Hodgkin's Disease Patents (Class 514/883)
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Patent number: 8945528Abstract: This invention relates to a use of IL-22 in the treatment of viral hepatitis. As illustrated in the examples of this invention, IL-22 can significantly reduce liver damage caused by hepatitis virus, and can significantly reduce the increase of transaminase ALT/AST induced by hepatitis virus. In addition, the IL-22 dimer of this invention can effectively treat viral hepatitis.Type: GrantFiled: August 30, 2011Date of Patent: February 3, 2015Assignee: Generon (Shanghai) Corporation Ltd.Inventors: Xiaoqiang Yan, Zhihua Huang, Hongzhou Yang, Yuliang Huang
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Patent number: 8367113Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: GrantFiled: May 15, 2007Date of Patent: February 5, 2013Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Benjamin A. Teply, Robert S. Langer, Omid C. Farokhzad
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Patent number: 8323698Abstract: The present invention generally relates to polymers and macromolecules, in particular, to block polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. The moiety, in some embodiments, may have a molecular weight greater than about 1000 Da; for example, the moiety may include a polypeptide or a polynucleotide, such as an aptamer. The moiety may also be a targeting moiety, an imaging moiety, a chelating moiety, a charged moiety, or a therapeutic moiety.Type: GrantFiled: September 1, 2010Date of Patent: December 4, 2012Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Frank X. Gu, Omid C. Farokhzad, Robert S. Langer, Benjamin A. Teply
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Patent number: 7935343Abstract: Specific binding members, in particular human anti-IL-13 antibody molecules and especially those which neutralize IL-13 activity. Methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related disorders, including asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and Hodgkin's lymphoma.Type: GrantFiled: July 15, 2004Date of Patent: May 3, 2011Assignee: MedImmune LimitedInventors: Phillip David Monk, Lutz Ulrich Jochen Jermutus, Ralph Raymond Minter, Celia Patricia Shorrock
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Patent number: 6958359Abstract: Vanadium compounds for inhibiting angiogenesis useful for treating or preventing diabetic retinopathy, hemangiomas, cancers with abnormal blood vessel supply, restenosis following vascular injury, and the like.Type: GrantFiled: November 15, 2000Date of Patent: October 25, 2005Assignee: Parker Hughes InstituteInventor: Fatih M. Uckun
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Patent number: 6878388Abstract: Vanadium compounds useful to prevent and/or inhibit adhesion, migration, and invasion of proliferative cells into surrounding tissue.Type: GrantFiled: November 15, 2000Date of Patent: April 12, 2005Assignee: Parker Hughes InstituteInventors: Fatih M Uckun, Rama Krishna Narla
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Patent number: 6774131Abstract: A pharmaceutical composition for therapeutically treating prostate cancer, the pharmaceutical composition containing N-[6-methoxy-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyri midinyl]-2-phenylethenesulfoneamide or a pharmaceutically acceptable salt thereof as the effective component.Type: GrantFiled: July 19, 2002Date of Patent: August 10, 2004Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hironori Yuyama, Akira Fujimori, Masanao Sanagi, Hironori Harada, Akiko Koakutsu, Mikiko Mori, Nobuyuki Yamamoto
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Patent number: 6642221Abstract: Vanadium compounds as anti-proliferative agents. These compounds act to disrupt mitotic and meiotic spindle formation and thus are useful to prevent cell mitosis (proliferation) and meiosis.Type: GrantFiled: November 15, 2000Date of Patent: November 4, 2003Assignee: Parker Hughes InstituteInventors: Faith M Uckun, Christopher S Navara
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Patent number: 6060505Abstract: Disclosed are modified bryostatins and their use as anticancer drugs.Type: GrantFiled: February 16, 1999Date of Patent: May 9, 2000Assignees: The United States of America as represented by the Department of Health and Human Services, Arizona Board of Regents of Arizona State UniversityInventors: Peter M. Blumberg, Zoltan Szallasi, George R. Pettit
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Patent number: 5958966Abstract: Biomodulators, which regulate cellular differentiation and proliferation, as well as methods of use thereof, e.g., for treating various conditions, e.g., cancer, senescence, immunological disorders and vascular disease; for stimulating normal tissue architecture after injury; for vaccination; for stimulating the production of biologically important molecules by cells or organs in culture; for maintaining organs or tissues outside of a body after removal from the body and prior to transplantation; and for producing of vascular grafts for transplantation; are provided.Type: GrantFiled: June 5, 1995Date of Patent: September 28, 1999Assignee: University of New MexicoInventors: Paul L. Mann, Eugene Mash, Terence J. Scallen
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Patent number: 5821236Abstract: 6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.Type: GrantFiled: May 24, 1995Date of Patent: October 13, 1998Assignee: Glaxo Wellcome Inc.Inventors: Thomas Anthony Krenitsky, Devron Randolph Averett, George Walter Koszalka
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Patent number: 5773425Abstract: Methods for the treatment of sarcoma, carcinoma and lymphoma in an animal by administering to the animal an effective amount of a polymeric acetylated mannan derivative.Type: GrantFiled: June 5, 1995Date of Patent: June 30, 1998Assignee: Carrington Laboratories, Inc.Inventors: Bill H. McAnalley, Robert H. Carpenter, Harley R. McDaniel
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Patent number: 5753203Abstract: There is disclosed a polypeptide (CD30-L) and DNA sequences, vectors and transformed host cells useful in providing CD30-L polypeptides. The CD30-L polypeptide binds to the receptor known as CD30, which is expressed on a number of cell types, among which are Hodgkin's Disease tumor cells, large cell anaplastic lymphoma cells, adult T-cell leukemia (T-ALL) cells, and a number of other malignant cell types. CD30-L polypeptides and oligomers find use as carriers for delivering diagnostic and cytotoxic agents to cells expressing the CD30 receptor.Type: GrantFiled: December 20, 1995Date of Patent: May 19, 1998Assignee: Immunex CorporationInventors: Raymond G. Goodwin, Craig A. Smith, Richard J. Armitage, Hans-Juergen Gruss
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Patent number: 5747502Abstract: The present invention relates to benzo?c!phenanthridinium derivative of the general formula A: ##STR1## wherein M and N individually represent a hydroxyl or lower alkoxy group, or M and N simultaneously represent a hydrogen atom or together form a methylenedioxy group, X.sup.- represents an acid residue or a hydrogen acid residue, and R represents a lower alkyl group, and a process for preparing such derivatives. The compounds exhibit both potent antitumor activity and platelet aggregation inhibition activity, and are expected to be useful for the treatment of tumors. The process has good reproducibility and may be effected under moderate conditions, and therefore the process is practically useful. In addition, hydrogen salts of the present compounds have an enhanced stability, which is an advantage in formulating the same into pharmaceutical preparations.Type: GrantFiled: March 16, 1992Date of Patent: May 5, 1998Assignee: Nippon Kayaku Kabushiki KaishaInventors: Miyoji Hanaoka, Hisao Ekimoto, Fumiko Kobayashi, Yukio Irie, Katsutoshi Takahashi, Masanobu Suzuki, Takeshi Nakanishi, Osamu Kogawa, Keizou Ishikawa
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Patent number: 5747472Abstract: 6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumour therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.Type: GrantFiled: May 31, 1995Date of Patent: May 5, 1998Assignee: Glaxo Wellcome Inc.Inventors: Thomas Anthony Krenitsky, Devron Randolph Averett, George Walter Koszalka, Gerald Wolberg
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Patent number: 5736579Abstract: A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: November 18, 1994Date of Patent: April 7, 1998Assignee: G.D. Searle & Co.Inventors: David B. Reitz, Robert E. Manning, Horng-Chi Huang, Jinglin Li
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Patent number: 5567720Abstract: Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10.sup.-5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis.Type: GrantFiled: June 27, 1994Date of Patent: October 22, 1996Assignee: DMS Pharmaceutical Inc.Inventor: Paul Averback
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Patent number: 5514661Abstract: Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) ##STR1## wherein R.sup.1 is H or .alpha.-L-rhamnopyranosyl;R.sup.2 is H or --CH(R.sup.4)--CH.sub.2 --COOH;R.sup.3 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl andR.sup.4 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl; are provided.Type: GrantFiled: August 28, 1995Date of Patent: May 7, 1996Inventors: Goran Piljac, Visnja Piljac
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Patent number: 5468499Abstract: The present invention provides an anti cancer treatment which has an improved stability and does not produce acrolein. The invention includes dichlorodiethyl phosphoramide drugs including, for example, the cyclohexylamine salt phosphoramide mustard and isophosphoramide mustard and mixtures thereof, which have been entrapped by liposomes. Preferably the liposomes contain sphingomyelin and cholesterol.Type: GrantFiled: November 15, 1993Date of Patent: November 21, 1995Assignee: Ohio State UniversityInventors: Kenneth K. Chan, Aeumporn Srigritsanapol
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Patent number: 5466675Abstract: Methods for treating various autoimmune diseases and for providing immunorestoration, by administering, to a subject in need thereof, an effective amount of a composition having, as active ingredient, one or more rhamnolipids of formula (I) ##STR1## wherein R.sup.1 is H or .alpha.-L-rhamnopyranosyl;R.sup.2 is H or --CH(R.sup.4)--CH.sub.2 --COOH;R.sup.3 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl andR.sup.4 is (C.sub.5 -C.sub.20)-saturated, mono or polyunsaturated hydrocarbyl;are provided.Type: GrantFiled: July 20, 1994Date of Patent: November 14, 1995Inventors: Goran Piljac, Visnja Piljac
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Patent number: 5415855Abstract: Modified ceramides are defined, together with their synthesis and compositions comprising them for topical application to human skin, hair and nails. The modified pseudoceramides have a structure: ##STR1## and an approximate summary is that R and R.sup.1 are aliphatic hydrocarbon, A is CH.sub.2, CHOR.sup.2, CH.dbd.CH or CHOY, and at least one of R.sup.2, R.sup.3 and R.sup.4 is sulphate, phosphate or similar. The presence of phosphate or sulphate facilitates skin absorption, after which the phosphate or sulphate is removed by enzymes present in vivo.Type: GrantFiled: June 22, 1993Date of Patent: May 16, 1995Assignee: Elizabeth Arden Co., Division of Conopco, Inc.Inventors: Peter Critchley, Susan E. Kirsch, Anthony V. Rawlings, Ian R. Scott
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Patent number: 5393790Abstract: A class of substituted spiro compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula III: ##STR1## wherein n is a number selected from 0, 1 and 2; wherein R.sup.3 is methylsulfonyl or sulfamyl; and wherein R.sup.8 is selected from hydrido, fluoro, chloro, bromo, iodo, methyl, ethyl, n-propyl, isopropyl, butyl, tert-butyl, isobutyl, methoxy, ethoxy, propoxy, butoxy, hydroxyl, mercapto, methylthio, ethylthio, cyano, fluoromethyl, difluoromethyl, trifluoromethyl, chloromethyl, dichloromethyl, trichloromethyl, pentafluoroethyl, heptafluoropropyl, difluorochloromethyl, dichlorofluoromethyl, difluoroethyl, difluoropropyl, dichloroethyl, dichloropropyl, trifluoromethoxy, hydroxymethyl, methoxymethyl and ethoxymethyl; or a pharmaceutically-acceptable salt thereof.Type: GrantFiled: February 10, 1994Date of Patent: February 28, 1995Assignee: G.D. Searle & Co.Inventors: David B. Reitz, Robert E. Manning, Horng-Chi Huang, Jinglin Li
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Patent number: 5112869Abstract: This invention concerns compounds having the structure: ##STR1## wherein each of R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.2', R.sup.3', R.sup.4', and R.sup.5', is independently hydrogen (--H), or a hydroxyl (--OH), methoxy (--OMe), methyl (--Me), carboxaldehyde (--CHO) or phenylformazen (Ph--N.dbd.CH--) group.This invention also provides a novel process of synthesizing the compounds of the subject invention, including intermediate compounds useful in the process.The present invention also provides pharmaceutical compositions comprising a pharmaceutically effective amount of a compound according to the subject invention and a pharmaceutically acceptable carrier. Finally, the invention provides spermicidal methods and methods of killing or of retarding the proliferation of, cancer cells.Type: GrantFiled: April 4, 1989Date of Patent: May 12, 1992Assignee: Sloan-Kettering Institute For Cancer ResearchInventors: Kyoichi A. Watanabe, Tsann-Long Su, Jai-Tung Huang
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Patent number: 4965352Abstract: The invention relates to new anthracycline derivatives having cytostatic activity and the general formula I ##STR1## wherein R.sup.1 is a CH.sub.3 (CH.sub.2).sub.n group with n=0 to 3,R.sup.2 is a hydrogen atom or a methyl group,R.sup.3 is a hydrogen atom, a methyl group or an acyl protective group, andR.sup.4 is a hydrogen atom or an acyl protective group,and which are optionally in the form of a salt of an inorganic or organic acid, to a process for their preparation and to their use in pharmaceuticals.Type: GrantFiled: June 12, 1989Date of Patent: October 23, 1990Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Michael Paal, Peter Hermentin, Hans P. Kraemer
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Patent number: 4952408Abstract: A composition made up of a liposome-encapsulated vinca alkaloid is disclosed. This composition possesses an increased antitumor activity and a substantially lower toxicity as compared to free drug.Type: GrantFiled: May 23, 1988Date of Patent: August 28, 1990Assignee: Georgetown UniversityInventor: Aquilur Rahman