Antacid, Oral Patents (Class 514/819)
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Patent number: 5399356Abstract: A process for making a bismuth-containing solid dose form composition is described which includes an agglomeration step with binder in a high shear mixer.Type: GrantFiled: March 24, 1994Date of Patent: March 21, 1995Assignee: The Procter & Gamble CompanyInventors: Francis B. Chapura, Daniel L. Barone, Michael G. Colacino
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Patent number: 5360793Abstract: This invention is an antacid composition capable of forming a floating gelatinous mass when contacted with aqueous acid and consisting essentially of, as active ingredients, xanthan gum; an effective acid neutralizing amount of hexitol stabilized aluminum hydroxide and a gas producing material capable of producing a non-toxic gas when contacted with aqueous acid which may be formulated as a solid, powder, tablet or suspension.Type: GrantFiled: May 24, 1993Date of Patent: November 1, 1994Assignee: Sterling Winthrop Inc.Inventor: William J. Brooks
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Patent number: 5348745Abstract: The invention discloses an aqueous granulating solution containing sodium, potassium or mixed sodium potassium salt of an edible organic acid selected from the group consisting of citric, malic, tartaric and fumaric acid and optionally containing sodium or potassium bicarbonate. The granulating solution is especially useful for granulating finely divided solids including acetaminophen, ketoprofen or calcium carbonate. The resulting granulate may be used to prepare a swallow tablet or mixed with an edible organic acid and the mixture tableted to provide an effervescent tablet without resorting to controlled reaction or special handling techniques.Type: GrantFiled: May 5, 1992Date of Patent: September 20, 1994Assignee: Miles Inc.Inventor: Lawrence J. Daher
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Patent number: 5330760Abstract: A solid effervescent antacid formulation comprising as primary ingredients from about 35 to about 53 percent by weight of calcium carbonate, from about 0 to about 14 percent by weight of magnesium carbonate, from about 3.5 to about 7 percent by weight of a bicarbonate salt, from about 3.5 to about 7 percent by weight of malic acid and from about 21 to about 35 percent by weight of a bulking agent.Type: GrantFiled: August 27, 1992Date of Patent: July 19, 1994Assignee: Sterling Winthrop Inc.Inventor: William C. Walton
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Patent number: 5320852Abstract: A biconvex tablet whose height and diameter are approximately equal and are from 1.5 to 4 mm and which, besides conventional pharmaceutical auxiliaries, contains an antacid as active substance is described.Type: GrantFiled: December 8, 1992Date of Patent: June 14, 1994Assignee: Nordmark Arzneimittel GmbHInventor: Thomas Moest
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Patent number: 5288506Abstract: Antacid powders, tablets etc. of prolonged gastric residence time have an internal phase of a solid antacid and excipient surrounded by a solid external phase containing a hydrophobic substance e.g. an ester of glycerol with palmitic or stearic acid, a hydroxylated polyalkene and a non-ionic emulsifier.Type: GrantFiled: April 20, 1989Date of Patent: February 22, 1994Assignee: Walton S.A.Inventors: Robert G. W. Spickett, Jose L. F. Vidal, Juan C. Escoi
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Patent number: 5280017Abstract: A method of treating acid poisoning in mammals or of lowering blood cholesterol levels in mammals, which involves administering to the mammals a pharmaceutically effective amount of an aminated dextrin where amine groups or residues are present in an amount of from 0.5 to 2 groups per glucose unit.Type: GrantFiled: January 29, 1991Date of Patent: January 18, 1994Assignee: M L Laboratories PLCInventor: Donald S. Davies
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Patent number: 5273759Abstract: An oral composition comprising in combination acetaminophen, dimenhydrinate and one or more antacid ingredients has been shown to be effective in the treatment of acute migraine attacks.Type: GrantFiled: September 17, 1992Date of Patent: December 28, 1993Assignee: Lipopharm Inc.Inventor: Donald L. Simmons
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Patent number: 5272137Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water soluble pharmaceutical active, e.g. acetaminophen; a suspension stabilizing effective amount of xanthan gum and microcrystalline cellulose; an effective amount of taste masking compositions; and water, as well as a process for producing such aqueous pharmaceutical suspensions.Type: GrantFiled: February 14, 1992Date of Patent: December 21, 1993Assignee: McNeil-PFC, Inc.Inventors: Cynthia M. Blase, Manoj N. Shah
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Patent number: 5260304Abstract: Granules, possibly pressed into the form of tablets, contain at least one insoluble, complexed or slightly soluble active substance in powder form which can bind or neutralize acids and which does not react with the acid of the effervescent system, and an effervescent system consisting of at least one organic, edible acid and at least one alkali metal and/or alkaline earth metal carbonate and/or bicarbonate. The active substance is present in an amount of 5 to 50, preferably 8 to 30, in particular 12 to 25%, by weight. It has an acid binding power of 2 to 40, preferably 3.5 to 25, meq/g, does not react with the acid of the effervescent system and increases the pH in 0.1N HCl during 2 min by a maximum of 0.5. It consists in particular of magnesium trisilicate, sucralfate and/or a bismuth salt. Each granule contains at least one acid component, at least one carbonate component and at least one active substance bound to one another.Type: GrantFiled: March 6, 1992Date of Patent: November 9, 1993Inventors: Gerhard Gergely, Thomas Gergely, Irmgard Gergely
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Patent number: 5248505Abstract: This invention relates to a pharmaceutical composition for treating gastrointestinal distress comprising an effective amount of an antidiarrheal composition, e.g. loperamide, and an antiflatulent effective amount of simethicone and methods of treating gastrointestinal distress comprising administering such pharmaceutical compositions.Type: GrantFiled: March 17, 1992Date of Patent: September 28, 1993Assignee: McNeil-PPC, Inc.Inventor: Jeffrey L. Garwin
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Patent number: 5244670Abstract: Ingestible pharmaceutical compositions comprising pharmaceutical actives useful for treating upper gastrointestinal tract distress (e.g., antacid agents) and 3-1-menthoxy propane 1,2-diol in amounts effective for providing a cooling sensation to the throat.Type: GrantFiled: May 20, 1992Date of Patent: September 14, 1993Assignee: The Procter & Gamble CompanyInventors: James G. Upson, Carmelita M. Russell
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Patent number: 5229137Abstract: Pharmaceutical medications and methods are disclosed for providing instant and sustained relief from pain or symptoms associated with episodic heartburn in humans. The medications consist essentially of antacids and histamine H.sub.2 -receptor antagonists, and may be administered on an as-needed basis in liquid or solid dosage forms. Typical antacids which may be used in combination with the histamine H.sub.2 -receptor antagonist are conventional antacids which are well known and widely used in the treatment of excess acid related gastrointestinal dysfunctions. Exemplary of typical antacids include, sodium bicarbonate, calcium carbonate, magnesium hydroxide and aluminum hydroxide, as well as commercially available high potency, flavored antacids. Histamine H.sub.2 -receptor antagonists which may be used in combination include those conventionally used in the treatment of peptic ulcers, such as, for example, cimetidine, ranitidine, famotidine and nizatidine.Type: GrantFiled: May 6, 1992Date of Patent: July 20, 1993Assignee: Brigham and Women's Hospital, Inc.Inventor: M. Michael Wolfe
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Patent number: 5213794Abstract: The present invention relates to an antacid preparation having a prolonged gastric residence time, comprising an antacid active substance, calcium polycarbophil and a water-insoluble, anionic polymer.Type: GrantFiled: November 13, 1991Date of Patent: May 25, 1993Assignee: Bayer AktiengesellschaftInventors: Christian Fritsch, Franz Hausler, Jurgen Seedig
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Patent number: 5099068Abstract: The invention provides compounds of the general formula (I) ##STR1## and physiologically acceptable salts and solvates thereof, wherein AR represents the group ##STR2## where Q.sup.1 represents a straight or branched C.sub.1-3 alkylene group, ##STR3## where Q.sup.2 represents a group R.sup.3 CO--, R.sup.3 NHCO--, R.sup.3 R.sup.4 NSO.sub.2 --, or R.sup.5 SO.sub.2 --, where R.sup.3 and R.sup.4 each represent a hydrogen atom or a C.sub.1-3 alkyl group, and R.sup.5 represents a C.sub.1-3 alkyl group, ##STR4## R represents a hydrogen atom or a C.sub.1-3 alkyl group; R.sup.1 and R.sup.Type: GrantFiled: December 5, 1990Date of Patent: March 24, 1992Assignee: Glaxo Group LimitedInventors: William L. Mitchell, Ian F. Skidmore, Lawrence H. C. Lunts, Harry Finch, Alan Naylor, David Hartley
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Patent number: 5085869Abstract: A wet granulate is provided for therapeutically useful substances having a water solubility 10 wt % or less and microcrystalline or microfine cellulose or a mixture of both, where substantial amounts of wet binders are avoided.Tableting mixtures with the new granulate possess a good flow pattern and may be compressed to tablets which show an excellent disintegration behavior.Type: GrantFiled: February 24, 1989Date of Patent: February 4, 1992Assignee: Gist-Brocades N.V.Inventors: Margaretha Olthoff, Bernardus L. J. Dijkgraaf, Piet J. Akkerboom
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Patent number: 5073385Abstract: Discosed are (i) a boehmite-type aluminum hydroxide which is represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1; and (ii) a process for preparing a boehmite-type aluminum hydroxide represented by the formulaAlO(OH).xSO.sub.4.nH.sub.2 Owherein 0.01<.times.<0.10 and 0.ltoreq.n<1, the process comprising surface-treating a boehmite-type aluminum hydroxide with sulfuric acid or a sulfate capable of forming sulfuric acid by heating or by hydrolysis, the boehmite-type aluminum hydroxide to be treated being represented by the formulaAlO(OH).mH.sub.2 Owherein 0.ltoreq.m<1.Type: GrantFiled: November 13, 1989Date of Patent: December 17, 1991Assignee: Tomita Pharmaceutical Co., Ltd.Inventors: Takeshi Suzuki, Mineaki Kabayama
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Patent number: 5068109Abstract: The present invention relates to an antacid composition with floating properties, and a method of treating or alleviating upper gastrointestinal dyspeptic disorders.Type: GrantFiled: December 5, 1989Date of Patent: November 26, 1991Assignee: Farma Food A/SInventors: Jorgen Foldager, Helle Toftkjor, Kim Kjornos
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Patent number: 5013716Abstract: The present invention pertains to an unpleasant taste masking composition which comprises a flavoring agent having a bitter taste or unpleasant off-note and a sufficient amount of a non-bitter intense sweetener to nullify the taste or off-note of the flavoring agent. The unpleasant taste masking composition may be used in ingestible products such as hard and soft confections, chewing gum compositions and the like. The present invention also pertains to a method for preparing the unpleasant taste masking compositions and the ingestible products in which they may be used.Type: GrantFiled: October 28, 1988Date of Patent: May 7, 1991Assignee: Warner-Lambert CompanyInventors: Subraman R. Cherukuri, Lucy L. Wong, Steven M. Faust
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Patent number: 4891356Abstract: A method of treating gastrointgestinal ulcer disease is provided which involves administration of a proteinase inhibitor or analogue to patients suffering from same. Of particular interest is the use of inhibitors of serine, cysteine, carboxyl, and metallo proteinases.Type: GrantFiled: July 15, 1987Date of Patent: January 2, 1990Assignee: Brigham & Women's HospitalInventor: Sandor Szabo
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Patent number: 4842734Abstract: Essentially pure acidic amine ligand aluminum complexes useful as antacids are prepared by first reacting an acidic amine ligand with an aluminum alkoxide under anhydrous conditions to form an intermediate and further reacting the intermediate with water, these complexes are useful as antacids and as such in the treatment of hyperacidity.Type: GrantFiled: May 27, 1988Date of Patent: June 27, 1989Assignee: Warner-Lambert CompanyInventors: Arthur P. G. Wright, Betty P. L. Wen, Terry G. Schenck, Antonina Maron
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Patent number: 4822876Abstract: Essentially pure polyalcohol aluminum complexes useful as antacids are prepared by first reacting a polyalcohol with an aluminum alkoxide under anhydrous conditions to form an intermediate and further reacting the intermediate with water.Type: GrantFiled: December 2, 1986Date of Patent: April 18, 1989Assignee: Warner-Lambert CompanyInventors: Arthur P. G. Wright, Betty Pui Lan Wen, Terry G. Schenck, Antonina Maron
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Patent number: 4820708Abstract: This invention relates to 2- and 4-pyrimidinylmethylsulphinyl(and thio)benzimidazoles in which the pyrimidyl group is substituted by an optionally substituted amino group. These compounds inhibit exogenously and endogenously stimulated gastric acid secretion.Type: GrantFiled: July 22, 1988Date of Patent: April 11, 1989Assignee: Smith Kline & French LaboratoriesInventors: Robert J. Ife, Thomas H. Brown
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Patent number: 4790991Abstract: The present invention relates to an ingestible aggregate comprising a pre-swelled substantially anhydrous hydrocolloid and a substrate. More particularly this invention relates to an aggregate having as a substrate a dietary fiber and/or drug wherein the composition can be administered in a therapeutically effective amount. Hydrocolloids useful include natural and modified gums, celluloses, modified celluloses, pectins, mucillages, modified starches, noncellulose polysaccharides, algal polysaccharides and mixtures thereof. The aggregate should be in the size range of about 4 to about 70 U.S. mesh. The unpleasant taste and mouthfeel of the fiber and/or drug is effectively masked and substantial hydration is delayed until the compositions reaches the stomach. The compositions are substantially more palatable, devoid of graininess, bitterness or fibrous texture. The pleasant taste of the composition encourages patient compliance with their fiber or drug therapy.Type: GrantFiled: February 29, 1988Date of Patent: December 13, 1988Assignee: Warner-Lambert CompanyInventors: James J. Shaw, Shri C. Sharma
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Patent number: 4788180Abstract: A pharmaceutical composition comprises magnesium oxide, hydroxide or a non-toxic salt of magnesium in a slow-release carrier; this material may be combined with or co-prescribed with a diuretic or cardiac glycoside or adrenergic receptor blocking agent or a calcium antagonist for the treatment of hypertension or angina pectoris.Type: GrantFiled: November 26, 1984Date of Patent: November 29, 1988Inventor: Maurice Bloch
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Patent number: 4704269Abstract: Disclosed are water soluble effervescent antacid, analgesic powder and tablet formulations which in a preferred embodiment are sodium, sucrose and aspirin free. The formulation is administered through the ingestion of an aqueous solution of the powder or tablet.The powder and tablet formulations of this invention preferably comprise a therapeutically effective amount of acetaminophen as the analgesic and an effective amount of agglomerated particles of an antacid and a food grade acid which will react in an aqueous solution to produce visible gaseous effervescence.The formulations of this invention preferably also comprise flavorants, which improve the taste and lubricants and hardening agents which aid in tableting the formulation.Type: GrantFiled: June 11, 1985Date of Patent: November 3, 1987Assignee: Hudson Pharmaceutical CorporationInventor: Theodore J. Korab
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Patent number: 4678661Abstract: Effervescent granulates, particularly for the manufacture of effervescent tablets, comprising at least one solid, crystalline edible organic acid and at least one carbonate which releases carbon dioxide upon reaction with the organic acid, the acid crystals comprising a coating which contains calcium carbonate adhering to the surface of the acid crystals by means of a bonding layer formed by a reaction at the interface with the crystal of a calcium carbonate coating material. The coating is built up in multi-layers and includes at least two carbonate layers, the layer which is bonded essentially to the acid crystal being composed of calcium carbonate with the succeeding layers adhering to the carbonate layer by means of a bonding layer formed by reaction of the acid and the carbonate. The invention also deals with methods of manufacture as well as fields of use for the new effervescent granulates.Type: GrantFiled: June 30, 1986Date of Patent: July 7, 1987Inventors: Gerhard Gergely, Thomas Gergely, Irmgard Gergely
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Patent number: 4613497Abstract: A substantially anhydrous foamable composition capable of forming a substantially stable foam on contact with water is formed from a mixture of water soluble polysaccharide gum, an effervescent base and a biocompatible gelling salt. These compositions upon contact with water form extremely stable foams which are capable of acting as carriers for pharmaceutically active compositions.Type: GrantFiled: February 29, 1984Date of Patent: September 23, 1986Assignee: Health Products Development, Inc.Inventor: Leonard Chavkin
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Patent number: 4581381Abstract: An improved deposited chewable antacid tablet containing solid antacid particles which includes solid antacid particles having a primary particle size of less than 100 millimicrons, which particles are thoroughly coated with a mixture composed of a fatty material or oil, a surfactant, and a flavorant selected from the group consisting of chocolate, mint-chocolate, butter, vanilla, butter fat and mint flavors. The fat or oil is present in an amount of from about 25% to about 45% of the mixture. As a result of the mixture coated on the antacid particles a non-chalky, non-gritty, antacid tablet is provided which readily disintegrates upon exposure to saliva as such way as to function as a liquid antacid.Type: GrantFiled: March 18, 1985Date of Patent: April 8, 1986Assignee: Nabisco Brands, Inc.Inventors: William M. Morris, Frank Witzel, Wayne J. Puglia, Donald A. M. Mackay, K. Warren Clark, K. J. Patanasinth
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Patent number: 4545989Abstract: A chewable comestible product is disclosed which comprises a frappe component having a density of at least 1.0, and a syrup component including corn syrup, sugar, and water. An antacid is optionally included and may preferably be incorporated into the frappe component. A related method of preparing the comestible product is also disclosed, which includes the processing of the product of the invention by cold processing techniques.In the instance where the product includes an antacid, metallic user aftertaste is absent.Type: GrantFiled: December 6, 1983Date of Patent: October 8, 1985Assignee: Warner-Lambert CompanyInventors: Amy J. Becker, Leonard P. Abbazia, Mario W. Medri
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Patent number: RE34222Abstract: A pharmaceutical composition comprises magnesium oxide, hydroxide or a non-toxic salt of magnesium in a slow-release carrier; this material may be combined with or co-prescribed with a diuretic or cardiac glycoside or adrenergic receptor blocking agent or a calcium antagonist for the treatment of hypertension or angina pectoris.Type: GrantFiled: November 28, 1990Date of Patent: April 13, 1993Inventor: Maurice Bloch