Expectorant Patents (Class 514/855)
  • Patent number: 11638722
    Abstract: The invention concerns a medicine and a prophylactic medicine for COVID-19 disease. The inventive medicine targets the endosomic, non-endosomic and/or intracellular viral pathways and inhibits them. The best mode of the invention is considered to be the medicine that blocks all three viral pathways. In the best mode the individual dose of a constituent component of the medicine is arranged to a dosage size sufficient to inhibit its designated SARS-CoV-2 viral pathway. This allows the dose of a particular pharmacological agent to be smaller than in a drug with just one kind of pharmacological agent. The best mode of the invention shuts the two cell membrane viral pathways and the one intracellular viral pathway with the minimum efficient dose, thereby preventing drug overdose, and enabling prophylactic or preventive use.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: May 2, 2023
    Assignee: THERAPEUTICA BOREALIS OY C/O AVANCE ATTORNEYS LTD.
    Inventors: Kalervo Väänänen, Lauri Kangas, Matti Rihko
  • Patent number: 8734787
    Abstract: Red blood cells can be used as effective drug delivery systems when they contain proteins that do not readily diffuse out and which form affinity complexes with the desired drug.
    Type: Grant
    Filed: June 7, 2010
    Date of Patent: May 27, 2014
    Assignee: Erydel S.p.A.
    Inventors: Mauro Magnani, Luigia Rossi, Sara Biagiotti, Marzia Bianchi
  • Patent number: 8679553
    Abstract: An herbal composition for providing a beneficial effect to the respiratory tract. The composition includes Thyme Leaf, Wild Cherry Bark, Cocoa Extract, Mullein Leaf Extract, and Boswellia Serrata. In particular, the composition may prevent or treat cough, specifically caused by exposure to smoke. Also described are methods of using the herbal composition.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: March 25, 2014
    Assignee: Aadvantics Pharmaceuticals, Inc.
    Inventors: Brian M. Levine, William E. Berger
  • Patent number: 8361519
    Abstract: An herbal composition for providing a beneficial effect to the respiratory tract. The composition includes Thyme Leaf, Wild Cherry Bark, Cocoa Extract, Mullein Leaf Extract, and Boswellia Serrata. In particular, the composition may prevent or treat cough, specifically caused by exposure to smoke. Also described are methods of using the herbal composition.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: January 29, 2013
    Assignee: Aadvantics Pharmaceuticals, Inc.
    Inventors: Brian M. Levine, William E. Berger
  • Patent number: 8211441
    Abstract: The present invention relates to a method of preventing or treating allergic diseases such as allergic rhinitis, atopic dermatitis, anaphylaxis, and asthma, which comprises administering an extract of Laurencia undulata in a therapeutically effective amount to a patient in need thereof.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: July 3, 2012
    Assignee: Pukyong National University Industry-Academic Cooperation
    Inventors: Won-Kyo Jung, Il-Whan Choi, Se-Kwon Kim, Sung Su Yea, Yung Hyun Choi, Inhak Choi
  • Patent number: 7094429
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Grant
    Filed: August 19, 2004
    Date of Patent: August 22, 2006
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 6869618
    Abstract: An active ingredient from the group of an antihistamine, a decongestant, an antitussive or anticholinergic is dissolved in a suitable solvent and added to a dispersion of tannic acid in water to form the tannate salt complex of the active ingredient. The active ingredient tannate salt complex without isolation or purification is then added to a liquid or semi-solid medium composed of thickening, suspending, coloring, sweetening and flavoring agents, with stirring. Thereafter, preservatives, pH-adjusting and anti-caking agents in a suitable solvent are mixed with the liquid or semi-solid medium to generate a therapeutic dosage form.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: March 22, 2005
    Assignee: Kiel Laboratories, Inc.
    Inventors: Jeffrey S. Kiel, H. Greg Thomas, Narasimhan Mani
  • Patent number: 6703376
    Abstract: A method of promoting drainage of mucous secretions in the congested airways of a bedridden/immobilized patient or an intubated/mechanically-ventilated patient is disclosed. The method comprises administering to the airways of the patient a uridine phosphate such as uridine 5′-triphsophate(UTP) or P1,P4-di(uridine-5′) tetraphosphate, an analog of UTP, or any other analog, in an amount effective to promote drainage of fluid in the congested airways, including sinuses, to create the ciliary beat frequency of cilia on the surface lumina epithelia cells, to increase the secretions of mucous by goblet cells and to promote the clearance of retained secretions by hydrating mucous secretions, by stimulating ciliary beat frequency in the airways and by stimulating surfactant production. Pharmaceutical formulations and methods of making the same are also disclosed.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: March 9, 2004
    Assignee: Inspire Pharmaceuticals, Inc.
    Inventors: Karla M. Jacobus, H. Jeff Leighton
  • Patent number: 6670370
    Abstract: The invention pertains to a composition comprising dextromethorphan tannate and to a method for preparing dextromethorphan tannate by reacting dextromethorphan at a temperature of about 80 to about 180° C. with tannic acid either neat or as an aqueous slurry containing about 5 to about 30 wt. % water. The dextromethorphan tannate has extended release properties and is useful in pharmaceutical compositions as an antitussive for human beings.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: December 30, 2003
    Assignee: Jame Fine Chemicals, Inc.
    Inventors: Vilas M. Chopdekar, James R. Schleck, Hemant S. Desai
  • Patent number: 6558618
    Abstract: A method of dispersing, in water vapor, an anti-infective therapeutic composition (10) into the air in a room (36), in order to treat or prevent transmission of upper respiratory infections, includes: adding to a reservoir of liquid water in a vaporizer (34), a therapeutic composition (10) containing one or more antibiotics (14), alcohol (16), an analgesic (18) and an expectorant (20); and vaporizing the therapeutic composition (10) into the air along with the water in the vaporizer reservoir for inhalation by persons in the room.
    Type: Grant
    Filed: April 27, 1999
    Date of Patent: May 6, 2003
    Inventor: James L Dent, Jr.
  • Patent number: 6440465
    Abstract: Compositions and methods of use thereof for the treatment of psoriasis and related skin ailments are disclosed. The compositions include topical skin formulations of glucosamine in an emollient base such as moisturizing cream. In addition to glucosamine, the formulations may include keratolytic substances such as coal tar extract or salicylic acid. The formulations may also include glucosamine and antioxidant anti-inflammatory herbal extracts such as oleuropein and berberine in an emollient base.
    Type: Grant
    Filed: May 1, 2000
    Date of Patent: August 27, 2002
    Assignee: Bioderm, Inc.
    Inventor: Lorraine Faxon Meisner
  • Patent number: 6121319
    Abstract: This invention is a method and composition for the inhibition of VCAM-1, and in particular for the treatment of cardiovascular or inflammatory disease, including atherosclerosis, that includes the administration of an effective amount of an ester of probucol.
    Type: Grant
    Filed: May 14, 1998
    Date of Patent: September 19, 2000
    Assignee: AtheroGenics, Inc.
    Inventor: Patricia K. Somers
  • Patent number: 6025334
    Abstract: The present invention relates to cartilage extracts and to a method of producing the same. Shark cartilage extracts having anti-angiogenic, direct anti-tumor proliferating, anti-inflammatory and anti-collagenolytic activities have been obtained by an improved process. The process comprises the steps of obtaining a homogenate of cartilage in an aqueous solution, this homogenate being centrifuged and further fractionated to obtain a total extract having molecules of a molecular weight comprised between 0 to 500 KDa. The composition of the liquid extract has then been investigated by different ways. Further fractionation of this extract led to the preliminary characterization of some of its active components. Due to the multiplicity of biological activities of the total liquid extract, it can be used for treating numerous diseases or conditions such as those having components selected from the group consisting of tumor proliferation, angiogenesis, inflammation and collagenolysis.
    Type: Grant
    Filed: October 30, 1995
    Date of Patent: February 15, 2000
    Assignee: Les Laboratoires Aeterna Inc.
    Inventors: Eric Dupont, Paul Brazeau, Christina Juneau, Daniel H. Maes, Kenneth Marenus
  • Patent number: 5994330
    Abstract: Treatment of acne through topical administration is an aspect of the present invention. Specifically, muscarinic agents may be applied in any therapeutically acceptable carrier including gels, creams, lotions, and sprays. Therapeutic effects observed with the present invention include decrease in redness, swelling, and inflammation. Treatment of other inflammatory conditions is also disclosed. Treatment of suitable conditions in accordance with the present invention results in significant improvements in healing of those conditions.
    Type: Grant
    Filed: November 9, 1998
    Date of Patent: November 30, 1999
    Inventor: Georges F. El Khoury
  • Patent number: 5985839
    Abstract: The present invention relates to shark cartilage extracts and to a method of producing the same, these extracts having anti-angiogenic properties (reduction of the area of blood vessels observed in vivo on experimentally induced tumors), tumor regressive activity in vivo as well as demonstrating a direct inhibitory effect on tumor cell lines. This process does not involve any denaturing solvent or product and does not involve the use of any enzymes. It consists of obtaining a blend of whole cartilage in an aqueous solution of neutral pH, preferably pure water, this blend being centrifuged and the pellet and supernatant kept for further processing. The pellet is lyophilized and tested for anti-tumor and anti-angiogenic activities in vivo and in vitro, with or without supernatant. The supernatant has been shown to have anti-angiogenic and tumor regressive activities in vivo. The composition of the supernatant has then been investigated by different ways.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: November 16, 1999
    Assignee: Les Laboratories Aeterna Inc.
    Inventors: Eric Dupont, Paul Brazeau, Christian Juneau
  • Patent number: 5939394
    Abstract: The present invention relates to compositions and methods for the prevention and/or treatment of allergic, autoimmune, septic shock or infectious diseases using magnesium gluconate alone or in combination with one or more antioxidants or an antiinflammatory agent. The invention also relates to the inhibition of production of inappropriate levels of lipid mediators and cytokines.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: August 17, 1999
    Assignee: Fleming & Company
    Inventors: Thomas E. Fleming, Herbert C. Mansmann, Jr.
  • Patent number: 5889048
    Abstract: A pharmaceutical formulation having immunomodulating and regenerating effect on abnormal function of cell tissue division-regulating system comprises, as an active ingredient, mercury dichloride or potassium arsenite or sodium arsenate in the amount of 0.01-1.5% by weight and of a diluent up to 100% by weight. The proposed pharmaceutical formulation preferably contains natural white grape wine with sugar content of 3-4% by weight or whey with sugar content of 3-4% by weight as the diluent.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: March 30, 1999
    Inventor: Tamara Vasilievna Vorobieva
  • Patent number: 5766610
    Abstract: Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
    Type: Grant
    Filed: April 26, 1995
    Date of Patent: June 16, 1998
    Assignee: Centre International De Recherches Dermatologiques Galderma
    Inventor: Jean-Michel Bernardon
  • Patent number: 5698537
    Abstract: The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: ##STR1## wherein one of X, Y, or Z represent: ##STR2## in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R.sup.1 in which R.sup.1 represents linear or branched C.sub.11-21 alkyl or C.sub.11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C.sub.1-6 linear or branched alkoxy or cyano.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: December 16, 1997
    Assignee: Clarion Pharmaceuticals Inc.
    Inventor: Thaddeus P. Pruss
  • Patent number: 5560913
    Abstract: The present invention relates to orally ingestible, pharmaceutical compositions containing at least one pharmaceutical active and a taste masking component.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: October 1, 1996
    Assignee: The Procter & Gamble Company
    Inventor: Philip L. Kupper
  • Patent number: 5534552
    Abstract: A clear, hypoallergenic sinus and allergy medication is orally administered in an aqueous, liquid dosage form. The formulation provides effective sinus and allergy relief without alcohol or dyes which adversely affect many allergy sufferers. Said relief is provided while still maintaining aesthetic appeal or pleasant taste and texture.
    Type: Grant
    Filed: March 2, 1994
    Date of Patent: July 9, 1996
    Assignee: Warner-Lambert Company
    Inventor: Swati Bapat
  • Patent number: 5508310
    Abstract: This invention relates to the use of a class of compounds as immunopotentiaters, compositions containing such compounds and their manufacture, combinations of such compounds with anti-tumor or anti-infective drugs and the use of such combinations in the prophylaxis or treatment of such diseases arising from tumors or infections.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: April 16, 1996
    Assignee: Burroughs Wellcome Co.
    Inventor: John R. Rhodes
  • Patent number: 5441938
    Abstract: A novel therapy for Pseudomonas aeruginosa infections, in particular in cystic fibrosis patients, is described. Macrophages provide the first line of defence in protecting the lung against bacterial infections. Nonetheless, Pseudomonas aeruginosa infections continue to be problematic in cystic fibrosis patients and are the leading cause of death in these patients. Previously, little was known regarding the factors which regulate the capacity of macrophages to mediate phagocytosis of Pseudomonas aeruginosa. The inventors have now shown that phagocytosis of nonopsonized Pseudomonas aeruginosa by macrophages is dependent upon the presence of glucose. They have also shown that the action of glucose is on the macrophage rather than the bacteria. Glucose therapy can therefore be used to prevent or combat Pseudomonas aeruginosa infections.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 15, 1995
    Assignee: University of British Columbia
    Inventors: David Speert, Sameer Barghouthi, Siamon Gordon
  • Patent number: 5409907
    Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water soluble pharmaceutical active, e.g. acetaminophen; a suspension stabilizing effective amount of xanthan gum and microcrystalline cellulose; an effective amount of taste masking compositions; and water, as well as a process for producing such aqueous pharmaceutical suspensions.
    Type: Grant
    Filed: December 16, 1993
    Date of Patent: April 25, 1995
    Assignee: McNeil-PPC, Inc.
    Inventors: Cynthia M. Blase, Manoj N. Shah
  • Patent number: 5401728
    Abstract: A soybean lecithin based topical liniment and method of making the same is disclosed. The liniment utilizes soybean lecithin as a base and major ingredient and as the emulsifier which is mixed with plant oils, natural menthol, calcium stearate, and magnesium stearate. The soybean lecithin, plant oils, natural menthol, calcium stearate, and magnesium stearate are mixed together in predetermined relative proportions with the amount of soybean lecithin being greater than the sum of the amounts of the plant oils, natural menthol, calcium stearate, and magnesium stearate. The soybean lecithin, plant oils, natural menthol, calcium stearate, and magnesium stearate are added to one another and mixed together in a predetermined sequence to prevent precipitation and provide a homogenous mixture having a viscosity suitable for topical application.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: March 28, 1995
    Inventor: John A. Simon
  • Patent number: 5279828
    Abstract: An ingestible mixture containing the extract from the chuchuhuasha plant is useful for the alleviation of cramps, colds, and nasal congestion. The mixture comprises: the therapeutic component being the extract from the chuchuhuasha plant; a taste and fermentation component being honey; and a liquid extraction component being chosen from the group consisting of alcohol and water. According to the present invention, the mixture comprises about 20% to 50% by weight of the extract from the chuchuhuasha plant as the therapeutic component; about 20% to 50% by weight of water or alcohol as the liquid extraction component; and about 25% to 35% by weight of honey as the taste and fermentation component. According to a specific embodiment of the present invention, the mixture comprises about 35% by weight of the extract from the chuchuhuasha plant; about 35% by weigh of water or alcohol; and about 30% by weight of honey.
    Type: Grant
    Filed: February 24, 1993
    Date of Patent: January 18, 1994
    Assignee: Tecma Laboratories, Inc.
    Inventor: Theodore Trenzeluk
  • Patent number: 5276061
    Abstract: Compositions containing 1.alpha.-hydroxyvitamin D homolog compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.
    Type: Grant
    Filed: August 24, 1990
    Date of Patent: January 4, 1994
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Connie M. Smith
  • Patent number: 5272137
    Abstract: The present invention relates to an aqueous pharmaceutical suspension composition comprising: from about 0.2% to 20% of a substantially water soluble pharmaceutical active, e.g. acetaminophen; a suspension stabilizing effective amount of xanthan gum and microcrystalline cellulose; an effective amount of taste masking compositions; and water, as well as a process for producing such aqueous pharmaceutical suspensions.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: December 21, 1993
    Assignee: McNeil-PFC, Inc.
    Inventors: Cynthia M. Blase, Manoj N. Shah
  • Patent number: 5213803
    Abstract: A method utilizing compositions for topical application which are adapted for the prevention and treatment of viral infections such as Herpes, AIDS and other envelope virus infections are disclosed. The compositions of the present invention produce a synergistic anti-viral effect when used in combination. The formulation contains a humectant such as sorbitol, glycerol, or other comparable compound in the range of 20-80% w/v final concentration, which facilitates structural and/or functional three dimensional disruption or disorientation of the viral envelope. The activation of the destruction of the envelope and subsequent death of the envelope virus is then achieved using combination of inorganic monovalent anions, nonionic detergents and anionic detergents. These monovalent anions can include sodium bicarbonate, sodium thiocyanate, sodium fluoride and sodium chloride at about 0.5 to 5% w/v final concentration; nonionic detergents such as Tween 20 at concentrations of about 0.
    Type: Grant
    Filed: February 24, 1992
    Date of Patent: May 25, 1993
    Assignee: Northeastern Ohio Universities College of Medicine
    Inventors: Jerry J. Pollock, John J. Docherty
  • Patent number: 5135934
    Abstract: Dihydrobenz[c]acridine carboxylic acid derivatives are provided which are useful for the treatment and/or prevention of organ transplantation rejection, graft versus host disease, autoimmune diseases, psoriasis and chronic inflammatory diseases.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: August 4, 1992
    Assignee: Du Pont Merck Pharmaceutical Company
    Inventors: Carl H. Behrens, Bruce D. Jafee
  • Patent number: 5104657
    Abstract: The invention relates to combination preparations containing chloramphenicol, gentamicin, nystatin and optionally a cortisone as active ingredients for the topical treatment of inflammatory skin disorders. The preparations are present preferably in the form of an ointment and have proved to be surprisingly effective particularly in the case of the treatment of skin disorders which are difficult to heal such as chronic eczema, inflammations in the anal and genital region, and of ulcus cruris and similar disorders.
    Type: Grant
    Filed: December 3, 1990
    Date of Patent: April 14, 1992
    Inventor: Souhail Abdulla
  • Patent number: 5080906
    Abstract: The blood level of orally administered N-acetylcysteine is substantially increased in a mammal when the N-acetylcysteine is administered in combination with tris(hydroxymethyl)aminomethane or a pharmaceutically acceptable salt thereof, in a molar ratio of about 1:0.8 to about l:l.2.
    Type: Grant
    Filed: July 27, 1990
    Date of Patent: January 14, 1992
    Assignee: Zambon Group, S.p.A.
    Inventors: Angelo Carenzi, Dario Chiarino, Antonio Longo
  • Patent number: 5047428
    Abstract: An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: September 10, 1991
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Yoshikuni Itoh, Hiroyuki Mizuno, Chikako Kiyohara, Susumu Sato, Tatsuhiko Katori
  • Patent number: 5013716
    Abstract: The present invention pertains to an unpleasant taste masking composition which comprises a flavoring agent having a bitter taste or unpleasant off-note and a sufficient amount of a non-bitter intense sweetener to nullify the taste or off-note of the flavoring agent. The unpleasant taste masking composition may be used in ingestible products such as hard and soft confections, chewing gum compositions and the like. The present invention also pertains to a method for preparing the unpleasant taste masking compositions and the ingestible products in which they may be used.
    Type: Grant
    Filed: October 28, 1988
    Date of Patent: May 7, 1991
    Assignee: Warner-Lambert Company
    Inventors: Subraman R. Cherukuri, Lucy L. Wong, Steven M. Faust
  • Patent number: 4963533
    Abstract: The present invention relates to a composition containing the compound 2', 3'-dideoxycytidinene which has an antiviral effect against human immunodeficiency virus (HIV) and may therefore be used as a therapeutic agent for the treatment of AIDS and AIDS related diseases.
    Type: Grant
    Filed: October 24, 1986
    Date of Patent: October 16, 1990
    Assignees: Stichting Rega VZW (REGA), The Government of the United States of America
    Inventors: Erik D. A. de Clercq, Piet A. M. M. Herdewijn, Samuel Broder, Jan M. R. Balzarini
  • Patent number: 4927631
    Abstract: A decongestant preparation is disclosed which comprises a set of active components and a petrolatum base wherein the active components consist essentially of menthol, camphor, eucalyptus oil, and spirits of turpentine, wherein the total concentration of the active components is no greater than about 1.0% by weight of the decongestant preparation, and wherein the set of active components consists essentially of in percent by weight from about 15 to about 25 menthol, from about 30 to about 40 camphor, from about 5 to about 10 eucalyptus oil, and from about 30 to about 40 spirits of turpentine, the decongestant being suitable for direct application to the nasal cavity.
    Type: Grant
    Filed: February 16, 1989
    Date of Patent: May 22, 1990
    Inventor: Harry L. Bates
  • Patent number: 4906665
    Abstract: Novel hydroxyalkylcysteine derivatives of the following formula (I) and an expectorant comprising the same are disclosed. ##STR1## wherein n represents an integer of 5 to 24. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.
    Type: Grant
    Filed: June 13, 1989
    Date of Patent: March 6, 1990
    Assignee: SS Pharmaceutical Co., Ltd.
    Inventors: Yoshikuni Itoh, Hiroyuki Mizuno, Chikako Kiyohara, Susumu Sato, Tatsuhiko Katori
  • Patent number: 4885290
    Abstract: Disclosed herein is an immunoregulator comprising a derivative of estradiol represented by the formula (I), which immunoregulator has a small influence to the non-specific immunoreactions in general and gives a specific influence to the immunoreactions against an isoantibody.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: December 5, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kiro Asano, Tadahiro Matsudaira, Humio Tamura, Toichi Suzuki, Hisayuki Wada
  • Patent number: 4812449
    Abstract: Differences in microenvironments associated with various cells and other conditions in this environment are used to advantage in effecting the in situ construction of biologically active agents at target locations in preference to surroundings which are desired to be unaffected.
    Type: Grant
    Filed: October 14, 1987
    Date of Patent: March 14, 1989
    Assignee: Scripps Clinic and Research Foundation
    Inventor: Darryl C. Rideout
  • Patent number: 4737519
    Abstract: The present invention provides certain novel substituted naphthalenes, indoles, benzofurans, and benzothiophenes of Formula I which are useful as inhibitors of leukotriene biosynthesis and as inhibitors of lipoxygenase. They are thus employed wherever it is medically necessary or desirable to inhibit these systems.
    Type: Grant
    Filed: June 25, 1986
    Date of Patent: April 12, 1988
    Assignee: The Upjohn Company
    Inventors: Ayako Yamashita, Herbert G. Johnson
  • Patent number: 4717727
    Abstract: Esters of pyridine-2,4- and -2,5-dicarboxylic acid act as inhibitors of proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants, in particular for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of Cl.sub.q.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: January 5, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volkmar Gunzler, Hartmut Hanauske-Abel, Jurgen Mohr, Georg Tschank, Kari Kivirikko, Kari Majamaa, Dietrich Brocks
  • Patent number: 4707354
    Abstract: There are disclosed sunscreen, protectant, moisturizing dermatological compositions and methods for administration of such compositions to human skin in a manner such that a high degree of epidermal, especially stratum corneum, rehydration is attained in conjunction with nearly complete screening of cancer-causing actinic radiation as well as mechanical skin protection.
    Type: Grant
    Filed: January 21, 1987
    Date of Patent: November 17, 1987
    Assignee: Alpen Tau, Inc.
    Inventors: David Garlen, Hilde R. Koehn, Peter W. Koehn, J. D. McColl