Abstract: The present invention relates to a method for treating psoriasis including: administering a Chinese medicine composition to a subject in need thereof; wherein the Chinese medicine composition is an extract of a first mixture including Pimenta officinalis, Paeonia veitchii, Anastatica hierochuntica, Zingiber officinale, Scutellaria baicalensis, and Ziziphus jujube.

Abstract: Materials with high levels of unsaponifiable matter, such as extracts from plants, produce hydrolysates with unique properties. Properties that are sought in traditional saponification of natural oils are a result of low levels of unsaponifiables. These properties include high levels of aqueous surfactant activity, water-solubility or ready water-dispersability, activity as foaming agents, and the like. An objective of traditional saponification processes is to increase the water-solubility and surfactant activity of naturally occurring materials. It has been found that the application of a hydrolysis process to materials, particularly materials with a high level of unsaponifiables (e.g., at least 6 weight percent of the material), produces a product with properties significantly different from those products resulting from the conventional saponification of materials with less than 6 weight percent of unsaponifiables.

Abstract: Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.

Abstract: A pharmaceutical formulation for treating tinea of feet and hands is disclosed, which is composed of Fructus Gleditsia, Alumen and Borneol. Also disclosed is a cream preparative method of the pharmaceutical formulation, which comprises Fructus Gleditsia is decocted with water, and the decocted liquid is dried under decompression into powder, which is formulated to a cream together with the powders of Alumen and Borneol as well as the respective excipients.

Abstract: The treatment of ungual and subungual diseases is disclosed.

Abstract: We disclose a colorless composition comprising silver particles and water, wherein said particles comprise an interior of elemental silver and an exterior of ionic silver oxide, wherein the silver particles are present in the water at a level of about 5–40 ppm, and wherein the composition manifests significant antimicrobial properties. Methods of use of the composition are described.

Abstract: Therapeutic agents for skin diseases such as atopic dermatitis and athlete's foot can be obtained from naturally occurring raw materials without requiring the use of steroids and their severe adverse effects. The therapeutic agents contain a fermentation solution as the active component. The fermentation solution is obtained by fermenting raw materials including sugar components, water, and pine leaf or pine leaf clusters. The pine leaf cluster may be a fresh pine leaf cluster, from which the short shoot is preliminarily removed and then the fresh pine leaves are cut into a given length.

Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.

Abstract: Solutions and aerosols of metal-containing compounds are disclosed. Methods of preparing and using the solutions and aerosols, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.

Abstract: The anti-itch solution is a solution of hydrogen peroxide, sodium bicarbonate and apple cider vinegar applied to feet to prevent a common fungal infection of feet known as “athlete's foot”.

Abstract: The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and silica.

Abstract: The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol or a pharmaceutically-acceptable ester thereof.

Abstract: Compositions are provided for the topical treatment of cancer consisting of lotions, creams, sprays, suppositories or slow-release transdermal patches containing lipid-soluble, skin-penetrating organic selenium compounds in combination with inert carriers in therapeutically effective amounts of selenium compound. The selenium compounds are medium linear chain dialkyl diselenides and precursors such as alkyl selenols. Preferred compositions employ R—Se—Se—R compounds where R is from 6 to 8 carbon atoms, and most specifically di-n-hexyl diselenide. Commonly used carriers may be purified hydrocarbon fractions, oils, with or without added fat-soluble vitamins, water and emulsifying agents.

Abstract: Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.

Abstract: A topical composition suitable for application to skin comprising an amount of antioxidant action vitamin and vitamin precursor sufficient to bring about an effect selected from the group consisting of a level of vitamin on the skin significantly above the amount of vitamin on normal vitamin untreated skin for a period of treating four hours after application of the said vitamin containing composition, a reduction of lipid peroxide levels brought about by an insult to the skin wherein the skin is treated with the said vitamin containing composition prior to said insult, a level of skin vitamin which is significantly above the level of vitamin on the skin brought about by oral ingestion of the vitamin, or a combination of any of a, b, or c.

Abstract: The present invention provides a dosage form for the treatment of bacterial, viral or fungal conditions which comprises, a pharmaceutically acceptable acidifying agent in an amount sufficient to reduce the pH at an environment of use to below pH4, and a pharmaceutically acceptable source of nitrite ions or a nitrate precursor therefor; wherein said acidifying agent and said source of nitrite ions or nitrate precursor are separately disposed in respective pharmaceutically acceptable carriers for admixture at the intended environment of use to release NO or NO2 ions. The invention also provides delivery systems for the topical medicament.

Abstract: A gel formulation is combined with a bactericidal concentrate which is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 mho with about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The bactericidal liquid concentrate in the amount of 3.5 to 12 ml in one liter of gel formulation is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.

Abstract: A carbon dioxide-containing viscous composition wherein carbon dioxide bubbles are retained in an aqueous viscous composition. Use of the composition makes it possible to treat or ameliorate itching accompanying mucocutaneous diseases or mucocutaneous disorders, mucocutaneous injury, dental diseases, skin ulcer, cryesthesia and numbness caused by peripheral circulatory disorders, musculoskeletal diseases, nervous system diseases, keratosis, constipation, unwanted hair re-growing after depilation, cosmetic troubles in the skin or hair, partial obesity, etc. while exerting little side effects.

Abstract: A composition for use by animals, including humans, to alleviate pain and/or inflammation around a painful joint, joint replacement surgery site, muscle, tendon, and/or ligament. A method to ameliorate pain and/or inflammation in or around a joint, muscle, tendon, and/or ligament, by topically applying Applicant's composition.

Abstract: In accordance with the present invention, there are provided methods for treatment of pathological conditions of the nail, said method comprising topically applying to the affected area an effective amount of a composition comprising an optionally substituted lower alcohol and an optionally substituted lower carboxylic acid. Invention methods effectively treat bacterial or fungal infections of the nail by utilizing a low viscosity composition having the ability to penetrate through and underneath the nail plate, thereby attacking the infection at its source.

Abstract: Novel pharmaceutically/cosmetically-active (poly)thiaalkynoic compounds have the structural formula (I): R1—Y—CH2—C≡C—CH2—S—CH2—R2  (I) and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example inflammation disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.

Abstract: The present invention provides a therapeutic agent for dermatitis, particularly a therapeutic agent for atopic dermatitis, which is very safe and which shows few adverse side-effects in comparison to, for example, steroidal agents. The present invention relates to a therapeutic agent containing a compound represented by the following formula (I) or a pharmaceutically acceptable salt or hydrate thereof as an effective ingredient: wherein R is hydrogen or a halogen. The therapeutic agent for dermatitis according to the present invention effectively and in a dose-dependent manner suppresses antigen-induced swelling in a mouse ear, a recognized animal model for atopic dermatitis, and suppresses the antigen-induced flare-up reaction in mice which occurred with the swelling reaction. In addition, no adverse reaction in the skin are observed.

Abstract: A topically applied composition capable of treating subcutaneous tissue comprising an alkali metal hypohalite (AMH) (preferably, sodium hypochlorite) and a conventional skin lotion. The skin lotion serves both as a carrier and as an antidrying agent for the AMH. The AMH penetrates through the skin's pores and lymph nodes into the subcutaneous tissue. The AMH stimulates the immune system to alleviate, and sometimes cure, inflammation, aches, pains, and other symptoms caused by microbial (e.g., viral, bacterial, fungal and parasitic) infection, arthritis, hemorrhoids, allergies, etc . . .

Abstract: Compositions comprising 4,4′-methylenebis(tetrahydro-1,2,4-thiadiazine) 1,1,1′,1′,-tetraoxide and their use in treating dermatologic disorders are disclosed.

Abstract: The concentrate is a liquid mixture of about 1000 parts by volume of ultra pure water having an electrical resistance of 16-26 megohms, total dissolved solids of less than 0.04 parts per million and a specific conductance of less than 0.10 microhmo to about 1.2 to 3 parts by volume of Willard Water as prepared in accordance with U.S. Pat. No. 3,893,943. The liquid concentrate is applied directly to a skin surface area having a burn or other dermal lesion to protect the area from bacterial contamination.

Abstract: The present invention is directed to methods and compositions for treating skin disorders. The present invention is easily administered and can be used for both humans and animals. The compositions of the present invention comprise borate compounds and provide relief from skin disorder symptoms and lesions. Additionally, the present invention can be used to provide long term maintenance of symptom-free skin.

Abstract: A method of treatment for a mammal in need of analgesia from an itching skin comprising applying by directional friction against the skin proximate to the itch a composition consisting essentially of dry elemental iodine in the form of an amorphous condensate. The method is found effective in producing analgesia to the affected skin within 1 to 5 minutes after application.

Abstract: The invention provides a herbal formulation useful as a therapeutic and cosmetic applications for the treatment of general skin disorders, said composition comprising at least two or more plant extracts in the form of oil or powder or mixtures thereof, the said plants extracts being selected from the group consisting of Gymnena sylvestrae water extract 3 to 6 wt. %; Tridax procumbens water extract 3 to 6 wt. %; its methanolic extract 4 to 6 wt. %, Allium sativum oilhexane extract 1 to 3 wt. %; dried juice of Aloe vera 2 to 6 wt. %; Gum olibanum powder in the natural form 4 to 7 wt. %; Gum olibanum resinoid or its organic extract 3 to 8 wt. %; and resinoid free Gum olibanum meal 5 to 10 wt. %., optionally, including any drug having anti-inflammatory and wound healing property or mixture thereof, the said drug being selected from the group consisting of Disclofenac sodium 1-3 wt. %, Salicyclic acid 1 to 4 wt. %, Piroxicam 1 to 2 wt. %, Turmeric powder 0.1 to 1 wt.

Abstract: Compounds of formula (1) are described: wherein L1 is a covalent bond or a linker atom or group; R is a carboxylic acid (—CO2H) or a derivative threof; R6 and R7 which may be the same or different is each an atom or group —L2(Alk2)tL3R12 in which L2, L3, Alk2 and t are as previously defined and R12 is a hydrogen or halogen atom or an —OR9, —NR9R10, —NO2, —CN, —CO2R9, —CONR9R10, —COR9, —N(R9)COR10, —N(R9)CSR10, —SO2N(R9)(R10), —N(R9)SO2R9, —N(R9)CON(R10)(R11), —N(R9)CSN(R10)(R11), —N(R9)SO2N(R10)(R11), or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group provided that R6 and R7 are not both hydrogen atoms and when R7 is a hydrogen atom then R4 and R5 is each a hydrogen or halogen atom or an alkyl, alkoxy or nitro group; and the salts, solvates, hydrates and N-oxides thereof, for use in modulating cell adhesion.

Abstract: The present invention relates to cosmetic or dermatological compositions capable of being applied to the skin, the keratinous fibers, the nails, the semimucous membranes and/or the mucous membranes, and which includes a dendritic polyester polymer having terminal hydroxyl functional groups or the combination of such a polymer with a film-forming polymer. It also relates to methods of cosmetic or dermatological treatment using these compositions as well as the use of the compositions for the preparation of dermatological or cosmetic compositions.

Abstract: The present invention relates to an antiwrinkle composition that includes, in a physiologically acceptable medium: a dispersion of a film-forming polymeric system containing at least one polymer capable of forming a film permeable to water vapor, having a Young's modulus ranging from 108 to 1010 N/m2 and producing, after application at a concentration of 7% in water and then drying, a retraction of the isolated stratum corneum greater than 1% at a temperature of 30° C. and a relative humidity of 40%, and a dendritic polyester polymer having terminal hydroxyl functional groups.

Abstract: The invention concerns fatty acids uninterrupted by a methylene group as anti-inflammatory agents in superficial tissues of mammals, more particularly a pharmaceutical or cosmetic topical composition comprising, as an active ingredient, at least one fatty acid uninterrupted by a methylene group corresponding to formula (I), an salt or ester thereof, wherein R1 is a C1-C5 alkyl group and R2 is a C2-C6 alkyl group. Preferably, the fatty acid uninterrupted by a methylene group is 20:3(5,11,14). The fatty acid uninterrupted by a methylene group is also used for preparing a composition for modulating the metabolism of lipids in the superficial tissue of mammals.

Abstract: Novel compositions containing at least one biologically active component derived from peat or similar composition, methods for their preparation and therapeutic uses for a variety of diseases, injuries, and conditions, including wound healing, pain, itch, inflammation, abnormal cell proliferation, or infections caused by fungal, bacterial, rickettsial or viral agents, psoriasis, allergic and other dermatitis, pruritis, eczema, actinic keratosis and similar conditions. In addition, the compositions can be used as diuretics, antiarrhythmics, and cardiac-stimulating agents, as well as for the treatment of mammalian diseases and disorders, including multiple drug resistance, cancers, asthma, rheumatoid arthritis, pain, wound healing, fungal disorders, and other inflammatory disorders. The compositions are derivable from peat or peat-related substances and may alternatively be synthetically produced.

Abstract: The present invention relates to a novel herbal composition having antimycotic activity effective against tinea infections, comprising plant substances as main ingredients, and method of treating a patient having a tinea infection. More particularly, the present invention relates to an antimycotic composition effective against tinea infections utilizing natural substances obtained from a combination of Angelicae Pubescentis Radix, Notopterygium Radix and Haliotis Diversicolor Reeve, and in some embodiments further comprising Pheretima Aspergillum (Perrier).

Abstract: The invention provides a herbal formulation useful as a therapeutic and cosmetic applications for the treatment of general skin disorders, the composition comprising at least two or more plant extracts in the form of oil or powder or mixtures thereof, the plant extracts being selected from the group consisting of Gymnena sylvestrae water extract 3 to 6 wt. %; Tridax procumbens water extract 3 to 6 wt. %; its methanolic extract 4 to 6 wt. %, Allium sativum oil hexane extract 1 to 3 wt. %; dried juice of Aloe vera 2 to 6 wt. %; Gum Olibanum powder in the natural form 4 to 7 wt. %; Gum Olibanum resinoid organic solvent extract 3 to 8 wt. %; and resinoid free Gum Olibanum meal 5 to 10 wt. %., optionally, including any drug having anti-inflammatory and wound healing property or mixture thereof, the drug being selected from the group consisting of Disclofenac sodium 1-3 wt. %, Salicyclic acid 1 to 4 wt. %, Piroxicam 1 to 2 wt. %, Turmeric powder 0.1 to 1 wt.

Abstract: The invention relates to the use of a) a compound or several compounds from the group consisting of flavonoids, or b) an active compound combination comprising a compound or several compounds chosen from the group consisting of flavonoids, in combination with a compound or several compounds chosen from the group consisting of cinnamic acid derivatives, and if appropriate additionally in each case a compound or several compounds from one of the groups or several of the groups c) of the antioxidants or d) of the endogenous energy metabolism metabolites or e) of the endogenous enzymatic antioxidant systems and synthetic derivatives thereof (mimics) or f) of the antimicrobial action systems or g) of the antiviral action systems or h) active compounds of the known, conventional treatment forms in each case for the treatment or prophylactic treatment of hyperreactive skin predisposed to dermatitis or deficient, hypoactive skin or dermatoses.

Abstract: A method of treating fungal diseases as well as pharmaceutical, veterinary and agricultural compositions useful in such treatment. The method includes administering an effective antifungal amount of a compound of the formula (I): ##STR1## wherein S is a spacer selected from a nitrogen, an oxygen, an alkyl, an alkenyl, an alcohol, an ester, a polyester, an amino acid, a carbohydrate, or a nitrogen-containing positively charged group;L is a ligand selected from a hydrogen, a hydroxyl residue, an alkyl residue, an alkenyl residue, a benzyl residue, an alcohol residue, an ester residue, a polyester residue, an alkyl acid residue, a carbohydrate, a steroid, a lipid, an organic polymer, a nitrogen-containing positively charged group or a vitamin;R.sub.1 and R.sub.3 are halogen or hydroxyl; andR.sub.2 is hydrogen or alkyl.

Abstract: A new class of general antiinfective agents extracted from pepper, ginger, and other plant species containing vanillyl and piperidine ring structures typical of the pungent principal found in pepper and ginger. The role of these structures, their attached hydrocarbons groups, and other agents found with the plant extract is demonstrated in the topical treatment of dermatophyte infections, tissue injuries, and abnormal proliferations of keratin.

Abstract: Entirely anhydrous topical preparations comprising (I) propylene carbonate, (II) one or more short carbon-chain alcohols and/or glycols including ethanol, isopropyl alcohol, propylene glycol, butylene glycol, polyethylene glycol, hexylene glycol, methoxypolyethylene glycol, and (III) either or both of glycerol and one or more therapeutically or cosmetically active ingredients.

Abstract: Disclosed is a composition comprising a water based nail lacquer and urea, which is useful in the partial or complete evulsion of the nails, and in the treatment of fungal, yeast and bacterial infections of the nails and the nail beds. Also disclosed are methods for evulsing nails, and for treating antifungal and antibacterial infections, comprising the administration of the composition of the invention to the toenails or fingernails of a mammal.

Abstract: Tannic acid solution either alone or in conjunction with zinc oxide provides a treatment for fungal infections of the skin and nails.

Abstract: The invention relates to the use ofa) a compound or several compounds from the group consisting of flavonoidsb) of the antioxidants orc) of the endogenous energy metabolism metabolites ord) of the endogenous enzymatic antioxidant systems and synthetic derivatives thereof (mimics) ore) of the antimicrobial action systems orf) of the antiviral action systems org) active compounds of the known, conventional treatment formsin each case for the treatment or prophylactic treatment of hyperreactive skin predisposed to dermatitis or deficient, hypoactive skin or dermatoses.

Abstract: A topical composition comprising soy molasses extract containing soy phytochemicals, useful in the treatment and amelioration of dermatologic disorders and for cosmetic purposes when applied topically.

Abstract: The invention concerns topical formulations such as nail varnishes comprising as the active agent the compound of formula I ##STR1## in free base form or in acid addition salt form, together with a polymeric film former and further excipients as appropriate. It also concerns a process of preparation of such preparations by mixing with an appropriate polymeric film former and conventional further excipients as appropriate, and a method of treatment of onychomycosis.

Abstract: Compositions and processes for the prophylaxis and therapeutic treatment of wounds, chronic non-healing wounds, burns, disease and other dermal disorders are disclosed. The compositions of the present invention comprise aqueous solutions of a metal chlorite having a concentration of from about 0.002% to about 0.5% by weight of metal chlorite. The process of the present invention comprises treating the dermal disorder with an aqueous solution of from about 0.002% to about 0.5% by weight of a metal chlorite. Wounds, chronic non-healing wounds, burns and other dermal disorders treated in this manner heal more quickly and with reduced scar formation. The antiseptic compositions and processes of the present invention exhibit anticollagenous activity such that the characteristics of the healed skin, such as elasticity and tensile strength, are similar to undamaged skin.

Abstract: Apparatus and methods for treating feet infected with fungi are disclosed. In one embodiment, such an apparatus includes a container adapted to hold a quantity of liquid aqueous medium and sized so that only a portion of an adult human body can be placed therein; an ozone generator sized and adapted to produce sufficient ozone to effectively ozonate the liquid aqueous medium in the container; and a transfer assembly cooperating with the container and said ozone generator to pass ozone produced by the ozone generator to the liquid aqueous medium in the container.

Abstract: The hydrophilic penetration agents customarily used for the transcutaneous penetration of active ingredients are, surprisingly, found to improve the penetration of antifungal agents through the nails. A corresponding dermatological composition contains at least one antifungal agent chosen, in particular, from among those of the allylamine family, such as terbinafine-HCl and naftifine-HCl; at least one hydrophilic penetration agent chosen, in particular, from among the glycols, glycol monoethers, glycol diethers, dimethylsulphoxide, caprolactam, dimethylisosorbide, isopropylidene glycerol, dimethylimidazolidinone, ethyl lactate, the polyoxyethylenated C.sub.8 -C.sub.10 glycerides, polyethylene glycol 20 glyceryl laurate and dimethylacetamide; and a water-alcohol solvent medium which dissolves the said antifungal agent(s) and in which the said penetration agent(s) is (or are) at least partially miscible.

Abstract: Vitamin B12 is used to stimulate heme oxygenase production. In turn, levels of the molecules 12(R)-HETE and 12(R)-DIHETE, which are arachidonic acid derivatives, are reduced. Various topical formulations containing vitamin B12, but no other vitamins, are described.

Abstract: The invention provides a method for treating fungal dermatitis comprising administering an effective amount of 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno?2,3-b!?1,5!benzodiazepine to a patient in need thereof.

Abstract: A nail oil composition is disclosed consisting essentially of a cosmetic oil containing at least 5% by weight jojoba oil, said cosmetic oil having at least 1% by weight tolnaftate dissolved therein. This composition is effective for treating and preventing fungal infestations in fingernails, particularly sculptured nails.