Anesthetic, Topical Patents (Class 514/817)
  • Patent number: 8822416
    Abstract: This invention concerns a synergistic combination of a topical anesthetic and wound barrier forming agent capable of providing extended analgesia of ‘significant open wounds’ (that being, for example, a laceration, surgical incision, abrasion, ulcer or burn, but not being a minor cut, scratch, sting, burn or abrasion) in which conventional management alternatives (such as suturing and/or administration of injected or systemic analgesia) are impractical, unaffordable or otherwise unavailable.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: September 2, 2014
    Assignee: Animal Ethics Pty Ltd.
    Inventors: Meredith Sheil, Allan Giffard, Charles Robert Olsson
  • Patent number: 8822410
    Abstract: The present invention provides compositions and methods for noninvasive delivery of therapeutic agents across an intact tympanic membrane. For example, the compositions include a penetration enhancer which increases the flux of a therapeutic agent (e.g., antibiotic) across the tympanic membrane. Such compositions are particularly useful in the treatment of otitis media. Additionally, the composition may include a sustained release agents that, in some embodiments form sustained release reservoirs, in situ, once administered to a patient.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: September 2, 2014
    Assignees: Children's Medical Center Corporation, Massachusetts Institute of Technology
    Inventors: Emmanuel John Simons, Todd R. Hoare, Daniel S. Kohane, Robert S. Langer
  • Patent number: 8652443
    Abstract: Described are ethanol-free foamable microemulsions for topical application, and method of making them. The propellants used in the compositions may be environmentally-friendly hydrofluoroalkanes. The foam compositions may also comprise one or more of a variety of active ingredients, including anti-inflammatory agents, anesthetics, and keratolytic agents.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: February 18, 2014
    Assignee: Precision Dermatology, Inc.
    Inventors: Ravi K. Varanasi, Roman V. Rariy
  • Patent number: 8603984
    Abstract: This invention provides methods of controlling pain in a canine comprising transdermally administering a composition comprising fentanyl, a penetration enhancer, and a volatile liquid, wherein the composition is a solution. The invention also provides a single unit dose of the composition.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: December 10, 2013
    Assignee: Eli Lilly and Company
    Inventors: Garret Conrad Newbound, Terrence Patrick Clark
  • Patent number: 8241660
    Abstract: This invention relates to a patch for the expulsion of insect poison from the skin after stings from membranous insects (Hymenoptera). The patch is characterized in comprising a poison-aspirating matrix comprising an expulsion agent as well as a swell layer, which swells after the addition of a liquid through a hole on the top of the patch and thus adds a light pressure to the poison-aspirating matrix towards the skin, whereby a local and relieving effect is achieved. In one embodiment, the matrix further comprises a local anesthetic. The expulsion agent is e.g. a carbohydrate. The swell layer consists e.g. of a silica gel.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: August 14, 2012
    Inventor: Martin Wenckens
  • Patent number: 7989496
    Abstract: A topical or transdermal composition including a polar derivative of ketoprofen and a pharmaceutically acceptable topical or transdermal carrier, wherein the polar derivative of ketoprofen comprises a polarity that is greater than that of ketoprofen.
    Type: Grant
    Filed: October 25, 2007
    Date of Patent: August 2, 2011
    Assignee: Noven Pharmaceuticals, Inc.
    Inventors: Rod Hartwig, David Houze
  • Patent number: 7833542
    Abstract: A method and composition for treating healed wounds including hypertrophic scars so as to prevent scarring or reduce the size and improve the appearance of scars comprises applying to the healed wound or scar a composition comprising a fluid, film-forming carrier which may contain one or more active topical ingredients, the carrier hardening to a solid, tangible, membrane juxtaposed to the skin. Novel compositions using the film-forming carrier are also useful to treat a variety of adverse skin disorders, and internal physiological conditions.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: November 16, 2010
    Inventor: Joel R. Studin
  • Patent number: 7820688
    Abstract: Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important function in providing peripheral pain relief. Topical administration of pain-relieving drugs to the periphery offers important advantages over systemic or local, non-topical administration. The present invention provides topical pharmaceutical compositions, formulated with at least one local anesthetic and at least one opioid analgesic in a topical excipient. The present invention also provides methods for relieving pain in a subject through topical administration of the pharmaceutical composition in an amount and a duration sufficient to synergistically potentiate an antinociceptive response. Synergistic potentiation of analgesia through topical administration of a local anesthetic/opioid pharmaceutical composition provides a new and improved approach to peripheral pain management.
    Type: Grant
    Filed: April 13, 2004
    Date of Patent: October 26, 2010
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Gavril Pasternak, Yuri Kolesnikov
  • Patent number: 7731983
    Abstract: A method and composition for treating healed wounds including hypertrophic scars so as to prevent scarring or reduce the size and improve the appearance of scars comprises applying to the healed wound or scar a composition comprising a fluid, film-forming carrier which may contain one or more active topical ingredients, the carrier hardening to a solid, tangible, membrane juxtaposed to the skin. Novel compositions using the film-forming carrier are also useful to treat a variety of adverse skin disorders, and internal physiological conditions.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: June 8, 2010
    Inventor: Joel R. Studin
  • Patent number: 7666914
    Abstract: Disclosed herein is a preparation for topically delivering and localizing therapeutic agents, comprising: a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; and a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Further disclosed is an associated method of topically delivering and localizing therapeutic agents, comprising the steps of: using a vasoconstrictor for retarding vascular dispersion of a therapeutic agent; in combination with using a penetration enhancer for facilitating penetration of the vasoconstrictor and the therapeutic agent through a patient's skin. Also disclosed are various courses of treatment which comprise applying the various disclosed combinations of agents to the patient's skin.
    Type: Grant
    Filed: June 3, 2004
    Date of Patent: February 23, 2010
    Inventors: David M. Richlin, George R. Doherty
  • Patent number: 7157106
    Abstract: Topical analgesics, generally comprising calendula oil and cornmint oil, and methods of use.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: January 2, 2007
    Inventor: Roger S. Salmonson
  • Patent number: 7090866
    Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (? receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: August 15, 2006
    Assignee: R.P. Scherer Technologies, Inc.
    Inventors: Edward Stewart Johnson, Jon Lacy
  • Patent number: 7041705
    Abstract: Irritation upon injection of a formulation containing propofol is reduced or substantially eliminated by administering a stable, sterile, and antimicrobial aqueous dispersion comprising a water-insoluble microdroplet matrix of mean diameter from about 50 nm to about 1000 nm consisting essentially of about 1% to about 15% of propofol, up to about 7% of a propofol-soluble diluent, and about 0.8% to about 4% of a surface stabilizing amphiphilic aent. The aqueous phase includes a pharmaceutically acceptable water-soluble polyhydroxy tonicity modifier. The propofol-containing dispersion is devoid of additional bactericidal or bacteriostatic preservative agents.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: May 9, 2006
    Assignee: Jagotec AG
    Inventors: Awadhesh K. Mishra, Gary W. Pace, Michael G Vachon
  • Patent number: 7029711
    Abstract: A transcutaneous pain relief composition for applying to the skin, comprising a mixture of dimethyl sulfoxide, stearic acid, emulsifying wax, glycerine, emu oil, sal butter, glucosamine, coconut oil, white beeswax, active calendula oil, slippery elm oil, Chamomile oil, arnica Oil, valenrian oil, peppermint oil, grapefruit seed extract, lavender oil and distilled water is disclosed.
    Type: Grant
    Filed: December 9, 2003
    Date of Patent: April 18, 2006
    Inventor: Shannon Lynn Farrell
  • Patent number: 7030100
    Abstract: Several lines of evidence have shown a role for the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway in the development of spinal hyperalgesia. However, the roles of effectors for cGMP are not fully understood in the processing of pain in the spinal cord. cGMP-dependent protein kinase (PKG) I? but not PKGI? was localized in the neuronal bodies and processes, and was distributed primarily in the superficial laminae of the spinal cord. Intrathecal administration of an inhibitor of PKGI?, Rp-8-[(4-Chlorophenyl)thio]-cGMPS triethylamine, produces significant antinociception. Moreover, PKGI? protein expression was dramatically increased in the lumbar spinal cord after noxious stimulation. This upregulation of PKGI? expression was completely blocked not only by a neuronal NO synthase inhibitor, and a soluble guanylate cyclase inhibitor, but also by an N-methyl-D-aspartate (NMDA) receptor antagonist, MK-801.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: April 18, 2006
    Assignee: Johns Hopkins University
    Inventors: Yuanxiang Tao, Roger A. Johns
  • Patent number: 6946145
    Abstract: Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: September 20, 2005
    Assignee: A.P. Pharma, Inc.
    Inventors: Steven Y. Ng, Jorge Heller
  • Patent number: 6921541
    Abstract: A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: July 26, 2005
    Assignee: Euro-Celtique S.A.
    Inventors: Mark Chasin, Paul Goldenheim, Richard Sackler, Joseph Tigner, Ronald M Burch
  • Patent number: 6894078
    Abstract: A method for applying a topical anesthetic to an area of skin comprising the steps of a) incorporating an anesthetic in a lipophilic base into a volatile solvent, to form a homogeneous solution; b) applying the homogeneous solution into the area of skin to be treated; and c) evaporating the volatile solvent from the homogeneous solution; wherein the volatile solvent is present in the formulation in amounts between 40-80%; and wherein said topical anesthetic rapidly penetrates the skin surface at said skin, leaving a cooling sensation on the skin. The topical anesthetic formulation contains a penetrating enhancer carrier that markedly enhances the delivery of the anesthetic across human skin without altering the acceptable delivery rate of the anesthetic that needs to be delivered through the skin and leaves a cooling sensation on the skin.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: May 17, 2005
    Inventor: James G. Castillo
  • Patent number: 6881756
    Abstract: The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol or a pharmaceutically-acceptable ester thereof.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: April 19, 2005
    Assignee: Johnson & Johnson Consumer Companies, Inc.
    Inventor: Gerard J. Gendimenico
  • Patent number: 6825234
    Abstract: The invention provides compositions and methods suitable for ameliorating female sexual dysfunction, and in particular, female sexual arousal disorder. In one embodiment, the invention provides a semisolid composition suitable for topical application comprising: an effective amount of a vasoactive prostaglandin, a polysaccharide thickener, a lipophilic component, and an acidic buffer system.
    Type: Grant
    Filed: July 2, 2002
    Date of Patent: November 30, 2004
    Assignee: NexMed (Holdings) , Inc.
    Inventors: James L. Yeager, Nadir Büyüktimkin, Servet Büyüktimkin
  • Patent number: 6797260
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: September 28, 2004
    Inventor: Terence Prevendar
  • Patent number: 6790855
    Abstract: Many chemical and pharmaceutical compositions are known to produce antinociceptive effects that are helpful in relieving pain and inflammation. Both opioids and local anesthetics serve an important function in providing peripheral pain relief. Topical administration of pain-relieving drugs to the periphery offers important advantages over systemic or local, non-topical administration. The present invention provides topical pharmaceutical compositions, formulated with at least one local anesthetic and at least one opioid analgesic in a topical excipient. The present invention also provides methods for relieving pain in a subject through topical administration of the pharmaceutical composition in an amount and a duration sufficient to synergistically potentiate an antinociceptive response. Synergistic potentiation of analgesia through topical administration of a local anesthetic/opioid pharmaceutical composition provides a new and improved approach to peripheral pain management.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: September 14, 2004
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: Gavril Pasternak, Yuri Kolesnikov
  • Patent number: 6780426
    Abstract: The present invention features methods and apparatus'for improving administration of drugs through the use of specifically controlled heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
    Type: Grant
    Filed: November 27, 2002
    Date of Patent: August 24, 2004
    Assignee: Zars, Inc.
    Inventors: Jie Zhang, Hao Zhang
  • Patent number: 6774131
    Abstract: A pharmaceutical composition for therapeutically treating prostate cancer, the pharmaceutical composition containing N-[6-methoxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyri midinyl]-2-phenylethenesulfoneamide or a pharmaceutically acceptable salt thereof as the effective component.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: August 10, 2004
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Hironori Yuyama, Akira Fujimori, Masanao Sanagi, Hironori Harada, Akiko Koakutsu, Mikiko Mori, Nobuyuki Yamamoto
  • Patent number: 6737068
    Abstract: The present invention relates to a liquid formulation for a feminine wipe. The preferred formulation has an anti-irritant agent, a pH adjuster namely citric acid, and at least one preservative.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: May 18, 2004
    Assignee: Playtex Products, Inc.
    Inventor: Catherine Durden
  • Patent number: 6733794
    Abstract: A composition for topical analgesic and antiseptic use which consists essentially of a approximately equal proportions of alcohol, turpentine, and eucalyptus oil.
    Type: Grant
    Filed: December 17, 1999
    Date of Patent: May 11, 2004
    Inventors: Edward L. Ingram, Mary Scott
  • Patent number: 6713527
    Abstract: The invention relates to surgical bone cement compositions and more particularly to bone cement compositions having aneasthetic properties, and to methods for producing analgesia.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: March 30, 2004
    Assignee: Queen's University at Kingston
    Inventors: David M. Bond, John F. Rudan, Michael A. Adams
  • Patent number: 6709663
    Abstract: A topical delivery composition which employs a multivesicular emulsion in combination with a pharmaceutically/pharmacologically active agent is disclosed. The multivesicular emulsion is formed from a quaternary amine salt emulsifier such as behentrimonium methosulfate. The emulsion is multi-lamellar which is a series of concentric spheres or vesiculars of oil and water phase that can be seen microscopically. As a result, the active is time released over a sustained period rather than spike released as is common with most topicals.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: March 23, 2004
    Assignee: HealthPoint, Ltd.
    Inventor: Robert Espinoza
  • Patent number: 6689339
    Abstract: A carbon dioxide-containing viscous composition wherein carbon dioxide bubbles are retained in an aqueous viscous composition. Use of the composition makes it possible to treat or ameliorate itching accompanying mucocutaneous diseases or mucocutaneous disorders, mucocutaneous injury, dental diseases, skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders, musculoskeletal diseases, nervous system diseases, keratosis, constipation, unwanted hair re-growing after depilation, cosmetic troubles in the skin or hair, partial obesity, etc. while exerting little side effects.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: February 10, 2004
    Assignee: Medion Research Laboratories Inc.
    Inventors: Masaya Tanaka, Masato Hiki
  • Patent number: 6680071
    Abstract: This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (&mgr;receptor) agonist, such as fentanyl, or a salt thereof, characterized in that the composition is in the form of a fast-dispersing dosage form designed to release the active ingredient rapidly in the oral cavity. A process for preparing such a composition and the use of such a composition as an analgesic, for the treatment of chronic pain and/or breakthrough pain, as an anesthetic premedication, for the induction of anesthesia, as a sedative and/or for the treatment of anxiety are also provided.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: January 20, 2004
    Assignee: R. P. Scherer Technologies, Inc.
    Inventors: Edward Stewart Johnson, Jon Lacy
  • Patent number: 6652840
    Abstract: A composition is disclosed which has been shown to stop or control bleeding and seal open small blood vessels while accelerating the healing process of abraded oral “gum” and other “skin” (epithelial) tissues. The composition is preferably in the form of a paste which promotes ease of application and use of the composition. A variety of instruments can be used in application and cleanup of the composition showing versatile unparalleled friendly usage. The composition preferably comprises aluminum chloride, ferric sulfate (subsulfate), regenerated oxidized cellulose, aluminum ammonium sulfate, absorbable gelatin and a solvent. The composition has many dental and medical procedure applications.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: November 25, 2003
    Inventor: Terence Prevendar
  • Patent number: 6638966
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Grant
    Filed: February 19, 2002
    Date of Patent: October 28, 2003
    Assignee: University of Iowa Research Foundation
    Inventors: Max T. Baker, Mohamed Naguib Attala
  • Patent number: 6638981
    Abstract: Topical compositions and methods for treating pain. The invention provides oil-in-water emulsions comprising an antidepressant; an NMDA-receptor antagonists; a lipophilic component; water; and a surfactant. The compositions induce a local-anesthetic effect when topically administered to intact skin thereby treating or preventing pain, for example, neuropathic pain.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: October 28, 2003
    Assignee: EpiCept Corporation
    Inventors: Robert O. Williams, Feng Zhang
  • Patent number: 6613350
    Abstract: Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.
    Type: Grant
    Filed: April 7, 2000
    Date of Patent: September 2, 2003
    Assignee: Zars, Inc.
    Inventors: Jie Zhang, Hao Zhang
  • Patent number: 6599513
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 29, 2003
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6593370
    Abstract: A topical capsaicin preparation for the treatment of painful cutaneous disorders and neural dysfunction is disclosed. The preparation contains a nonionic, amphoteric or cationic surfactant in an amount effective to eliminate or substantially ameliorate burning pain caused by capsaicin.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: July 15, 2003
    Assignee: Maruishi Pharmaceutical Co., Ltd.
    Inventors: Takashi Tamura, Urao Kawakami, Yuichi Teratani, Masakazu Yoshimura, Masahiko Seto
  • Patent number: 6582710
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: June 24, 2003
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6579543
    Abstract: A composition for topical application to an animal's skin for relief from a variety of symptoms caused by medical conditions or physical injuries. The composition includes at least one compound having analgesic activity, at least one compound having anti-inflammatory activity, at least one compound having antioxidant activity, at least one compound having anti-neuralgic activity, at least one compound having blood circulation promotion activity, and at least one compound having antidepressant activity. A method for relieving pain by topical application of the composition is also provided.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: June 17, 2003
    Inventor: Jackie H. McClung
  • Patent number: 6562855
    Abstract: A pharmaceutical composition is described. The composition comprises a formulation. The formulation comprises an NMDA antagonist and an alpha-2 adrenergic agonist. In a preferred aspect, there is provided an improved anaesthetic comprising an NMDA antagonist and an alpha-2 adrenergic agonist.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: May 13, 2003
    Inventors: Nicholas Peter Franks, Mervyn Maze
  • Patent number: 6562326
    Abstract: A method of treating skin includes applying a topical composition to an affected area of skin, such as a burn, irritation, blister, rash or other similar skin condition. The topical composition has as the active ingredients an anesthetic and a surfactant. The anesthetic is preferably tetracaine in a concentration of from about 1% to 2% by weight and the surfactant is preferably sodium lauryl sulfate in a concentration of from about 0.5% to about 5.0% by weight.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: May 13, 2003
    Inventor: Bruce W. Miller
  • Patent number: 6552064
    Abstract: Melatonin (N-acetyl-5-methoxytryptamine), or its biologically active analogues, are used to induce anesthesia.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: April 22, 2003
    Assignee: University of Iowa Research Foundation
    Inventor: Mohamed Naguib Attala
  • Patent number: 6534048
    Abstract: An aqueous gel in unit dose form and suitable for topical delivery of clonidine and comprising clonidine, a water-gelling amount of a pharmaceutically acceptable gelling agent and having a pH value in the range of about 6 to about 8.5. Clonidine is present in an amount in the range of about 0.05 to about 3.5 milligrams per unit dose and at a concentration in the range of about 0.01 to about 0.5 weight percent.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: March 18, 2003
    Assignee: Curatek Pharmaceuticals Holding, Inc.
    Inventor: Robert J. Borgman
  • Patent number: 6528086
    Abstract: This invention relates to an apparatus and method of drug delivery on a human body surface. The formulation comprises a drug, a conversion agent capable of converting the formulation from a less solid phase to a coherent, soft, solid phase, and a vehicle medium or carrier for the drug and conversion agent. The drug formulation is applied to this human body surface in its less than solid phase and is subsequently converted to a soft solid phase while the drug is being delivered through the human body surface. After delivery of the drug is complete, the soft solid formulation can be removed or peeled from the body surface as a coherent solid formulation. The drug formulation provides control over drug delivery rates and allows the formulation to be removed without leaving a messy, residual formulation on the body surface.
    Type: Grant
    Filed: September 28, 1999
    Date of Patent: March 4, 2003
    Assignee: Zars, Inc.
    Inventor: Jie Zhang
  • Patent number: 6521259
    Abstract: A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when inplanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.
    Type: Grant
    Filed: March 10, 2000
    Date of Patent: February 18, 2003
    Assignee: Euro-Celtique S.A.
    Inventors: Mark Chasin, Richard Sackler, Ronald M. Burch, Paul Goldenheim, Joseph Tigner
  • Patent number: 6509028
    Abstract: Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption. The compositions of the invention are particularly suitable for application to the mucous membrane of the nasal cavity and buccal cavity. To relieve pain, the compositions or the invention are topically applied directly to the affected area.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: January 21, 2003
    Assignee: EpiCept Corporation
    Inventors: Robert O. Williams, Feng Zhang, John J. Koleng, Gavril W. Pasternak, Yuri A. Kolesnikov
  • Patent number: 6506802
    Abstract: Novel disulfide derivatives useful for preventing or treating allergic diseases of the eye, nose, skin, ear, gastrointestinal tract, airways or lung and preventing or treating manifestations of systemic mastocytosis are disclosed. The disulfide derivatives act as mast cell stabilizers.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: January 14, 2003
    Assignee: Alcon Universal Ltd.
    Inventors: Zixia Feng, Mark R. Hellberg, Steven T. Miller
  • Patent number: 6461600
    Abstract: A cream carrier is provided which has use as a cream-type carrier for topical delivery of medicaments including analgesics. The carrier comprises a mixture of: squalane NF, an emulsifier such as Tween 80, glycerin, cetyl alcohol NF, glyceryl monostearate, lecithin organogel preserved, BHT, urea USP, EDTA, water, stearic acid, simethicone USP, and ethoxy diglycol reagent. The invention also comprises a combination of the carrier, with either or both of ketamine hydrochloride and amitriptyline hydrochloride, which has use as a topically applied analgesic.
    Type: Grant
    Filed: July 12, 2001
    Date of Patent: October 8, 2002
    Inventor: Peter R. Ford
  • Patent number: 6429228
    Abstract: A local anesthetic for external use is prepared by blending a) an active ingredient selected from lidocaine, prilocaine, and pharmaceutically acceptable salts thereof; b) a percutaneous absorption accelerator, c) ethanol and/or isopropyl alcohol, and d) water, such that the blending ratio of ethanol and/or isopropyl alcohol to water is 0.5 to 1.2 by weight, and the pH is 6.0 to 8.5.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: August 6, 2002
    Assignee: Kowa Company, Ltd.
    Inventors: Toshio Inagi, Akira Mada
  • Patent number: RE38407
    Abstract: Liposome-encapsulated opioid analgesic agents delivered by the pulmonary route provide local, or systemic analgesia superior to that produced by the solution form of these agents administered by parentral (intravenous, intramuscular, or subcutaneous injection) or oral routes.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: January 27, 2004
    Assignee: Delex Therapeutics Inc.
    Inventors: Michael Mezel, Orlando Hung
  • Patent number: RE41998
    Abstract: Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an ?-1-adrenergic antagonist, ?-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: December 14, 2010
    Assignee: Arclon Therapeutics, Inc.
    Inventor: James N. Campbell