Caries Patents (Class 514/835)
  • Patent number: 8852559
    Abstract: A stabilized oral care composition comprising a borinic acid derivative, e.g., a borinic ester.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: October 7, 2014
    Assignee: Colgate-Palmolive Company
    Inventors: Venda Porter, Andre Morgan, Stanislav Jaracz, Jennifer Gronlund, Guofeng Xu, Donghui Wu, Michael Prencipe, Ravi Subramanyam
  • Patent number: 8524197
    Abstract: A chewable confectionery dental composition delivering to the mouth a unit dose of a plaque reducing enzyme the composition comprising an enzyme and a non-cariogenic sweetener, the enzyme being incorporated in the composition at a temperature less than about 80° C.
    Type: Grant
    Filed: January 23, 2008
    Date of Patent: September 3, 2013
    Assignee: Colgate-Palmolive Company
    Inventors: Laurence Du-Thumm, Lori H. Szeles, Richard J. Sullivan, James G. Masters, Richard S. Robinson
  • Patent number: 8496915
    Abstract: Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: July 30, 2013
    Assignees: Matsutani Chemical Industry Co., Ltd., National University Corporation Kagawa University
    Inventors: Tetsuo Iida, Takashi Ichihara, Ken Izumori, Masaaki Tokuda, Takaaki Ogawa
  • Patent number: 8343483
    Abstract: New strains of Lactobacillus that have been selected for their capability of improved reduction the number of Streptococcus mutans in the mouth of mammals through inhibiting activity in combination with better binding to the oral mucins and dental plaque, thereby preventing, reducing or treating dental caries, and products derived from said strains, including agents for treatment or prophylaxis of caries for administration to humans.
    Type: Grant
    Filed: October 15, 2008
    Date of Patent: January 1, 2013
    Assignee: Biogaia AB
    Inventors: Bo Mollstam, Eamonn Connolly
  • Patent number: 8142764
    Abstract: The present invention provides streptococcal SspB Adherence Region (BAR) peptides consisting of Formula I: R18-R1- R2-Val-R3-R4-Leu-Leu-R5-R6-R7-Ile-R8-R9-Lys-R10-R19 , wherein R2, is 1-3 Lys residues; R3 is any amino acid residue except a Pro residue; R4 is any amino acid residue except a Pro residue; R5 is 1-3 Lys residues; R6 is 1-10 amino acid residues; R7 is any amino acid residue except Asp, Glu, Gly or Pro; R8 is any amino acid residue except Ala, Asp, Gly, His, Ile, Pro, Trp or Tyr; R9 is a Val, Ile, Phe, or Trp residue; R10 is 0-1 Cys residue; R18 is 0 amino acids or R12-R11-Pro-, wherein R11 is 0-3 amino acids, wherein the amino acid residues are not Gly or Pro; and R12 is 0-1 Cys residues; and R19 is R13-R14-R15-R16-R17, wherein R13 is 0-1 is Gly residue; R14 is 0-1 Ala residue; R15 is 0-1 Phe residue; R16 is 0-1 Gln residue; R17 is 0-1 Cys residue; and wherein R1 is an ornithine residue; or wherein both R1 and R10 are both Cys and R1 and R10 are covalently linked to form a circular peptide; or whe
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: March 27, 2012
    Assignee: University of Louisville Research Foundation
    Inventors: Donald R. Demuth, Carlo Amorin Daep
  • Patent number: 7754701
    Abstract: The present invention relates to a difructose anhydride (DFA)-containing composition and use thereof. DFA is a cyclic disaccharide in which the reducing termini of two fructose molecules bind each other to hydroxyl groups at the other nonreducing termini. According to the present invention, it has been revealed that DFA is effective in accelerating the absorption of magnesium, zinc or copper, accelerating bone formation, accelerating diuretic action, and improving bowel movement and is useful in inhibiting dental caries. A composition of the present invention can be used as a composition for a medicinal product and a food or drink product (including feed for animal use). Examples of a medicinal product and a food or drink product for human or animal use include formulated powder milk, parenteral nutrients, health food and drink products, and additives for feed and are not particularly limited as long as they are ultimately in an orally administrable form.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: July 13, 2010
    Assignees: Fancl Corporation, Nippon Beet Sugar Manufacturing Co., Ltd.
    Inventors: Takuya Shiomi, Yasuhide Okuhara, Akiko Tamura, Kyoko Tomita, Norihiro Shigematsu, Hiroto Kikuchi, Tsutomu Aritsuka, Fusao Tomita
  • Patent number: 7732478
    Abstract: The present invention provides methods for facilitating metabolic control in a subject by decreasing the level of Il-1? in the GCF. The present invention further provides methods for decreasing the level of circulating TNF in a subject. Also provided are uses of anti-inflammatory agents in these methods.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: June 8, 2010
    Assignee: The Trustees of Columbia University in The City of New York
    Inventor: Steven P. Engebretson
  • Patent number: 7393519
    Abstract: A non-aqueous toothpaste comprises ascorbic acid or a salt thereof, mixed in a base which is a combination of hydroxypropyl cellulose and 1,3-butylene glycol which is thereby essentially water-free thereby stabilizing the ascorbic acid or a salt thereof.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: July 1, 2008
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Shinji Sugiyama, Shigeyuki Ejiri, Mitsufumi Matsumoto
  • Patent number: 7354569
    Abstract: A chewable confectionery dental composition delivering to the mouth a unit dose of a plaque reducing enzyme the composition comprising an enzyme and a non-cariogenic sweetener, the enzyme being incorporated in the composition at a temperature less than about 80° C.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: April 8, 2008
    Assignee: Colgate-Palmolive Company
    Inventors: Laurence Du-Thumm, Lori H. Szeles, Richard J. Sullivan, James G. Masters, Richard S. Robinson
  • Patent number: 7300645
    Abstract: Disclosed is an oral composition comprising palatinit. More particularly, disclosed is an oral composition comprising palatinit which exerts a synergistic effect when combined with a fluorine or zinc compound.
    Type: Grant
    Filed: October 24, 2002
    Date of Patent: November 27, 2007
    Assignee: Sunstar Kabushiki Kaisha
    Inventors: Tsutomu Takatsuka, Akira Nakao
  • Patent number: 7101562
    Abstract: The present invention provides glucan-based compositions and methods for stimulating an immune response against mutans streptococci components and vaccines and methods for the treatment and prevention of dental caries. In a preferred embodiment, a glucan polymer, preferably WSG, is covalently bound to one or more T cell-dependent antigens to form a conjugate vaccine. The T cell-dependent antigen preferably contains epitopes of one or more mutans streptococcal proteins, such as a glucosyltransferase. Moreover, one or more moieties, including haptens, may be conjugated to the glucan-T cell-dependent composition. In a preferred embodiment, these moieties are peptides which contain immunogenic epitopes corresponding to components of a mutans streptococcus.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: September 5, 2006
    Assignees: The Forsyth Institute, Henry M. Jackson Foundation for the Advancement of Military Medicine
    Inventors: Andrew Lees, Martin A. Taubman, Daniel J. Smith
  • Patent number: 7048910
    Abstract: The invention relates to the use of one or more compounds selected from compounds of formulae Ia and Ib, the physiologically compatible salts of compounds of formula Ia and Ib and the stereoisomer forms of compounds of formula La and Ib, wherein R1, R2, R3, R4 and n have the meaning cited in claim 1.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: May 23, 2006
    Assignee: Merck Patent GmbH
    Inventors: Joachim Buenger, Hansjuergen Driller, Olaf den Hollander
  • Patent number: 7029690
    Abstract: Disclosed are articles and oral compositions which enable positioning material(s) which absorb oral fluids into controlled, direct contact with at least one dental arch, or portion thereof, of a subject at the location where teeth emerge from dental arch gum tissue, in a manner conducive to increasing crevicular fluid flow while maintaining a relatively dry application field for a therapeutic and/or cosmetic result effecting period of time. The method is applicable to introduction of gingivally absorbed substances and to treatment of, for instance, periodontal gum disease wherein bacteria is swept along in the crevicular fluid and lysed.
    Type: Grant
    Filed: November 4, 2002
    Date of Patent: April 18, 2006
    Assignee: Clinically Clean Inc.
    Inventor: Janet M. Wehrli
  • Patent number: 7022314
    Abstract: Anti-plaque emulsions and methods of use are provided. The emulsion comprises a surfactant, emulsifier, and triclosan.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: April 4, 2006
    Assignee: Wm. Wrigley Jr. Company
    Inventors: Roman M. Barabolak, Dave L. Witkewitz
  • Patent number: 6939535
    Abstract: A method for preventing tooth decay by initially treating the tooth surface with a laser with a coherent or noncoherent light source. This process makes the tooth more resistant to acid and more able to bond fluoride, thus requiring a lower concentration of fluoride. The method allows for a deeper penetration of the tooth then previously accomplished with other methods.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: September 6, 2005
    Assignee: Nocari, LLC
    Inventors: Colette Cozean, Lynn Powell, Samir Nammour
  • Patent number: 6919070
    Abstract: A stomatic composition has particles of hydroxyapatite with an average particle size in length (l), width (d) and thickness (h) of: l from 0.2 ?m to about 0.01 ?m, d from about 0.1 ?m to about 0.001 ?m and h from about 0.1 ?m to about 0.001 ?m.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: July 19, 2005
    Assignee: Zakrytoe Aktsionernoe Obschestvo “OSTIM”
    Inventors: Vsevolod Nikolaevich Rudin, Vladislav Petrovich Zuev, Vladimir Fedorovich Komarov, Igor Vitallevich Melikhov, Vladimir Vasillevich Minaev, Andrei Yurlevich Orlov, Anatoly Aleksandrovich Mishin, Viktor Evgenievich Bozhevolnov
  • Patent number: 6669931
    Abstract: A method of treating dental carries and remineralizing lesions includes the steps of directing a stream of oxidizing gas onto a carious lesions for a period of time sufficient to kill microorganisms within the carious lesion; and thereafter applying to the lesion a remineralization formulation.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: December 30, 2003
    Assignee: Curozone Ireland Limited
    Inventors: Edward Lynch, Jurgen Schemmer
  • Patent number: 6649148
    Abstract: A reductant rinse including xylitol prevents buildup in ozone carrying lines in apparatus for the treatment of dental caries.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: November 18, 2003
    Assignee: Curozone Ireland Limited
    Inventors: Edward Lynch, Jurgen Schemmer
  • Patent number: 6524558
    Abstract: The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: February 25, 2003
    Assignee: The Research Foundation of the State University of New York
    Inventors: Israel Kleinberg, Ana Marie Acevedo, Robi Chatterjee
  • Patent number: 6280775
    Abstract: This invention provides a liquid antimicrobial composition that is particularly useful as a mouthwash for treating or reducing the risk of dental disease. The composition is prepared by mixing a first solution comprising a water soluble metal chlorite compound with a second solution comprising sodium persulfate and hydrogen peroxide. The resulting composition, containing chlorine dioxide, is preferably used at the time of preparation by applying the composition to the locus where treatment is desired.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: August 28, 2001
    Inventors: Joseph Alan Sasson, Riccardo Panicucci
  • Patent number: 6036952
    Abstract: Enterococcus spp. 1357, Lactobacillus acidophilus V20 and Lactococcus lactis 1370, lactic acid bacterial strains having a potent and lasting inhibitory activity against the formation of glucan and dental plaque in human mouths.
    Type: Grant
    Filed: January 27, 1998
    Date of Patent: March 14, 2000
    Inventor: Jong Suk Oh
  • Patent number: 5932193
    Abstract: Disclosed are toothpaste compositions and a process for preparing such compositions comprising dental abrasive, humectant, fluidized polymer suspension and a suitable vehicle for the humectant, wherein the fluidized polymer suspension comprises: polyethylene glycol, carboxymethyl cellulose and hydrated thickening silica.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: August 3, 1999
    Assignee: Hercules Incorporated
    Inventors: Jean-Paul Lopez, Mohand Melbouci, Gerhard Dewald
  • Patent number: 5665374
    Abstract: The present invention relates to unique interdental delivery devices, other than dental floss, which are suitable for cleaning, massaging, and/or treating surfaces of teeth and gums including interproximal and subgingival areas; wherein these devices contain ULTRAMULSION.TM. dispersions of high viscosity silicones dispersed in surfactants, these dispersions are released into the oral cavity from these devices during use wherein the dispersed silicone:a. is insoluble in the surfactant and oriented so as to form coatings in the oral cavity with enhanced substantivity,b. functions as a reservoir for various lipid soluble and/or liquid dispersible ingredients to be released onto oral cavity surfaces, andc. has a particle size from between about 0.1 and about 10 microns with from between about 80% and about 95% of the particles within this range.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 9, 1997
    Assignee: WhiteHill Oral Technologies, Inc.
    Inventors: Ira D. Hill, Peter P. Walters, Dale G. Brown
  • Patent number: 5624906
    Abstract: The present invention is related to new oral hygiene compositions that have improved foam, viscosity, clarity and good taste due to the inclusion of a new type of alkyl aldonamide compound, specifically heteroatom containing alkyl aldonamide compounds.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: April 29, 1997
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventor: Robert Vermeer
  • Patent number: 5622940
    Abstract: Methods of treating or preventing infection-induced oral tissue destruction or gingivitis in a mammal, comprising administering a therapeutically effective amount of a .beta.(1,3)-glucan, such as poly-.beta.(1-6)-glucotriosyl-.beta.(1-3)-glucopyranose glucan (PGG-glucan), are disclosed.
    Type: Grant
    Filed: July 14, 1994
    Date of Patent: April 22, 1997
    Assignee: Alpha-Beta Technology
    Inventor: Gary R. Ostroff
  • Patent number: 5500206
    Abstract: The present invention relates to compositions and methods for inhibiting or preventing growth of dental plaque on tissues within the human oral cavity comprising topical administration, to tissues of a human oral cavity, of a composition comprising a safe and effective amount of Actinomyces viscosus fimbriae.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: March 19, 1996
    Assignee: The Procter & Gamble Company
    Inventor: Duane L. Charbonneau
  • Patent number: 5460802
    Abstract: The present invention is generally related to an oral disinfectant for companion animals. A preferred disinfectant is a concentrated composition containing a fatty acid monoester, one or more fatty acids, an acid or chelating agent, a polyalcohol, a surfactant and water. When used the concentrate is diluted with water and then applied to the teeth and oral cavity tissues of the animal.
    Type: Grant
    Filed: July 18, 1994
    Date of Patent: October 24, 1995
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Takao Asami, Manabu Takhashi, Jeffrey F. Andrews, Thomas E. Boettcher
  • Patent number: 5435996
    Abstract: Moisturizing compositions for application to human skin which contain oxyethylene functional organosilanes. When used in skin care applications, these compounds exhibit humectant properties. The oxyethylene functional organosilane is a compound having the formula RSiR'.sub.3 in which R is the radical --O(CH.sub.2 CH.sub.2 O).sub.x R"; R' is an R group or an alkyl radical having one to six carbon atoms; R" is a radical such as hydrogen; an alkyl group of one to six carbon atoms; and an aryl group; and x is an integer having a value of six to thirty.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: July 25, 1995
    Assignee: Dow Corning Corporation
    Inventors: David A. Glover, Gary E. LeGrow, Linda M. Madore, Regina M. Malczweski
  • Patent number: 5433941
    Abstract: Glassy coatings are made by curing in situ a coating of a sol gel of tetraethoxysilicon, water, alcohol, and the alkoxides of: Al, Ti and Na; or of Na and Zr.The coating may be applied to teeth as a dental fissure sealant or varnish to protect restorations, or (if filled) as an inherently coloured cosmetic coating, or as a prophylactic coating.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: July 18, 1995
    Assignee: British Technology Group Limited
    Inventor: Bipin C. M. Patel
  • Patent number: 5433956
    Abstract: Glassy coatings are made by curing in situ a coating of a sol gel of tetraethoxysilicon, water and alcohol, filled with kaolinite or with flat plates (1-2 .mu.m.times.10-50 .mu.m) of mica, which may be colored by Fe.sub.2 O.sub.3 /TiO.sub.2 coatings.The coating may be applied to teeth as a dental fissure sealant or varnish to protect restorations, or as an inherently colored cosmetic coating, or as a prophylactic coating.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: July 18, 1995
    Assignee: British Technology Group Limited
    Inventor: Bipin C. M. Patel
  • Patent number: 5431914
    Abstract: A method of treating a pathological condition of an internal organ in a patient which comprises topically applying capsaicin to the skin of the patient containing nerves which lead to the spinal cord segments corresponding to the internal organ without the need of systemic absorption of the capsaicin.
    Type: Grant
    Filed: March 16, 1994
    Date of Patent: July 11, 1995
    Inventors: Michael Adekunle, James L. Flowers
  • Patent number: 5314877
    Abstract: Disclosed is water-soluble composition made by subjecting pentacyclic triterpene compound belonging to amylin group such as oleanolic acid, ursolic acid and hederagenin to inclusion in cyclodextrins. Though the aforementioned pentacyclic triterpene compound has various pharmacological functions, it has suffered a disadvantage such that it is insoluble in water. However, by subjecting the compound to inclusion in cyclodextrins, the water-soluble composition can be made with maintaining the pharmacological functions, and applied for foods, drinks, toothpaste, gargle and chewing gum, exhibiting the effect of cariostatic.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: May 24, 1994
    Assignee: Hokkaido Sugar Co., Ltd.
    Inventors: Hiroshi Suzuki, Sigeru Watano, Tadashi Sasazuka, Taira Tsutsumi
  • Patent number: 5273753
    Abstract: A functional food which comprises a glucosyltransferase and/or a fructosyltransferase each having a water-soluble polysaccharide production ability, and a base therefor.
    Type: Grant
    Filed: July 19, 1991
    Date of Patent: December 28, 1993
    Assignee: Kabushiki Kaisha Advance
    Inventors: Kazuoki Ishihara, Masao Takahashi
  • Patent number: 5204350
    Abstract: Compounds of the general formula ##STR1## Y is an integer of from 0 to 6 is chosen from: O,SO.sub.2,--CONH--,--NHCO--,--CH2-- or ##STR2## R.sup.1 is substituted or unsubstituted mono- or polycyclic saturated hetero-cyclic ring system having 1, 2 or 3 heteroatoms where said heteroatoms are independently chosen from N, O and S and said substituents are chosen from the group comprising R.sup.2 ;R.sup.2 isC.sub.1-6 alkyl,aryl C.sub.0-6 alkyl,hydroxy C.sub.0-6 alkyl,C.sub.1-6 alkoxy C.sub.0-6 alkyl,carboxy C.sub.0-6 alkyloxo,halogen,CF.sub.3,C.sub.0-4 alkylamino-C.sub.0-6 alkyl orC.sub.0-4 dialkylamino-C.sub.0-6 alkyl;R.sup.3 isC.sub.1-8 alkyl or cycloalkyl,aryl C.sub.0-4 alkyl,hydroxy C.sub.0-4 alkylC.sub.1-4 alkyloxy C.sub.0-4 alkyl,carboxy C.sub.0-4 alkyl,halogen,CF.sub.3 orhydrogen;R.sup.4 ishydrogen,C.sub.1-6 alkyl,aryl C.sub.0-4 alkyl orC.sub.1-6 alkylcarbonyloxymethyl; andR.sup.5 isC.sub.1-6 alkyl,aryl C.sub.0-4 alkyl orheterocycly C.sub.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: April 20, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Melissa S. Egbertson, George D. Hartman, Robert J. Gould
  • Patent number: 5110583
    Abstract: This invention relates to a method for treating or preventing anaerobe infections in humans and lower animals. This invention further relates to compositions and kits containing peroxy acids useful for treating or preventing anaerobe infections according to the method of the present invention.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: May 5, 1992
    Assignee: The Procter & Gamble Company
    Inventor: Padmini Sampathkumar
  • Patent number: 5100651
    Abstract: Health product, in particular for the caring of the teeth of a dog, constituted by a support incorporating or having absorbed various watersoluble active elements or constituents, this support being made from a natural or synthetic digestible material suitable for being gnawed, chewed or licked by the dog.
    Type: Grant
    Filed: December 3, 1987
    Date of Patent: March 31, 1992
    Inventor: Danielle Boyer
  • Patent number: 5080887
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncatationic antibacterial agent such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (Triclosan).
    Type: Grant
    Filed: August 8, 1991
    Date of Patent: January 14, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, Brian S. Jannone
  • Patent number: 5064640
    Abstract: Improved anticariogenic oral preparations having a pH of about 2.5 to about 5.0 comprise an anticariogenically effective amount of a water-soluble aluminum salt in a surfactant-containing emulsion system suitable for use in the mouth.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: November 12, 1991
    Assignee: Purdue Research Foundation
    Inventors: Carl J. Kleber, Mark S. Putt
  • Patent number: 5057308
    Abstract: This invention relates to a method of treating the oral cavity with ingestible, non-foaming, non aqueous, liquid and semi-solid oral hygiene preparations containing: a nonionic surfactant, a coating substance insoluble in said surfactant and a microbially active form of stannous fluoride.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: October 15, 1991
    Inventors: Ira D. Hill, Robert D. White
  • Patent number: 5057310
    Abstract: This invention relates to the manufacturing of ingestible, non-foaming, nonaqueous liquid and semi-solid oral hygiene preparations containing: a nonionic surfactant, a coating substance insoluble in said surfactant and a microbially active form of stannous fluoride, wherein the coating substance is emulsified with the surfactant using a hot-melt emulsion process and the resulting emulsion is added to a solution of stannous fluoride.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: October 15, 1991
    Inventors: Ira D. Hill, Robert D. White
  • Patent number: 5057309
    Abstract: This invention describes ingestible, non-foaming, non-aqueous liquid and semi-solid oral hygiene preparations containing: a nonionic surfactant, a coating substance insoluble in said surfactant and a microbially active form of stannous fluoride.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: October 15, 1991
    Inventors: Ira D. Hill, Robert D. White
  • Patent number: 5057307
    Abstract: This invention relates to a method of relieving gum discomfort in children and endentulous persons comprising applying to the gums an ingestible, non foaming, oral hygiene gel that cleans, massages and conditions gums and removes the "plaque-like" film that forms on gums while disrupting the subsequent formation of plaque-like film on said gums.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: October 15, 1991
    Inventors: Ira D. Hill, Robert D. White
  • Patent number: 5057306
    Abstract: The invention relates to the manufacturing of oral hygiene gels wherein a coating substance is emulsified with a surfactant using a hot-melt emulsion process and the resulting emulsion is subsequently gelled with a viscosifier.
    Type: Grant
    Filed: June 8, 1990
    Date of Patent: October 15, 1991
    Inventors: Ira D. Hill, Robert D. White
  • Patent number: 5047231
    Abstract: Process for preparing raw hide containing at least one inorganic pyrophosphate compound, comprising: (a) subjecting raw hide to a solution containing at least one inorganic pyrophosphate compound; and (b) drying the raw hide containing the inorganic pyrophosphate salt. The raw hide containing the inorganic pyrophosphate is chewed and/or eaten by dogs, with the result that tartar accumulation on their teeth is reduced or prevented.
    Type: Grant
    Filed: May 30, 1989
    Date of Patent: September 10, 1991
    Assignee: Nabisco Brands, Inc.
    Inventors: Henry C. Spanier, Lorna C. Staples, Felice Scaglione
  • Patent number: 5045305
    Abstract: An oral hygiene product especially for inhibiting caries is the form of toothpaste or mouthwash. The product maintains a low fluoride ion concentration in the mouth for longer periods than conventional products by the rapid precipitation of calcium fluoride either in the mouth or immediately prior to use. The product comprises a composition containing calcium ions and a further composition containing fluoride ions. The ion product of the calcium and fluoride ions of the combined product preferably exceeds 3.times.10.sup.-8 mol.sup.3 dm.sup.-9.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: September 3, 1991
    Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc.
    Inventors: John R. Clarkson, Ralph M. Duckworth, Andrew M. Murray, Timothy J. Price
  • Patent number: 5043154
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (Triclosan).
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: August 27, 1991
    Assignee: Colgate-Palmolive Co.
    Inventors: Abdul Gaffar, Nuran Nabi, Brian S. Jannone
  • Patent number: 5037637
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-tricholoro-2.sup.1 -hydroxydiphenyl ether (Triclosan).
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: August 6, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Abaul Gaffar, Nuran Nabi, Brian S. Jannone
  • Patent number: 5028415
    Abstract: The present invention relates to oral compositions, such as dentifrices, toothpastes and mouthwashes, which provide an anticalculus benefit. These compositions comprise a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salts, along with a pharmaceutically-acceptable carrier. The present invention also relates to a method for inhibiting or reducing the development of dental calculus by contacting the oral cavity with a safe and effective amount of an anticalculus agent which is a polyepoxysuccinic acid, or its pharmaceutically-acceptable salt.
    Type: Grant
    Filed: December 16, 1988
    Date of Patent: July 2, 1991
    Assignee: The Procter & Gamble Company
    Inventors: James J. Benedict, Rodney D. Bush, Richard J. Sunberg
  • Patent number: 5028412
    Abstract: Anti-calculus oral compositions include an aluminum salt and an aliphatic carboxylic acid or water-soluble salt thereof capable of complexing with the aluminum, together with a carrier suitable for use in the oral cavity. Such compositions exhibit marked effectiveness in inhibiting the formation and growth of calculus on the dental enamel.
    Type: Grant
    Filed: July 17, 1990
    Date of Patent: July 2, 1991
    Assignee: Purdue Research Foundation
    Inventors: Mark S. Putt, Carl J. Kleber
  • Patent number: 4994441
    Abstract: Adhesion of bacteria in the buccal cavity which are responsible for the formation of dental plaque and caries is inhibited by kappa-caseino-glycopeptide compounds and desialylated derivaties thereof contained in compositions having a form suitable for being empolyed for treating the bacteria in the buccal cavity.
    Type: Grant
    Filed: February 8, 1988
    Date of Patent: February 19, 1991
    Assignee: Nestec S.A.
    Inventor: Jean-Richard Neeser