks
  • Patent number: 6679918
    Abstract: The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physical properties, wherein the composition of the material includes collagen and water. The present invention also provides a method for using the implantable putty material.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: January 20, 2004
    Assignee: Centerpulse Biologics Inc.
    Inventors: James J. Benedict, Christopher J. Damien
  • Patent number: 6652840
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 25, 2003
    Inventor: Terence Prevendar
  • Patent number: 6576249
    Abstract: A method for the preparation of bone gel and bone putty which comprises producing a viscous supernatant by dissolving demineralized bone matrix in water or a solution comprising water and at least one component normally found in human blood serum, at a temperature above about 25° C. Agitation and/or ultrasound or pressure accelerates dissolution of the demineralized bone. The resulting viscous supernatant is cooled, then mixed with demineralized or non-demineralized bone matrix particles to form a gel-like suspension or putty-like material.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: June 10, 2003
    Inventors: El Gendler, Eli Gendler, Simon Gendler
  • Patent number: 6548080
    Abstract: The invention is directed toward a sterile bone structure for application to a bone defect site to promote new bone growth at the site comprising a partially demineralized cortical bone structure, said bone structure comprising a cross sectional surface are ranging from 85% to 95% of the original bone surface area before demineralization with the remaining partially demineralized cortical bone structure having an outer demineralized layer ranging in thickness from about 0.05 mm to about 0.14 mm and a mineralized core.
    Type: Grant
    Filed: April 18, 2002
    Date of Patent: April 15, 2003
    Assignee: Musculoskeletal Transplant Foundation
    Inventors: Arthur A. Gertzman, Moon Hae Sunwoo
  • Patent number: 6468514
    Abstract: The use of one or more cosurfactants (surfactant B) in a mixture with one or more surfactants different from surfactant B (surfactant A) for reducing the binding of surfactant A to the surface of the skin.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: October 22, 2002
    Assignee: Beiersdorf AG
    Inventors: Robert Schmucker, Martin Sugár
  • Patent number: 6454787
    Abstract: A hemostatic device formed of collagen particles and methods for producing and using the hemostatic device to control bleeding are provided. The collagen particles of the hemostatic device have a hemostatic activity that is equivalent to the hemostatic activity of the collagen particles from which the hemostatic device is formed. More preferably, the hemostatic devices are formed of Avitene® flour and the collagen particles of the hemostatic devices of the invention have a hemostatic activity equivalent to the hemostatic activity of Avitene® flour. The hemostatic devices optionally include hemostatic agents and/or therapeutic agents, to further promote hemostasis and wound healing.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: September 24, 2002
    Assignee: C. R. Bard, Inc.
    Inventors: Francis B. Maddalo, Mark V. Iampietro, Stephen N. Eldridge, Robert D. Torgerson
  • Patent number: 6448378
    Abstract: Disclosed herein are collagen films which rapidly dissolve at 35° C. Also disclosed are methods for the preparation of the collagen films and their use as a vehicle for delivering a dose of therapeutic compound to a specific tissue site.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: September 10, 2002
    Inventors: Dale P. DeVore, Richard A. Eiferman, Edwin U. Keates
  • Publication number: 20020068103
    Abstract: A constitution improving agent for horses comprising collagen, preferably in combination with a proanthocyanidin.
    Type: Application
    Filed: October 10, 2001
    Publication date: June 6, 2002
    Applicant: Kikkoman Corporation
    Inventors: Nobushige Ishida, Makoto Saito, Norikazu Fujii, Shoichi Tokutake
  • Patent number: 6387391
    Abstract: This invention provides a claycy and sticky substance as a new biomaterial that cannot be found in the current medical field, which is bioresorbable, shows tackiness, plasticity and shape holding ability at a temperature of approximately from 30 to 40° C. and can give unrestricted shapes at body temperature or more by increasing its fluidity. This clayey and sticky substance comprises a copolymer of two or more bioresorbable monomers, preferably any one of copolymers of p-dioxanone with D-lactic acid, L-lactic acid, D,L-lactic acid, trimethylene carbonate and &egr;-caprolactone, or a mixture of two or more of these copolymers. This clayey and sticky or clayey substance is suited for a hemostatic material, an adhesive material for tissues, a prosthetic material for tissue reconstruction use, a carrier of drug delivery system, a plugging material, an accretion-preventing material and a scaffold material for tissue engineering use.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: May 14, 2002
    Assignee: Takiron Co., Ltd.
    Inventors: Yasuo Shikinami, Hiroyuki Kawarada, Chika Nishi